KR20220048388A - Food composition for promoting bile secretion - Google Patents

Abstract

Disclosed is a food composition for promoting bile secretion. The food composition for promoting bile secretion according to the present invention can include calamansi juice, lemon juice, lime juice, and dermis extract, and stimulate the sphincter of the bile duct to promote the secretion of bile. The sphincter of the bile duct regulates the excretion of bile stored in the gallbladder, and digestive juices secreted by the pancreas.

Description

Bile secretion promoting food composition {FOOD COMPOSITION FOR PROMOTING BILE SECRETION}

The present invention relates to a food composition that promotes bile secretion, and more particularly, to a food composition that promotes bile secretion by stimulating the sphincter of the biliary duct.

Bile secreted from the liver is composed of 97% water and other components including bile salts (bile acids), bile pigments, phosphatidylcholine, cholesterol, trace albumin, electrolytes, etc., and is a pathway for excretion of toxic substances and lipolysis products In addition, it participates in fat digestion and absorption to perform various physiological functions, discharges endogenous waste products such as bilirubin, drugs, and various toxic substances, increases normal fat absorption in the intestine, and increases human cholesterol ( It plays a central role in maintaining the equilibrium of cholesterol) metabolism. Among these, the main function of bile is to promote digestion and absorption of fatty acids by bile acids. Bile acids are cholesterol derivatives, and the liver synthesizes primary bile acids, cholic acid and chenodeoxycholic acid. The primary bile acid is combined with taurine or glycine to form taurocholic acid or glycocholic acid. The sodium and potassium salts of bile acids are called bile salts. do. It acts as a surfactant that emulsifies the fat contained in food into micelles, helping digestion and absorption of dietary fat and vitamins. Most of the bile acids secreted into the intestine undergo intestinal-hepatic circulation, where most of them are reabsorbed into the liver using the hepatic portal vein, and the amount of bile acids excreted in the feces is produced in the liver. In this way, the level of bile acids in the body is maintained.

When the secretion of bile is insufficient, it is difficult to digest and absorb the fat contained in food, the concentration of cholesterol in the blood rises, and constipation is easy due to poor bowel movements, and excessive accumulation of adrenaline and noradrenaline secreted from the adrenal medulla into the blood And due to delayed discharge, stress and blood pressure increase, blood sugar increase, sleep disturbance, etc. may occur, and uncomfortable symptoms such as abnormal fever, headache, vomiting, and nausea may be caused due to excessive accumulation and delayed discharge of wastes and toxic substances.

Substances that promote bile excretion include Ursodeoxycholic acid (UDCA), Liquiritigenin extracted from licorice (Patent No. 10-1003900), and 15-keto-prostaglandin compound (registered patent). No. 10-0874626) and the like are known. Among them, ursodeoxycholic acid has been developed and marketed as a pharmaceutical, but Liquiritigenin and 15-keto-prostaglandin compounds have not been developed as pharmaceuticals.

Therefore, when the above symptoms occur due to poor bile excretion, it can be easily consumed like general food or health functional food, and can act not only as a simple digestive agent but also as a first-aid medicine to improve an urgent pathological condition. composition is needed.

Korea Patent Publication No. 10-0874626 (Registration date: 2008. 12. 11) Korea Patent Publication No. 10-1003900 (Registration date: 2010. 12. 17)

The present invention has been made in order to prevent or improve the above-mentioned problems that may occur due to poor bile secretion. to provide a composition.

The above-described problem of the present invention can be solved by a bile secretion promoting food composition comprising calamansi juice, lemon juice, lime juice and dermis extract.

The bile duct connected to the gallbladder and the pancreatic duct connected to the pancreas meet to form the biliary-pancreatic duct. The biliary duct sphincter regulates the excretion of bile stored in the gallbladder and digestive juices secreted by the pancreas.

Calamansi juice, lemon juice, lime juice, and dermis extract constituting the present invention are all ingredients with strong taste and flavor, and stimulate and expand the sphincter of the bile ducts to facilitate the secretion of bile and pancreatic digestive juice.

Bile contains not only cholesterol derivatives (bile acids), but also wastes and pathological products filtered by the liver, and various hormones secreted into the blood. Therefore, smooth excretion of bile means that there are the following effects.

First, it helps the excretion of cholesterol derivatives from the blood and plays the following roles.

① It aids in digestion of fat contained in food. Cholesterol derivatives contained in bile help to emulsify the fat contained in food and facilitate digestion and absorption. Accordingly, the present invention is effective in relieving indigestion that may occur after excessive consumption of meat or the like.

② It lowers the concentration of cholesterol in the blood. Except for water, bile is mainly composed of cholesterol derivatives. Excess blood cholesterol is filtered by the liver, sent to the gallbladder for storage, and then discharged to the duodenum. do.

③ Helps with bowel movements. Cholesterol mixed with the stool softens and lubricates the stool, helping to defecate. When taking the present invention, dark mugwort-colored biliary stools due to excessive bile secretion are also seen.

Second, it lowers the concentration of the adrenal medulla excreted in the blood, and plays the following roles.

① Relieves stress caused by sympathetic nerve stimulation. Adrenalin and noradrenaline secreted from the adrenal medulla into the blood stimulate the stress response by strengthening the sympathetic nerve. In addition, when the blood concentration of adrenal medulla is excessive, the state of continuous stress is maintained. In this case, the present invention can improve the stress state by lowering the blood concentration of the adrenal medulla hormone.

② It helps control sudden rise in blood pressure. The adrenal medulla hormone secreted into the blood induces excitability of the sympathetic nerve, constricts peripheral blood vessels, and increases blood output from the heart, thereby temporarily raising blood pressure. The present invention helps to normalize the elevated blood pressure by helping the release of the adrenal medulla.

③ Helps control sudden rise in blood sugar. The sympathetic nerve excited by the adrenal medulla hormone secreted into the blood promotes the secretion of glucagon from the pancreas and raises blood sugar. According to the present invention, when the adrenal medulla hormone and glucagon are rapidly discharged, the sympathetic nerve is stabilized, the mechanism of blood sugar rise by glucagon is improved, and it helps to normalize the increased blood sugar.

④ Improve sleep disorders. Inflammatory substances and excess adrenal medulla excite the sympathetic nervous system, which stimulates the body, makes it uncomfortable, and interferes with sleep. At this time, the present invention promotes the discharge of inflammatory substances and adrenal medulla to the outside of the body to stabilize the mind and body, thereby leading to a comfortable sleep.

Third, it helps the discharge of wastes and toxic substances and plays the following roles.

① Reduces high fever that is not relieved even by antipyretic drugs. When an inflammatory substance stimulates the thermoregulatory center in the hypothalamus of the diencephalon, the body temperature rises to a high temperature of 39°C or higher, and such high fever is not easily relieved by general antipyretic drugs. At this time, the secretion of bile also promotes the discharge of inflammatory substances that cause fever, thereby rapidly dissolving fever. However, it does not cause antipyretic action in general fever below 39℃.

② It reduces severe pain and inflammation that cannot be controlled even with anti-inflammatory analgesics. Inflammatory substances and toxic substances promote the secretion of adrenal medulla, which causes sympathetic nerve excitation. The stimulation of the sympathetic nerve lowers the pain threshold and makes the pain feel severe, and the strong stimulation of adrenaline and noradrenaline secreted into the blood stimulates the inflamed area, exacerbates the inflammation, and causes severe pain. At this time, the present invention lowers the blood concentration of inflammatory substances and toxic substances, adrenaline and noradrenaline produced in inflammation, thereby reducing severe pain and improving inflammation.

③ Excellent for hangover removal. After excessive drinking, the accumulation of acetaldehyde generated during the decomposition of alcohol and impurities in the alcohol cause uncomfortable symptoms such as headache, vomiting, and nausea. The digestive action of the present invention promotes the discharge of acetaldehyde and impurities contained in alcohol to improve the cause of a hangover, and the gastric action normalizes the gastrointestinal function to improve nausea and vomiting.

As described above, the present invention is made in the form of food, it can be seen that not only the role of a simple digestive agent, but also a first aid action to improve an emergency morbidity.

As described above, the biliary-pancreatic duct sphincter controls the discharge of digestive juices secreted from the pancreas as well as bile stored in the gallbladder. If the sphincter of the biliary duct is stimulated and expanded, it not only facilitates bile as above but also facilitates the secretion of pancreatic digestive juices.

In addition, the bile secretion promoting food composition according to the present invention stimulates the mucous membranes of the stomach, duodenum, small intestine, etc., and activates the secretion of gastrointestinal hormones such as gastrin, small intestine gastrin, secretin, and cholecystokinin. Gastrin secreted by parietal cells activates gastric gland secretion. The gastric glands secrete alkaline mucus to protect the stomach wall. Gastrin promotes the secretion of hydrochloric acid and pepsinogen, and the inactive form of pepsinogen is converted to the active form of pepsin by hydrochloric acid to digest proteins. The food composition for promoting bile secretion according to the present invention activates mucus and secretory glands in the stomach, duodenum, small intestine, large intestine, bile duct, gallbladder, pancreas, pancreatic duct, and the like. Secretin promotes the secretion of bicarbonate from the pancreas and neutralizes hydrochloric acid secreted from parietal cells of the stomach, thereby preventing duodenal ulcer. Cholecystokinin stimulates the secretion of high concentrations of digestive juices from the pancreas and promotes the secretion of bile. Stimulation of pancreatic digestive juice secretion and gastrointestinal motility facilitate digestion of food and improve constipation.

1 is a diagram showing the bile excretion of test group 1.
Figure 2 is a diagram showing the bile discharge of test group 2.
Figure 3 is a diagram showing the bile output of the control group 2.
4 is a comparison of the average values of bile discharge of Test Group 1, Test Group 2 and Control.

The food composition for promoting bile secretion according to the present invention includes calamansi juice, lemon juice, lime juice and dermis extract.

The food composition for promoting bile secretion according to the present invention has an appropriate stimulating effect on the biliary duct sphincter or gastric mucosa with taste and aroma, and is safe without adverse effects on the liver or kidney even when absorbed. The food composition for promoting bile secretion according to the present invention does not act by being digested and absorbed, but exhibits the effect of bile secretion by providing appropriate stimulation of the strong taste and flavor components to the biliary duct sphincter while staying in the stomach and intestines.

Calamansi is a fruit of a plant belonging to the rutaceae family, which is native to Southeast Asia, and has a strong unique taste and fragrance. Calamansi contains a large amount of vitamin C, so it is effective for dry cough and cold, and is known to help with fatigue recovery, skin beauty, and strengthening immunity.

Lemon is a fruit of a plant belonging to the rutaceae family, which is native to the Himalayas, and has a strong sour taste and unique flavor due to excess vitamin C and citric acid.

Lime is a fruit of a plant belonging to the rutaceae family that is native to northeastern India and Southeast Asia. It has a strong sour taste and aroma similar to lemon.

The dermis is the mature rind of a mandarin orange, which is a fruit of the rutaceae family, or a related plant.

For calamansi juice, lemon juice and lime juice, the juice can be used as it is, or concentrated juice obtained by concentrating these juices to 50% or less of the original capacity can be used. For the dermis extract, a dermis extract powder may be used.

To make a liquid tea, orange juice, tangerine juice, brown sugar powder, xylitol powder, citric acid and grapefruit seed extract are further added to calamansi juice, lemon juice, lime juice and dermis extract, and the concentration can be adjusted using purified water.

<Preparation of sample>

<Sample 1>

Prepare 450 g of calamansi 30% concentrate, 280 g of lemon 30% concentrate, 390 g of lime 30% concentrate, 100 g of dermis extract powder and 780 g of purified water. After adding and stirring until the dermis extract is dissolved, add calamansi concentrate, lemon concentrate, and lime concentrate, stir until the raw materials are mixed, and sterilize for 30 minutes while maintaining the sterilization temperature within 90 ° C, 2 kg of Sample 1 was obtained.

<Sample 2>

Calamansi 30% Concentrate 45g, Orange 30% Concentrate 278g, Citrus 30% Concentrate 278g, Lemon 30% Concentrate 28g, Lime 30% Concentrate 39g, Dermal Extract Powder 10g, Brown Sugar Powder 2,056g, Xylitol Powder 1,834g, Citric Acid 30g, Prepare 5 g of grapefruit seed extract and 5,397 g of purified water, add purified water to the mixing tank and maintain 70~80°C, add xylitol powder, brown sugar powder, dermis extract powder and citric acid and stir until the raw materials are dissolved, Add calamansi concentrate, orange concentrate, citrus concentrate, lemon concentrate, lime concentrate and grapefruit seed extract, stir until the raw materials are mixed, and sterilize for 30 minutes while maintaining the sterilization temperature within 90℃, 10 kg of sample 2 got

<Animal test>

Specific pathogen-free (SPF) rats 6 weeks of age, 30 male rats were used. The rats used in this test were selected because they are widely used in various drug efficacy and toxicity tests, and abundant basic test data have been accumulated, and the interpretation and evaluation of test results using these data are easy. An individual identification card distinguished by color was attached to the breeding box, and an animal room usage record was attached to the entrance to the breeding room. This test was conducted in rodents set at a temperature of 23±3 ℃, relative humidity of 55±15%, ventilation frequency of 10 to 20 times/hr, illumination time of 12 hours (lights on at 8 am to off at 8 pm), and illuminance of 150 to 300 Lux. It was carried out in the breeding area. During the breeding period, environmental conditions such as temperature/humidity, ventilation frequency, and illumination of the animal room were measured regularly. Feed should be freely ingested for laboratory animals, and water should be freely ingested using a polycarbonate drinking bottle. For the rug, a wooden rug was used. During the period of acclimatization and experimentation, 5 animals/crate or less were bred in a polycarbonate cage for rodents (W 235 x L 380 x H 175 mm). Breeding boxes, rugs and water bottles were exchanged at least once a week. During the acclimatization period, the weights of animals determined to be healthy were measured, and 20 animals in the test group and 10 animals in the control group were randomly divided into groups so that the average weight of each group was distributed as uniformly as possible according to the ranked weights.

1) Sample and dose of test group 1

Sample 1 according to the present invention was orally administered to 10 rats (M1 to M10) of the test group 6 times a day for 3 days in a unit of 300 μg/kg.

2) Sample and dose of test group 2

Sample 2 according to the present invention was orally administered to 10 rats (M11 to M20) of the test group 6 times a day for 3 days in a unit of 300 μg/kg.

3) Control

10 control rats (m1 to m10) were also administered with 300 μg/kg of vehicle, that is, 0.01% polysorbate 80 in distilled water, and 0.5% ethanol.

4) measurement of bile excretion

On the day after the last dose (day 4), a tubule was inserted into the common bile duct of each rat under ether anesthesia, and the rats were placed in a ball man gauge for 2 hours to recover from anesthesia. Bile excreted during 2 hours of tubular insertion was collected to measure bile excretion.

5) Measurement result

As a result of the measurement, the effects of the present invention on bile flow in normal rats are shown in Tables 1 to 3, or FIGS. 1 is the bile discharge of test group 1, FIG. 2 is the bile discharge of the test group 2, FIG. 3 is the bile discharge of the control group 2, respectively, and FIG. 4 is the average value of the bile discharge of the test group 1, the test group 2 and the control group will be compared

<Bile discharge for 2 hours for 10 animals in Test Group 1>
test group

M1
M2
M3
M4
M5
M6
M7
M8
M9
M10
Average
Standard Deviation
gall
Discharge (μl/
100 g BW)



710


723


718


731


709


715


724


715


718


707


717.0


7.09

<Bile output for 2 hours for 10 animals in Test Group 2>
test group

M11
M12
M13
M14
M15
M16
M17
M18
M19
M20
Average
Standard
Deviation
gall
Discharge (μl/
100 g BW)



730


722


748


710


750


715


768


716


717


759


733.5


18.97

<Bile output over 2 hours for 10 control animals>
test group

m1
m2
m3
m4
m5
m6
m7
m8
m9
m10
Average
Standard
Deviation
gall
Discharge (μl/
100 g BW)



592


584


575


599


601


579


588


605


612


581


591.6


11.64

As can be seen in Tables 1 to 3 or 4, it can be seen that the bile discharge of test group 1 increased by 21. 20% compared to the control group, and the bile discharge of test group 2 increased by 23.99% compared to the control group. On the other hand, there was no significant difference in bile output between Test Group 1 and Test Group 2. On the other hand, the deviation of the measured values of Test Group 1 is the smallest, and the deviation of the measured values of Test Group 2 is the largest. It can be understood as a deviation due to the influence of additionally added additives.

The ingredients with strong taste and fragrance of the present invention stimulate the sphincter of the biliary-pancreatic duct of the duodenum to facilitate the secretion of bile and pancreatic digestive juice. In addition, fat contained in food promotes the secretion of cholecystokinin in the small intestine, and the secreted cholecystokinin contracts the gallbladder to promote the secretion of bile. As a result, test group 1 and test group 2 to which the present invention was applied showed significant bile excretion results compared to the control group.

Bile secretion promotion according to the present invention functions as a detox, detoxifies, removes toxins in the body, improves inflammation, reduces pathological symptoms, and improves body condition. In addition, the promotion of bile secretion according to the present invention solves indigestion and anorexia, improves nausea and vomiting, improves hangover by promoting secretion of acetaldehyde, which is the cause of hangover, and promotes the discharge of fatigue substances. It helps recovery and improves stress by promoting the release of adrenal medulla hormone secreted from the adrenal medulla into the blood during stress. In addition, the promotion of bile secretion according to the present invention helps the bowel movement by softening and smoothing the stool by the fatty substances contained in the bile, and combining with the facilitated gastrointestinal movement. Most of the fats in adipocytes have high molecular weight, so they do not enter the capillaries directly, but instead enter the lymphatic vessels, enter the vena cava, circulate throughout the body, and are filtered out by the liver and discharged into the bile. Stimulation of bile secretion by the diet also helps. Soshihotang, introduced in Sanghanron, is a representative prescription for pruritus, and the indications are bitter taste, dry mouth, tired and dizzy eyes, repeated cold and hot temperatures, and complaints of uncomfortable sensations when pressed under the ribs. This indication of Soshiho-tang is a symptom caused by insufficient relaxation of the sphincter of the biliary-pancreatic duct, which is secreted by the union of bile and pancreatic juice, and thus the secretion of bile and pancreatic juice is not smooth. If the bile is not expelled smoothly, the bile accumulated in the liver flows back into the blood, causing bitter taste, dry mouth, tired and dizzy eyes, and repeating hot and cold. Then, both the liver and pancreas are swollen, and since the liver is a silent organ without nerves, it is more sensitive to feel pain or discomfort when pressing under the left rib with the pancreas than when pressing under the right rib where the liver is located. In severe cases, acute pancreatitis may cause severe pain. The promotion of bile secretion according to the present invention rapidly improves this situation included in Soshihotang. Most of the bilirubin produced by the breakdown of hemoglobin in red blood cells is excreted from the liver into bile. Jaundice is caused by liver disease or other causes, resulting in excessive bile production or obstruction in bile excretion, resulting in excessive bilirubin accumulation in the body, resulting in yellow pigmentation on the whites of the eyes, skin, and mucous membranes. When bile excretion from the liver is promoted according to the present invention, the excretion of bilirubin is also promoted, which helps to improve jaundice. Liver cirrhosis is a condition in which normal liver tissue is transformed into a fibrous regenerative nodule due to chronic hepatitis B or chronic hepatitis C, continuous excessive drinking, and chronic inflammation caused by liver toxic substances, and liver function deteriorates. When liver function is severely degraded, fat and protein intake may be restricted depending on the degree. The regenerative ability of hepatocytes is faster and more certain than other cells, so even if 80% of normal people are excised, they will be normalized after 6 months. The reason why these hepatocytes are transformed into fibrous regenerative nodules is because the environment of hepatocytes is an environment that interferes with normal cell regeneration. Regenerated nodules in which hepatocytes are fibrous can be seen as a type of keloid that occurs on the wound surface. In order not to create fibrous regenerative nodules as described above, it is necessary to make hepatocytes an environment in which cell regeneration is smooth. Since the promotion of bile secretion according to the present invention enables the discharge of inflammatory substances and wastes accumulated in the liver, it is possible to normalize the hepatocellular environment, thereby preventing the fibrotic regenerated nodules of hepatocytes.

Claims (1)

A food composition for promoting bile secretion comprising calamansi juice, lemon juice, lime juice and dermis extract.

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