KR20230029919A - Cosmetic sunscreen composition, use of cosmetic sunscreen composition, and method for preparing cosmetic sunscreen composition - Google Patents

Abstract

The present invention provides a novel cosmetic sunscreen composition with a high SPF and anti-wrinkle and anti-spot efficacy, which may or may not tint the skin, comprising at least one UV filter, at least one active compound and at least one polymer. It is about. The present invention also relates to the use of cosmetic sunscreen compositions and to methods of preparing cosmetic sunscreen compositions.

Description

Cosmetic sunscreen composition, use of cosmetic sunscreen composition, and method for preparing cosmetic sunscreen composition

The present invention relates to novel novel products with high sun protection factor (SPF), anti-wrinkle and anti-spot efficacy, which may or may not tint the skin, comprising at least one UV filter, at least one active compound and at least one polymer. It relates to a cosmetic sunscreen composition. The present invention also relates to the use of cosmetic sunscreen compositions and to methods of preparing cosmetic sunscreen compositions.

Photoprotection of keratin materials, including skin and hair, is considered very important to protect against sun damage, sunburn, and photoaging, as well as to reduce the likelihood of developing skin cancer due to exposure to ultraviolet ("UV") radiation. Typically, there are two types of UVA/UVB cosmetic sunscreen compositions used to achieve light protection: inorganic UV filters and organic UV filters.

In addition to the damage of sun damage, sunburn and photoaging due to solar radiation, at various times in life, particularly during aging and as a result of UVA radiation, some people develop darker patches on their skin, particularly their hands and/or face. and/or more pigmented spots appear, giving the skin an uneven appearance. These spots are due to high concentrations of melanin, particularly in keratinocytes located on the surface of the skin.

The mechanism of melanogenesis, i.e., the formation of melanin, is particularly complex and includes, schematically, the following main steps:

Tyrosine is involved in the mechanism of skin pigmentation, which involves the following major steps schematically:

Tyrosine → DOPA → Dopaquinone → Dopachrome → Melanin

Tyrosinase is an essential enzyme involved in these reactions. In particular, it catalyzes the conversion of tyrosine to DOPA (dihydroxyphenylalanine) due to its hydroxylase activity, and the conversion of DOPA to dopaquinone due to its oxidase activity. These tyrosinase acts only when it matures under the influence of specific biological factors.

In addition, UVA radiation can make a significant contribution to the clinical consequences of solar UV exposure, particularly pigmentation due to solar radiation.

UVA induces immediate pigmentation (IPD) in as little as a few hours by acting on pre-existing melanin. UVA can also cause persistent pigmentation (PPD) in the skin. Among the UV wavelengths reaching the earth's surface, long-wavelength UVA (340-400 nm) accounts for up to 80% of the total UV and shows high penetrability, reaching deep dermis.

If a person already has hyperpigmentation spots or melasma (skin discoloration) on their skin, a possible solution to reducing their color is to use some of the ingredients that work in the hyperpigmentation process to lighten these spots and even out the skin tone. to use active ingredients. UVA reaches the dermal layer of the skin, and despite its effects on photoaging and keratinocyte invasion, melanocytes appear to be more sensitive to the damaging effects of UVA. For example, exposure of cultured melanocytes and keratinocytes from the same donor to UVA and UVB showed that UVA-induced oxidative lesions contributed more to DNA damage in melanocytes than in keratinocytes.

The degree of UV protection provided by a cosmetic sunscreen composition is directly related to the amount and type of UV filter contained therein. The higher the amount of UV filter, the higher the degree of UV protection (UVA/UVB).

In particular, a cosmetic sunscreen composition should provide good protection against the sun, a measure of which is the sun protection factor (SPF) value, but should have a pleasing sensory perception, such as a soft but non-greasy feel upon application. However, this combination of properties has been difficult to achieve, especially since many sunscreen active compounds themselves have an oily or oily feel, and increasing their content tends to affect the final product.

Also, most organic sunscreen filters are oil-based and/or oil-soluble materials. A high level of sunscreen filter in sunscreen products reduces the product's attractiveness due to its oily skin feel, stickiness, long drying time, and leaves a greasy residue on the skin after application. Filters also tend to whiten the skin after application and after being wet with water or perspiration, an undesirable property.

In addition, a significant problem with cosmetic sunscreen compositions is that they tend to be unstable due to the large amount of sunscreen filter associated with the large amount of fillers in order to ensure good sensory properties and pigments in the O/W emulsion.

It is also desirable to formulate cosmetic sunscreen compositions that not only impart photoprotection to keratin materials, but also provide additional properties. For example, it is desirable to prepare cosmetic sunscreen compositions with high SPF, anti-wrinkle and anti-spot efficacy, or even compositions that, in addition to these properties, have the ability to tint the skin to correct imperfections. However, the combination of high SPF and good sensation in formulations with an anti-wrinkle effect is a complicating factor for stabilizing formulations due to the presence of a large amount of actives and an oily phase, which in the case of colored formulations is exacerbated by pigments.

Therefore, there is a need for cosmetic sunscreen compositions with high SPF, anti-wrinkle and anti-spot efficacy, which may or may not color the skin, which are stable and do not feel heavy on the consumer's skin.

The inventors of the present application have surprisingly succeeded in developing a cosmetic sunscreen composition with high SPF, anti-wrinkle and anti-spot efficacy, which may or may not tint the skin, while the formulation has good sensory properties and stability. .

The present invention provides a novel cosmetic sunscreen composition with high SPF, anti-wrinkle and anti-spot efficacy, which may or may not tint the skin, comprising at least one UV filter, at least one active compound and at least one polymer. It is about. The present invention also relates to the use of cosmetic sunscreen compositions and to methods of preparing cosmetic sunscreen compositions.

Other features and advantages of the present invention will become apparent from the following more detailed description of preferred embodiments illustrating the principles of the present invention by way of example.

In one embodiment, the cosmetic sunscreen composition of the present invention comprises:

(a) from about 5.0 to about 20.0% by weight relative to the total weight of the composition of octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane, ethylhexyl triazone and mixtures thereof one or more UV filters selected;

(b) from about 0.1 to about 10.0% by weight, relative to the total weight of the composition, of one selected from hydrolyzed hyaluronic acid, capryloyl salicylic acid, phenylethyl resorcinol, ferulic acid, niacinamide, and mixtures thereof. more active compounds; and

(c) from about 1.5 to about 5.0 weight percent, relative to the total weight of the composition, of xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate, poly C _10-30 alkyl acrylate, and any of these one or more polymers selected from the mixture.

In a preferred embodiment, the amount of one or more UV filters is about 5.0 to about 20.0%, about 6.0 to about 19.0%, about 7.0 to about 18.0%, about 8.0 to about 17.0%, about 9.0 to about 16.0 weight percent, about 10.0 to about 17.0 weight percent, about 10.0 to about 15.0 weight percent, about 11.0 to about 14.0 weight percent, about 12.0 to about 15.0 weight percent, about 14.0 to about 17.0 weight percent; , inclusive of all ranges and subranges therebetween.

In a preferred embodiment, the amount of one or more active compounds is about 0.1 to about 10.0%, about 0.5 to about 10.0%, about 0.75 to about 9.0%, about 1.0 to 7.5%, about 0.1 to about 10.0% by weight relative to the total weight of the composition. 2.0 to about 8.0%, about 2.5 to about 6.0%, about 4.0 to about 5.0%, about 0.8 to about 5.0%, including all ranges and subranges therebetween.

In a preferred embodiment, the amount of the one or more polymers ranges from about 1.5 to about 5.0%, from about 2.0 to about 4.5%, from about 2.5 to about 4.0%, from about 3.0 to about 3.5% by weight relative to the total weight of the composition. , including all ranges and subranges therebetween.

In a preferred embodiment, the cosmetic sunscreen composition of the present invention is about 5.0 to about 15.0% by weight, preferably about 6.0 to about 14.0% by weight, about 7.0 to about 13.0% by weight, about 8.0% by weight, based on the total weight of the composition. to about 12.0 weight percent, about 9.0 to about 11.0 weight percent of at least one pigment selected from titanium dioxide, iron oxide, and mixtures thereof, including all ranges and subranges therebetween.

In a preferred embodiment, the cosmetic sunscreen composition of the present invention contains cosmetically acceptable ingredients selected from perfumes/fragrances, polymers, preservatives, solvents, additional actives, surfactants, fatty substances, vitamins, fillers, and mixtures thereof. Including additional ingredients.

In a preferred embodiment, the cosmetic sunscreen composition of the present invention exhibits a sun protection factor (SPF) in the range of 30 to 80, preferably in the range of 40 to 70, more preferably about 50. In various embodiments, the cosmetic sunscreen composition of the present invention may exhibit a sun protection index of 30, 35, 40, 45, 50, 55, 60, 65, 70 and 80.

In one embodiment, the cosmetic sunscreen composition of the present invention may exhibit a sun protection factor of 50.

In one embodiment, the cosmetic sunscreen composition of the present invention may exhibit a sun protection factor of 60.

In one embodiment, the cosmetic sunscreen composition of the present invention may exhibit a sun protection factor of 70.

In one embodiment, the cosmetic sunscreen composition of the present invention may exhibit a sun protection factor of 80.

The cosmetic sunscreen composition of the present invention is in the form of an oil-in-water (O/W) emulsion.

The cosmetic sunscreen composition of the present invention can be used as a daily product for the skin.

The present invention also relates to the use of said cosmetic sunscreen composition for preparing a photoprotective product of keratin materials having a high SPF, anti-wrinkle and anti-spot efficacy.

Terms

As used herein, the expression "at least" means one or more, and thus includes individual components and mixtures/combinations.

As used herein, the term "anti-spotting" relates to the lightening of hyperpigmented spots or melasma (skin discoloration) for even-toned skin. Synonyms may include "skin bleaching", "pigment loss", "skin tone correction", and the like.

As used herein, all ranges given are meant to include all specific ranges within the given range and combinations of subranges there between. Thus, a range of 1-5 specifically includes 1, 2, 3, 4, and 5, as well as sub-ranges such as 2-5, 3-5, 2-3, 2-4, 1-4, and the like. All ranges and values disclosed herein are inclusive and combinable. For example, any value or point described herein that falls within a range described herein may serve as a minimum or maximum value from which to derive subranges and the like.

The terms "comprising", "having" and "comprising" are used in an open and non-limiting sense.

The compositions and methods of the present invention comprise, consist of, or consist of, the essential elements and limitations of the disclosure set forth herein, as well as any additional or optional elements, ingredients, or limitations described herein or otherwise useful. or may consist essentially of.

As used herein, the expression "at least one" is interchangeable with the expression "one or more" and thus includes individual components and mixtures/combinations.

The terms “indefinite article” and “definite article” are understood to include the plural as well as the singular. Accordingly, the term "mixtures thereof" also relates to "mixtures thereof". Throughout this specification, the term "mixture thereof" is used after a list of elements, as shown in the following example where the letters A-F represent elements: "A, B, C, D, E, F, and any of these one or more elements selected from the group consisting of mixtures". The term “mixture thereof” does not require the mixture to include all of A, B, C, D, E and F (but may include all of A, B, C, D, E and F). Rather, it indicates that mixtures of any two or more of A, B, C, D, E and F may be included. That is, the phrase “at least one element selected from the group consisting of A, B, C, D, E, F, and mixtures of any two or more of A, B, C, D, E, and F” is the same.

All percentages, parts and ratios herein are based on the total weight of the composition of the present invention unless otherwise indicated.

Except in working examples or otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are in all cases +/- 10 %, +/- 8 %, +/- 6 %, +/- 5 %, +/- 4 %, +/- 3 %, +/- 2 %, +/- 1 %, or +/- 0.5 %.

All numbers expressing pH values are to be understood as being modified by the term "about" in all cases up to and including +/- 3%.

As used herein, “substituted” means including one or more substituents. Non-limiting examples of substituents include atoms such as oxygen atoms and nitrogen atoms, as well as hydroxyl groups, ether groups, alkoxy groups, acyloxyalkyl groups, oxyalkylene groups, polyoxyalkylene groups, carboxylic acid groups, amine groups, acyl groups. functional groups such as amino groups, amide groups, halogen-containing groups, ester groups, thiol groups, sulfonate groups, thiosulfate groups, siloxane groups and polysiloxane groups. Substituents may be further substituted.

Similarly, the term “salts thereof” also relates to “salts thereof”. Thus, when the present invention refers to "an element selected from the group consisting of A, B, C, D, E, F, salts thereof, and mixtures thereof", it refers to one or more of A, B, C, D and F may be included, or one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or A, B, C, D, E, F, A salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

The salts referred to throughout this specification may include salts having counter ions such as alkali metal, alkaline earth metal or ammonium counter ions. However, this list of counter ions is non-limiting.

All components and elements that are positively described herein may be negatively excluded from the claims. That is, the compositions of the present invention may not contain or may not contain essentially all of the components and elements positively referred to throughout this specification.

All publications and patent applications cited in this specification are herein incorporated by reference for any and all purposes, as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. In the event of any inconsistency between the present invention and any publication or patent application incorporated herein by reference, the present invention shall prevail.

Additional UV filters

In addition to at least one UV filter selected from octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane, ethylhexyl triazone and mixtures thereof, the cosmetic sunscreen composition of the present invention additionally A UV filter may additionally be included.

According to the present invention, the concentration of additional sunscreen/UV filter in the system is from about 5 to about 35%, preferably from about 7 to about 30%, and more preferably from about 10 to about 35% by weight of the total weight of the composition. 29% by weight.

Additional non-limiting suitable UV filters of the present invention may be:

Oil Soluble Organic Sunscreen Ingredients

"Oil-soluble organic sunscreen ingredient" is any completely soluble in molecular form or miscible in oily phase, or soluble in colloidal form (eg micelle form) in oily fat phase, for blocking UV radiation. of organic compounds.

Non-limiting examples of oil-soluble organic sunscreen ingredients useful in the present invention include, for example, cinnam derivatives; anthranilate; salicyl derivatives; dibenzoylmethane derivatives; camphor derivatives; benzophenone derivatives; diphenyl acrylate derivatives; triazine derivatives; benzotriazole derivatives; benzalmalonate derivatives, especially those cited in patent US 5624663; benzimidazole derivatives; imidazoline; bis-benzoazolyl derivatives as described in patents EP 669323 and US 2463264; p-aminobenzoic acid (PABA) derivatives; methylene bis(hydroxyphenylbenzotriazole) derivatives as described in applications US 5237071, US 5166355, GB 2303549, DE 19726184 and EP 893119; benzoxazole derivatives as described in patent applications EP 0832642, EP 1027883, EP 1300137 and DE 10162844; screening polymers and screening silicones, especially as described in patent application WO 93/04665; dimers derived from alkyl-styrenes such as those described in patent application DE 19855649; 4,4-diarylbutadiene as described in patent applications EP 0967200, DE 19746654, DE 19755649, EP-A-1008586, EP 1133980 and EP 1133981, patent applications WO 04/006878, WO 05/058269 and WO 06/032741 merocyanine derivatives as described in; and mixtures thereof, the entire contents of which patents and patent applications are hereby incorporated by reference in their entirety.

As examples of other suitable oil-soluble organic sunscreen ingredients, mention may be made of those indicated herein below by their INCI names:

Cinnamic Derivatives:

Examples of suitable cinnamic derivatives include, but are not limited to, ethylhexyl methoxycinnamate, isopropyl methoxycinnamate, isoamyl methoxycinnamate, DEA methoxycinnamate, diisopropyl methylcinnamate, glyceryl ethylhexano Eight dimethoxycinnamate.

Dibenzoylmethane derivatives:

Examples of suitable dibenzoylmethane derivatives include, but are not limited to, isopropyl dibenzoylmethane.

Salicyl derivatives:

Examples of suitable salicyl derivatives include, but are not limited to, homosalate, ethylhexyl salicylate, dipropylene glycol salicylate and TEA salicylate.

Beta, beta-diphenylacrylate derivatives:

Examples of suitable beta, beta-diphenylacrylate derivatives include, but are not limited to, ethocrylene.

Benzophenone derivatives:

Examples of suitable benzophenone derivatives include, but are not limited to, benzophenone-1, benzophenone-2, benzophenone-3 or oxybenzone, benzophenone-4, benzophenone-5, benzophenone-6, benzophenone-8, benzophenone-9, benzophenone-12, n-hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate, or mixtures with octyl methoxycinnamate.

Benzylidenecamphor derivatives:

Examples of suitable benzylidene camphor derivatives include, but are not limited to, prepared 3-benzylidene camphor, prepared 4-methylbenzylidene camphor, prepared polyacrylamidomethyl benzylidene camphor.

Phenylbenzotriazole derivatives:

Examples of suitable phenylbenzotriazole derivatives include, but are not limited to, methylene bis-benzotriazolyl tetramethylbutyl-phenol, or in micronized form as an aqueous dispersion.

Triazine Derivatives:

Examples of suitable triazine derivatives include, but are not limited to, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylhexyl butamido triazone, 2,4,6-tris(dineopentyl 4'-aminobenzalmalonate )-s-triazine, 2,4,6-tris(diisobutyl 4'-aminobenzalmalonate)-s-triazine, 2,4-bis(dineopentyl 4'-aminobenzalmalonate)- 6-(n-Butyl 4'-aminobenzoate)-s-triazine, patent US 6,225,467, patent application WO 2004/085412 (see compounds 6 and 9) or "Symmetrical Triazine Derivatives" IP.COM Journal, IP .COM Inc., West Henrietta, NY, US (20 September 2004), in particular 2,4,6-tris(biphenyl)-1,3,5-triazine (patent pending in particular 2,4,6-tris(biphenyl-4-yl)-1 contained in WO 06/035000, WO 06/034982, WO 06/034991, WO 06/035007, WO 2006/034992 and WO 2006/034985; 3,5-triazine and 2,4,6-tris(terphenyl)-1,3,5-triazine).

Anthranil derivatives:

Examples of suitable anthranil derivatives include, but are not limited to, methyl anthranilate.

Imidazoline derivatives:

Examples of suitable imidazoline derivatives include, but are not limited to, ethylhexyl dimethoxybenzylidene dioxoimidazoline propionate.

Benzalmalonate derivatives:

Examples of suitable benzalmalonate derivatives include, but are not limited to, polyorganosiloxanes containing benzalmalonate functional groups, such as polysilicone-15.

4,4-diarylbutadiene derivatives:

Examples of suitable 4,4-diarylbutadiene derivatives include, but are not limited to, 1-dicarboxy(2,2'-dimethylpropyl)-4,4-diphenyl-butadiene.

Benzoxazole derivatives:

Examples of suitable benzoxazole derivatives include, but are not limited to, 2,4-bis[5-(1-dimethylpropyl)benzoxazol-2-yl-(4-phenyl)imino]-6-(2-ethylhexyl) imino-1,3,5-triazines, and mixtures thereof.

Preferably, the oil-soluble organic sunscreen ingredient will be selected from ethylhexyl salicylate, bis-ethylhexyloxyphenol methoxyphenyl triazine, and mixtures thereof.

The oil-soluble organic sunscreen component is preferably present in an amount of about 3 to about 25% by weight, preferably in an amount of about 5 to about 20% by weight, and most preferably in an amount of about 7 to about 18% by weight relative to the total weight of the composition. It is present in the composition according to the invention in an amount of % by weight.

Water Soluble Organic Sunscreen Ingredients

"Water-soluble organic sunscreen ingredients" are completely soluble in molecular form or miscible in liquid aqueous phase, or soluble in colloidal form (eg micelle form) in liquid aqueous phase, for blocking UV radiation means any organic compound.

Non-limiting examples of water-soluble organic sunscreen ingredients useful in the present invention include, for example, phenylbenzimidazole sulfonic acid, benzophenone-4, aminobenzoic acid (PABA), 4-bis(polyethoxy)-para-aminobenzoic acid poly Ethoxyethyl ester (PEG-25 PABA), camphor benzalkonium methosulfate, methylene bis-benzotriazolyl tetramethylbutylphenol (bisoctrizole), disodium phenyl dibenzimidazole tetrasulfonate (bisdisulizol di sodium), and tris-biphenyl triazine; derivatives and corresponding salts thereof; naphthalene bisimide derivatives such as those described in European Patent Application EP 1990372 A2, the entire contents of which are incorporated herein by reference; and cinnamido amine cationic quaternary salts and derivatives such as those described in U.S. Patent No. 5,601,811, the entire contents of which are incorporated herein by reference, and mixtures thereof.

Salts of the compounds which can be used according to the invention are in particular salts of alkali metals, for example sodium or potassium; salts of alkaline earth metals, for example calcium, magnesium or strontium; metal salts such as zinc, aluminum, manganese or copper salts; Ammonium salts of formula NH4 ⁺ ; quaternary ammonium salts; Salts of organic amines, such as methylamine, dimethylamine, trimethylamine, triethylamine, ethylamine, 2-hydroxyethylamine, bis(2-hydroxyethyl)amine or tris(2-hydroxyethyl)amine salt of; lysine or arginine salts. Salts selected from sodium, potassium, magnesium, strontium, copper, manganese or zinc salts are preferably used. Sodium salts are preferably used.

Preferably, the water-soluble organic sunscreen ingredient will be selected from methylene bis-benzotriazolyl tetramethylbutylphenol, and mixtures thereof.

The water-soluble organic sunscreen component is preferably in an amount of about 0.1 to about 10% by weight, preferably in an amount of about 0.5 to about 8% by weight, and most preferably in an amount of about 1 to about 7% by weight relative to the total weight of the composition. It is present in the composition according to the invention in an amount of % by weight.

Silica Coated Titanium Dioxide Sunscreen Ingredients

"Silica coated titanium dioxide sunscreen component" means spherical beads formed by encapsulating titanium dioxide particles in silica.

A non-limiting example of a silica coated titanium dioxide sunscreen ingredient useful in the present invention has a composition of about 55:45 silica:titanium dioxide and has a particle size of about 2 microns to about 7 microns, for example coated with silica. titanium dioxide, such as the name silica (and) titanium dioxide.

The silica coated titanium dioxide sunscreen component is preferably in an amount of about 1 to about 10 weight percent, preferably in an amount of about 2 to about 10 weight percent, and most preferably in an amount of about 5 to about 10 weight percent relative to the total weight of the composition. to about 10% by weight.

Additional Ingredients

In addition to the essential ingredients described above, the cosmetic sunscreen composition of the present invention may in particular contain, for example, additional sunscreens, fragrances/fragrances, preservatives, solvents, active agents, surfactants, fatty compounds, vitamins, fillers, silicones, polymers, pigments, and any conventional cosmetically acceptable ingredients which may be selected from mixtures thereof.

The cosmetic sunscreen composition of the present invention contains water. The water used is sterile demineralized and/or deionized water, and/or floral water, such as rose water, cornflower water, chamomile water or lime water, and/or natural spring water or mineral water, for example: water from Vittel, from the Vichy basin. Water from Uriage, Water from La Roche Posay, Water from La Bourboule, Water from Enghien-les-Bains, Water from Saint Gervais-les-Bains, Water from Neris-les-Bains, Allevar -water from les-Bains, water from Digne, water from Maizieres, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from EauxBonnes, water from Rochefort, water from Saint Christau water, water from Les Fumades, water from Tercis-les-Bains, or water from Avene. The water may also include reconstituted thermal spring water, i.e. water containing trace elements such as zinc, copper, magnesium, etc. which reconstitute the characteristics of the thermal spring water.

One skilled in the art will take care to select optional additional ingredients and/or amounts thereof such that the advantageous properties of the composition according to the present invention are not adversely affected or substantially unaffected by the foreseeable additions.

Suitable polymers include, but are not limited to, acrylates/C _10-30 alkyl acrylate crosspolymers, styrene/acrylate copolymers, and mixtures thereof.

The composition may also include one or more silicone components, which may be dimethicone and caprylyl methicone, among others.

A non-limiting example of a preservative that may be used in accordance with the present invention includes phenoxyethanol.

Additional suitable solvents include, but are not limited to, C _12-15 alkyl benzoates, pentylene glycol, caprylyl glycol, and mixtures thereof.

Suitable surfactants may be selected in particular from potassium cetyl phosphate, sodium methyl stearoyl taurate and inulin lauryl carbamate.

In various embodiments, the solvent comprises about 15 to 100 weight percent, or about 25 to about 80 weight percent, or about 30 to about 70 weight percent, or about 35 to about 75% by weight, or preferably from about 40 to about 70% by weight, and more preferably from about 40 to about 60% by weight, including ranges and subranges therebetween.

Suitable additional active agents include, but are not limited to, disodium EDTA, triethanolamine, and mixtures thereof.

The composition may include one or more dyes/pigments, preferably titanium oxide or iron oxide.

Exemplary fatty or oily substances include, but are not limited to, isopropyl lauroyl sarcosinate, stearyl alcohol, and mixtures thereof.

The composition may also include one or more fillers such as silica or polylactic acid.

The additional component may represent 50 to 85% by weight, such as 55 to 82% by weight, or eg 60 to 80% by weight of the total weight of the composition.

Next, by way of non-limiting example, the present invention will be described with reference to the following examples.

Manufacturing method of cosmetic sunscreen composition

Non-limiting examples of the preparation of a cosmetic sunscreen composition according to the present invention may be as follows:

Step (A): Main vessel—hot oily phase containing oil stock at a temperature ranging from 75° C. to 80° C.;

Step (B): Secondary vessel - room temperature aqueous phase containing aqueous feedstock;

Step (C): adding the aqueous phase of step (B) to the oily phase of step (A), then subsequently adding an emulsifier, and then mixing the mixture;

Step (D): adding a polymer to the mixture obtained in step (C) followed by subsequent neutralization;

Step (E): slowly adding the filler to the mixture obtained in step (D) and mixing until uniform at a temperature below 30°C.

Another non-limiting example of the preparation of a cosmetic sunscreen composition according to the present invention may be:

Step (A): Main vessel - room temperature aqueous phase containing the aqueous stock;

Step (B): Sub-vessel—hot oily phase comprising an oil stock at a temperature ranging from 75° C. to 80° C.;

Step (C): adding the oily phase of step (B) to the aqueous phase of step (A), then subsequently adding an emulsifier and then mixing the mixture;

Step (D): adding a polymer to the mixture obtained in step (C) followed by subsequent neutralization;

Step (E): slowly adding the filler to the mixture obtained in step (D) and mixing until uniform at a temperature below 30°C.

embodiment

Examples of suitable cosmetic sunscreen compositions according to the present invention include:

- 15.0% to 18.0% of octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane and ethylhexyl triazone;

- 4.0% to 6.0% of hydrolyzed hyaluronic acid, capryloyl salicylic acid, phenylethyl resorcinol and niacinamide;

- 2.0% to 3.0% of xanthan gum, aluminum starch octenylsuccinate and ammonium polyacryloyldimethyl taurate;

- from 0.4% to 0.6% of phenoxyethanol;

- from 4.0% to 6.0% of dimethicone and vinyl dimethicone/methicone silsesquioxane crosspolymers;

- 3.0% to 4.0% of potassium cetyl phosphate, poloxamer 338 and glyceryl stearate (and) PEG-100 stearate;

- 11.0% to 17.5% of glycerin, caprylyl glycol and C _12-15 alkyl benzoates;

- from 3.5% to 10.0% of additional cosmetically acceptable ingredients such as vitamins, fillers, fatty compounds, fragrances, triethanolamine and disodium EDTA;

- 40.0% to 50.0% water.

Another suitable cosmetic sunscreen composition according to the present invention comprises:

- 12.0% to 17.0% of octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane and ethylhexyl triazone;

- 0.5% to 2.0% of hydrolyzed hyaluronic acid, capryloyl salicylic acid and phenylethyl resorcinol;

- 2.0% to 4.0% of xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate and poly C _10-30 alkyl acrylate;

- 8.5% to 12.0% of titanium dioxide and iron oxide;

- from 0.4% to 0.6% of phenoxyethanol;

- from 4.0% to 6.0% of dimethicone and vinyl dimethicone/methicone silsesquioxane crosspolymers;

- 3.0% to 4.0% of potassium cetyl phosphate, poloxamer 338 and glyceryl stearate (and) PEG-100 stearate;

- 10.0% to 20.0% of glycerin, caprylyl glycol and C _12-15 alkyl benzoates;

- from 4.0% to 8.0% of additional cosmetically acceptable ingredients such as vitamins, fillers, fatty compounds, fragrances, triethanolamine and disodium EDTA;

- 30.0% to 40.0% water.

Additional suitable cosmetic sunscreen compositions according to the present invention include:

- 10.0% to 20.0% of octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane and ethylhexyl triazone;

- 0.5% to 1.5% of hydrolyzed hyaluronic acid, capryloyl salicylic acid and phenylethyl resorcinol;

- 2.0% to 5.0% of xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate and poly C _10-30 alkyl acrylate;

- 6.5% to 11.0% of titanium dioxide and iron oxide;

- from 0.4% to 0.6% of phenoxyethanol;

- from 4.0% to 6.0% of dimethicone and vinyl dimethicone/methicone silsesquioxane crosspolymers;

- 3.0% to 4.0% of potassium cetyl phosphate, poloxamer 338 and glyceryl stearate (and) PEG-100 stearate;

- 11.0% to 17.5% of glycerin, caprylyl glycol and C _12-15 alkyl benzoates;

- from 5.0% to 10.0% of additional cosmetically acceptable ingredients such as vitamins, fillers, fatty compounds, fragrances, triethanolamine and disodium EDTA;

- 30.0% to 40.0% water.

All percentages herein are based on the total weight of the cosmetic sunscreen composition.

Example

Examples 1 to 5

Suitable compositions according to the state of the art are as Example 1, and suitable cosmetic sunscreen compositions according to the present invention are as Examples 2 to 5, as follows:

Example 6

Safety test 1

In order to evaluate the skin tolerance and subjective evaluation of the cosmetic sunscreen composition of Example 3, used under normal or reasonably predictable conditions under dermatological management, subjects between the ages of 18 and 70 for 28 (± 2) days An in vivo study was conducted on 50 male and female adult volunteers.

The product was used by 50 adults for 28 days, all picture types were used, and there were 2 visits (first day, D0 and last day, D28). Each subject was its own control (comparison before and after application).

Application of the cosmetic sunscreen composition of the present invention was carried out by the subject according to instructions provided by the team and presented in the subject's diary.

In conclusion, the composition according to Example 3 is safe for the skin.

In addition, most of the subjects fully or partially agreed with the following: The product has a light texture, has a pleasant texture, does not leave a greasy feeling on the skin, does not leave an oily feeling on the skin, is quickly absorbed, Does not leave stickiness, makes skin brighter/shinier, covers visible pores, provides a comfortable touch, brightens skin, makes skin look more even, makes skin softer, right after application makes the skin feel more hydrated on the skin, makes the skin feel hydrated throughout the day, the product tightens the skin, makes the skin firmer, is easy to spread, does not clog pores, and has a pleasant smell.

Example 7

Safety test 2

To demonstrate the absence of photoallergy and phototoxicity potential of the cosmetic sunscreen composition of the present invention upon exposure to ultraviolet radiation, under maximized conditions with a dermatologist, controlling the area and amount of application, at the age of 23 Thirty-three male and female adult volunteers aged between 67 years of age were subjected to an in vivo study using phototypes II and III for 6 weeks.

After applying the cosmetic sunscreen composition of the present invention and the control composition according to Examples 2 and 3 to a filter disk in a contact test (patch test), they were fixed to the volunteer's right or left back (scapular region), and a skilled expert It was allowed to remain on the volunteer's skin until removal, and ultraviolet radiation A and B were irradiated to the affected area.

A dermatological clinical evaluation was performed at the beginning and end of the study, and volunteers were accompanied by a dermatologist throughout the study.

During the study, the participants did not show any skin-related clinical signs associated with the cosmetic sunscreen composition of the present invention, which also did not induce skin photoallergy in the study group and did not cause skin phototoxicity in the study group.

Therefore, the cosmetic sunscreen composition of the present invention was considered safe under the conditions evaluated.

Example 8

Sun Protection Factor (SPF)

In vivo study to determine the sun protection factor (SPF) of a cosmetic sunscreen composition of the present invention, before and after water immersion of a single topical use of the cosmetic sunscreen composition, according to methodology ISO 24444 and guideline Colipa 2005 was performed. The study was conducted using photo types I to III for 57 days on 16 women between the ages of 20 and 58 years.

The cosmetic sunscreen composition of the present invention according to Example 2 was applied to the subject's dry skin and irradiated with a controlled dose of ultraviolet radiation. Thereafter, the cosmetic sunscreen composition of the present invention was applied to another area and the irradiation was repeated after 40 minutes when the study subject remained in the bath. Sites were evaluated after 16-24 hours.

The average static SPF of the cosmetic sunscreen composition of Example 3 was 62.0, and was 24.8 after immersion.

Example 9

UVA protection

In accordance with ISO 24442, an in vivo study was conducted to evaluate the UVA protection (PF-UVA) efficacy of the cosmetic sunscreen composition of Example 2.

The study was conducted using photo types III to IV for 33 days on 10 women between the ages of 21 and 48 years.

The cosmetic sunscreen composition of Example 2 exhibited a PF-UVA of 19.0.

Example 10

consumer use test

In order to understand users' perceptions of the cosmetic sunscreen compositions of Examples 2 to 5, an in vivo study was conducted on 80 female volunteers between the ages of 35 and 55 with mixed skin tones and types.

Applicants were interviewed to comment on several aspects of cosmetic sunscreen compositions, such as ease of application, lightness of texture, ease of spread, comfort of texture, as well as results related to anti-wrinkle and bright spot efficacy. did For example, they feel that the composition relieves and/or lessens skin imperfections, further replenishes the skin, prevents and repairs signs of photoaging and expression wrinkles.

The cosmetic sunscreen compositions of Examples 4-5 were evaluated for additional characteristics such as ability to even out skin spots and/or imperfections, high coverage and ability to even out skin tone.

The cosmetic sunscreen compositions of the present invention according to Examples 2 to 5 had very good consumer results, with high approval in all evaluation criteria.

Claims (11)

A cosmetic sunscreen composition with high SPF, anti-wrinkle and anti-spot efficacy, comprising:
(a) 5.0 to 20.0% by weight relative to the total weight of the composition selected from octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane, ethylhexyl triazone and mixtures thereof; one or more UV filters;
(b) 0.1 to 10.0% by weight of at least one active selected from hydrolyzed hyaluronic acid, capryloyl salicylic acid, phenylethyl resorcinol, ferulic acid, niacinamide, and mixtures thereof, relative to the total weight of the composition. compound; and
(c) from 1.5 to 5.0 weight percent, relative to the total weight of the composition, of xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate, poly C _10-30 alkyl acrylate, and mixtures thereof; one or more polymers selected. 2. The composition of claim 1, wherein the amount of at least one UV filter ranges from 10.0 to 17.0% by weight relative to the total weight of the composition, inclusive of all ranges and subranges therebetween. 2. The composition according to claim 1, wherein the amount of at least one active compound ranges from 0.8 to 5.0% by weight relative to the total weight of the composition. 2. The composition of claim 1, wherein the amount of the one or more polymers ranges from 2.5 to 4.0% by weight relative to the total weight of the composition. The composition according to claim 1 , further comprising from 5.0 to 15.0% by weight of at least one pigment selected from titanium dioxide, iron oxide, and mixtures thereof, relative to the total weight of the composition. 6. The composition according to claim 5, wherein the amount of the one or more pigments ranges from 8.0 to 11.0% by weight relative to the total weight of the composition. The composition of claim 1 , further comprising cosmetically acceptable ingredients selected from perfumes/perfumes, polymers, preservatives, solvents, additional actives, surfactants, fatty substances, vitamins, fillers, and mixtures thereof. The composition of claim 1 exhibiting a sun protection factor (SPF) in the range of 30 to 80. Use of a cosmetic sunscreen composition comprising:
(a) 5.0 to 20.0% by weight relative to the total weight of the composition selected from octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane, ethylhexyl triazone and mixtures thereof; one or more UV filters;
(b) 0.1 to 10.0% by weight of at least one active selected from hydrolyzed hyaluronic acid, capryloyl salicylic acid, phenylethyl resorcinol, ferulic acid, niacinamide, and mixtures thereof, relative to the total weight of the composition. compound; and
(c) from 1.5 to 5.0 weight percent, relative to the total weight of the composition, of xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate, poly C _10-30 alkyl acrylate, and mixtures thereof; one or more polymers selected;
Here, the use is for preparing a product for photoprotection of a keratin material having a high SPF, anti-wrinkle and anti-spot effect. A method for preparing a cosmetic sunscreen composition comprising:
(a) 5.0 to 20.0% by weight relative to the total weight of the composition selected from octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane, ethylhexyl triazone and mixtures thereof; one or more UV filters;
(b) 0.1 to 10.0% by weight of at least one active selected from hydrolyzed hyaluronic acid, capryloyl salicylic acid, phenylethyl resorcinol, ferulic acid, niacinamide, and mixtures thereof, relative to the total weight of the composition. compound; and
(c) from 1.5 to 5.0 weight percent, relative to the total weight of the composition, of xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate, poly C _10-30 alkyl acrylate, and mixtures thereof; one or more polymers selected;
Here, the method includes the following steps:
Step (A): Main vessel—hot oily phase containing oil stock at a temperature ranging from 75° C. to 80° C.;
Step (B): Secondary vessel - room temperature aqueous phase containing aqueous feedstock;
Step (C): adding the aqueous phase of step (B) to the oily phase of step (A), then subsequently adding an emulsifier, and then mixing the mixture;
Step (D): adding a polymer to the mixture obtained in step (C) followed by subsequent neutralization;
Step (E): Slowly adding the filler to the mixture obtained in step (D) and mixing until uniform at a temperature below 30°C. A method for preparing a cosmetic sunscreen composition comprising:
(a) 5.0 to 20.0% by weight relative to the total weight of the composition selected from octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane, ethylhexyl triazone and mixtures thereof one or more UV filters;
(b) 0.1 to 10.0% by weight of at least one active selected from hydrolyzed hyaluronic acid, capryloyl salicylic acid, phenylethyl resorcinol, ferulic acid, niacinamide, and mixtures thereof, relative to the total weight of the composition. compound; and
(c) from 1.5 to 5.0 weight percent, relative to the total weight of the composition, of xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate, poly C _10-30 alkyl acrylate, and mixtures thereof; one or more polymers selected;
(d) 5.0 to 15.0% by weight, relative to the total weight of the composition, of at least one pigment selected from titanium dioxide, iron oxide, and mixtures thereof;
Here, the method includes the following steps:
Step (A): Main vessel - room temperature aqueous phase containing the aqueous stock;
Step (B): Sub-vessel—hot oily phase comprising an oil stock at a temperature ranging from 75° C. to 80° C.;
Step (C): adding the oily phase of step (B) to the aqueous phase of step (A), then subsequently adding an emulsifier and then mixing the mixture;
Step (D): adding a polymer to the mixture obtained in step (C) followed by subsequent neutralization;
Step (E): Slowly adding the filler to the mixture obtained in step (D) and mixing until uniform at a temperature below 30°C.