KR20230013116A - 신경보호 유도용 화합물 및 조성물 - Google Patents
신경보호 유도용 화합물 및 조성물 Download PDFInfo
- Publication number
- KR20230013116A KR20230013116A KR1020227044712A KR20227044712A KR20230013116A KR 20230013116 A KR20230013116 A KR 20230013116A KR 1020227044712 A KR1020227044712 A KR 1020227044712A KR 20227044712 A KR20227044712 A KR 20227044712A KR 20230013116 A KR20230013116 A KR 20230013116A
- Authority
- KR
- South Korea
- Prior art keywords
- tetramethyl
- oxo
- oxazaphosphinane
- subject
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 163
- 230000004112 neuroprotection Effects 0.000 title claims abstract description 82
- 230000001939 inductive effect Effects 0.000 title claims abstract description 23
- 239000000203 mixture Substances 0.000 title description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 88
- 230000007170 pathology Effects 0.000 claims description 69
- 208000024827 Alzheimer disease Diseases 0.000 claims description 61
- 238000011282 treatment Methods 0.000 claims description 42
- 230000004770 neurodegeneration Effects 0.000 claims description 37
- 230000015654 memory Effects 0.000 claims description 33
- 210000003169 central nervous system Anatomy 0.000 claims description 32
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 25
- 208000010877 cognitive disease Diseases 0.000 claims description 24
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 24
- 208000028867 ischemia Diseases 0.000 claims description 22
- 208000018737 Parkinson disease Diseases 0.000 claims description 20
- 230000001149 cognitive effect Effects 0.000 claims description 19
- 210000002569 neuron Anatomy 0.000 claims description 19
- 230000016273 neuron death Effects 0.000 claims description 18
- 230000036542 oxidative stress Effects 0.000 claims description 18
- 238000002636 symptomatic treatment Methods 0.000 claims description 18
- 208000028698 Cognitive impairment Diseases 0.000 claims description 17
- 201000002832 Lewy body dementia Diseases 0.000 claims description 16
- 230000003930 cognitive ability Effects 0.000 claims description 16
- RQHKZUBCUZVZEF-UHFFFAOYSA-N 1-phenyl-1-cyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester Chemical compound C1CCCCC1(C=1C=CC=CC=1)C(=O)OCCN1CCOCC1 RQHKZUBCUZVZEF-UHFFFAOYSA-N 0.000 claims description 14
- 102000010970 Connexin Human genes 0.000 claims description 14
- 108050001175 Connexin Proteins 0.000 claims description 14
- 208000023105 Huntington disease Diseases 0.000 claims description 14
- 201000004810 Vascular dementia Diseases 0.000 claims description 14
- 239000012634 fragment Substances 0.000 claims description 14
- 206010003694 Atrophy Diseases 0.000 claims description 13
- 206010019196 Head injury Diseases 0.000 claims description 13
- 208000006011 Stroke Diseases 0.000 claims description 13
- 208000034799 Tauopathies Diseases 0.000 claims description 13
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 13
- 230000037444 atrophy Effects 0.000 claims description 13
- 230000001988 toxicity Effects 0.000 claims description 13
- 231100000419 toxicity Toxicity 0.000 claims description 13
- 208000006264 Korsakoff syndrome Diseases 0.000 claims description 12
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 12
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 12
- 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 claims description 12
- 208000029650 alcohol withdrawal Diseases 0.000 claims description 12
- 239000000544 cholinesterase inhibitor Substances 0.000 claims description 12
- 230000006735 deficit Effects 0.000 claims description 12
- 229960003530 donepezil Drugs 0.000 claims description 12
- 206010015037 epilepsy Diseases 0.000 claims description 12
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 12
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims description 11
- 230000013016 learning Effects 0.000 claims description 11
- 230000003959 neuroinflammation Effects 0.000 claims description 11
- 230000002265 prevention Effects 0.000 claims description 11
- BLZVCIGGICSWIG-UHFFFAOYSA-N 2-aminoethoxydiphenylborane Chemical compound C=1C=CC=CC=1B(OCCN)C1=CC=CC=C1 BLZVCIGGICSWIG-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 claims description 9
- SRRUPDPTTGLICG-RBUKOAKNSA-N (1s,2r)-n-[2-(3,4-dichlorophenyl)ethyl]-n-methyl-2-pyrrolidin-1-ylcyclohexan-1-amine Chemical compound CN([C@@H]1[C@@H](CCCC1)N1CCCC1)CCC1=CC=C(Cl)C(Cl)=C1 SRRUPDPTTGLICG-RBUKOAKNSA-N 0.000 claims description 9
- UVSWWUWQVAQPJR-UHFFFAOYSA-N 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine Chemical compound C1=C(OC)C(OC)=CC=C1CCN1CCN(CCCC=2C=CC=CC=2)CC1 UVSWWUWQVAQPJR-UHFFFAOYSA-N 0.000 claims description 9
- TZZGTNZBLPCBIS-UHFFFAOYSA-N 1-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-methoxy-3,4-dihydroquinolin-2-one Chemical compound O=C1CCC=2C(OC)=CC=CC=2N1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 TZZGTNZBLPCBIS-UHFFFAOYSA-N 0.000 claims description 9
- SYYDYQMUKFERQR-UHFFFAOYSA-N 6-[(4-benzylpiperazin-1-yl)methyl]-2,3-dimethoxyphenol Chemical compound OC1=C(OC)C(OC)=CC=C1CN1CCN(CC=2C=CC=CC=2)CC1 SYYDYQMUKFERQR-UHFFFAOYSA-N 0.000 claims description 9
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims description 9
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 9
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 9
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000003112 inhibitor Substances 0.000 claims description 9
- 229960003803 meclofenamic acid Drugs 0.000 claims description 9
- 229960001962 mefloquine Drugs 0.000 claims description 9
- YGKUEOZJFIXDGI-UHFFFAOYSA-N pridopidine Chemical compound C1CN(CCC)CCC1C1=CC=CC(S(C)(=O)=O)=C1 YGKUEOZJFIXDGI-UHFFFAOYSA-N 0.000 claims description 9
- HELCSESNNDZLFM-UHFFFAOYSA-N 4-iodo-N-[1-(phenylmethyl)-4-piperidinyl]benzamide Chemical compound C1=CC(I)=CC=C1C(=O)NC1CCN(CC=2C=CC=CC=2)CC1 HELCSESNNDZLFM-UHFFFAOYSA-N 0.000 claims description 8
- 230000000971 hippocampal effect Effects 0.000 claims description 8
- VCZSWYIFCKGTJI-JLHYYAGUSA-N igmesine Chemical compound C1CC1CN(C)C(C=1C=CC=CC=1)(CC)C\C=C\C1=CC=CC=C1 VCZSWYIFCKGTJI-JLHYYAGUSA-N 0.000 claims description 8
- 230000009467 reduction Effects 0.000 claims description 8
- -1 dibenzoate Chemical compound 0.000 claims description 7
- BOTHKNZTGGXFEQ-UHFFFAOYSA-N 1-(2,2-diphenyloxolan-3-yl)-n,n-dimethylmethanamine Chemical compound CN(C)CC1CCOC1(C=1C=CC=CC=1)C1=CC=CC=C1 BOTHKNZTGGXFEQ-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 6
- 229960003980 galantamine Drugs 0.000 claims description 6
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 6
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 claims description 6
- 229960004136 rivastigmine Drugs 0.000 claims description 6
- 230000006886 spatial memory Effects 0.000 claims description 6
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 5
- JFABCGNHSUIPEL-UHFFFAOYSA-N 2-(3-chlorophenyl)-3,3,5,5-tetramethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound ClC=1C=C(C=CC=1)P1(OCC(NC1(C)C)(C)C)=O JFABCGNHSUIPEL-UHFFFAOYSA-N 0.000 claims description 5
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 5
- 229950008995 aducanumab Drugs 0.000 claims description 5
- 229960003720 enoxolone Drugs 0.000 claims description 5
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 claims description 5
- LYUGHJPXLXICHT-UHFFFAOYSA-N 2-(2,3-dichlorophenyl)-3,3,5,5-tetramethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound ClC1=C(C=CC=C1Cl)P1(OCC(NC1(C)C)(C)C)=O LYUGHJPXLXICHT-UHFFFAOYSA-N 0.000 claims description 4
- VXPDJTOUDMXYGJ-UHFFFAOYSA-N 2-(3,5-dichlorophenyl)-3,3,5,5-tetramethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound ClC=1C=C(C=C(C=1)Cl)P1(OCC(NC1(C)C)(C)C)=O VXPDJTOUDMXYGJ-UHFFFAOYSA-N 0.000 claims description 4
- ORMOQBLZUSJWOD-UHFFFAOYSA-N 2-(3-chlorophenyl)-3,3,4,5,5-pentamethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound CN1C(C)(C)COP(=O)(c2cccc(Cl)c2)C1(C)C ORMOQBLZUSJWOD-UHFFFAOYSA-N 0.000 claims description 4
- WDEYHKLCVZHFMA-UHFFFAOYSA-N 2-(3-chlorophenyl)-3,3,5,5-tetramethyl-2-sulfanylidene-1,4,2lambda5-oxazaphosphinane Chemical compound ClC=1C=C(C=CC=1)P1(OCC(NC1(C)C)(C)C)=S WDEYHKLCVZHFMA-UHFFFAOYSA-N 0.000 claims description 4
- BZPVRUBMPXSHSF-UHFFFAOYSA-N 2-(3-fluorophenyl)-3,3,5,5-tetramethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound FC=1C=C(C=CC=1)P1(OCC(NC1(C)C)(C)C)=O BZPVRUBMPXSHSF-UHFFFAOYSA-N 0.000 claims description 4
- PRYUCEKGZMTVRK-UHFFFAOYSA-N 2-(4-chlorophenyl)-3,3,5,5-tetramethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound ClC1=CC=C(C=C1)P1(OCC(NC1(C)C)(C)C)=O PRYUCEKGZMTVRK-UHFFFAOYSA-N 0.000 claims description 4
- DWFOUYWIWBQGFK-UHFFFAOYSA-N 2-(4-fluorophenyl)-3,3,5,5-tetramethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound FC1=CC=C(C=C1)P1(OCC(NC1(C)C)(C)C)=O DWFOUYWIWBQGFK-UHFFFAOYSA-N 0.000 claims description 4
- QRLPFCPYPGPLQA-UHFFFAOYSA-N 3,3,5,5-tetramethyl-2-(3-nitrophenyl)-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound [N+](=O)([O-])C=1C=C(C=CC=1)P1(OCC(NC1(C)C)(C)C)=O QRLPFCPYPGPLQA-UHFFFAOYSA-N 0.000 claims description 4
- ZZUXYMPHBPDSHM-UHFFFAOYSA-N 3,3,5,5-tetramethyl-2-pyridin-2-yl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound N1=C(C=CC=C1)P1(OCC(NC1(C)C)(C)C)=O ZZUXYMPHBPDSHM-UHFFFAOYSA-N 0.000 claims description 4
- VXUGJNHPSMNENH-UHFFFAOYSA-N 3,3,5,5-tetramethyl-2-pyridin-3-yl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound N1=CC(=CC=C1)P1(OCC(NC1(C)C)(C)C)=O VXUGJNHPSMNENH-UHFFFAOYSA-N 0.000 claims description 4
- QMRXABLHOIKGLG-UHFFFAOYSA-N 3,3,5,5-tetramethyl-2-pyridin-4-yl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound N1=CC=C(C=C1)P1(OCC(NC1(C)C)(C)C)=O QMRXABLHOIKGLG-UHFFFAOYSA-N 0.000 claims description 4
- KVIVXPHEVVIJKS-UHFFFAOYSA-N 3,3,5,5-tetramethyl-2-pyrimidin-2-yl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound N1=C(N=CC=C1)P1(OCC(NC1(C)C)(C)C)=O KVIVXPHEVVIJKS-UHFFFAOYSA-N 0.000 claims description 4
- DAGQXYMRYJXTAJ-UHFFFAOYSA-N 3,3,5,5-tetramethyl-2-pyrimidin-5-yl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound N1=CN=CC(=C1)P1(OCC(NC1(C)C)(C)C)=O DAGQXYMRYJXTAJ-UHFFFAOYSA-N 0.000 claims description 4
- MOFNUJIYNQDGQJ-UHFFFAOYSA-N 3-(3,3,5,5-tetramethyl-2-oxo-1,4,2lambda5-oxazaphosphinan-2-yl)aniline Chemical compound NC=1C=C(C=CC=1)P1(OCC(NC1(C)C)(C)C)=O MOFNUJIYNQDGQJ-UHFFFAOYSA-N 0.000 claims description 4
- MWTSWMNORCYSBO-UHFFFAOYSA-N 4-(3,3,5,5-tetramethyl-2-oxo-1,4,2lambda5-oxazaphosphinan-2-yl)aniline Chemical compound NC1=CC=C(C=C1)P1(OCC(NC1(C)C)(C)C)=O MWTSWMNORCYSBO-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- DGZZDMAMAYTPSV-UHFFFAOYSA-N N-phenylmethoxy-4-(3,3,5,5-tetramethyl-2-oxo-1,4,2lambda5-oxazaphosphinan-2-yl)benzamide Chemical compound C(C1=CC=CC=C1)ONC(=O)C1=CC=C(C=C1)P1(OCC(NC1(C)C)(C)C)=O DGZZDMAMAYTPSV-UHFFFAOYSA-N 0.000 claims description 4
- 102100028656 Sigma non-opioid intracellular receptor 1 Human genes 0.000 claims description 4
- 101710104750 Sigma non-opioid intracellular receptor 1 Proteins 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 230000004224 protection Effects 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- ZLFXNXSOPHRFNV-UHFFFAOYSA-N 2-(2-chlorophenyl)-3,3,5,5-tetramethyl-1,4,2lambda5-oxazaphosphinane 2-oxide Chemical compound ClC1=C(C=CC=C1)P1(OCC(NC1(C)C)(C)C)=O ZLFXNXSOPHRFNV-UHFFFAOYSA-N 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 229940072107 ascorbate Drugs 0.000 claims description 3
- 235000010323 ascorbic acid Nutrition 0.000 claims description 3
- 239000011668 ascorbic acid Substances 0.000 claims description 3
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims description 3
- 229940077388 benzenesulfonate Drugs 0.000 claims description 3
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 claims description 3
- 230000006727 cell loss Effects 0.000 claims description 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 3
- 230000005764 inhibitory process Effects 0.000 claims description 3
- LGQCVMYAEFTEFN-UHFFFAOYSA-N n-allylnormetazocine Chemical compound C1C2=CC=C(O)C=C2C2(C)C(C)C1N(CC=C)CC2 LGQCVMYAEFTEFN-UHFFFAOYSA-N 0.000 claims description 3
- RFPMGSKVEAUNMZ-UHFFFAOYSA-N pentylidene Chemical group [CH2+]CCC[CH-] RFPMGSKVEAUNMZ-UHFFFAOYSA-N 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 3
- 229960001860 salicylate Drugs 0.000 claims description 3
- 230000006403 short-term memory Effects 0.000 claims description 3
- 229940095064 tartrate Drugs 0.000 claims description 3
- 230000009223 neuronal apoptosis Effects 0.000 claims description 2
- 238000012360 testing method Methods 0.000 description 97
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 76
- 229960004640 memantine Drugs 0.000 description 75
- 241000699670 Mus sp. Species 0.000 description 56
- 230000000694 effects Effects 0.000 description 39
- 241001465754 Metazoa Species 0.000 description 38
- 206010012289 Dementia Diseases 0.000 description 35
- 108090000765 processed proteins & peptides Proteins 0.000 description 33
- 230000000324 neuroprotective effect Effects 0.000 description 19
- 241000699666 Mus <mouse, genus> Species 0.000 description 18
- 230000006907 apoptotic process Effects 0.000 description 18
- 210000004556 brain Anatomy 0.000 description 18
- 230000007423 decrease Effects 0.000 description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
- 210000001320 hippocampus Anatomy 0.000 description 18
- 208000024891 symptom Diseases 0.000 description 18
- 230000001965 increasing effect Effects 0.000 description 17
- 230000000626 neurodegenerative effect Effects 0.000 description 17
- 238000002347 injection Methods 0.000 description 16
- 239000007924 injection Substances 0.000 description 16
- 238000012549 training Methods 0.000 description 16
- 238000011302 passive avoidance test Methods 0.000 description 15
- 201000010099 disease Diseases 0.000 description 14
- 239000000243 solution Substances 0.000 description 13
- 239000003814 drug Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 206010029350 Neurotoxicity Diseases 0.000 description 11
- 206010044221 Toxic encephalopathy Diseases 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 206010027175 memory impairment Diseases 0.000 description 11
- 230000007135 neurotoxicity Effects 0.000 description 11
- 231100000228 neurotoxicity Toxicity 0.000 description 11
- 241000282412 Homo Species 0.000 description 10
- 208000009829 Lewy Body Disease Diseases 0.000 description 10
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 10
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 10
- 239000003550 marker Substances 0.000 description 10
- 210000001130 astrocyte Anatomy 0.000 description 9
- 230000007850 degeneration Effects 0.000 description 9
- 230000003492 excitotoxic effect Effects 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 8
- 108700000707 bcl-2-Associated X Proteins 0.000 description 8
- 102000055102 bcl-2-Associated X Human genes 0.000 description 8
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 8
- 230000004054 inflammatory process Effects 0.000 description 8
- 230000035987 intoxication Effects 0.000 description 8
- 231100000566 intoxication Toxicity 0.000 description 8
- 230000003859 lipid peroxidation Effects 0.000 description 8
- 208000014670 posterior cortical atrophy Diseases 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 239000000018 receptor agonist Substances 0.000 description 8
- 229940044601 receptor agonist Drugs 0.000 description 8
- 238000001061 Dunnett's test Methods 0.000 description 7
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 7
- 102000004889 Interleukin-6 Human genes 0.000 description 7
- 108090001005 Interleukin-6 Proteins 0.000 description 7
- 238000012347 Morris Water Maze Methods 0.000 description 7
- 208000009668 Neurobehavioral Manifestations Diseases 0.000 description 7
- 238000000540 analysis of variance Methods 0.000 description 7
- 238000010171 animal model Methods 0.000 description 7
- 230000006399 behavior Effects 0.000 description 7
- 230000030833 cell death Effects 0.000 description 7
- 230000019771 cognition Effects 0.000 description 7
- 231100000063 excitotoxicity Toxicity 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 7
- 229940100601 interleukin-6 Drugs 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 230000004044 response Effects 0.000 description 7
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 6
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 6
- 238000012544 monitoring process Methods 0.000 description 6
- 230000035772 mutation Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000011002 quantification Methods 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 230000003542 behavioural effect Effects 0.000 description 5
- 230000001413 cellular effect Effects 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 238000002059 diagnostic imaging Methods 0.000 description 5
- 238000013401 experimental design Methods 0.000 description 5
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 5
- 230000001771 impaired effect Effects 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 210000000274 microglia Anatomy 0.000 description 5
- 230000001936 parietal effect Effects 0.000 description 5
- 239000011550 stock solution Substances 0.000 description 5
- 102000013498 tau Proteins Human genes 0.000 description 5
- 108010026424 tau Proteins Proteins 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 208000037259 Amyloid Plaque Diseases 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 206010002022 amyloidosis Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 230000006999 cognitive decline Effects 0.000 description 4
- 210000001947 dentate gyrus Anatomy 0.000 description 4
- 230000001627 detrimental effect Effects 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 230000021824 exploration behavior Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000002055 immunohistochemical effect Effects 0.000 description 4
- 238000007914 intraventricular administration Methods 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 208000015122 neurodegenerative disease Diseases 0.000 description 4
- 231100000572 poisoning Toxicity 0.000 description 4
- 230000000607 poisoning effect Effects 0.000 description 4
- 239000004800 polyvinyl chloride Substances 0.000 description 4
- 208000028173 post-traumatic stress disease Diseases 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 102100026882 Alpha-synuclein Human genes 0.000 description 3
- 208000000044 Amnesia Diseases 0.000 description 3
- 208000031091 Amnestic disease Diseases 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 206010018341 Gliosis Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000000692 Student's t-test Methods 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 230000006986 amnesia Effects 0.000 description 3
- 230000003109 amnesic effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 208000037875 astrocytosis Diseases 0.000 description 3
- 230000007341 astrogliosis Effects 0.000 description 3
- 238000009227 behaviour therapy Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 230000001054 cortical effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000002939 deleterious effect Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229960004038 fluvoxamine Drugs 0.000 description 3
- 210000001652 frontal lobe Anatomy 0.000 description 3
- 230000008449 language Effects 0.000 description 3
- 230000007787 long-term memory Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000008655 medium-term memory Effects 0.000 description 3
- 230000004065 mitochondrial dysfunction Effects 0.000 description 3
- 239000002052 molecular layer Substances 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 230000007505 plaque formation Effects 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 238000002600 positron emission tomography Methods 0.000 description 3
- 229950003764 pridopidine Drugs 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000009182 swimming Effects 0.000 description 3
- 238000012353 t test Methods 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 230000003936 working memory Effects 0.000 description 3
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 description 2
- 102100029470 Apolipoprotein E Human genes 0.000 description 2
- 101710095339 Apolipoprotein E Proteins 0.000 description 2
- 101150017888 Bcl2 gene Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 2
- 102000018899 Glutamate Receptors Human genes 0.000 description 2
- 108010027915 Glutamate Receptors Proteins 0.000 description 2
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 description 2
- 101000619542 Homo sapiens E3 ubiquitin-protein ligase parkin Proteins 0.000 description 2
- 101000941879 Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 102100032693 Leucine-rich repeat serine/threonine-protein kinase 2 Human genes 0.000 description 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 2
- 229940099433 NMDA receptor antagonist Drugs 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 208000027626 Neurocognitive disease Diseases 0.000 description 2
- 208000025966 Neurological disease Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 description 2
- 102100038836 Superoxide dismutase [Cu-Zn] Human genes 0.000 description 2
- 208000032859 Synucleinopathies Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 2
- 238000011230 antibody-based therapy Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000012742 biochemical analysis Methods 0.000 description 2
- 238000012984 biological imaging Methods 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 208000015114 central nervous system disease Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007278 cognition impairment Effects 0.000 description 2
- 230000003920 cognitive function Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 230000005750 disease progression Effects 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000000537 electroencephalography Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 231100000318 excitotoxic Toxicity 0.000 description 2
- 239000000834 fixative Substances 0.000 description 2
- 108010050848 glycylleucine Proteins 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 230000006951 hyperphosphorylation Effects 0.000 description 2
- 229950004066 igmesine Drugs 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000003364 immunohistochemistry Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000007087 memory ability Effects 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 230000007388 microgliosis Effects 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 230000004769 mitochondrial stress Effects 0.000 description 2
- 230000008450 motivation Effects 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 2
- 230000002887 neurotoxic effect Effects 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 102000045222 parkin Human genes 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000008447 perception Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 210000003478 temporal lobe Anatomy 0.000 description 2
- 230000031836 visual learning Effects 0.000 description 2
- 230000002747 voluntary effect Effects 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- ORZHVTYKPFFVMG-UHFFFAOYSA-N xylenol orange Chemical compound OC(=O)CN(CC(O)=O)CC1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(CN(CC(O)=O)CC(O)=O)C(O)=C(C)C=2)=C1 ORZHVTYKPFFVMG-UHFFFAOYSA-N 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- FRIBMENBGGCKPD-UHFFFAOYSA-N 3-(2,3-dimethoxyphenyl)prop-2-enal Chemical compound COC1=CC=CC(C=CC=O)=C1OC FRIBMENBGGCKPD-UHFFFAOYSA-N 0.000 description 1
- HUYVZSFADWYSHD-UHFFFAOYSA-N 3-(2-fluoroethyl)adamantan-1-amine Chemical compound C1C(C2)CC3CC1(N)CC2(CCF)C3 HUYVZSFADWYSHD-UHFFFAOYSA-N 0.000 description 1
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 239000012103 Alexa Fluor 488 Substances 0.000 description 1
- 102100034112 Alkyldihydroxyacetonephosphate synthase, peroxisomal Human genes 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 108091010877 Allograft inflammatory factor 1 Proteins 0.000 description 1
- 102100040121 Allograft inflammatory factor 1 Human genes 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 102000014303 Amyloid beta-Protein Precursor Human genes 0.000 description 1
- 108010079054 Amyloid beta-Protein Precursor Proteins 0.000 description 1
- 101800001718 Amyloid-beta protein Proteins 0.000 description 1
- 206010002023 Amyloidoses Diseases 0.000 description 1
- 206010002368 Anger Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000256837 Apidae Species 0.000 description 1
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 description 1
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 description 1
- 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010051288 Central nervous system inflammation Diseases 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 239000004381 Choline salt Substances 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 108010069241 Connexin 43 Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 201000010374 Down Syndrome Diseases 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 102100037858 G1/S-specific cyclin-E1 Human genes 0.000 description 1
- 102100021337 Gap junction alpha-1 protein Human genes 0.000 description 1
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 description 1
- DGKBSGNCMCLDSL-BYULHYEWSA-N Gly-Ile-Asn Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)CN DGKBSGNCMCLDSL-BYULHYEWSA-N 0.000 description 1
- HAXARWKYFIIHKD-ZKWXMUAHSA-N Gly-Ile-Ser Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(O)=O HAXARWKYFIIHKD-ZKWXMUAHSA-N 0.000 description 1
- IALQAMYQJBZNSK-WHFBIAKZSA-N Gly-Ser-Asn Chemical compound [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O IALQAMYQJBZNSK-WHFBIAKZSA-N 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 101000799143 Homo sapiens Alkyldihydroxyacetonephosphate synthase, peroxisomal Proteins 0.000 description 1
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 description 1
- 101001037074 Homo sapiens GRB10-interacting GYF protein 2 Proteins 0.000 description 1
- 101000887201 Homo sapiens Polyamine-transporting ATPase 13A2 Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- YNMQUIVKEFRCPH-QSFUFRPTSA-N Ile-Ile-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)O)N YNMQUIVKEFRCPH-QSFUFRPTSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 238000012313 Kruskal-Wallis test Methods 0.000 description 1
- ITWQLSZTLBKWJM-YUMQZZPRSA-N Lys-Gly-Ala Chemical compound OC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](N)CCCCN ITWQLSZTLBKWJM-YUMQZZPRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- QAHFGYLFLVGBNW-DCAQKATOSA-N Met-Ala-Lys Chemical compound CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCCCN QAHFGYLFLVGBNW-DCAQKATOSA-N 0.000 description 1
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 102000013535 Proto-Oncogene Proteins c-bcl-2 Human genes 0.000 description 1
- 108010090931 Proto-Oncogene Proteins c-bcl-2 Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 101710150875 TAR DNA-binding protein 43 Proteins 0.000 description 1
- 102100040347 TAR DNA-binding protein 43 Human genes 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- ZHAFUINZIZIXFC-UHFFFAOYSA-N [9-(dimethylamino)-10-methylbenzo[a]phenoxazin-5-ylidene]azanium;chloride Chemical compound [Cl-].O1C2=CC(=[NH2+])C3=CC=CC=C3C2=NC2=C1C=C(N(C)C)C(C)=C2 ZHAFUINZIZIXFC-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000036626 alertness Effects 0.000 description 1
- 108090000185 alpha-Synuclein Proteins 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000000848 angular dependent Auger electron spectroscopy Methods 0.000 description 1
- 230000003496 anti-amnesic effect Effects 0.000 description 1
- 230000002424 anti-apoptotic effect Effects 0.000 description 1
- 230000002205 anti-dementic effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000006736 behavioral deficit Effects 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 230000008238 biochemical pathway Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000008004 cell lysis buffer Substances 0.000 description 1
- 230000007248 cellular mechanism Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 235000019417 choline salt Nutrition 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 210000002932 cholinergic neuron Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000003931 cognitive performance Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000008150 cryoprotective solution Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 210000005064 dopaminergic neuron Anatomy 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 238000012362 drug development process Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000000350 effect on amnesia Effects 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000003976 gap junction Anatomy 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000037417 hyperactivation Effects 0.000 description 1
- 238000002991 immunohistochemical analysis Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000003933 intellectual function Effects 0.000 description 1
- 210000003963 intermediate filament Anatomy 0.000 description 1
- 238000000185 intracerebroventricular administration Methods 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 201000010901 lateral sclerosis Diseases 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000027928 long-term synaptic potentiation Effects 0.000 description 1
- 108010064235 lysylglycine Proteins 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- YKSNLCVSTHTHJA-UHFFFAOYSA-L maneb Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S YKSNLCVSTHTHJA-UHFFFAOYSA-L 0.000 description 1
- 229920000940 maneb Polymers 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 description 1
- 229960000967 memantine hydrochloride Drugs 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 230000006993 memory improvement Effects 0.000 description 1
- 230000007334 memory performance Effects 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 230000002025 microglial effect Effects 0.000 description 1
- 230000000897 modulatory effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 208000005264 motor neuron disease Diseases 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000007230 neural mechanism Effects 0.000 description 1
- 230000003188 neurobehavioral effect Effects 0.000 description 1
- 230000019581 neuron apoptotic process Effects 0.000 description 1
- 230000004693 neuron damage Effects 0.000 description 1
- 230000007996 neuronal plasticity Effects 0.000 description 1
- 230000007171 neuropathology Effects 0.000 description 1
- 231100000189 neurotoxic Toxicity 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000006384 oligomerization reaction Methods 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- FIKAKWIAUPDISJ-UHFFFAOYSA-L paraquat dichloride Chemical compound [Cl-].[Cl-].C1=C[N+](C)=CC=C1C1=CC=[N+](C)C=C1 FIKAKWIAUPDISJ-UHFFFAOYSA-L 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000004983 pleiotropic effect Effects 0.000 description 1
- 108010040003 polyglutamine Proteins 0.000 description 1
- 229920000155 polyglutamine Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000861 pro-apoptotic effect Effects 0.000 description 1
- 230000003414 procognitive effect Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000002633 protecting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940080817 rotenone Drugs 0.000 description 1
- JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 101150062190 sod1 gene Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000007596 spatial working memory Effects 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 230000007607 synaptic alteration Effects 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 230000003956 synaptic plasticity Effects 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 230000016978 synaptic transmission, cholinergic Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229960001685 tacrine Drugs 0.000 description 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012034 trail making test Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 230000036967 uncompetitive effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR2005138A FR3110393B1 (fr) | 2020-05-20 | 2020-05-20 | Compose et composition pour induire une neuroprotection |
| FRFR2005138 | 2020-05-20 | ||
| PCT/FR2021/050929 WO2021234324A1 (fr) | 2020-05-20 | 2021-05-20 | Compose et composition pour induire une neuroprotection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230013116A true KR20230013116A (ko) | 2023-01-26 |
Family
ID=73013493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227044712A Pending KR20230013116A (ko) | 2020-05-20 | 2021-05-20 | 신경보호 유도용 화합물 및 조성물 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4142703B8 (https=) |
| JP (1) | JP2023531869A (https=) |
| KR (1) | KR20230013116A (https=) |
| CN (1) | CN116981449A (https=) |
| CA (1) | CA3178633A1 (https=) |
| ES (1) | ES2970378T3 (https=) |
| FR (1) | FR3110393B1 (https=) |
| WO (1) | WO2021234324A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3149773B1 (fr) | 2023-06-19 | 2026-04-17 | Rest Therapeutics | Nouvelles combinaisons synergiques a base de fenm |
| WO2026003229A1 (fr) | 2024-06-26 | 2026-01-02 | Rest Therapeutics | Derives de fluoroethylnormemantine pour leur utilisation en tant que medicament |
| FR3163835A1 (fr) | 2024-06-26 | 2026-01-02 | Rest Therapeutics | Derives de fluoroethylnormemantine |
| FR3163834A1 (fr) | 2024-06-26 | 2026-01-02 | Rest Therapeutics | Derives de fluoroethylnormemantine |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100777904B1 (ko) * | 2002-10-24 | 2007-11-28 | 메르츠 파마 게엠베하 운트 코. 카가아 | 1-아미노시클로헥산 유도체 및 아세틸콜린에스테라제 저해제를 포함하는 약학적 제품 및 이를 이용한 복합 치료 |
| BRPI0516112A (pt) * | 2004-10-15 | 2008-08-26 | Janssen Pharmaceutica Nv | métodos para neuroproteção |
| US20090118376A1 (en) * | 2007-11-02 | 2009-05-07 | Ru-Band Lu | Memantine Protects Inflammation-Related Degeneration of Dopamine Neurons Through Inhibition of Over-Activated Microglia and Release of Neurotrophic Factors from Astroglia |
| FR2935611B1 (fr) | 2008-09-10 | 2010-10-15 | Commissariat Energie Atomique | Utilisation d'agents anti-connexines pour moduler l'effet therapeutique de molecules psychotropes |
| US20120115943A1 (en) * | 2008-10-01 | 2012-05-10 | National Taiwan University | Composition and method for neuroprotection against excitotoxic injury |
| EP2586436A1 (en) * | 2011-10-31 | 2013-05-01 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Use of anti-connexin agents for enhancing the therapeutic effect of acetylcholinesterase inhibitor |
| FR3006193B1 (fr) | 2013-05-29 | 2015-06-19 | Holis Technologies | Nouveaux composes chimiques derives de la memantine et susceptibles de se fixer sur les recepteurs de n-methyl-d-aspartate (nmda) |
| FR3050732B1 (fr) | 2016-05-02 | 2019-06-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nouveaux derives de phosphinolactones et leurs utilisations pharmaceutiques |
| FR3075038B1 (fr) | 2017-12-15 | 2020-03-06 | Melchior Material And Life Science France | Utilisation de la fluoroethylnormemantine pour la prevention de l'apparition et le traitement de l'anxiete |
| WO2020232246A1 (en) * | 2019-05-15 | 2020-11-19 | The Trustees Of Columbia University In The City Of New York | Compositions and methods against stress-induced affective disorders and their associated symptoms |
-
2020
- 2020-05-20 FR FR2005138A patent/FR3110393B1/fr active Active
-
2021
- 2021-05-20 ES ES21734182T patent/ES2970378T3/es active Active
- 2021-05-20 KR KR1020227044712A patent/KR20230013116A/ko active Pending
- 2021-05-20 CN CN202180060125.1A patent/CN116981449A/zh active Pending
- 2021-05-20 CA CA3178633A patent/CA3178633A1/fr active Pending
- 2021-05-20 EP EP21734182.5A patent/EP4142703B8/fr active Active
- 2021-05-20 WO PCT/FR2021/050929 patent/WO2021234324A1/fr not_active Ceased
- 2021-05-20 JP JP2022571216A patent/JP2023531869A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR3110393B1 (fr) | 2022-05-06 |
| EP4142703B8 (fr) | 2023-11-22 |
| US20230270695A1 (en) | 2023-08-31 |
| FR3110393A1 (fr) | 2021-11-26 |
| CN116981449A (zh) | 2023-10-31 |
| CA3178633A1 (fr) | 2021-11-25 |
| ES2970378T3 (es) | 2024-05-28 |
| EP4142703A1 (fr) | 2023-03-08 |
| WO2021234324A1 (fr) | 2021-11-25 |
| EP4142703C0 (fr) | 2023-10-18 |
| EP4142703B1 (fr) | 2023-10-18 |
| JP2023531869A (ja) | 2023-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20230013116A (ko) | 신경보호 유도용 화합물 및 조성물 | |
| US9144558B2 (en) | Baclofen and acamprosate based therapy of neurological disorders | |
| ES2327521T3 (es) | Procedimientos de prevencion, tratamiento y diagnostico de trastornos de la agregacion de proteinas. | |
| Christensen | Changing the course of Alzheimer's disease: anti-amyloid disease-modifying treatments on the horizon | |
| EP3606525B1 (en) | Compositions for treating aging-associated impairments using ccr3-inhibitors | |
| JP2011518119A (ja) | ４−フェニル酪酸（４ｐｂａ）およびその医薬上許容し得る塩についての新規用途 | |
| Easton et al. | Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer’s disease | |
| US10912819B2 (en) | Neuroprotective peptides derived from activity-dependent neuroprotective protein for treatment of neurological diseases | |
| Liu et al. | Bexarotene attenuates focal cerebral ischemia–reperfusion injury via the suppression of JNK/Caspase-3 signaling pathway | |
| Zaky et al. | Neurodegenerative disorders: available therapies and their limitations | |
| KR102630042B1 (ko) | 알츠하이머병의 치료를 위한 항-a베타 원시섬유 항체 및 베타-세크레타제 bace1 억제제를 포함하는 조성물 | |
| US20220105106A1 (en) | Compositions and methods relating to use of agonists of alpha5-containing gabaa receptors | |
| JP2024543056A (ja) | エダラボンデクスボルネオール含有組成物の認知障害の治療における応用 | |
| US12611387B2 (en) | Compound and composition for inducing neuroprotection | |
| JP7249433B2 (ja) | 蜂毒抽出物を有効成分として含有する神経炎症疾患の予防または治療用組成物 | |
| US20220031680A1 (en) | Donecopride As Neuroprotective Agent In the Treatment of Neurodegenerative Diseases | |
| CN121586584A (zh) | Glp-1受体激动剂在治疗神经退行性疾病或病症中的应用 | |
| US11179358B2 (en) | Compound for use in the prevention and treatment of neurodegenerative diseases | |
| Bales et al. | Phosphodiesterase inhibition to target the synaptic dysfunction in Alzheimer’s disease | |
| ES2650175B1 (es) | Tratamiento de enfermedades neurodegenerativas | |
| RU2786476C2 (ru) | Композиция, содержащая антитело против протофибрилл абета и ингибитор бета-секретазы васе1 для лечения болезни альцгеймера | |
| Tamanna | Bio-similar drug development and accessible drugs in the market for the treatment of Alzheimer's Disease: Current status | |
| WO2025184834A1 (zh) | 一种庚酸酯化合物及其用于制备预防和/或治疗神经退行性疾病的药物或功能食品中的用途 | |
| JP2021520412A (ja) | タンパク質ミスフォールディング疾患のための療法 | |
| JP2017132742A (ja) | Ａβオリゴマー特異的抗体の新規薬理用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20221220 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application |