KR20230024456A - Composition for skin moisturizing, anti-wrinkle or wound healing comprising ginseng fruit and deer antlers - Google Patents

Abstract

Disclosed in the present application is a composition for moisturizing skin, reducing skin wrinkles, and/or promoting wound healing, comprising ginseng fruits and deer antlers as active ingredients. The ginseng fruits and the deer antlers may be mixed in a weight ratio of 1 : 3 to 7. The composition is very effective in preventing, alleviating, and/or treating skin moisture reduction, wrinkle formation, elasticity reduction, wounds, and/or skin damage caused by ultraviolet rays by using the ginseng fruits and the deer antlers together.

Description

Composition for skin moisturizing, wrinkle improvement or wound healing containing ginseng fruit and antler

The present disclosure discloses a composition for moisturizing skin, improving wrinkles, and/or promoting wound healing, including ginseng fruit and antler as active ingredients.

As a primary barrier, the skin protects the human body from external environmental stimuli such as temperature and humidity changes, ultraviolet rays, and pollutants, and plays an important role in maintaining homeostasis of the human body. Such skin aging occurs due to various internal and external factors, and aging is largely divided into endogenous aging due to genetic causes and extrinsic aging caused by environmental causes. Recently, the destruction of the ozone layer due to environmental pollution has increased the amount of ultraviolet rays, and accordingly, research on photoaging, that is, aging by ultraviolet rays, is attracting attention. In photoaged skin, external features such as roughness, dryness, loss of elasticity, wrinkles, and irregular pigmentation are observed. It is known that the synthesis, decomposition and moisture content of collagen, which is a major component of skin, affects skin elasticity and wrinkle formation.

The skin can be divided into three layers: epidermis, dermis, and subcutaneous fat tissue. The epidermis is the outermost layer of the skin, and most of the cells are keratinocytes. Starting from the cells located in the basal layer, which is the deepest layer of the epidermis, as they go up to the epidermal layer, the vitality of the cells disappears and changes into a solid and regular cell layer. However, once it reaches the skin surface, it is shed. When a wound occurs on the surface of the skin, it plays a role in preventing further infection by promoting recovery of the wound due to the rapid regeneration ability of the epidermis. The dermis is a tissue that maintains the skin, and various organs such as nerve endings, sweat glands, and various glands including sebaceous glands and blood vessels exist. Among the main matrix proteins produced by fibroblasts of the skin, collagen accounts for about 30% of the total weight of biological proteins, and most of them are present in the dermis of the skin. Collagen plays an important role in wound healing.

Among collagens, type IV collagen (COL4A1) is involved in the process of constructing the basal dermoepidermal membrane and in particular the supramolecular organization of the extracellular matrix (ECM) with respect to cell orientation in the matrix. plays an important role in Type IV collagen deficiency is closely related to aging and loss of elasticity, and type IV collagen is known to be involved in elastin biosynthesis and wound healing. Type VII collagen (COL7A1) acts as an important protein for anchoring fibril formation at the dermal-epidermal junction (DEJ).

KR 10-2008-0094540 A

In one aspect, an object of the present disclosure is to provide a composition for moisturizing skin, improving wrinkles, and/or promoting wound healing, including ginseng fruit and antler as active ingredients.

In one aspect, the present disclosure provides a composition for moisturizing skin, improving wrinkles, or promoting wound healing, including ginseng fruit and antler as active ingredients.

In an exemplary embodiment, the ginseng fruit may be included in less than 2% by weight based on the total weight of the composition.

In an exemplary embodiment, the deer antler may be included in less than 8% by weight based on the total weight of the composition.

In an exemplary embodiment, the mixed weight of the ginseng fruit and the antler may be 5% by weight or less based on the total weight of the composition.

In an exemplary embodiment, the ginseng fruit and the antler may be mixed in a weight ratio of 1:0.1 to 10.

In an exemplary embodiment, the ginseng fruit and the antler may be mixed in a weight ratio of 1:3 to 7.

In an exemplary embodiment, the ginseng fruit may be a concentrate of ginseng fruit.

In an exemplary embodiment, the deer antler may be an extract of deer antler.

In an exemplary embodiment, the extract of the deer antler may be a hot water extract of the deer antler.

In an exemplary embodiment, the composition may be a cosmetic composition.

In one exemplary embodiment, the composition may be a food composition.

In an exemplary embodiment, the composition may be a pharmaceutical composition for preventing or treating dry skin or preventing or treating wounds or skin damage caused by ultraviolet rays.

In one aspect, the technology disclosed in the present disclosure has an effect of providing a composition for moisturizing skin, improving wrinkles, and/or promoting wound healing, including ginseng fruit and antler as active ingredients.

1 shows the results of cytotoxicity evaluation of ginseng fruit according to an experimental example.
Figure 2 shows the results of evaluating the cytotoxicity of antler according to an experimental example.
3 shows the results of cytotoxicity evaluation of a mixture of ginseng fruit and antler antler according to an experimental example.
Figure 4 shows the evaluation results of hyaluronic acid synthetase 2 (HAS2) expression level according to an experimental example.
5 shows results of evaluating the expression level of type VII collagen (COL7A1) according to an experimental example.
6 shows results of evaluating the expression level of type IV collagen (COL4A1) according to an experimental example.

Hereinafter, the present disclosure will be described in detail.

In one aspect, the present disclosure provides a composition for moisturizing skin, improving wrinkles, or promoting wound healing, including ginseng fruit and antler as active ingredients.

As used herein, 'active ingredient' refers to a component that can exhibit the desired activity alone or together with a carrier having no activity itself.

In an exemplary embodiment, the ginseng fruit may be included in less than 2% by weight, preferably less than 1% by weight based on the total weight of the composition. In another exemplary embodiment, the ginseng fruit is present in an amount of 0.001 wt% or more, 0.01 wt% or more, 0.1 wt% or more, or 0.5 wt% or more, less than 2 wt%, 1.8 wt% or less, 1.6 wt% or more, based on the total weight of the composition. It may be included in less than 1.4% by weight, less than 1.2% by weight, less than 1% by weight, less than 0.8% by weight or less than 0.6% by weight.

In an exemplary embodiment, the antler may be included in less than 8% by weight, preferably less than 4% by weight based on the total weight of the composition. In another exemplary embodiment, the antler is 0.001% by weight or more, 0.01% by weight or more, 0.1% by weight or more, or 0.5% by weight or more, less than 8% by weight, 7.5% by weight or less, 7% by weight based on the total weight of the composition. % or less, 6.5% or less, 6% or less, 5.5% or less, 5% or less, 4.5% or less, 4% or less, 3.5% or less, 3% or less, 2.5% or less, 2% or less % or less, 1.5% by weight or less, 1% by weight or less, or 0.5% by weight or less.

In an exemplary embodiment, the mixed weight of the ginseng fruit and the antler may be 5% by weight or less, preferably 4% by weight or less, based on the total weight of the composition. In another exemplary embodiment, the mixed weight of the ginseng fruit and the antler is 0.1% by weight, 0.5% by weight or more, 1% by weight or more, 1.5% by weight or more, 2% by weight or more, or 2.5% by weight based on the total weight of the composition. or more than 3% by weight, and may be 5% by weight or less, 4.8% by weight or less, 4.6% by weight or less, 4.4% by weight or less, 4.2% by weight or less, or 4% by weight or less.

In an exemplary embodiment, the ginseng fruit and the antler may be mixed in a weight ratio of 1:0.1 to 10.

In an exemplary embodiment, the ginseng fruit and the antler may be mixed in a weight ratio of 1:3 to 7.

In an exemplary embodiment, the ginseng fruit may be processed by a method such as drying, pulverizing, concentrating, extracting, fractionating, or fermenting ginseng fruit.

In an exemplary embodiment, the ginseng fruit may be a concentrate of ginseng fruit obtained by removing seeds from the ginseng fruit and concentrating the flesh and juice. The concentrate may be concentrated under conditions of 50 to 60 °C, 50 to 55 °C or 55 to 60 °C.

In an exemplary embodiment, the deer antler may be processed by a method such as drying, grinding, concentration, extraction, fractionation, fermentation, or the like.

In an exemplary embodiment, the antler antler may be an extract of antler obtained by pulverizing and then extracting dried antler. In another exemplary embodiment, the antler antler may be a concentrate of antler obtained by pulverizing dried antler and then extracting and concentrating. The concentrate may be concentrated under conditions of 50 to 60 °C, 50 to 55 °C or 55 to 60 °C.

In an exemplary embodiment, the extract of the antler may be extracted with one or more solvents selected from the group consisting of water and lower alcohols having 1 to 4 carbon atoms.

In an exemplary embodiment, the antler extract may be extracted at a temperature of 85 °C or higher, 90 °C or higher, 95 °C or higher, 85 to 100 °C, 90 to 100 °C, or 95 to 100 °C.

In an exemplary embodiment, the extract of the deer antler may be a hot water extract of the deer antler.

In one exemplary embodiment, the composition may have collagen synthesis promoting activity, collagen degradation inhibition, and/or moisturizing factor synthesis promoting activity.

In one exemplary embodiment, the wrinkle improvement may mean including elasticity improvement.

In one exemplary embodiment, the promotion of wound healing may mean including skin regeneration.

In an exemplary embodiment, the composition may prevent, improve, and/or treat skin moisture loss, wrinkle formation, elasticity loss, wounds, and/or skin damage caused by ultraviolet rays.

In an exemplary embodiment, the composition may prevent, improve, and/or treat dry skin, or prevent, improve, and/or treat skin damage caused by wounds and/or ultraviolet rays.

In an exemplary embodiment, the composition may be a cosmetic composition.

In addition to the active ingredient, the cosmetic composition may further include functional additives and ingredients included in general cosmetic compositions in appropriate amounts. The functional additive may include at least one component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed extracts. Ingredients that may be included in addition to this include oils and fats, humectants, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, and fragrances. , blood circulation promoters, cooling agents, antiperspirants, and purified water. The above components can be formulated within a range not impairing the objects and effects of the present disclosure.

The formulation of the cosmetic composition is not particularly limited, and may be appropriately selected according to the purpose. For example, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream, moisture cream, hand cream, foundation, essence, oil, nutrient essence, pack, patch , Soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, make-up base, it may be prepared in one or more formulations selected from the group consisting of foundation and shadow, but is not limited thereto.

When the formulation of the present disclosure is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present disclosure is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / May contain a propellant such as butane or dimethyl ether.

When the formulation of the present disclosure is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butyl glycol oil, glycerol fatty esters, polyethylene glycol or fatty acid esters of sorbitan may be used.

When the formulation of the present disclosure is a suspension, water as a carrier component, liquid diluents such as ethanol or propylene glycol, ethoxylated isostearyl alcohols, suspending agents such as polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.

When the formulation of the present disclosure is a surfactant-containing cleansing, as a carrier component, fatty alcohol sulfate, fatty alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

In one exemplary embodiment, the composition may be a food composition.

The food composition may be a liquid or solid formulation, for example, various foods, beverages, gum, tea, vitamin complexes, health supplements, health functional foods, etc., powders, granules, tablets, capsules or beverages It can be prepared in phosphorus form. The food composition of each formulation can be selected and blended without difficulty by a person skilled in the art according to the formulation or purpose of use other than the active ingredient, and synergistic effects can occur when applied simultaneously with other ingredients.

The food composition may include various flavoring agents or natural carbohydrates as additional components, like conventional beverages, as liquid components that may be contained in addition to active ingredients, but the liquid components are not particularly limited. Examples of the natural carbohydrate include monosaccharides, disaccharides such as glucose and fructose, polysaccharides such as maltose and sucrose, common sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. etc. As the flavoring agent, natural flavoring agents (thaumatin, stevia extract (eg rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (eg saccharin, aspartame, etc.) can be advantageously used. The proportion of the natural carbohydrate may generally be about 1 to 20 g, and in one aspect about 5 to 12 g per 100 ml of the composition disclosed in the present disclosure.

In one aspect, the food composition includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH regulators, stabilizers, preservatives, glycerin, alcohol, carbonation agents used in carbonated beverages, and the like may be included. In another aspect, it may further include fruit flesh for preparing natural fruit juice and vegetable beverages. These components may be used independently or in combination. The proportions of these additives may vary, but may be selected in the range of 0.001 to 20 parts by weight per 100 parts by weight of the composition disclosed in this disclosure.

In an exemplary embodiment, the composition may be a pharmaceutical composition for preventing or treating dry skin or preventing or treating wounds or skin damage caused by ultraviolet rays.

In an exemplary embodiment, the skin damage caused by the ultraviolet rays may be wrinkle formation or elasticity loss.

The pharmaceutical composition may further contain pharmaceutical adjuvants and other therapeutically useful substances such as preservatives, stabilizers, hydration or emulsification accelerators, salts and/or buffers for osmotic pressure control, in addition to active ingredients, and may be used in conventional methods. It can be formulated into various oral or parenteral dosage forms according to the

The oral administration agent includes, for example, tablets, pills, hard and soft capsules, solutions, suspensions, emulsifiers, syrups, powders, powders, granules, granules, pellets, etc., and these formulations contain surfactants in addition to active ingredients , diluent, and lubricant. Tablets may also contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose and polyvinylpyrrolidine, optionally starch, agar, alginic acid or its sodium salt. It may contain pharmaceutical additives such as disintegrants, absorbents, colorants, flavors and sweeteners. The tablets may be prepared by conventional mixing, granulating or coating methods.

In addition, the parenteral dosage form may be a transdermal dosage form, for example, an injection, drop, ointment, lotion, gel, cream, spray, suspension, emulsion, patch, etc. It is not limited.

Determination of the dose of the active ingredient is within the level of a skilled person, and the daily dose of the drug varies depending on various factors such as the degree of progression of the subject to be administered, the time of onset, age, health condition, and complications, but adult Based on 1 μg / kg to 200 mg / kg in one aspect, 50 μg / kg to 50 mg / kg in another aspect can be divided and administered once to three times a day, the dosage is It does not limit the scope of this disclosure in any way.

The pharmaceutical composition may include a composition for external application for skin. The composition for external application for the skin is a general term that can include anything that is applied to the outside of the skin, and pharmaceuticals and quasi-drugs of various formulations may be included here.

Hereinafter, the present disclosure will be described in more detail through examples. These examples are only for exemplifying the present disclosure, and it will be apparent to those skilled in the art that the scope of the present disclosure is not to be construed as being limited by these examples.

comparative example 1. Ginseng Fruit Concentrate ( GBP ) manufacture of

After harvesting the fruits of 4-year-old ginseng cultivated in Geumsan, Chungcheongnam-do, Korea, the seeds were removed. With the seeds removed, the pulp and juice were concentrated at 55 °C to prepare a concentrate.

comparative example 2. Preparation of antler concentrate (DA)

After shaving the dried antler, it was pulverized to obtain 500 g of pulverized material, and 5,000 mL of purified water was added thereto, followed by extraction at 95 °C for 240 minutes. Thereafter, the extract was concentrated at 55 °C to prepare a concentrate.

Example 1. Preparation of ginseng fruit and antler mixture

Ginseng fruit concentrate (GBP) and antler concentrate (DA) prepared in Comparative Examples 1 and 2 were mixed in various weight ratios as shown in Table 1 below to prepare a mixture of ginseng fruit and antler.

Example 1-1 Example 1-2 Example 1-3 Example 1-4 Example 1-5 Example 1-6 Examples 1-7 GBP 0.5 One 1.5 2 2.5 3 3.5 DA 3.5 3 2.5 2 1.5 One 0.5

Experimental example 1. Cytotoxicity Assessment

The cytotoxicity of each of the concentrates and mixtures prepared in Comparative Examples 1 and 2 and Example 1 was evaluated and shown in FIGS. 1 to 3.

The fibroblasts used in the experiment were human-derived fibroblasts, Hs68 (ATCC, #CRL 1635), and the cells were DMEM (Dulbecco's Modified Eagle Medium) containing 10% FBS (fetal bovine serum) and 1% penicillin-streptomycin. ) medium. Each sample was prepared by diluting in serum-free DMEM medium containing 1% penicillin-streptomycin to treat cells at various concentrations. Hs68 cells 1×10 ⁵ were seeded in a 48-well plate, cultured for 24 hours, and prepared samples were treated. CCK-8 (Dojindo, Japan) KIT was used to confirm cytotoxicity 24 hours after sample treatment. The cell viability was calculated by measuring the absorbance at 450 nm of water soluble tetrazolium salt (WST) reacting with enzymes present in viable cells included in KIT.

As a result, the ginseng fruit concentrate showed cytotoxicity at a concentration of 2% or more, and the antler concentrate showed cytotoxicity at a concentration of 8% or more. In the case of mixtures of ginseng fruit and antler antler, when mixed in various weight ratios with a maximum concentration of 4%, ginseng fruit concentrate and antler concentrate were found to be non-cytotoxic in mixtures at a weight ratio of 0.5:3.5 and 1:3. appear.

Experimental Example 2. Evaluation of HAS2, COL7A1 and COL4A1 expression levels

For each sample confirmed to have no cytotoxicity in Experimental Example 1, the effect of these on HAS2, COL7A1 and COL4A1 expression levels was evaluated and shown in Table 2 and FIGS. 4 to 6 below.

Hs68 human-derived fibroblasts were added to 2×10 ⁵ cells/well in a 6-well plate with Dulbecco's Modified Eagle Medium (DMEM) containing 10% fetal bovine serum (FBS). After growing to 90%, the medium was removed, and each sample was dissolved in serum-free DMEM at the concentration (v/v) shown in Table 2 below and treated with cells. A sample to which no sample was added was used as a control. After 24 hours, total RNA was isolated using the RNeasy Mini Kit (#74101, Qiagen). Isolated total RNA was quantified using NanoDrop 1000 (Thermo Fisher Scientific Inc. Waltham, MA, USA). Quantified 1 μg of RNA was converted to cDNA using the SuperScript® III First-Strand Synthesis System (#18080-051, Invitrogen) and PCR machine (TP600, Takara, Japan) at 42°C for 60 minutes and 70°C for 5 minutes. synthesized. qPCR was performed using an ABI 7500 Fast Real-Time PCR system (Applied Biosystems, CA, USA) by mixing 2 μL cDNA, TaqMan™ Gene Expression Master Mix (#4369016, ThermoFisher Scientific), and the following specific pre-inventoried TaqMan primers. conducted. It was confirmed that the loading amount of mRNA was constant with GAPDH.

HAS2 (hyaluronan synthase 2)-Hs00193435_m1

COL7A1 (collagen type VII alpha 1) - Hs00164310_m1

COL4A1 (collagen type IV alpha 1 chain) - Hs00266237_m1

GAPDH (glyceraldehyde-3-phosphate dehydrogenase) - Hs02786624_g1

Comparison of mRNA expression level HAS2 COL7a1 COL4a1 CTL (unprocessed) 100% 100% 100% GBP_0.5% 18% 144% 160% GBP_1% 24% 176% 172% DA_1% 161% 133% 113% DA_2% 287% 104% 102% DA_4% 271% 96% 103% GBP_1%+DA_3%
(Example 1-2) 468% 265% 185% GBP_0.5%+DA_3.5%
(Example 1-1) 409% 179% 186%

As a result, when ginseng fruit was treated alone, it was found that the HAS2 mRNA expression level was greatly reduced and the COL7A1 and COL4A1 mRNA expression levels were increased compared to the untreated group. On the other hand, when the antler was treated alone, the HAS2 mRNA expression level was significantly increased compared to the untreated group, but the COL7A1 and COL4A1 mRNA expression levels were found to be lower than the low concentration treatment group when the treatment concentration was increased. On the other hand, when the mixture of ginseng fruit and antler was treated, it was confirmed that the mRNA expression levels of HAS2, COL7A1 and COL4A1 were all significantly increased. That is, when ginseng fruit and deer antler are used together, the problem of HAS2 mRNA expression decrease that occurs when ginseng fruit is used alone is solved, and COL7A1, which is similar to or slightly increased when ginseng fruit is used alone, is similar to that of the untreated group. and COL4A1 mRNA expression were more significantly increased to show a synergistic effect.

Therefore, it was confirmed that the mixture of ginseng fruit and antler greatly increased the expression level of genes known to contribute to skin moisturization and homeostasis, thereby having excellent effects in skin moisturizing, anti-aging and wound healing.

Formulation examples of the composition according to one aspect of the present disclosure will be described below, but can also be applied to various other formulations, which are only intended to be specifically described, not intended to limit the present disclosure.

[Formulation Example 1] Capsules

10 mg of the mixture of Example 1-1, 3 mg of crystalline cellulose, 14.8 mg of lactose, and 0.2 mg of magnesium stearate were mixed according to a conventional capsule preparation method and filled into gelatin capsules to prepare capsules.

[ formulation example 2] liquid medicine

20 mg of the mixture of Example 1-1, 10 g of isomerized sugar, 5 g of mannitol, and appropriate amounts of purified water were dissolved by adding each component to purified water according to a conventional liquid preparation method, adding an appropriate amount of lemon flavor, and then mixing the above components After adjusting the total volume to 100 ml by adding purified water, the solution was prepared by filling a brown bottle and sterilizing it.

[ formulation example 3] Ointment

An ointment was prepared in a conventional manner according to the composition described below (% by weight).

Mixture of Example 1-1 ............ 3.0

Glycerin ........................... 8.0

Butylene Glycol ................................. 4.0

Liquid paraffin ............. 15.0

Beta glucan ................................. 7.0

Carbomer ................................. 0.1

Caprylic/Capric Triglyceride...... 3.0

Squalane ................................. 1.0

Cetearyl glucoside ............ 1.5

Sorbitan Stearate ............ 0.4

Cetearyl Alcohol ................... 1.0

Waxing ................................. 4.0

Preservatives, Colors, Flavors ........ Appropriate amount

Purified water ................................. Remaining amount

[ formulation example 4] Lotion

A lotion was prepared in a conventional manner according to the composition described below (% by weight).

Mixture of Example 1-1 ............ 0.1

Glycerin ................................. 3.0

Butylene glycol ................................. 3.0

Propylene glycol ........................... 3.0

Carboxyvinyl polymer ............. 0.1

Waxing ................................................ 4.0

Polysorbate 60........................... 1.5

Caprylic/capric triglyceride ......... 5.0

Squalane ................................. 5.0

Sorbitan sesquioleate ................... 1.5

Cetearyl Alcohol ................................. 1.0

Tromethamine ................................. 0.2

Preservatives, flavorings ................................. Appropriate amount

Purified water ................................. Remaining amount

[ formulation example 5] lotion

A lotion was prepared in a conventional manner according to the composition described below (% by weight).

Mixture of Example 1-1 .......... 1.00

Diethyl Ascorbic Acid ........ .... ........1.00

Sodium citrate ............................0.10

Licorice Extract ..................0.20

1,3-Butylene Glycol ............ 3.00

Purified water ........................... Remaining amount

[ formulation example 6] Cream

A cream was prepared in a conventional manner according to the composition described below (% by weight).

Mixture of Example 1-1 ............ 0.1

Glycerin ................................ 3.5

Butylene glycol ................................. 3.0

Liquid paraffin ................................. 7.0

Beta glucan ................................. 7.0

Carbomer ................................. 0.1

Caprylic/Capric Triglyceride......... 3.0

Squalane ................................. 5.0

Cetearyl glucoside ............. 1.5

Sorbitan Stearate ............. 0.4

Polysorbate 60........................... 1.2

Tromethamine ................................. 0.1

Preservatives, flavorings ................................. Appropriate amount

Purified water ................................. Remaining amount

[ formulation example 7] Soap

Soap was prepared in a conventional manner according to the composition described below (% by weight).

Mixture of Example 1-1 .................... 0.1

Maintenance ................................. Appropriate amount

Sodium Hydroxide ............ Appropriate amount

Sodium Chloride ........................... Appropriate amount

Spices ................................. Small amounts

Purified water ................................. Remaining amount

In the above, specific parts of the present disclosure have been described in detail, and for those skilled in the art, it is clear that these specific descriptions are only preferred embodiments, and the scope of the present disclosure is not limited thereby. something to do. Accordingly, the substantial scope of the disclosure will be defined by the appended claims and their equivalents.

Claims (12)

A composition for moisturizing skin, improving wrinkles, or promoting wound healing, comprising ginseng fruit and antler as active ingredients.
According to claim 1,
The ginseng fruit is contained in less than 2% by weight based on the total weight of the composition, a composition for moisturizing skin, improving wrinkles or promoting wound healing.
According to claim 1,
The deer antler is contained in less than 8% by weight based on the total weight of the composition, the composition for moisturizing the skin, improving wrinkles or promoting wound healing.
According to claim 1,
A composition for moisturizing skin, improving wrinkles, or promoting wound healing, wherein the mixed weight of the ginseng fruit and the antler is 5% by weight or less based on the total weight of the composition.
According to claim 1,
The ginseng fruit and the antler are mixed in a weight ratio of 1: 0.1 to 10, a composition for moisturizing skin, improving wrinkles, or promoting wound healing.
According to claim 5,
The ginseng fruit and the antler are mixed in a weight ratio of 1: 3 to 7, a composition for moisturizing skin, improving wrinkles, or promoting wound healing.
According to claim 1,
The ginseng fruit is a concentrate of ginseng fruit, a composition for moisturizing skin, improving wrinkles or promoting wound healing.
According to claim 1,
The antler is an extract of antler, a composition for moisturizing skin, improving wrinkles, or promoting wound healing.
According to claim 8,
The extract of the deer antler is a hot water extract of the deer antler, a composition for moisturizing skin, improving wrinkles, or promoting wound healing.
According to claim 1,
The composition is a cosmetic composition, a composition for moisturizing skin, improving wrinkles or promoting wound healing.
According to claim 1,
The composition is a food composition, a composition for moisturizing skin, improving wrinkles or promoting wound healing.
According to claim 1,
The composition is a pharmaceutical composition for preventing or treating dry skin or preventing or treating wounds or skin damage caused by ultraviolet rays, a composition for moisturizing skin, improving wrinkles, or promoting wound healing.

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