KR20160140133A - Apparatus and method for noninvasively measuring blood sugar - Google Patents

Abstract

The present invention discloses an apparatus and a method for noninvasively measuring blood sugar. According to an aspect of the present invention, the apparatus for noninvasively measuring blood sugar includes: a collection unit which applies a current to a skin to collect glucose in epidermis; a light radiation unit which radiates light to a portion where the glucose is collected; a light detection unit which receives light reflected or scattered from the portion where the glucose is collected, and disperses the collected light to obtain a spectrum; and a measurement unit which measures glucose concentrations based on the obtained spectrum.

Description

[0001] Apparatus and method for measuring non-invasive blood glucose [0002]

And more particularly to a non-invasive blood glucose measurement apparatus and method.

Diabetes is one of the illnesses of modern people. Diabetes can lead to complications such as hypertension, renal failure, and visual impairment due to the fact that insulin secreted from the pancreas is secreted or not functioned properly.

Diet, exercise, and medication are being used to manage blood sugar. In order to manage the sugar in the blood, it is essential to make the blood sugar correctly.

The method of measuring blood glucose is an invasive method for directly measuring blood glucose and a non-invasive method for measuring blood without taking blood.

The invasive method has a high reliability of measurement, but the risk of infection, inconvenience and disease infestation of blood sampling using injection is high, and consumables such as strips for measuring ingredient composition and consumables such as a syringe are used.

Various non-invasive techniques have been applied to various optical technologies such as Raman spectroscopy, near infrared spectroscopy, and mid infrared spectroscopy. However, in the case of Raman spectroscopy, it is difficult to measure the signal intensity of the Raman spectrum obtained by light irradiation, and it is difficult to separate signals corresponding to blood glucose due to various skin noises in the near-infrared spectroscopy and the mid-infrared spectroscopy.

It is an object of the present invention to provide a non-invasive blood glucose measurement apparatus and method capable of estimating blood glucose based on a spectrum obtained by applying current to skin and collecting glucose to the epidermis and irradiating light to the collected region.

An apparatus for measuring non-invasive blood glucose according to an aspect includes a collecting unit for collecting glucose on the skin by applying an electric current to the skin, a light irradiating unit for irradiating light to the site where glucose is collected, An optical detector for receiving the light, spectroscopically receiving the light to obtain a spectrum, and a measurement unit for measuring the concentration of glucose based on the obtained spectrum.

The light may include at least one of near-infrared light and heavy infrared light.

The collecting portion includes a current source and two electrodes, and the cathode of the two electrodes may be a transparent electrode.

The transparent electrode may be formed of indium tin oxide (ITO), transparent conduction oxide (TCO), silver nanowire, carbon nanotube (CNT), graphene, And may be one of a conducting polymer.

The photodetecting unit may include a plurality of light receiving units that receive light reflected or scattered at the glucose capturing site, and the light irradiating unit and the plurality of light receiving units may be disposed on the cathode electrode of the two electrodes.

The light detecting unit may include a plurality of light receiving units that receive light reflected or scattered at the glucose collecting site, and each light receiving unit may be disposed at uniform intervals in the form of a circle around the light irradiating unit.

The light irradiating unit can irradiate light at a predetermined time interval to the glucose collecting site.

The measuring unit may generate a dynamic spectrum indicating a change in spectra over time based on the obtained spectrum, and measure the concentration of glucose by comparing the generated dynamic spectrum with a previously stored dynamic spectrum.

The non-invasive blood glucose measurement apparatus may further include a display unit for displaying the concentration of glucose measured.

The non-invasive blood glucose measurement device can output an alarm when the measured glucose concentration is below the first threshold value or above the second threshold value.

Another aspect of the present invention is a method for measuring non-invasive blood glucose, comprising the steps of: collecting glucose on the epidermis by applying an electric current to the skin; irradiating light on the glucose-captured site; and irradiating light reflected or scattered at the glucose- Receiving and spectrally separating the received light to obtain a spectrum, and measuring the concentration of glucose based on the obtained spectrum.

The light may include at least one of near-infrared light and heavy infrared light.

In the step of irradiating light, light may be irradiated to the glucose-trapped site at a predetermined time interval.

The measuring step includes the step of generating a dynamic spectrum showing a change in spectra over time based on the obtained spectrum and a step of measuring the concentration of glucose by comparing the generated dynamic spectrum with a previously stored dynamic spectrum per concentration can do.

The non-invasive blood glucose measurement method may further include the step of displaying the concentration of the measured glucose.

The non-invasive blood glucose measurement method may further include outputting an alarm when the measured concentration of glucose is equal to or less than the first threshold value or equal to or greater than the second threshold value.

By applying current to the skin to collect glucose on the epidermis and measuring the glucose on the basis of the spectrum obtained by irradiating the collected region with light, the accuracy of blood glucose measurement can be improved by a noninvasive method.

1 is a block diagram showing an embodiment of a non-invasive blood glucose measurement device.
FIG. 2A is an exemplary view showing the distribution of glucose before current is applied to the skin. FIG.
FIG. 2B is an illustration showing the distribution of glucose after a first time (t1) has elapsed after current is applied to the skin.
FIG. 2C is an exemplary diagram showing the distribution of glucose after a second time (t2) has elapsed after current is applied to the skin.
3A is an exemplary view of a spectrum obtained by the optical detector 130
FIG. 3B is an example of a dynamic spectrum generated based on the obtained spectrum. FIG.
FIG. 3C is an exemplary view of the pre-stored dynamic spectrum per concentration. FIG.
4 is a view showing an embodiment of the arrangement of the electrodes 111a and 111b, the light irradiation unit 120, and the light receiving unit 131. In FIG.
5 is a view showing another embodiment of the non-invasive blood glucose measurement device.
6 is a flowchart showing an embodiment of a non-invasive blood glucose measurement method.
7 is a flow chart showing another embodiment of the non-invasive blood glucose measurement method.

Hereinafter, an embodiment of the present invention will be described in detail with reference to the accompanying drawings. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear. In addition, the terms described below are defined in consideration of the functions of the present invention, which may vary depending on the intention of the user, the operator, or the custom. Therefore, the definition should be based on the contents throughout this specification.

1 is a block diagram showing an embodiment of a non-invasive blood glucose measurement device.

1, the non-invasive blood glucose measuring apparatus 100 may include a collecting unit 110, a light irradiating unit 120, a light detecting unit 130, and a measuring unit 140.

The collecting unit 110 can accumulate glucose on the epidermis by applying a constant current to the skin. For this purpose, the collecting unit 110 may include two electrodes 111a and 111b and a current source 113. [

According to one embodiment, the collecting unit 110 collects a small and constant current (for example, a current equal to or less than 0.3 mA / cm ² ) that does not affect the skin through the current source 113 and the two electrodes 111a and 111b. To the skin, it is possible to collect glucose on the epidermis.

An anion (for example, Cl ^- or the like) in the body moves toward the anode electrode 111a and a cation in the body (for example, Na ⁺ or the like) migrates toward the anode electrode 111a by applying a constant current to the skin through the two electrodes 111a and 111b. Is moved toward the cathode electrode 111b. Charge-free substances, such as glucose, move through the skin like ions, and this phenomenon is called electro-osmosis. Since the skin generally contains a large amount of positive ions, body fluids move toward the cathode electrode, and glucose is accumulated on the skin of the cathode electrode 111b. This glucose accumulation method is called iontophoresis method. That is, the collecting unit 110 can collect glucose on the epidermis based on the iontophoresis method.

The electrodes 111a and 111b may be formed of a metal electrode such as Ag or a transparent electrode such as indium tin oxide (ITO), a transparent conduction oxide (TCO), a silver nanowire ), Carbon nanotubes (CNTs), graphenes, and conducting polymers, etc.).

According to another embodiment, the electrodes 111a and 111b may be opaque electrodes. For example, the transparent electrode may be used when the light detecting unit 130 is positioned on the path of the light irradiated from the light irradiating unit 120. The opaque electrode may be used when the photodetector part 130 is not located on the path of the light irradiated from the light irradiation part 120. Of course, the transparent electrode can also be used when the light detecting unit 130 is not positioned on the path of the light irradiated from the light irradiating unit 120.

The light irradiating unit 120 can irradiate light to the site where glucose is collected. According to one embodiment, the light irradiating unit 120 can irradiate light at a predetermined time interval to a skin-collected portion, that is, a skin on the cathode electrode 111b side. For this, the light irradiation unit 120 may include a light source that generates light. At this time, the light emitted from the light irradiation unit 120 may be an infrared (IR) band. According to one embodiment, the light irradiated by the irradiation unit 120 may be near infrared (NIR) in a wavelength range of 800-2500 nm or mid infrared (MIR) in a wavelength range of 2500-10000 nm.

The near infrared light region has a small absorption coefficient of glucose, and the influence of glucose on the refractive index of the medium is also nonspecific. A weak spectrum band of glucose overlaps with a strong spectrum band of water, hemoglobin, protein, fat, etc. in the near infrared light region, and the effect of the solute on the refractive index of the medium, that is, the scattering coefficient becomes nonspecific. That is, near-infrared light is advantageous in terms of transmission of tissues, but it is nonspecific in measuring the concentration of glucose compared to the medium-infrared.

According to one embodiment, the non-invasive blood glucose measuring apparatus 100 collects glucose on the epidermis through the collecting unit 110 and irradiates near-infrared light through the light irradiating unit 120 to the glucose- It is possible to obtain a specific near-infrared light spectrum.

The extraneous light is more specific than the spectral band produced by glucose. However, since the external light has a longer wavelength than the near infrared light, scattering phenomenon is less, and a large amount of light is absorbed before the light reaches the tissue. Therefore, penetration depth is not deep enough to obtain information on glucose present in the dermis layer.

According to one embodiment, the non-invasive blood glucose measuring apparatus 100 collects glucose present in the dermis layer through the collecting unit 110 toward the epidermis and irradiates the external light through the light irradiating unit 120 to produce glucose present in the dermis layer It is possible to obtain information about

The photodetector 130 may receive light reflected or scattered by the light irradiator 120, and may spectrally measure the received light to obtain a spectrum. For this purpose, the light detecting unit 130 may include a plurality of light receiving units 131 for receiving reflected or scattered light.

The measuring unit 140 can measure the concentration of glucose using the obtained spectrum. According to one embodiment, the measuring unit 140 generates a dynamic spectrum representing a change in spectra with respect to time based on the obtained spectrum, compares the generated dynamic spectrum with previously stored dynamic spectra of concentrations The concentration of glucose can be measured.

When a constant current is applied to the skin, glucose is captured on the epidermis and the absorbance or intensity of the spectrum specific to glucose over time increases in proportion to the amount of glucose captured. The measuring unit 140 can obtain a more specific spectrum for the blood sugar change by converting the wavelength to the rate of change of the spectrum per hour for each wavelength to generate the dynamic spectrum.

On the other hand, the concentration-specific dynamic spectrum can be constructed in advance. For example, when the amount of glucose increases proportionally with an increase in blood glucose, the flux of glucose generated when a constant current is applied increases, and accordingly, the amount of spectrum change of a specific wavelength also increases. By converting this amount of spectrum change into a concentration, a model having a constant correlation between the amount of spectrum change and blood glucose, that is, a dynamic spectrum according to concentration, can be constructed.

FIGS. 2A to 2C are schematic diagrams for explaining a method of measuring the glucose concentration. FIG. More specifically, FIG. 2A is an example of a distribution of glucose before application of a current to skin, FIG. 2B is an example of a distribution of glucose after a first time (t1) And FIG. 2C is an exemplary diagram showing the distribution of glucose after a second time (t2) has elapsed after application of current to the skin. At this time, t2 = 2 * t1.

The glucose 220 is present throughout the skin 210 before current is applied to the skin 210 through the current source 113 and the two electrodes 111a and 111b as shown in FIG.

When a constant current (for example, a current of 0.3 mA / cm ² or less) is applied to the skin 210 through the current source 113 and the two electrodes 111a and 111b, the glucose 220, (111b). When a first time t1 elapses after a constant current is applied to the skin 210, a part of the glucose 220 is collected on the skin of the cathode electrode 111b as shown in FIG. 2B. 2C, when the second time t2 elapses after applying a constant current to the skin 210, a greater amount of glucose 220 than the amount of time elapsed after the first time t1, And is collected on the skin of the electrode 111b side.

When the first time t1 elapses, the light irradiating unit 120 irradiates the skin on the side of the cathode electrode 111b where the glucose 220 is collected first, and the light detecting unit 130 irradiates light to the light receiving unit 131, Receives the reflected or scattered light, and splits the received light to obtain a first spectrum.

When the second time t2 elapses, the light irradiating unit 120 irradiates light to the skin on the side of the cathode electrode 111b where the glucose 220 is collected, and the light detecting unit 130 irradiates light to the light receiving unit 131, And splits the received light to obtain a second spectrum.

Thereafter, the measuring unit 140 generates a dynamic spectrum representing a change in spectra with respect to time based on the obtained first spectrum and the second spectrum, and outputs the generated dynamic spectrum as a pre-stored dynamic spectrum per concentration And the concentration of glucose is measured.

Hereinafter, a method of measuring the glucose concentration by the measuring unit 140 will be described in detail with reference to FIGS. 3A to 3C. FIG.

FIG. 3A is a diagram showing an example of a spectrum obtained by the optical detector 130, FIG. 3B is a diagram showing an example of a dynamic spectrum generated based on the obtained spectrum, FIG. 3C is a graph showing an example of a dynamic spectrum Fig. The illustrated example is an example of measuring glucose concentration using near-infrared light.

Referring to FIG. 3A, a spectrum (first spectrum) 310 obtained when a current is applied and a first time t1 elapses and a second time t2 (t2 = 2 * t1) The elapsed acquired spectrum (second spectrum) 320 is shown. At this time, the band of 1600-1800 nm wavelength is specific to glucose, and absorbance increases with time after application of electric current to the skin. This means that as time elapses, the amount of glucose captured at the site irradiated with the near-infrared light, that is, the epidermis at the cathode electrode 111b is increased.

When the first time t1 elapses after applying a constant current to the skin, the light irradiating unit 120 first irradiates the near-infrared light to the cathode electrode 111b, and the light detecting unit 130 irradiates the reflected light of the near- And receives the scattered light to acquire the first spectrum 310.

When the second time t2 (t2 = 2 * t1) has elapsed after applying a constant current to the skin, the light irradiation unit 120 irradiates the cathode electrode 111b with the near- Receives the reflected or scattered light of the irradiated near-infrared light, and acquires the second spectrum 320.

Referring to FIG. 3B, a dynamic spectrum 330 generated based on the first spectrum 310 and the second spectrum 320 is shown. The measurement unit 140 generates a dynamic spectrum 330 indicating a change in spectra over time based on the acquired first and second spectra 310 and 320.

Referring to FIG. 3C, a pre-stored dynamic spectrum by concentration is shown. In this case, reference numeral 340 denotes a dynamic spectrum when the glucose concentration is 50 mg / dL, reference numeral 350 denotes a dynamic spectrum when the glucose concentration is 70 mg / dL, reference numeral 360 denotes a dynamic spectrum when the glucose concentration is 90 mg / Respectively. ≪ tb > < TABLE >

The measuring unit 140 measures the glucose concentration by comparing the generated dynamic spectrum 330 with the previously stored dynamic spectrum. In the illustrated example, the dynamic spectrum 330 coincides with the dynamic spectrum 340 when the glucose concentration is 50 mg / dL, so that the measurement unit 140 determines that the glucose concentration is 50 mg / dL.

4 is a view showing an embodiment of the arrangement of the electrodes 111a and 111b, the light irradiation unit 120, and the light receiving unit 131. In FIG.

Referring to FIG. 4, the light irradiating unit 120 and the light receiving unit 131 may be disposed on the cathode electrode 111b where glucose is collected. At this time, the number of the light receiving units 131 may be plural, and each of the light receiving units 131 may be arranged at uniform intervals in the form of a circle around the light irradiating unit 120.

The electrodes 111a and 111b may be formed of a transparent electrode such as indium tin oxide (ITO), transparent conduction oxide (TCO), or the like to reduce interference with the light irradiating unit 120 and the light receiving unit 131. [ Such as a silver nanowire, a carbon nanotube (CNT), a graphene, and a conductive polymer, etc.). Also, the electrodes 111a and 111b may be implemented as opaque electrodes.

For example, the transparent electrode may be used when the light detecting unit 130 is positioned on the path of the light irradiated from the light irradiating unit 120. The opaque electrode may be used when the photodetector part 130 is not located on the path of the light irradiated from the light irradiation part 120. Of course, the transparent electrode can also be used when the light detecting unit 130 is not positioned on the path of the light irradiated from the light irradiating unit 120.

The electrodes 111a and 111b may be formed of a metal electrode such as Ag or the like and the cathode electrode 111b and the light receiving unit 131 may be disposed as close to each other as the metal electrode.

The anode electrode 111b may be spaced apart from the cathode electrode 111b around the cathode electrode 111b so as to surround the cathode electrode 111b.

5 is a view showing another embodiment of the non-invasive blood glucose measurement device.

5, the non-invasive blood glucose measurement apparatus 500 may further include a storage unit 510, a display unit 520, and an alarm unit 530 in the non-invasive blood glucose measurement apparatus 100 of FIG. 1 .

The storage unit 510 may store the dynamic spectrum according to the concentration.

The storage unit 510 may be a flash memory type, a hard disk type, a multimedia card micro type, a card type memory (e.g., SD or XD memory), a RAM (Random Access Memory), SRAM (Static Random Access Memory), ROM (Read Only Memory), EEPROM (Electrically Erasable Programmable Read Only Memory), PROM (Programmable Read Only Memory), magnetic memory, And the like.

The display unit 520 can visually display and output information processed in the non-invasive blood glucose measurement apparatus 500. The display unit 520 can visually display and output the glucose concentration measured by the measuring unit 140.

The display unit 520 may be a liquid crystal display, a thin film transistor liquid crystal display, an organic light emitting diode, a flexible display, a 3D display A head mounted display (HMD), a face mounted display (FMD), an eye mounted display (EMD), an eye glass display (EGD), and the like.

The alarm unit 530 can output an alarm when the measured glucose concentration is below the first threshold value (hypoglycemia) or above the first threshold value (hyperglycemia). For example, when the measured glucose concentration is less than 60 mg / dL and the blood glucose level is not less than 160 mg / dL, the alarm unit 530 may be an auditory method (such as a speaker), a visual method Etc.), and a tactile method (e.g., vibration, etc.).

6 is a flowchart showing an embodiment of a non-invasive blood glucose measurement method.

Referring to FIGS. 1 and 6, a non-invasive blood glucose measurement method 600 first applies current to the skin to collect glucose (510). For example, the collecting unit 110 supplies a small and constant current (for example, a current of 0.3 mA / cm ² or less) to the skin through the current source 113 and the two electrodes 111a and 111b so as not to affect the skin , It is possible to collect glucose on the epidermis.

The electrodes 111a and 111b may be formed of a metal electrode such as Ag or the like, a transparent electrode such as indium tin oxide (ITO), a transparent conduction oxide (TCO), a silver nanowire ), Carbon nanotubes (CNTs), graphenes, and conducting polymers, etc.), or opaque electrodes.

The transparent electrode may be used when the light detecting unit 130 is located on the path of the light irradiated from the light irradiating unit 120. The opaque electrode may be used when the photodetector part 130 is not located on the path of the light irradiated from the light irradiation part 120. Of course, the transparent electrode can also be used when the light detecting unit 130 is not positioned on the path of the light irradiated from the light irradiating unit 120.

Thereafter, light is irradiated to the site where glucose is collected (620). For example, the light irradiating unit 120 can irradiate light at a certain time interval to the skin-collected portion, that is, the skin on the side of the cathode electrode 111b. At this time, the light emitted from the light irradiation unit 120 may be an infrared (IR) band. According to one embodiment, the light emitted from the irradiation unit 120 may be near infrared (NIR) in a wavelength range of 800 to 2500 nm or mid infrared (MIR) in a wavelength range of 2500 to 10000 nm.

Thereafter, the reflected or scattered light is received and a spectrum is acquired based on the received light (630). For example, the photodetector 130 may receive light reflected or scattered by using a plurality of light-receiving units 131, and may spectrally measure the received light to obtain a spectrum.

Thereafter, the concentration of glucose is measured using the obtained spectrum (640). For example, the measuring unit 140 generates a dynamic spectrum indicating a change in spectra over time based on the obtained spectrum, and compares the generated dynamic spectrum with the previously stored dynamic spectrum to determine the concentration of glucose Can be measured.

7 is a flow chart showing another embodiment of the non-invasive blood glucose measurement method.

5 to 7, the non-invasive blood glucose measuring method 700 may further include a glucose concentration displaying step 710 and an alarm providing step 720 in the non-invasive blood glucose measuring method 600 of FIG. 6 .

In the glucose concentration display step 710, the glucose concentration measured in step 640 is displayed. For example, the display unit 520 can visually display and output the glucose concentration measured by the measuring unit 140.

In the alarm providing step 720, an alarm is output when the glucose concentration measured in step 640 is below the first threshold value (hypoglycemia) or above the first threshold value (hyperglycemia). For example, when the measured glucose concentration is less than 60 mg / dL and the blood glucose level is not less than 160 mg / dL, the alarm unit 530 may be an auditory method (such as a speaker), a visual method Etc.), and a tactile method (e.g., vibration, etc.).

One aspect of the present invention may be embodied as computer readable code on a computer readable recording medium. The code and code segments implementing the above program can be easily deduced by a computer programmer in the field. A computer-readable recording medium may include any type of recording device that stores data that can be read by a computer system. Examples of the computer-readable recording medium include ROM, RAM, CD-ROM, magnetic tape, floppy disk, optical disk, and the like. In addition, the computer-readable recording medium may be distributed to networked computer systems and written and executed in computer readable code in a distributed manner.

The present invention has been described with reference to the preferred embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the scope of the present invention should not be limited to the above-described embodiments, but should be construed to include various embodiments within the scope of the claims.

100, 500: Non-invasive blood glucose measuring device
110: collecting part
111a: anode electrode
111b: cathode electrode
113: current source
120:
130:
131:
140:
510:
520:
530:

Claims (16)

A collecting part for collecting glucose on the epidermis by applying an electric current to the skin;
A light irradiating unit for irradiating light to a site where glucose is captured;
A photodetector receiving light reflected or scattered at a glucose capture site and spectroscopically receiving light to obtain a spectrum; And
A measuring unit for measuring the concentration of glucose based on the obtained spectrum; Wherein the non-invasive blood glucose measuring device comprises: The method according to claim 1,
Wherein the light includes at least one of near-infrared light and heavy infrared light. The method according to claim 1,
The collector includes a current source and two electrodes,
Wherein the cathode of the two electrodes is a transparent electrode. The method of claim 3,
The transparent electrode may be formed of indium tin oxide (ITO), transparent conduction oxide (TCO), silver nanowire, carbon nanotube (CNT), graphene, Non-invasive blood glucose measuring device which is one of the conducting polymers. The method of claim 3,
Wherein the light detecting unit includes a plurality of light receiving units that receive light reflected or scattered at a glucose capture site,
Wherein the light irradiating unit and the plurality of light receiving units are disposed on the cathode side of the two electrodes. The method according to claim 1,
Wherein the light detecting unit includes a plurality of light receiving units that receive light reflected or scattered at a glucose capture site,
Wherein each of the light receiving portions is arranged at a uniform interval in the form of a circle around the light irradiation portion. The method according to claim 1,
Wherein the light irradiating unit irradiates light at a predetermined time interval to a glucose collecting site. The method according to claim 1,
Wherein the measuring unit is configured to generate a dynamic spectrum representing a change in spectrum over time based on the obtained spectrum and to compare the generated dynamic spectrum with a previously stored dynamic spectrum to determine concentration of glucose. The method according to claim 1,
A display unit for displaying a concentration of the measured glucose; Wherein the non-invasive blood glucose measuring device further comprises: The method according to claim 1,
An alarm unit for outputting an alarm when the measured concentration of glucose is lower than or equal to a first threshold value or higher than a second threshold value; Wherein the non-invasive blood glucose measuring device further comprises: Collecting glucose on the epidermis by applying an electric current to the skin;
Irradiating light to a site where glucose is captured;
Receiving light reflected or scattered at the site where glucose is captured, and spectroscopically receiving light to obtain a spectrum; And
Measuring the concentration of glucose based on the obtained spectrum; Wherein the non-invasive blood glucose measurement method comprises the steps of: 12. The method of claim 11,
Wherein the light includes at least one of near-infrared light and heavy infrared light. 12. The method of claim 11,
Wherein the step of irradiating the light irradiates light at a predetermined time interval to a site where glucose is collected. 12. The method of claim 11,
Wherein the measuring step comprises:
Generating a dynamic spectrum representing a change in spectrum over time based on the obtained spectrum; And
Measuring the concentration of glucose by comparing the generated dynamic spectrum with a previously stored dynamic spectrum; Wherein the non-invasive blood glucose measurement method comprises the steps of: 12. The method of claim 11,
Displaying the measured concentration of glucose; Wherein the non-invasive blood glucose measurement method further comprises: 12. The method of claim 11,
Outputting an alarm when the measured glucose concentration is below a first threshold or above a second threshold; Wherein the non-invasive blood glucose measurement method further comprises:

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