KR20230072389A - Blood glucose measurement device using near-infrared spectroscopy and blood glucose measurement method using the same - Google Patents

Abstract

Disclosed are a blood glucose measurement device using a near-infrared spectroscopy and a blood glucose measurement method using the same. The disclosed blood glucose measurement device comprises: a body unit provided with a measuring tool on which the end of a finger is placed to enable non-invasive blood glucose measurement through the finger; a light source unit provided on the body unit and emitting near-infrared light to the end of the finger placed on the measuring tool; a light detection unit provided in the body unit, receiving the near-infrared light emitted from the light source unit and reflected from the end of the finger, and obtaining spectrum data by spectralizing the received light; a control unit provided on the body unit, comprising a data calculation unit for calculating the blood glucose level of a subject based on the obtained spectrum data, and outputting the blood glucose level calculated through the data calculation unit to a display unit; and a darkening channel unit which extends from the measuring tool and blocks external light transmitted to the measuring tool by inserting the finger so as to create a dark state around the end of the finger. According to the present invention, measurement reliability can be improved.

Description

Blood glucose measurement device using near-infrared spectroscopy and blood glucose measurement method using the same}

The present invention relates to a blood glucose measurement device using near-infrared spectroscopy and a blood glucose measurement method using the same, and more particularly, to a blood glucose measurement method using the same, which is compact and portable, and allows blood glucose measurement using a simple finger, and which is measured by inflow of external light. The present invention relates to a blood glucose measurement device using near-infrared spectroscopy capable of improving measurement precision and reliability by providing a measurement environment in a dark state to prevent errors, and a blood glucose measurement method using the same.

BACKGROUND OF THE INVENTION With the development of medicine and the extension of life expectancy, interest in health care is increasing. In this regard, interest in medical devices is also increasing. This is expanding its scope to not only various medical devices used in hospitals or inspection institutions, but also small and medium-sized medical devices provided in public institutions, etc., small-sized medical devices and health care devices that can be owned or carried by individuals.

Invasive measurement methods are often used in medical devices or medical examinations. An invasive measurement method for a subject may be performed, for example, by collecting the subject's blood and performing measurement and analysis on the collected blood. However, in this invasive measurement method, the subject suffers pain during blood collection, causes external infection to the subject, and requires additional disinfection after blood collection. However, there are inconveniences such as the need to use colorimetric assays and optical equipment.

In order to solve this problem, many developments have recently been made regarding non-invasive measurement technology of blood sugar. Although various optical technologies such as Raman spectroscopy, spectroscopy, infrared spectroscopy, and photo-acoustic spectroscopy are applied to these existing technologies, measurement errors are severe, resulting in the accuracy of measured blood glucose levels. However, reliability is not satisfactory, and due to this, actual productization is not being achieved.

Registered Patent No. 10-0883153 Patent Publication No. 10-2002-0055364 Patent Publication No. 10-2016-0028229 Publication No. 10-2016-0140133

The present invention has been devised to solve the above conventional problems, and non-invasive blood glucose measurement without blood sampling using near-infrared spectroscopy is possible, while being compact and portable, and blocking external light to provide a measurement environment in a dark state. An object of the present invention is to provide a blood glucose measurement device using near-infrared spectroscopy and a blood glucose measurement method using the same, which can reduce measurement errors and improve the reliability of measurement values by providing the same.

However, the object of the present invention is not limited thereto, and even if not explicitly mentioned, the purpose or effect that can be grasped from the solution or embodiment of the problem is also included therein, of course.

In order to achieve the above object, a blood glucose measuring device using a near-infrared spectroscopy method according to the present invention includes a main body having a measuring sphere on which a tip of a finger is raised so as to measure blood sugar non-invasively through a finger; a light source unit provided in the main body and radiating near-infrared light to an end of a finger placed on the measuring sphere; a photodetector provided in the main body, receiving spectrum data by receiving near-infrared light irradiated from the light source unit and reflected from a fingertip; a control unit provided in the main body, comprising a data calculation unit configured to calculate a blood sugar level of the subject based on the obtained spectrum data, and outputting the blood sugar level calculated through the data calculation unit to a display unit; It is characterized in that it includes; a dark precursor composition channel part extending from the measurement sphere and creating a dark state around the end of the finger by inserting a finger and blocking external light transmitted to the measurement sphere.

A light blocking member configured along the inner surface of the rear end of the dark precursor composition channel unit, inflated by air supply, and in close contact with a finger when inflated to block the inflow of external light through the space between the dark precursor composition channel unit and the finger. can be configured to

an air supply unit formed in the main body and including an air supply source for supplying air to the light blocking member, and an air supply passage connecting the air supply source and the light blocking member to supply air; It may be configured to further include.

The length of the dark precursor composition channel part may be configured to be longer than at least the length from the distal end of the finger placed on the measurement sphere to the first joint of the finger.

The cancer precursor composition channel is configured to be adjustable in length, and the cancer precursor composition channel includes a tubular fixed channel having an end fixed to the main body so as to surround the measurement unit; It may be configured to include; a length-variable channel into which a rear end of the fixed channel is inserted and capable of sliding along the fixed channel so that the length can be adjusted.

The control unit proceeds with first near-infrared light irradiation to the fingertip through the light source unit, and performs primary measurement to acquire first spectrum data through the detection unit, and second-order near-infrared light to the fingertip through the light source unit. Investigation is performed and secondary measurement is performed to obtain secondary spectrum data through the detection unit, and the data operation unit is configured to calculate the blood sugar level of the subject based on the primary spectrum data and the secondary spectrum data. It can be.

The data calculation unit extracts first input data from the first spectrum data, extracts second input data from the second spectrum data, and performs an F-test on the extracted first and second input data. The p-value value is calculated through, and the blood sugar level is calculated through the blood sugar calculation formula based on the first input data, the second input data, and the calculated p-value value, and the blood sugar calculation formula is “blood sugar level = (( The average value of the second input data - the average value of the first input data) * p-value value) / 2 ".

In addition, the blood glucose measuring method using the blood glucose measuring device of the present invention includes a main body having a measuring ball on which the tip of a finger is raised, a light source for irradiating light, and receiving near-infrared light emitted from the light source and reflected from the finger tip. , a control unit composed of a photodetector for obtaining spectral data by splitting the received light and a data calculation unit for calculating the blood sugar level of the subject based on the obtained spectral data, and formed extending from the measuring sphere, by inserting a finger In the blood glucose measurement method using a blood glucose measuring device comprising a dark precursor composition channel portion to create a dark state around the fingertip by blocking external light transmitted to the measurement sphere, insert a finger into the dark precursor composition channel portion and A dark precursor composition and measurement preparation step in which the environment around the fingertip is placed in a dark state while waiting for blood glucose measurement through the finger by placing it on the measurement sphere, and irradiating near-infrared light to the fingertip located on the measurement sphere, and the fingertip It is characterized in that it includes; a spectrum acquisition step of acquiring a spectrum by receiving and splitting the reflected light, and a blood sugar calculation step of calculating a blood sugar level based on the obtained spectrum.

The darkening composition and measurement preparation step may further include an additional light blocking step of blocking the inflow of external light through the space between the darkening composition channel and the finger by filling a light blocking member between the darkening composition channel and the finger. can be configured.

In the spectrum acquisition step, primary measurement is performed by performing primary near-infrared light irradiation on the fingertip through the light source unit to obtain primary spectrum data through the detector, and secondary measurement is performed on the fingertip through the light source unit. It is configured to proceed with near-infrared light irradiation and sequentially and continuously perform secondary measurement so that secondary spectrum data is obtained through the detector, and in the blood sugar calculation step, the data operation unit calculates the primary spectrum data and the secondary spectrum data. It may be configured to calculate the blood sugar level of the subject based on the data.

In the blood glucose calculation step, the data calculation unit extracts first input data from the first spectrum data, extracts second input data from the second spectrum data, and extracts the first input data and the second input data. A p-value value is calculated through an F-test for , and a blood sugar level is calculated through a blood sugar calculation formula based on the first input data, the second input data, and the calculated p-value value, and the blood sugar calculation formula is, "Glucose level = ((average value of the second input data - average value of the first input data) * p-value value) / 2 ".

According to the above, the blood glucose measuring device of the present invention is non-invasive, compact, and portable, and simple and convenient measurement is possible through the tip of a finger, so convenience is improved. By providing the surroundings of the fingertips as a measurement environment in a dark state, signal distortion due to external light does not occur, so blood glucose level measurement by NIR spectroscopy is very precise and error-free, and measurement reliability can be improved.

In addition, the present invention proceeds with the first spectrum acquisition and the second spectrum acquisition through the finger, and calculates the blood sugar level by applying a newly developed calculation algorithm based on the acquired first and second spectrum data, thereby reducing blood sampling. Even compared to invasive blood glucose measurement through a blood glucose measurement system, the reliability is not lowered at all to almost the same level, and there is an effect of showing precision with almost no error, and through this, there is an effect of achieving actual commercialization of a non-invasive portable blood glucose measurement device.

In addition, the various beneficial advantages and effects of the present invention are not limited to the above description, and will be more easily understood in the process of describing specific embodiments of the present invention.

1 is a diagram showing a blood glucose measurement device using near-infrared spectroscopy according to an embodiment of the present invention;
FIG. 2 is a view showing some processes of a blood glucose measurement method using the blood glucose measurement device of FIG. 1;
3 is a control block diagram of a blood glucose measurement device according to an embodiment of the present invention;
4 is a block diagram showing a blood glucose measurement method using a blood glucose measurement device according to an embodiment of the present invention;
FIG. 5 is a view showing another form of the dark precursor composition channel in FIG. 1;
6 is a block diagram showing a blood glucose measurement method using a blood glucose measurement device according to another embodiment of the present invention;
7 is a block diagram for explaining the preprocessing step of FIG. 6;
8 is a block diagram for explaining the correction data generating step of FIG. 6 .

The above objects, other objects, features and advantages of the present invention will be easily understood through the following preferred embodiments in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosed content will be thorough and complete and the spirit of the present invention will be sufficiently conveyed to those skilled in the art.

In this specification, when an element is referred to as being on another element, it means that it may be directly formed on the other element or a third element may be interposed therebetween. Also, in the drawings, the thickness of components is exaggerated for effective description of technical content.

Although terms such as first and second are used to describe various components in various embodiments of the present specification, these components should not be limited by these terms. These terms are only used to distinguish one component from another. Embodiments described and illustrated herein also include complementary embodiments thereof.

Terms used in this specification are for describing embodiments, and are not intended to limit the present invention. In this specification, singular forms also include plural forms unless specifically stated otherwise in a phrase. The terms 'comprises' and/or 'comprising' used in the specification do not exclude the presence or addition of one or more other elements.

In describing the specific embodiments below, various specific contents are prepared to more specifically describe the invention and aid understanding. However, a reader having knowledge in this field to the extent of being able to understand the present invention can recognize that it can be used without these various specific details. In some cases, it is mentioned in advance that parts that are commonly known in describing the invention and are not greatly related to the invention are not described in order to prevent confusion for no particular reason in explaining the present invention.

Hereinafter, referring to FIGS. 1 to 4 , a blood glucose measurement device using near-infrared spectroscopy and a blood glucose measurement method using the device according to an embodiment of the present invention will be described.

The blood glucose measurement device 10 using the near-infrared spectroscopy of the present invention includes a body portion 101 equipped with a measuring ball 103 on which the tip of a finger is raised so that blood glucose measurement is non-invasive through a finger, and a body portion 101. It consists of a light source unit 110 configured to irradiate near-infrared light to the fingertips placed on the measurement sphere 103, and a body portion configured to receive the light emitted from the light source unit 110 and reflected from the fingertips to obtain spectrum data. A control unit including a photodetector 130 that controls the light source unit 110 and the photodetector 130 and a data calculation unit 142 that calculates a blood sugar level based on the spectral data obtained by the photodetector 130 ( 140), and a dark precursor composition channel unit 105 extending from the measurement sphere 103 on the body portion 101 and inserting a finger to block transmission of external light to the measurement sphere to create a dark side state around the fingertip. It is configured to include.

The measurement sphere 103 is formed in a groove shape on the upper surface of one side of the main body 101, and both sides of the bottom surface are configured to form inclined surfaces 103a on both sides facing each other at a predetermined angle.

The light source unit 110 is composed of an LED light emitting diode, and is configured on one inclined surface of both inclined surfaces 103a to irradiate near-infrared light in a wavelength range of 780 nm to 2500 nm to the tip of the finger placed on the measurement sphere 103.

The light detector 130 is configured to receive light emitted from the light source 110 to the fingertip and reflected, and obtain spectrum data by splitting the received light.

The light detection unit 130 may include a splitter 120 for splitting received light, and the splitter 120 may be formed of a diffraction grating or a prism.

The light reflected from the fingertip is mixed with various wavelengths, and the spectrometer 120 diffracts the mixed light for each wavelength to perform monochromatic (separation) spectroscopy, and is configured to enter the photodetector 130. .

The photodetector 130 is configured to receive the light split by the spectrometer 120 and obtain spectrum data for each wavelength from the received light. Here, the spectrum data may consist of light intensity (light intensity) for each wavelength.

The photodetector 130 receives the light of each wavelength divided by the spectrometer 120, performs photoelectric conversion, converts the photoelectrically converted analog signal into a digital signal to generate spectrum data, and transmits the spectrum data to the controller 140. configured to transmit.

In the present invention, the spectroscopic unit 120 is configured to split the LED light reflected from the fingertip into 2496 wavelength-specific LED lights between 400 nm and 1057 nm wavelength range, and the photodetector 130 is configured to split the LED light reflected from the fingertip between 400 nm and 1057 nm wavelength range It may be configured to obtain 2496 spectrum data by receiving light for each 2496 wavelengths.

The control unit 140 is configured to include a data operation unit 142, and the data operation unit 142 receives the spectrum data obtained from the photodetector 130 and calculates a blood sugar level based on this, and the calculated blood sugar level is A screen may be displayed on the display unit 145 configured in the body unit 101, or, although not shown, a speaker may be configured in the body unit 101 so that the calculated blood sugar level may be output as audio.

In the present invention, the control unit 140 controls the light source unit 110 and the spectrometer 130 to sequentially perform first and second near-infrared light irradiation on the tip of the finger placed on the measurement sphere 103, The first measurement in which the first spectrum data is acquired and the second measurement in which the second spectrum data is acquired may be continuously performed.

That is, the controller 140 primarily irradiates near-infrared light from the light source unit 110 to the tip of the finger placed on the measurement sphere 103 to obtain primary spectrum data, and then continuously and secondarily irradiates near-infrared light to It may be configured to acquire secondary spectral data.

The data calculator 142 may calculate the blood sugar level based on the first spectrum data and the second spectrum data received from the photodetector 130 .

Specifically, the data operation unit 142 extracts first input data from the first spectrum data, extracts second input data from the second spectrum data, and F-tests the first input data and the second input data. The p-value value (probability value) is calculated through the (f-test), and the blood sugar level can be calculated by the blood sugar calculation formula below based on the first input data, the second input data, and the calculated p-value value. there is.

Here, the blood sugar calculation formula is “blood sugar level = ((average value of the second input data - average value of the first input data) * p-value value) / 2”.

In the present invention, the first input data extracted from the first spectrum data is obtained by extracting spectrum data in the wavelength range of 400 nm to 550 nm among 2496 first spectrum data for each wavelength between 400 nm and 1057 nm received from the photodetector 130, and Secondary input data extracted from the difference spectrum data is obtained by extracting spectrum data in a wavelength range of 400nm to 550nm among 2496 received secondary spectrum data for each wavelength between 400nm and 1057nm.

The darkening composition channel unit 105 is configured to turn the measurement environment at the tip of the finger into a dark state by inserting a finger and blocking transmission of external light toward the measurement sphere 103.

As shown in the drawing, the dark precursor composition channel 105 is made in the form of a tubular body so that a finger can be inserted, and one end is connected to the upper end of the body portion 101 so as to surround the measurement sphere 103, and the body portion It may extend from (101).

In the present invention, the length of the cancer precursor composition channel part 105 is configured to be longer than the length from the end of the finger to the first joint of the finger so that the finger end can be stably placed in the measuring instrument 103 by limiting the joint movement of the finger. it is desirable to be

On the other hand, the present invention is installed on the inner circumferential surface of the rear end of the dark precursor composition channel unit 105, expands by air supply, and is configured to contract by air discharge. A light blocking member 150 may be further included to block the inflow of external light by filling a gap in the space.

The light blocking member 150 is made of a soft and flexible synthetic tube, and may be configured to supply and recover air by means of an air supply unit configured in the main body 101 .

The air supply means 150 is constituted in the main body 101 and includes an air supply source 160 for supplying air to the light blocking member 150, the air supply source 160 and the light blocking member 150 It may be configured to include an air supply passage 165 composed of a flexible hose connecting the.

Here, the air supply source 160 may be composed of a small compressor or blower, and in this case, the air supply control unit 144 for driving and controlling the air supply source 160 may be configured in the control unit 140.

In addition, the air supply source 160 may be composed of a compressed air tank in which compressed air is stored and a solenoid valve is configured at a discharge port. In this case, the air supply control unit 144 controls the solenoid valve of the compressed air tank to Air supply to the blocking member 150 may be controlled.

Referring to FIG. 5 , the dark precursor composition channel unit 105 may be configured to have a variable length so as to correspond to various physical conditions for each user, that is, the length of a finger.

The dark precursor composition channel unit 105' includes a fixed channel 105a fixedly installed on the top of the body unit 101 so as to surround the measurement sphere 103, and a rear end of the fixed channel 105a inserted into the fixed channel. It may be configured to include a variable-length channel 105b that is moved along 105 and adjusts the overall length of the dark precursor composition channel 105'.

Although not shown, it is configured to connect the fixed channel 105a and the variable-length channel 105b, and operates under the control of the control unit 140 to move the variable-length channel 105b relative to the fixed channel 105a to increase the length. A variable channel shifting means can be further configured. At this time, the channel moving means may be composed of a linear actuator such as an electric cylinder.

Hereinafter, a blood glucose measurement method using a blood glucose measurement device according to an embodiment of the present invention will be described with reference to FIGS. 1 to 4 .

It is configured to include a pre-dark composition and measurement preparation step (s10), a spectrum data acquisition step (s20), and a blood sugar calculation step (s30).

In the dark precursor composition and measurement preparation step (s10), a finger is inserted into the dark precursor composition channel unit 105 and the end of the finger is placed in the measurement sphere 103 to wait for blood glucose measurement through the finger so that the environment around the finger end is in a dark state. let it become

In the darkening composition and measurement preparation step (s10), in a state in which the finger is inserted into the darkening composition channel 105, the gap between the finger and the darkening composition channel unit 105 is blocked by the light blocking member 150 to additionally transmit external light. An additional light blocking step (s15) for complete blocking may be further included.

In this additional light blocking step, air is supplied to the light blocking member 150 by the operation of the air supply source 160, and expansion is performed, and the inner circumferential surface of the light blocking member 150 is expanded by the expansion of the light blocking member 150. It is configured to block the inflow of external light into the dark precursor composition channel 105 by being in close contact with the finger and filling the gap between the finger and the dark precursor composition channel 105 .

In the present invention, the tip of the finger is placed in the measurement sphere s10 through the darkening composition and measurement preparation step (s10), and the finger is covered by the darkening composition channel unit 105, and in particular, by the light blocking member 150. Measurement is performed in a state in which the gap between the finger and the dark precursor composition channel unit 105 is completely blocked and external light is completely blocked, so signal distortion due to external light does not occur, so blood glucose level measurement by NIR spectroscopy is very precise and error-free. Measurement reliability can be improved without

In the present invention, the spectral data acquisition step (s20) and blood sugar calculation step (s30) may be performed with a conventional near-infrared spectroscopy method and blood sugar calculation through this method, but the spectrum data acquisition step (s20) and blood sugar calculation step (s30) of the present invention It is in a differentiated part from the existing spectrum data acquisition and blood glucose calculation, and the difference will be focused on.

In the spectral data acquisition step (s20), the near-infrared light in the wavelength range of 780 nm to 2500 nm is irradiated from the light source unit 110 to the tip of the finger located in the measurement sphere 103, and the light reflected from the finger end is reflected from the spectrometer 120. The split light is received by the photodetector 130 to obtain spectrum data.

In the present invention, the light emitted from the light source unit 110 and reflected from the finger is split by the spectrometer 120 into light for each of 2496 wavelengths between 400 nm and 1057 nm, and the split light for each of these 2496 wavelengths is split into a light detecting unit. 130 receives and detects light intensity for each wavelength to obtain spectrum data.

In the present invention, spectral data may be acquired twice in succession. That is, the spectrum data acquisition step (s20) may include a first spectrum acquisition step and a second spectrum acquisition step.

That is, the light source unit 110 first irradiates near-infrared light to the tip of the finger positioned at the measurement sphere 103, the spectrometer 120 receives and splits the reflected light, and the split light is transmitted to the photodetector 130 is received to obtain primary spectrum data, after a predetermined set time, the fingertip is secondarily irradiated with near-infrared light, the spectrometer 120 receives and splits the reflected light, and the divided light is divided into a photodetector ( 130) may be configured to receive and obtain secondary spectral data. Here, each of the first and second spectrum data consists of spectrum data for each of 2496 wavelengths between 400 nm and 1057 nm wavelength range.

In the blood glucose calculation step (s30), the data calculation unit 144 receives 2496 pieces of primary spectrum data and 2496 pieces of secondary spectrum data from the photodetector 130, and calculates a blood sugar level based thereon.

Specifically, the blood glucose calculation step (s30) includes a first extraction step (s32) of extracting the first input data from the first spectrum data, a second extraction step (s34) of extracting the second input data from the second spectrum data, An operation step (s36) of calculating a p-value through an F-test on the first input data and the second input data, and the blood sugar below based on the first input data, the second input data, and the p-value. It is configured to include a calculation step (s38) of calculating the blood sugar level by a calculation formula. Here, the blood sugar calculation formula is “blood sugar level = ((average value of the second input data - average value of the first input data) * p-value value) / 2”.

The first extraction step extracts the spectral data in the 400nm ~ 550nm wavelength range from the first spectrum data to generate the first input data, and the second extraction step extracts the spectrum data in the 400nm ~ 550nm wavelength range from the second spectrum data. Create secondary input data.

The calculation step performs the F-test with the first input data consisting of the first spectrum data in the 400 nm to 550 nm wavelength range and the second input data consisting of the second spectrum data for each wavelength in the 400 nm to 550 nm wavelength range, and from this, p -value Can be configured to compute values.

Thereafter, the calculation step calculates the average value of the first input data, calculates the average value of the second input data, calculates the average value of the first input data, the average value of the second input data, and the p-value value calculated in the calculation step. It may be configured to calculate the blood sugar level by inputting the blood glucose calculation formula, "blood sugar level = ((average value of the second input data - average value of the first input data) * p-value value) / 2".

Meanwhile, the present invention may further include a preprocessing step of calculating reference spectrum data for each of 2496 wavelengths between 400 nm and 1057 nm before the spectral data acquisition step (s20).

In the preprocessing step (s5), the spectrum data for each of 2496 wavelengths between 400 nm and 1057 nm is obtained through the photodetector 130 in a state in which the light source unit 110 is turned off without inserting a finger into the dark predication channel unit 105. obtained, and the control unit receives it, generates and stores it as first condition spectrum data for each 2496 wavelengths, and then, without inserting a finger into the dark precursor composition channel unit 105, in a state in which the light source unit 110 is turned on, The photodetector 130 acquires spectrum data for each of 2496 wavelengths between 400 nm and 1057 nm, the control unit generates and stores second condition spectrum data for each of 2496 wavelengths, and the control unit obtains the second condition spectrum data for each 2496 wavelengths. 2496 reference spectrum data for each wavelength may be generated by subtracting the first condition spectrum data for each 2496 wavelengths in a one-to-one ratio.

In this case, the blood glucose calculation step (s30) may further include a correction data generation step (s31) before the primary extraction step.

In the correction data generating step, the data calculation unit 142 irradiates near-infrared light to the tip of the finger from the light source unit 110 in a state where the subject inserts the finger into the dark precursor composition channel 105 and places the tip of the finger in the measurement sphere 103. 2496 primary spectrum data acquired by the photodetector 130 and secondary spectrum data for each 2496 wavelengths are received, and reference spectrum data for each 2496 wavelengths is subtracted in a one-to-one correspondence from the 2496 primary spectrum data. generate primary error correction spectrum data, and generate secondary error correction spectrum data for each 2496 wavelengths by subtracting the reference spectrum data for each wavelength in a one-to-one correspondence from the 2496 secondary spectrum data.

At this time, the first extraction step extracts the spectral data of the 400 nm to 550 nm wavelength range among the 2496 first error correction spectral data for each wavelength between 400 nm and 1057 nm wavelength range and generates it as the first input data, and the second extraction step is to extract the 400 nm It can be configured to generate secondary input data by extracting spectral data in a wavelength range of 400 nm to 550 nm among 2496 secondary error correction spectral data for each wavelength between ~ 1057 nm wavelength range, and the primary input data and the secondary input data thus generated Based on the input data, the blood sugar level may be calculated through the same calculation step as described above.

In the above, the present invention has been shown and described in relation to preferred embodiments for illustrating the principles of the present invention, but the present invention is not limited to the configuration and operation as shown and described. Rather, those skilled in the art will appreciate that many changes and modifications to the present invention can be made without departing from the spirit and scope of the appended claims. Accordingly, all such appropriate changes and modifications and equivalents should be regarded as belonging to the scope of the present invention.

101..Body part
103...measuring ball
105 ... dark pre-cursive channel unit
110 ... light source
120 ... spectrometer
130 ... light detection unit
140 ... control unit
142 ... data operation unit
144 ... air supply control unit
150 ... light blocking member
160 ... air supply source

Claims (10)

a main body having a measurement sphere on which a tip of a finger is raised so that non-invasive blood glucose measurement is performed through a finger;
a light source unit provided in the main body and radiating near-infrared light to an end of a finger placed on the measuring sphere;
a photodetector provided in the main body to receive near-infrared light irradiated from the light source and reflected from the fingertip, and to obtain spectrum data by splitting the received light;
a control unit provided in the body unit and comprising a data calculation unit configured to calculate a blood sugar level of the subject based on the acquired spectrum data;
Blood glucose using near-infrared spectroscopy, characterized in that it comprises: a dark precursor composition channel part extending from the measurement sphere and blocking external light transmitted to the measurement sphere by inserting a finger to create a dark state around the fingertip. measuring device.
According to claim 1,
A light blocking member formed along the inner surface of the rear end of the dark precursor composition channel unit and in close contact with a finger to block the inflow of external light through the space between the dark precursor composition channel unit and the finger by filling a gap between the finger and the dark precursor composition channel unit. A blood glucose measuring device using near-infrared spectroscopy, characterized in that it further comprises;
According to claim 2,
an air supply unit formed in the main body and including an air supply source for supplying air to the light blocking member, and an air supply passage connecting the air supply source and the light blocking member to supply air; A blood glucose measuring device using near-infrared spectroscopy, characterized in that it further comprises.
According to claim 1,
The blood glucose measuring device using near-infrared spectroscopy, characterized in that the length of the dark precursor composition channel is at least longer than the length from the distal end of the finger placed on the measurement sphere to the first joint of the finger.
According to claim 1,
The control unit proceeds with first near-infrared light irradiation to the fingertip through the light source unit, and performs primary measurement to acquire first spectrum data through the detection unit, and second-order near-infrared light to the fingertip through the light source unit. Investigation is performed to perform secondary measurement to acquire secondary spectrum data through the detection unit;
The blood glucose measuring device using near-infrared spectroscopy, characterized in that the data calculation unit calculates the blood sugar level of the subject based on the first spectrum data and the second spectrum data.
According to claim 5,
The data calculation unit,
First input data is extracted from the first spectrum data, second input data is extracted from the second spectrum data, and p-value values are obtained through an F-test on the extracted first and second input data. Calculate,
Based on the primary input data, the secondary input data, and the calculated p-value value, the blood glucose level is calculated through the blood glucose calculation formula,
The blood sugar calculation formula is,
Blood glucose level = ((average value of secondary input data - average value of primary input data) * p-value value) / 2 " blood glucose measuring device using near-infrared spectroscopy, characterized in that consisting of.
A body part equipped with a measurement sphere on which the tip of a finger is raised, a light source unit that irradiates, a photodetector unit that receives the near-infrared light emitted from the light source unit and reflected from the fingertip, and splits the received light to obtain spectrum data; , A control unit comprising a data calculation unit configured to calculate the blood sugar level of the subject based on the obtained spectrum data, and extending from the measurement sphere, and blocking external light transmitted to the measurement sphere by inserting a finger therein, In the blood glucose measurement method using a blood glucose measurement device composed of a dark pre-cursive channel unit that creates a dark state,
A dark precursor composition and measurement preparation step of inserting a finger into the dark precursor composition channel unit and positioning the tip of the finger in the measurement sphere so that the environment around the finger end is in a dark state while waiting for blood glucose measurement through the finger;
A spectrum acquisition step of obtaining a spectrum by radiating near-infrared light to the fingertips located in the measuring sphere, receiving and splitting the light reflected from the fingertips;
A blood glucose measurement method comprising a blood sugar calculation step of calculating a blood sugar level based on the obtained spectrum.
According to claim 7,
In the darkening composition and measurement preparation step, an additional light blocking step of blocking the inflow of external light through the space between the darkening composition channel and the finger by filling a light blocking member between the darkening composition channel and the finger; further comprising A blood glucose measurement method, characterized in that.
According to claim 7,
In the spectrum acquisition step, primary measurement is performed by performing primary near-infrared light irradiation on the fingertip through the light source unit to obtain primary spectrum data through the detector, and secondary measurement is performed on the fingertip through the light source unit. It is configured to proceed with near-infrared light irradiation to perform secondary measurement to acquire secondary spectrum data through the detector,
In the blood sugar calculation step, the data calculation unit is configured to calculate the blood sugar level of the subject based on the first spectrum data and the second spectrum data.
According to claim 9,
In the blood glucose calculation step, the data calculation unit extracts first input data from the first spectrum data, extracts second input data from the second spectrum data, and extracts the first input data and the second input data. A p-value value is calculated through an F-test for , and a blood sugar level is calculated through a blood sugar calculation formula based on the first input data, the second input data, and the calculated p-value value, and the blood sugar calculation formula is, Blood glucose level = ((average value of the second input data - average value of the first input data) * p-value value) / 2 ".

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