KR20230059374A - Antimicrobial compositions using chemical reaction of hypochlorous acid - Google Patents
Antimicrobial compositions using chemical reaction of hypochlorous acid Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 27
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 15
- 230000000845 anti-microbial effect Effects 0.000 title description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 25
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 17
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 17
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000004108 freeze drying Methods 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims description 14
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 7
- 206010000496 acne Diseases 0.000 abstract description 7
- 241000894006 Bacteria Species 0.000 abstract description 4
- 230000004913 activation Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000025721 COVID-19 Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
본 발명은 하이포 염소산의 화학반응을 이용한 항균 조성물에 대한 것으로서, 보다 상세하게는, 하이포 염소산의 화학 반응을 이용하여 여드름균의 항균 활성화 기능을 보다 향상시킨 항균 조성물에 대한 것이다. The present invention relates to an antibacterial composition using a chemical reaction of hypochlorous acid, and more particularly, to an antibacterial composition using a chemical reaction of hypochlorous acid to further improve the antibacterial activation function of acne bacteria.
현재 화장품 산업의 2020년 수출금액은 약 8조 3천억원으로 전년 대비 15.6% 증가로 연간 최대 수출 실적 기록하였다. Currently, the export amount of the cosmetics industry in 2020 is about 8.3 trillion won, an increase of 15.6% from the previous year, recording the highest annual export performance.
또한 코로나19로 인하여 개개인들은 마스크를 상시적으로 착용하기 시작하였고, 그로 인해 발생하는 피부 트러블 중의 여드름을 개선하기 위해 K-뷰티 화장품을 선도하는 글로벌 경쟁력이 있는 조성물의 개발이 필요한 실정이다.In addition, due to COVID-19, individuals have started to wear masks regularly, and it is necessary to develop a composition with global competitiveness that leads K-beauty cosmetics to improve acne among skin troubles caused by it.
종래 여드름 치료제의 경우 다량 사용시 피부 과각화, 발적, 홍반 등의 부작용이 빈번하게 발생하는 문제점이 있었다. 따라서 안정성과 친환경성을 겸비한 화학 소재가 필요한 실정이다. In the case of conventional acne treatment, side effects such as skin hyperkeratosis, redness, and erythema frequently occur when used in large amounts. Therefore, there is a need for chemical materials that combine stability and eco-friendliness.
한편, 하이포 염소산(hypochlorous acid)은 인체 면역 체계인 백혈구에서 천연적으로 생성되는 안전한 면역 물질로, 체내의 호중구에서 만들어내는 살균물질이다. 특히, 하이포 염소산은 유기물과 결합하여 물로 환원되고, 공기와 햇빛에 의해 분해되므로 친환경적이라는 장점이 있으며, 미국 FDA, 미국 환경 보호국, 미국 농무부, 일본 후생노동성, 식약처 등에서 인가받은 물질로서, 광범위한 세균인 인플루엔자, 아포균, 사상균 및 곰팡이류, 바이러스까지 살균이 가능하다는 장점이 있다. On the other hand, hypochlorous acid is a safe immune substance naturally produced by white blood cells, which are the body's immune system, and is a sterilizing substance produced by neutrophils in the body. In particular, hypochloric acid is reduced to water by combining with organic matter, and is decomposed by air and sunlight, so it has the advantage of being eco-friendly. It has the advantage of being able to sterilize influenza, spores, filamentous fungi, fungi, and viruses.
이에, 본 발명자는, 하이포 염소산의 화학 반응을 이용하여 여드름균의 항균 활성화 기능을 보다 향상시킨 항균 조성물을 발명하기에 이르렀다. Accordingly, the present inventors came to invent an antibacterial composition in which the antibacterial activating function of acne bacillus is further improved by using the chemical reaction of hypochlorous acid.
본 발명은 상술된 문제점을 해결하기 위해 발명된 것으로서, 본 발명의 목적은 친환경적이며 피부 저자극이고 보다 효과적인 항균 조성물을 개발하는 것이다. The present invention was invented to solve the above problems, and an object of the present invention is to develop an antibacterial composition that is environmentally friendly, mild to the skin, and more effective.
본 발명에 따른 하이포 염소산의 화학 반응을 이용한 항균 조성물 제조 방법은, (a) 히알루론산과 펩타이드를 동결 건조하는 단계; (b) 하이포 염소산을 준비하는 단계; 및 (c) 상기 동결 건조된 히알루론산과 펩타이드와 하이포 염소산을 혼합하는 단계;를 포함할 수 있다. A method for preparing an antibacterial composition using a chemical reaction of hypochlorite according to the present invention includes the steps of (a) freeze-drying hyaluronic acid and peptides; (b) preparing hypochloric acid; and (c) mixing the freeze-dried hyaluronic acid, the peptide, and hypochlorite.
바람직하게는, 상기 (a) 단계에 있어서, 상기 히알루론산과 펩타이드는 약 -40도에서 냉동되고, 진공 및 건조될 수 있다. Preferably, in step (a), the hyaluronic acid and peptides may be frozen at about -40 degrees, vacuumed, and dried.
바람직하게는, 상기 (c) 단계는, 상기 항균 조성물의 사용 직전에 혼합될 수 있다.Preferably, step (c) may be mixed immediately before use of the antimicrobial composition.
또한 본 발명에 따른 항균 조성물은, 동결 건조된 히알루론산과 펩타이드; 및 상기 동결 건조된 히알루론산과 펩타이드가 용해 가능한 하이포 염소산;을 포할 수 있다. In addition, the antibacterial composition according to the present invention, freeze-dried hyaluronic acid and peptides; and hypochloric acid capable of dissolving the freeze-dried hyaluronic acid and the peptide.
본 발명에 따르면, 친환경적이며 피부 저자극이고 보다 효과적인 항균 조성물을 개발 가능하다.According to the present invention, it is possible to develop an antibacterial composition that is environmentally friendly, mild to the skin, and more effective.
구체적으로 본 발명의 조성물에 따르면, 각질 개선, 피부 진정, 여드름균 3종을 99.9% 살균 가능하다. 또한 가격 역시 1l당 1.62원으로 기존 제품에 비하여 사업성이 있다. Specifically, according to the composition of the present invention, it is possible to sterilize 99.9% of three types of dead skin cells, skin soothing, and acne bacteria. In addition, the price is also 1.62 won per 1 liter, which is business feasible compared to existing products.
도 1은 하이포 염소산의 화학 반응을 이용한 항균 조성물을 제조하여 사용하는 방법에 대한 개략도이다.
도 2는 하이포 염소산의 화학 반응을 이용한 항균 조성물을 제조하는 방법에 대한 개략도이다. 1 is a schematic diagram of a method for preparing and using an antibacterial composition using a chemical reaction of hypochlorous acid.
Figure 2 is a schematic diagram of a method for preparing an antibacterial composition using a chemical reaction of hypochlorous acid.
본 발명을 상세히 설명하면 다음과 같다. 여기서, 반복되는 설명, 본 발명의 요지를 불필요하게 흐릴 수 있는 공지 기능 및 구성에 대한 상세한 설명은 생략한다. 본 발명의 실시형태는 당 업계에서 평균적인 지식을 가진 자에게 본 발명을 완전하게 설명하기 위해서 제공되는 것이다.The present invention will be described in detail as follows. Here, repeated descriptions and detailed descriptions of well-known functions and configurations that may unnecessarily obscure the subject matter of the present invention will be omitted. Embodiments of the present invention are provided to completely explain the present invention to those skilled in the art.
명세서 전체에서, 어떤 부분이 어떤 구성 요소를 "포함"한다고 할 때, 이는 특별히 반대되는 기재가 없는 한 다른 구성 요소를 제외하는 것이 아니라 다른 구성 요소를 더 포함할 수 있는 것을 의미한다.Throughout the specification, when a certain component is said to "include", it means that it may further include other components without excluding other components unless otherwise stated.
이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시한다. 그러나 하기의 실시예는 본 발명을 보다 용이하게 이해하기 위하여 제공되는 것일 뿐, 실시예에 의해 본 발명의 내용이 한정되는 것은 아니다.Hereinafter, a preferred embodiment is presented to aid understanding of the present invention. However, the following examples are only provided to more easily understand the present invention, and the content of the present invention is not limited by the examples.
도 1은 하이포 염소산의 화학 반응을 이용한 항균 조성물을 제조하여 사용하는 방법에 대한 개략도이다. 도 2는 하이포 염소산의 화학 반응을 이용한 항균 조성물을 제조하는 방법에 대한 개략도이다. 1 is a schematic diagram of a method for preparing and using an antibacterial composition using a chemical reaction of hypochlorous acid. Figure 2 is a schematic diagram of a method for preparing an antibacterial composition using a chemical reaction of hypochlorous acid.
도 1 및 도 2에 의하면, 본 발명에 따른 하이포 염소산의 화학 반응을 이용한 항균 조성물 제조 방법은, (a) 히알루론산과 펩타이드를 동결 건조하는 단계; (b) 하이포 염소산을 준비하는 단계; 및 (c) 상기 동결 건조된 히알루론산과 펩타이드와 하이포 염소산을 혼합하는 단계;를 포함할 수 있다. 1 and 2, the method for preparing an antibacterial composition using the chemical reaction of hypochlorous acid according to the present invention includes: (a) freeze-drying hyaluronic acid and peptides; (b) preparing hypochloric acid; and (c) mixing the freeze-dried hyaluronic acid, the peptide, and hypochlorite.
또한 (a) 단계에 있어서, 상기 히알루론산과 펩타이드는 약 -40도에서 냉동되고, 진공 및 건조될 수 있다. Also, in step (a), the hyaluronic acid and peptides may be frozen at about -40 degrees, vacuumed, and dried.
또한 (c) 단계는, 상기 항균 조성물의 사용 직전에 혼합될 수 있다.Also, in step (c), the antimicrobial composition may be mixed immediately before use.
한편, 본 발명에 따른 항균 조성물은, 동결 건조된 히알루론산과 펩타이드; 및 상기 동결 건조된 히알루론산과 펩타이드가 용해 가능한 하이포 염소산;을 포할 수 있다. On the other hand, the antibacterial composition according to the present invention, freeze-dried hyaluronic acid and peptides; and hypochloric acid capable of dissolving the freeze-dried hyaluronic acid and the peptide.
이러한 구성으로 인하여, 친환경적이며 피부 저자극이고 보다 효과적인 항균 조성물이 개발 가능할뿐 만 아니라, 각질 개선, 피부 진정, 여드름균 3종을 99.9% 살균 가능하다. 또한 가격 역시 1l당 1.62원으로 기존 제품에 비하여 사업성이 있다.Due to this configuration, it is possible to develop an antibacterial composition that is eco-friendly, mild to the skin, and more effective, as well as 99.9% sterilization of three kinds of dead skin cells, skin soothing, and acne bacteria. In addition, the price is also 1.62 won per 1 liter, which is business feasible compared to existing products.
상기 본 발명의 바람직한 실시예를 참조하여 설명하였지만, 당 업계의 통상의 지식을 가진 자라면 이하의 특허 청구범위에 기재된 본 발명의 사상 및 영역을 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 및 변경시킬 수 있음을 이해할 수 있을 것이다.Although described with reference to the preferred embodiments of the present invention, those skilled in the art will variously modify and change the present invention within the scope not departing from the spirit and scope of the present invention described in the claims below. You will understand that it can be done.
Claims (4)
(b) 하이포 염소산을 준비하는 단계; 및
(c) 상기 동결 건조된 히알루론산과 펩타이드와 하이포 염소산을 혼합하는 단계;를 포함하는 것을 특징으로 하는,
하이포 염소산의 화학 반응을 이용한 항균 조성물 제조 방법.
(a) freeze-drying hyaluronic acid and peptides;
(b) preparing hypochloric acid; and
(c) mixing the lyophilized hyaluronic acid, peptide, and hypochlorite; characterized in that it comprises,
A method for preparing an antibacterial composition using a chemical reaction of hypochlorite.
상기 (a) 단계에 있어서,
상기 히알루론산과 펩타이드는 약 -40도에서 냉동되고, 진공 및 건조되는 것을 특징으로 하는,
하이포 염소산의 화학 반응을 이용한 항균 조성물 제조 방법.
According to claim 1,
In step (a),
Characterized in that the hyaluronic acid and peptides are frozen at about -40 degrees, vacuumed and dried,
A method for preparing an antibacterial composition using a chemical reaction of hypochlorite.
상기 (c) 단계는, 상기 항균 조성물의 사용 직전에 혼합되는 것을 특징으로 하는, 하이포 염소산의 화학 반응을 이용한 항균 조성물 제조 방법.
According to claim 2,
The step (c) is characterized in that mixing immediately before use of the antibacterial composition, a method for producing an antibacterial composition using a chemical reaction of hypochlorite.
상기 동결 건조된 히알루론산과 펩타이드가 용해 가능한 하이포 염소산;을 포함하는 항균 조성물.
lyophilized hyaluronic acid and peptides; and
An antibacterial composition comprising; the freeze-dried hyaluronic acid and hypochloric acid capable of dissolving the peptides.
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