KR20230052881A - 접합 부위를 갖는 t-세포 조절 폴리펩티드 및 이의 사용 방법 - Google Patents

접합 부위를 갖는 t-세포 조절 폴리펩티드 및 이의 사용 방법 Download PDF

Info

Publication number
KR20230052881A
KR20230052881A KR1020237004718A KR20237004718A KR20230052881A KR 20230052881 A KR20230052881 A KR 20230052881A KR 1020237004718 A KR1020237004718 A KR 1020237004718A KR 20237004718 A KR20237004718 A KR 20237004718A KR 20230052881 A KR20230052881 A KR 20230052881A
Authority
KR
South Korea
Prior art keywords
polypeptide
cell
sequence
mod
epitope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237004718A
Other languages
English (en)
Korean (ko)
Inventor
로날드 디. 3세 세이델
로돌포 제이. 차파로
존 에프. 로스
치 멩 로우
아니쉬 수리
레이몬드 제이. 모니즈
구르파나 삭구
Original Assignee
큐 바이오파마, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 큐 바이오파마, 인크. filed Critical 큐 바이오파마, 인크.
Publication of KR20230052881A publication Critical patent/KR20230052881A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020237004718A 2020-07-14 2021-07-14 접합 부위를 갖는 t-세포 조절 폴리펩티드 및 이의 사용 방법 Pending KR20230052881A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063051472P 2020-07-14 2020-07-14
US63/051,472 2020-07-14
US202063110929P 2020-11-06 2020-11-06
US63/110,929 2020-11-06
US202063120677P 2020-12-02 2020-12-02
US63/120,677 2020-12-02
PCT/US2021/041675 WO2022015880A2 (en) 2020-07-14 2021-07-14 T-cell modulatory polypeptides with conjugation sites and methods of use thereof

Publications (1)

Publication Number Publication Date
KR20230052881A true KR20230052881A (ko) 2023-04-20

Family

ID=79556024

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237004718A Pending KR20230052881A (ko) 2020-07-14 2021-07-14 접합 부위를 갖는 t-세포 조절 폴리펩티드 및 이의 사용 방법

Country Status (10)

Country Link
US (1) US20230279076A1 (https=)
EP (1) EP4182465A4 (https=)
JP (1) JP2023534460A (https=)
KR (1) KR20230052881A (https=)
CN (1) CN116437952A (https=)
AU (1) AU2021309842A1 (https=)
CA (1) CA3174097A1 (https=)
IL (1) IL299834A (https=)
TW (1) TW202216750A (https=)
WO (1) WO2022015880A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017201210A1 (en) * 2016-05-18 2017-11-23 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
ES2973548T3 (es) 2016-12-22 2024-06-20 Cue Biopharma Inc Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso
EP3565829A4 (en) 2017-01-09 2021-01-27 Cue Biopharma, Inc. T-CELL-MODULATING MULTIMERIC POLYPEPTIDES AND METHOD OF USING THEREOF
US20200010528A1 (en) 2017-03-15 2020-01-09 Cue Biopharma, Inc. Methods for modulating an immune response
JP2020534352A (ja) 2017-09-07 2020-11-26 キュー バイオファーマ，インコーポレーテッド コンジュゲーション部位を有するｔ細胞調節多量体ポリペプチド及びその使用方法
WO2021231376A2 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2022056014A1 (en) 2020-09-09 2022-03-17 Cue Biopharma, Inc. Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof
CN119317447A (zh) * 2022-04-12 2025-01-14 米纳瓦生物技术公司 抗可变muc1*抗体及其用途
JP2025515575A (ja) * 2022-04-14 2025-05-20 キュー バイオファーマ， インコーポレイテッド Ｔ細胞エンゲージングポリペプチドおよびその使用方法
WO2024206207A1 (en) * 2023-03-24 2024-10-03 Neximmune, Inc. Injectable artificial antigen presenting cells for immune therapy
EP4484441A1 (en) * 2023-06-26 2025-01-01 Eberhard-Karls-Universität Tübingen Mhc-class i derived polypeptide
CN118027176B (zh) * 2024-03-27 2024-12-24 郑春杨 人β2-微球蛋白突变体
WO2025207816A1 (en) * 2024-03-27 2025-10-02 Cue Biopharma, Inc. Treatment of b-cell mediated immune disorders by t-cell mediated depletion of b cells, plasmablasts and plasma cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014096015A1 (en) * 2012-12-21 2014-06-26 F. Hoffmann-La Roche Ag Disulfide-linked multivalent mhc class i comprising multi-function proteins
WO2017151818A2 (en) * 2016-03-02 2017-09-08 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US20200010528A1 (en) * 2017-03-15 2020-01-09 Cue Biopharma, Inc. Methods for modulating an immune response
EP3678691A4 (en) * 2017-09-07 2021-06-09 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
RU2763798C1 (ru) * 2017-12-23 2022-01-11 Рубиус Терапьютикс, Инк. Искусственные антигенпрезентирующие клетки и способы их применения
WO2020132366A2 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof
TWI856047B (zh) * 2018-12-19 2024-09-21 美商信號生物製藥公司 多聚體ｔ細胞調節多肽及其使用方法
WO2021127487A2 (en) * 2019-12-20 2021-06-24 Regeneron Pharmaceuticals, Inc. Novel il2 agonists and methods of use thereof

Also Published As

Publication number Publication date
TW202216750A (zh) 2022-05-01
EP4182465A2 (en) 2023-05-24
WO2022015880A2 (en) 2022-01-20
AU2021309842A1 (en) 2023-02-16
US20230279076A1 (en) 2023-09-07
CN116437952A (zh) 2023-07-14
WO2022015880A3 (en) 2022-03-03
CA3174097A1 (en) 2022-01-20
EP4182465A4 (en) 2024-08-07
IL299834A (en) 2023-03-01
JP2023534460A (ja) 2023-08-09

Similar Documents

Publication Publication Date Title
JP7762068B2 (ja) 多量体ｔ細胞調節性ポリペプチド及びその使用方法
KR20230052881A (ko) 접합 부위를 갖는 t-세포 조절 폴리펩티드 및 이의 사용 방법
US20250041404A1 (en) T Cell Modulatory Polypeptides with Conjugation Sites and Methods of Use Thereof
US20220017597A1 (en) Multimeric t-cell modulatory polypeptides and methods of use thereof
JP7481342B2 (ja) 多量体ｔ細胞調節ポリペプチド及びその使用方法
US20240034770A1 (en) T-cell modulatory multimeric polypeptides and methods of use thereof
US20240082411A1 (en) T-Cell Modulatory Polypeptides with Conjugation Sites and Methods of Use Thereof
IL309479A (en) Methods for modulating an immune response
US20230201335A1 (en) Antigen Presenting Polypeptide Complexes and Methods of Use Thereof
US20240317815A1 (en) T-cell modulatory multimeric polypeptides and methods of use thereof
US20250041396A1 (en) T Cell Modulatory Polypeptides with Conjugation Sites and Methods of Use Thereof
EA049738B1 (ru) Модулирующие т-клетки мультимерные полипептиды и способы их применения
CN118401252A (zh) T细胞调节多聚体多肽及其使用方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D13 Search requested

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D13-SRH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000