KR20230061433A - 항-vegf-항-pd-l1 이중특이적 항체, 이의 약제학적 조성물, 및 이의 용도 - Google Patents

항-vegf-항-pd-l1 이중특이적 항체, 이의 약제학적 조성물, 및 이의 용도 Download PDF

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KR20230061433A
KR20230061433A KR1020237010695A KR20237010695A KR20230061433A KR 20230061433 A KR20230061433 A KR 20230061433A KR 1020237010695 A KR1020237010695 A KR 1020237010695A KR 20237010695 A KR20237010695 A KR 20237010695A KR 20230061433 A KR20230061433 A KR 20230061433A
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antibody
val
thr
gly
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샤오뉴 먀오
쳉 첸
지준 위안
웨이펭 후앙
앤디 트선
조앤 트소우에
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바이오세우스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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KR1020237010695A 2020-08-31 2021-08-30 항-vegf-항-pd-l1 이중특이적 항체, 이의 약제학적 조성물, 및 이의 용도 Pending KR20230061433A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010897917.1 2020-08-31
CN202010897917.1A CN114106190B (zh) 2020-08-31 2020-08-31 一种抗vegf/pd-l1双特异性抗体及其用途
PCT/CN2021/115308 WO2022042719A1 (zh) 2020-08-31 2021-08-30 抗vegf-抗pd-l1双特异性抗体、其药物组合物及用途

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KR20230061433A true KR20230061433A (ko) 2023-05-08

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KR1020237010695A Pending KR20230061433A (ko) 2020-08-31 2021-08-30 항-vegf-항-pd-l1 이중특이적 항체, 이의 약제학적 조성물, 및 이의 용도

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US (2) US12325759B2 (https=)
EP (2) EP4209513A4 (https=)
JP (1) JP2023539501A (https=)
KR (1) KR20230061433A (https=)
CN (2) CN114106190B (https=)
AU (1) AU2021334042A1 (https=)
CA (1) CA3192812A1 (https=)
MX (1) MX2023002331A (https=)
WO (1) WO2022042719A1 (https=)

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WO2024032664A1 (zh) * 2022-08-09 2024-02-15 上海济煜医药科技有限公司 一种靶向pd-l1和vegf的抗体及其应用
AU2023417485A1 (en) * 2022-12-29 2025-06-26 Shanghai Henlius Biologics Co., Ltd. Anti-pdl1/vegf antibodies and methods of use
CN120361206A (zh) * 2024-01-25 2025-07-25 中山康方生物医药有限公司 抗pd-1-抗vegfa的双特异性抗体的医药用途
WO2025185161A1 (en) * 2024-03-07 2025-09-12 Biotheus Inc. Combination therapy comprising a bispecific anti-vegf-a and anti-pd-l1 antibody and a chemotherapy for cancer treatment
WO2025184858A1 (en) * 2024-03-07 2025-09-12 Biotheus Inc. Combination therapy comprising a bispecific anti-vegf-a and anti-pd-l1 antibody and a chemotherapy for cancer treatment
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CN120025456B (zh) * 2024-03-13 2025-11-07 寻济生物科技（北京）有限公司 一种抗vegfa融合构建体及其制备方法和应用
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