KR20230014676A - Food composition for promoting bile secretion - Google Patents

Abstract

Disclosed is a food composition having a bile secretion promoting effect. The food composition having a bile secretion promoting effect according to the present invention includes calamansi fruit juice, lemon juice, lime juice and dermal extract, and can stimulate the sphincter muscle of bile duct to promote bile secretion.

Description

Food composition with bile secretion promoting effect {FOOD COMPOSITION FOR PROMOTING BILE SECRETION}

The present invention relates to a food composition having a bile secretion promoting effect, and more particularly, to a food composition having a bile secretion promoting effect capable of promoting the secretion of bile by stimulating the sphincter of the cholangiopancreatic duct.

Bile secreted from the liver consists of 97% water and other components, including bile salts (bile acids), bile pigments, phosphatidylcholine, cholesterol, trace albumin, electrolytes, etc., and serves as a pathway for excretion of toxic substances and lipolysis products. In addition to work, it is involved in the digestion and absorption of fat to perform various physiological functions, discharge endogenous waste products such as bilirubin, drugs and various toxic substances, increase normal absorption of fat in the intestine, and increase human cholesterol ( It plays a pivotal role in maintaining the equilibrium of cholesterol metabolism. Among these, the main function of bile is to facilitate the digestion and absorption of fatty acids by bile acids. Bile acids are cholesterol derivatives that are synthesized in the liver from cholic acid and chenodeoxycholic acid, which are primary bile acids. Primary bile acids are combined with taurine or glycine to form taurocholic acid or glycocholic acid. The sodium and potassium salts of bile acids are called bile salts. do. It acts as a surfactant that emulsifies fat contained in food into micelles, helping digestion and absorption of dietary fat and vitamins. The bile acids secreted into the intestines go through the entero-hepatic circulation in which most of them are reabsorbed into the liver using the hepatic portal vein, and the amount of bile acids excreted in feces is produced in the liver. In this way, the level of bile acids in the body is maintained.

Insufficient secretion of bile makes it difficult to digest and absorb fat contained in food, the concentration of cholesterol in the blood rises, constipation easily occurs due to poor bowel movements, and excessive accumulation of adrenaline and noradrenaline secreted from the adrenal medulla into the blood In addition, stress, increased blood pressure, increased blood sugar, and sleep disorders may occur due to delayed discharge, and uncomfortable symptoms such as abnormal fever, headache, vomiting, and nausea may be caused due to excessive accumulation and delayed discharge of wastes and toxic substances.

Substances that promote bile excretion include Ursodeoxycholic acid (UDCA), Liquiritigenin extracted from licorice (Patent No. 10-1003900), 15-keto-prostaglandin compound (Registered Patent 10-0874626) and the like are known. Among them, ursodeoxycholic acid has been developed and marketed as a medicine, but liquiritigenin or a 15-keto-prostaglandin compound has not been developed as a medicine.

Therefore, when the above symptoms occur due to poor bile discharge, it can be easily consumed like general food or health functional food. There is a need for a food composition with

Korea Registered Patent Registration No. 10-0874626 (registration date: 2008. 12. 11) Korea Registered Patent Publication Registration No. 10-1003900 (registration date: 2010. 12. 17)

The present invention has been made in order to prevent or improve the above-mentioned problems that may occur due to poor bile secretion, and the problem to be solved by the present invention is to promote bile secretion by stimulating the sphincter of the bile duct to promote bile secretion. It is to provide a food composition with.

The above object of the present invention can be solved by a food composition having a bile secretion stimulating effect including calamansi fruit juice, lemon juice, lime juice and dermal extract.

The bile duct connected to the gallbladder and the pancreatic duct connected to the pancreas meet to form the biliary pancreatic duct, and the end of the duct connects to the duodenum. The cholangiopancreatic duct sphincter regulates the excretion of bile stored in the gallbladder and digestive juices secreted by the pancreas.

Calamansi juice, lemon juice, lime juice, and dermal extract constituting the present invention are all ingredients with strong taste and aroma, and stimulate and expand the sphincter of the bile pancreatic duct, thereby facilitating the secretion of bile and pancreatic digestive juices.

Bile contains not only cholesterol derivatives (bile acids), but also waste products and pathological products filtered by the liver, and various hormones secreted into the blood. Therefore, the smooth discharge of bile means that there are the following effects.

First, it helps the discharge of cholesterol derivatives in the blood and plays the following roles.

① It helps digestion of fat contained in food. Cholesterol derivatives contained in bile help to emulsify the fat contained in food, thereby facilitating digestion and absorption. Therefore, the present invention has an effect of resolving indigestion that may occur after excessive intake of meat or the like.

② Lower the concentration of cholesterol in the blood. The composition of bile, with the exception of water, consists mainly of cholesterol derivatives. Excess cholesterol in the blood is filtered by the liver, sent to the gallbladder, stored, and excreted into the duodenum. do.

③ Helps with bowel movements. Cholesterol, which mixes with feces, softens and lubricates the feces, helping with bowel movements. When taking the present invention, dark mugwort-colored biliary loose stools due to excessive bile secretion may be seen.

Second, it plays the following roles by lowering the concentration of adrenal medulla hormone released into the blood.

① Relieves stress caused by sympathetic nerve stimulation. Adrenalin and noradrenaline secreted from the adrenal medulla into the blood stimulate the stress response by strengthening the sympathetic nervous system. In addition, when the blood concentration of adrenal medulla hormone is excessive, a state of continuous stress is maintained. At this time, the present invention can improve the stress state by lowering the blood concentration of adrenal medulla hormone.

② It helps control the sudden rise in blood pressure. Adrenal medulla hormone secreted into the blood induces excitation of the sympathetic nerve, constricts peripheral blood vessels, increases blood output from the heart, and temporarily raises blood pressure. By helping the release of adrenal medulla hormone according to the present invention, it helps to normalize high blood pressure.

③ Helps control blood sugar that rises suddenly. The sympathetic nerve stimulated by adrenal medulla hormone secreted into the blood promotes the secretion of glucagon from the pancreas to raise blood sugar. Rapid release of adrenal medulla hormone and glucagon by the present invention stabilizes the sympathetic nerve and improves the mechanism of blood glucose rise by glucagon, helping to normalize elevated blood sugar.

④ Improve sleep disorders. Inflammatory substances and excess adrenal medulla hormone excite the sympathetic nerve, stimulating the body, making it uncomfortable, and disturbing sleep. At this time, the present invention promotes the discharge of inflammatory substances and adrenal medullary hormones present in the blood to the outside of the body to stabilize the mind and body and lead to comfortable sleep.

Third, it helps to discharge waste and toxic substances and plays the following roles.

① Reduce high fever that is not relieved by antipyretics. When an inflammatory substance stimulates the thermoregulatory center in the hypothalamus of the diencephalon, the body temperature rises to a high fever of 39 ° C or higher, and this high fever is not well relieved by general antipyretics. At this time, the secretion of bile promotes the discharge of inflammatory substances that cause fever, and the fever is quickly cleared. However, it does not cause antipyretic action in general fever below 39℃.

② It reduces extreme pain and inflammation that cannot be controlled even with anti-inflammatory drugs. Inflammatory substances and toxic substances promote the secretion of adrenal medullary hormones, resulting in sympathetic nerve stimulation. Excitation of the sympathetic nerve lowers the threshold of pain, resulting in severe pain, and strong stimulation of adrenaline and noradrenaline secreted into the blood stimulates the inflamed area and exacerbates the inflammation, resulting in severe pain. At this time, the present invention reduces the extreme pain and improves inflammation by lowering the blood concentration of inflammatory substances and toxic substances, adrenaline and noradrenaline, generated from inflammation.

③ It is excellent for removing hangovers. After excessive drinking, uncomfortable symptoms such as headache, vomiting, and nausea are caused by the accumulation of acetaldehyde generated during the decomposition of alcohol and impurities in alcohol. The choleretic action of the present invention promotes the excretion of acetaldehyde and impurities contained in alcohol, thereby improving the cause of hangover, and the gastric action normalizes gastrointestinal functions to improve nausea and vomiting.

As described above, it can be seen that the present invention is made in the form of food, and acts as a first aid to improve critical morbid conditions as well as a role as a simple digestive agent.

As described above, the cholangiopancreatic duct sphincter regulates the excretion of bile stored in the gallbladder as well as digestive juices secreted by the pancreas. If the sphincter of the cholangiopancreatic duct is stimulated and expanded, as above, not only bile flow is facilitated, but also pancreatic digestive juices are secreted smoothly.

In addition, the food composition having a bile secretion promoting effect according to the present invention stimulates the mucous membranes of the stomach, duodenum, small intestine, etc., and activates the secretion of gastrointestinal hormones such as gastrin, small intestine gastrin, secretin, and cholecystokinin. Gastrin secreted from the cells of the stomach lining activates the secretion of the gastric glands. The gastric glands secrete alkaline mucus to protect the stomach wall. Gastrin promotes the secretion of hydrochloric acid and pepsinogen, and the inactive form of pepsinogen is converted into active form of pepsin by hydrochloric acid to digest proteins. The food composition having a bile secretion promoting effect according to the present invention activates mucous and secretory glands such as the stomach, duodenum, small intestine, large intestine, bile duct, gallbladder, pancreas, and pancreatic duct. Secretin promotes the secretion of bicarbonate in the pancreas and neutralizes the hydrochloric acid secreted from the parietal cells of the stomach to prevent duodenal ulcer. Cholecystokinin stimulates the secretion of high concentrations of digestive juices from the pancreas and promotes the secretion of bile. The secretion of pancreatic digestive juices and the promotion of gastrointestinal motility help digest food and improve constipation.

1 is a graphical representation of bile excretion in test group 1.
2 is a graphical representation of bile excretion in test group 2.
Figure 3 is a graphical representation of the bile excretion of the control group 2.
Figure 4 compares the average values of bile excretion in test group 1, test group 2 and control group.

The food composition having a bile secretion stimulating effect according to the present invention includes calamansi fruit juice, lemon juice, lime juice and dermal extract.

The food composition having a bile secretion promoting effect according to the present invention has an appropriate stimulating effect on the sphincter of the cholangiopancreatic duct or gastric mucosa with taste and aroma, and safety is secured without side effects on the liver or kidney even when absorbed. The food composition having a bile secretion promoting effect according to the present invention does not act by digestion and absorption, but shows the effect of bile secretion by giving appropriate stimulation to the sphincter of the bile pancreatic duct while staying in the stomach and intestines.

Calamansi is the fruit of a plant belonging to the Rutaceae family, native to Southeast Asia, and has a unique taste and aroma. Calamansi contains a large amount of vitamin C, so it is effective for dry coughs and colds, and is known to help recover from fatigue, skin beauty, and strengthen immunity.

Lemon is a fruit of a plant belonging to the Rutaceae family, which is native to the Himalayas, and has a strong sour taste and unique scent due to excessive vitamin C and citric acid.

Lime is the fruit of a plant belonging to the Rutaceae family, native to northeastern India and Southeast Asia, and has a strong sour taste and aroma similar to that of lemon.

The dermis is the mature rind of tangerine, which is a fruit of a rue family plant, or a related plant of the same genus.

For calamansi juice, lemon juice, and lime juice, squeezed juice can be used as it is or concentrated juice obtained by concentrating these juices to 50% or less of the original capacity can be used. As the dermal extract, dermal extract powder may be used.

To make liquid tea, orange juice, tangerine juice, brown sugar powder, xylitol powder, citric acid and grapefruit seed extract can be further added to calamansi juice, lemon juice, lime juice and dermis extract, and the concentration can be adjusted using purified water.

<Preparation of sample>

<Sample 1>

Prepare 450g of Calamansi 30% concentrate, 280g of lemon 30% concentrate, 390g of lime 30% concentrate, 100g of dermal extract powder, and 780g of purified water, and add purified water to the mixing tank to maintain 70~80℃, while dermal extract powder is prepared. After stirring until the dermal extract is dissolved, add calamansi concentrate, lemon concentrate, and lime concentrate, stir until the raw materials are mixed, and sterilize for 30 minutes while maintaining the sterilization temperature within 90 ° C. Sample 1 was obtained.

<Sample 2>

Calamansi 30% concentrate 45g, orange 30% concentrate 278g, tangerine 30% concentrate 278g, lemon 30% concentrate 28g, lime 30% concentrate 39g, dermal extract powder 10g, brown sugar powder 2,056g, xylitol powder 1,834g, citric acid 30g, Prepare 5g of grapefruit seed extract and 5,397g of purified water, add purified water to the mixing tank, and while maintaining 70~80℃, add xylitol powder, brown sugar powder, dermal extract powder, and citric acid, stir until the ingredients are dissolved, Add calamansi concentrate, orange concentrate, citrus concentrate, lemon concentrate, lime concentrate, and grapefruit seed extract, stir until the ingredients are mixed, and sterilize for 30 minutes while maintaining the sterilization temperature within 90 ° C. got

<Animal test>

Thirty male specific pathogen-free (SPF) rats, 6 weeks old, were used. Rats used in this test were selected because they are widely used in various drug efficacy and toxicity tests, have accumulated abundant basic test data, and are easy to interpret and evaluate test results using these data. A color-coded individual identification card was attached to the breeding box, and an animal room use record sheet was attached to the entrance of the breeding room. This test was conducted on rodents set at a temperature of 23±3 ℃, relative humidity of 55±15%, ventilation frequency of 10 to 20 times/hr, lighting time of 12 hours (8 am to 8 pm lights off), and illuminance of 150 to 300 Lux. It was conducted in the breeding area. During the breeding period, environmental conditions such as temperature/humidity, ventilation frequency, and illumination of the animal room were regularly measured. For feed, feed for laboratory animals is freely consumed, and for water, purified water is freely consumed using a drinking bottle made of polycarbonate. A wooden rug was used as the rug. During the acclimation and experiment period, they were reared in a polycarbonate breeding box for rodents (W 235 x L 380 x H 175 mm) at 5 animals/box or less. Breeding crates, rugs and water bottles were exchanged at least once a week. During the acclimatization period, the animals judged to be healthy were weighed, and 20 test groups and 10 control groups were randomly divided into groups according to the ranked weights so that the average weight of each group was distributed as uniformly as possible.

1) Sample and dose of test group 1

Sample 1 according to the present invention was orally administered to 10 (M1-M10) test group rats 6 times a day for 3 days at 300 μg/kg.

2) Sample and dose of test group 2

Sample 2 according to the present invention was orally administered to 10 (M11 to M20) test group rats 6 times a day for 3 days at a rate of 300 μg/kg.

3) control group

10 control rats (m1-m10) were also administered with 300 μg/kg of the vehicle, that is, 0.01% polysorbate 80 in distilled water and 0.5% ethanol.

4) Measurement of bile output

On the day after the final administration (day 4), tubules were inserted into the common bile duct of each rat under ether anesthesia, and the rats were placed in a ball man gauge for 2 hours to recover from anesthesia. Bile output was measured by collecting the bile excreted during the 2-hour tubule insertion.

5) Measurement results

As a result of the measurement, the effect of the present invention on the bile flow of normal rats is shown in Tables 1 to 3 or FIGS. 1 to 3. Figure 1 shows the bile output of test group 1, Figure 2 shows the bile output of test group 2, Figure 3 shows the bile output of control group 2, respectively, Figure 4 shows the average value of bile output of test group 1, test group 2 and control group it was compared

<Bile output for 2 hours for 10 animals in test group 1>
test group

M1
M2
M3
M4
M5
M6
M7
M8
M9
M10
Average
Standard Deviation
gall
Discharge (μl/
100g BW)



710


723


718


731


709


715


724


715


718


707


717.0


7.09

<Bile output for 2 hours for 10 animals in test group 2>
test group

M11
M12
M13
M14
M15
M16
M17
M18
M19
M20
Average
Standard
Deviation
gall
Discharge (μl/
100g BW)



730


722


748


710


750


715


768


716


717


759


733.5


18.97

<Bile output for 2 hours for 10 control group>
test group

m1
m2
m3
m4
m5
m6
m7
m8
m9
m10
Average
Standard
Deviation
gall
Discharge (μl/
100g BW)



592


584


575


599


601


579


588


605


612


581


591.6


11.64

As can be seen in Tables 1 to 3 or FIG. 4, the bile output of test group 1 increased by 21.20% compared to the control group and the bile output of test group 2 increased by about 23.99% compared to the control group. On the other hand, the bile excretion of test group 1 and test group 2 did not show a significant difference. On the other hand, test group 1 has the smallest measured value deviation, and test group 2 has the largest measured value deviation. It can be understood as a deviation caused by the influence of additionally added additives.

The ingredients with strong taste and aroma of the present invention stimulate the sphincter of the bile duct of the duodenum to facilitate the secretion of bile and pancreatic digestive juices. In addition, fat contained in food promotes the secretion of cholecystokinin in the small intestine, and the secreted cholecystokinin contracts the gallbladder and promotes the secretion of bile. As a result, test group 1 and test group 2 to which the present invention was applied showed significant bile excretion compared to the control group.

The promotion of bile secretion according to the present invention has a detoxifying function, detoxification, eliminating toxins in the body, improving inflammation, reducing pathological symptoms, and improving physical condition. In addition, the promotion of bile secretion according to the present invention solves indigestion and anorexia, improves nausea and vomiting, improves hangover by promoting the secretion of acetaldehyde, which is the cause of hangover, and promotes the discharge of fatigue substances, resulting in fatigue. It helps recovery and improves stress by promoting the release of adrenal medullary hormone secreted from the adrenal medulla into the blood during stress. In addition, the stimulation of bile secretion according to the present invention softens and smoothes the stool by the fatty substances contained in the bile, and helps defecation activity in combination with the gastrointestinal motility that is promoted. Most of the fats in adipocytes have a high molecular weight, so they cannot enter capillaries directly, but instead enter the lymphatic vessels and enter the vena cava, circulate throughout the body, and are filtered in the liver and discharged out of the body along the process of being discharged into bile. The promotion of bile secretion by the diet also helps. Soshihotang, introduced in Sanghanron, is a representative prescription for pruritus disease. Its indications are bitter taste, dry mouth, tired and dizzy eyes, repeating hot and cold cycles, and uncomfortable sensations when pressed under the ribs. These indications for Soshihotang are symptoms caused by insufficient relaxation of the sphincter of the bile and pancreatic ducts, which are secreted when bile and pancreatic juice are combined, resulting in poor discharge of bile and pancreatic juice. If the bile is not discharged smoothly, the bile accumulated in the liver flows back into the blood, causing a bitter taste, dry mouth, tired and dizzy eyes, and repeating cold and hot. Then, both the liver and pancreas become swollen. Since the liver is a silent organ without nerves, pressing under the left rib with the pancreas is more sensitive to pain or discomfort than pressing under the right rib with the liver. In severe cases, acute pancreatitis can cause excruciating pain. Stimulation of bile secretion according to the present invention rapidly improves this situation included in Xiaoshihotang. Most of the bilirubin produced by the breakdown of hemoglobin in red blood cells is excreted in the bile by the liver. Jaundice is a yellow coloration of the whites of the eyes, skin, mucous membranes, etc., due to excessive accumulation of bilirubin in the body due to excessive production of bile or obstruction of bile excretion due to liver disease or other causes. When the present invention promotes bile excretion from the liver, excretion of bilirubin is also promoted, helping to improve jaundice. Liver cirrhosis is a deterioration of liver function as normal liver tissue is changed into fibrotic regenerative nodules due to chronic hepatitis B or chronic hepatitis C, continuous excessive drinking, and chronic inflammation caused by liver toxic substances. When liver function is severely deteriorated, depending on the degree, fat and protein intake may be restricted. The regenerative ability of liver cells is faster and more certain than other cells, and in the case of normal people, 80% resection is normalized after 6 months. These hepatocytes change into fibrotic regenerative nodules because the environment of hepatocytes interferes with normal cell regeneration. Regenerative nodules in which hepatocytes are fibrotic can be seen as the same kind as keloids formed on the wound surface. In order to avoid the formation of fibrotic regenerative nodules as described above, it is necessary to make hepatocytes an environment in which cell regeneration is smooth. By promoting bile secretion according to the present invention, it is possible to discharge inflammatory substances and waste products accumulated in the liver, so that the environment of hepatocytes can be normalized and fibrotic regenerative nodules of hepatocytes can be prevented.

Claims (1)

It has the effect of promoting the secretion of bile, including calamansi fruit juice, lemon juice, lime juice and dermal extract,
Calamansi juice, lemon juice, and lime juice are prepared in a concentrated state, dermal extract is prepared in a powder state, and the dermal extract powder is added to purified water maintained at 70 to 80 ° C and stirred until the dermal extract is dissolved After that, a food composition having a bile secretion promoting effect obtained by adding calamansi concentrate, lemon concentrate, and lime concentrate and stirring until the raw materials are mixed.

Images