KR20230007680A - Skin Moisturizing and Nutrition Cream Cosmetic Composition Containing Bee Veom Extract And Vegetable Placenta - Google Patents

Abstract

An Oil in Water (O/W) type-moisturizing nutritional cream of the present invention contains bee venom extract, vegetable placenta, sh-Oligopeptide-1, and hyaluronic acid as active ingredients, but it is optimized for emulsification using natural substances as its main raw material, and contains animal oils which have a similar structure to the fatty acids making up skin tissue. Accordingly, the O/W type-moisturizing nutritional cream of the present invention has the advantage of excellent spreadability due to optimized emulsification, not irritating the skin due to use of natural substances, and excellent effects in preventing skin aging, supplying skin nutrition, skin restoration, and maintaining skin moisture by containing animal oil and promoting skin absorption of active ingredients.

Description

Skin Moisturizing and Nutrition Cream Cosmetic Composition Containing Bee Veom Extract And Vegetable Placenta}

The present invention relates to a moisturizing and nourishing cream cosmetic composition comprising bee venom extract and plant placenta.

Bee venom is a defense substance of bees composed of about 40 active peptides. It has excellent resistance to harmful substances and is known as a natural ingredient that manages wrinkles, soothes and reduces sebum production. Placenta, also known as placenta, has excellent wound resilience as it contains various growth factors, and has the function of replacing collagen with young collagen. It has the effect of preventing the phenomenon.

The bee venom and placenta are included in cosmetics as stagnant extracts to prevent aging, restore skin, maintain moisture, promote blood circulation to help remove wastes, and are used to improve the function of dermal tissue by supplying nutrients. there is.

Among cosmetic compositions, emulsions emulsified are mainly used for essences, lotions, and creams except skin. The emulsion is classified into a Water in Oil (W / O) type in which water is inside and oil is outside, as opposed to an Oil in Water (O / W) type in which oil is inside and water is outside, and among them, Oil in Water ( O/W) type has good spreadability, so it is easy to apply multiple layers and has excellent compatibility with others.

The active ingredient of the aqueous phase included in the cosmetic composition is mixed with the oily ingredient in the emulsified emulsion and is located on the surface or inside it, and the oily ingredient plays a role in penetrating the active ingredient into the skin when applied to the skin. In order to increase the skin penetration and efficacy of the active ingredient, artificial chemicals are sometimes used, but there is a problem of reducing the application property by changing the viscosity of the cosmetic composition or inducing skin trouble by stimulating the skin.

The patents and references mentioned herein are incorporated herein by reference to the same extent as if each document were individually and expressly specified by reference.

Korean Patent Publication No. 10-2010-0118629 Korean Patent Publication No. 10-2019-0035285

Toxins 2015, 7, 4758-4772. Journal of Integrative Medicine, 2013, Vol.11, No. 5, 320-326. Kor. J. Aesthet. Cosmetol., Vol. 13, no. 5, 679-688.

In order to solve the above problems, the present invention provides a moisturizing and nutritious cream cosmetic composition that has excellent application properties and does not induce skin trouble by using natural substances that have skin protection effects and do not cause skin irritation, including bee venom and placenta components. The purpose.

Other objects and technical features of the present invention are presented more specifically by the following detailed description, claims and drawings.

The present invention is an Oil in Water (O/W) type containing Bee Venom Extract, Vegetable Placenta, sh-Oligopeptide-1, and Hyaluronic acid. -Provides a moisturizing and nourishing cream cosmetic composition.

The Oil in Water (O/W) type-moisturizing nourishing cream is prepared by mixing water phase components and oil phase components at a weight ratio of 2.7 to 3.0: 1, bee venom extract, vegetable placenta, sh-oligopeptide-1, hyaluronic acid, an aqueous phase component composed of purified water, glycerin, and butylene glycol; An oily component composed of animal oils such as horse oil, emu oil, and lanolin, and vegetable oils such as Rexpil Oil and MCT Oil; It is prepared by mixing emulsion stabilizers composed of emulsifying wax, cetearyl alcohol, olive oil wax and ethylhexane.

The aqueous phase component includes bee venom extract, vegetable placenta, sh-oligopeptide-1, and hyaluronic acid in a ratio of 1:1:1:1, and the oil phase component includes animal oil and vegetable oil in a weight ratio of 1.8 to 2.2:1. It is characterized in that the bee venom extract, vegetable placenta, sh-oligopeptide-1 and hyaluronic acid of the aqueous phase component and the animal oil of the oil phase component are included in a weight ratio of 0.6 to 1:1.

In addition, the Oil in Water (O/W) type moisturizing nutrient cream of the present invention has a viscosity of 21000 to 24000 dPa·S and a moisture content of 50 to 55% after 12 hours of application.

The Oil in Water (O/W) type moisturizing nutrient cream of the present invention contains Bee Venom Extract, Vegetable Placenta, sh-Oligopeptide-1 and hyaluronic acid as active ingredients. It includes hyaluronic acid, but it is optimized for emulsification with natural substances as the main raw material, and is characterized by containing animal oils that are similar in structure to fatty acids constituting skin tissue.

Therefore, the Oil in Water (O/W) type-moisturizing nutrient cream of the present invention has optimized emulsification and excellent spreadability, and uses natural substances so there is no skin irritation and contains animal oil to promote skin absorption of active ingredients. It has outstanding advantages in preventing skin aging, supplying skin nutrients, restoring skin, and maintaining skin moisture.

1 shows the results of infrared spectrum analysis of the present invention.
Figure 2 shows the results of measuring the viscosity of the present invention.
Figure 3 shows the moisture moisturizing evaluation results of the present invention.
Figure 4 shows the results of preparing the oil in water (O / W) type-moisturizing nutritional cream cosmetic composition of the present invention.

The present invention is an Oil in Water (O/W) type containing Bee Venom Extract, Vegetable Placenta, sh-Oligopeptide-1, and Hyaluronic acid. -Provides a moisturizing and nourishing cream cosmetic composition.

The bee venom extract is a purified secretion secreted from the venom of worker bees among honey bees, and contains melittin, apamin, secapine, dopamine, adolafin, protease inhibitor, MCD peptide, procamine, histamine, and hyaludase Active peptides may be included. It is preferable to use bee venom extracts for use in cosmetic compositions that have passed the cytotoxicity and skin irritation tests of accredited certification institutions as the bee venom extract. The bee venom extract has excellent resistance to harmful substances and has effects of wrinkle care, skin soothing, and suppression of sebum production.

The plant placenta refers to a placenta extract extracted from a plant, and preferably refers to a phytoplacenta extract extracted from soybeans. The phytoplacenta extract can be extracted from germinated soybeans and is rich in amino acids and cell activators, so it is effective in promoting skin cell regeneration and supplying nutrients, so it can be used as a composition for improving skin wrinkles and preventing skin aging.

The sh-oligopeptide-1 is a fermented single-chain human recombinant peptide component derived from synthetic human epidermal growth factor (sh_EGF). The sh-oligopeptide-1 is effective in firmly filling and strengthening the skin barrier, being involved in providing elasticity to wrinkles caused by skin aging, and promoting the conversion to a new skin layer by promoting the circulation of the skin cycle.

The hyaluronic acid is a biosynthetic natural substance mainly present in the skin and has a moisturizing effect on the skin. The hyaluronic acid of the present invention may be an oligo-hyaluronic acid having a molecular weight (Mw) of less than 10000, and it is preferable to use one prepared for skin conditioning purposes.

The Oil in Water (O/W) type means an emulsion type formed through emulsification and has a structure in which oil is inside and water is outside. The Oil in Water (O/W) type is used for essence, lotion, and cream properties excluding skin, and has excellent application properties and compatibility.

The Oil in Water (O/W) type moisturizing nourishing cream of the present invention is characterized in that it is prepared by emulsifying the aqueous phase component and the oil phase component, and the first step of preparing the aqueous phase component by dissolving the active ingredient in a water-soluble solvent; A second step of preparing an oil component; A third step of mixing the aqueous phase component, oil phase component and emulsion stabilizer; And it can be prepared according to the fourth step of preparing an Oil in Water (O / W) type-moisturizing nutritious cream cosmetic composition by aging and emulsifying the mixed aqueous phase component, oil phase component and emulsion stabilizer.

The aqueous phase component is characterized in that it includes bee venom extract, vegetable placenta, sh-oligopeptide-1, hyaluronic acid, purified water, glycerin, and butylene glycol; The oily component is characterized in that it includes horse oil, emu oil, and lanolin, which are animal oils, and rexfil oil and MCT oil, which are vegetable oils; The emulsion stabilizer is characterized by including emulsifying wax, cetearyl alcohol, olive oil wax and ethylhexane. Additionally, as the animal oil, mink oil, squalane, egg yolk oil, or tortoise oil may be further used; Monta wax, beeswax, lecithin, or candelilla wax may be further used as the emulsion stabilizer.

The Oil in Water (O/W) type moisturizing nourishing cream of the present invention is characterized in that the aqueous phase component and the oil phase component are mixed in a weight ratio of 2.7 to 3.0: 1, and the emulsion stabilizer and oil phase component are 0.1 to 2: 1 (emulsion stabilizer: oil component) characterized in that it is included in a weight ratio.

When the water phase component and the oil phase component are mixed at a weight ratio of less than 2.7: 1 (aqueous component: oil component), water in oil (W/O) type emulsification, not oil in water (O/W) type emulsification, may occur at the same time. And there is a problem that more emulsion stabilizers should be used for emulsification. Even if the aqueous phase component and the oil phase component are mixed in a weight ratio of more than 3:1 (aqueous phase component:oil component), the degree of emulsification of the Oil in Water (O/W) type is not further improved, and the viscosity is increased due to the lack of oil phase component. It lowers the spreadability, and the permeability and skin moisturizing properties of the active ingredients decrease due to the decrease in the content of oily components similar to the fatty acid structure constituting the skin tissue.

The il in Water (O/W) type-moisturizing nutrient cream of the present invention contains the aqueous ingredients containing the bee venom extract, plant placenta, sh-oligopeptide-1 and hyaluronic acid in a ratio of 1:1:1:1 and the animal oil. and vegetable oils in a weight ratio of 1.8 to 2.2: 1. Since the animal oil has a structure very similar to fatty acids constituting skin tissue, it has an effect of improving the skin penetration of the bee venom extract, vegetable placenta, and sh-oligopeptide-1. However, the animal oil has a disadvantage in that it is difficult to store due to a severe change in viscosity according to temperature. In the present invention, to compensate for this, more stable vegetable oil is further included, and the optimal mixing ratio is characterized by including animal oil and vegetable oil in a weight ratio of 1.8 to 2.2: 1.

When the oil in water (O/W) type-moisturizing nutritious cream cosmetic composition of the present invention is emulsified according to the above manufacturing method, the active ingredients of the water phase are located inside the emulsion and the oily oil layer is surrounded outside the emulsion. At this time, the skin penetration ability and stability of the emulsion are determined according to the composition ratio of the active ingredient of the aqueous phase constituting the inside of the emulsion and the animal oil constituting the exterior of the emulsion. The Oil in Water (O/W) type-moisturizing and nutritious cream cosmetic composition of the present invention contains bee venom extract, vegetable placenta, sh-oligopeptide-1, and hyaluronic acid as water-phase components and animal oil as oil-phase components in a ratio of 0.6 to 1:1. It is characterized in that included in the weight ratio of. If the weight ratio is less than 0.6: 1, it may be difficult to form an Oil in Water (O / W) type emulsion, and even if the emulsion is formed, skin penetration may be reduced, and even if the weight ratio exceeds 1: 1, skin penetration is not further increased. don't

The Oil in Water (O/W) type moisturizing nutrient cream of the present invention has a viscosity of 21000 to 24000 dPa·S and a water content of 50 to 55% after 12 hours of application. If the viscosity is less than 21000 dPa·S, it is too thin and flows down, so repeated use may be limited, and the water content may be reduced to less than 50% after 12 hours of application. In addition, when the viscosity exceeds 24000 dPa·S, there is a problem in that the application property is deteriorated due to excessive stickiness or a strong crumbly feeling.

The present invention will be described in detail through examples below.

Example

Example: Moisturizing and nourishing cream

1. Materials

The cosmetic composition of the present invention is a moisturizing and nourishing cream cosmetic composition. In the present invention, bio placenta, bee venom peptide, nano oligopeptide and low molecular weight sodium hyaluronate were used as aqueous phase active ingredients. The bioplacenta is a soy phytoplacenta extract derived from soybeans, and raw materials prepared for skin and hair conditioning were used. For the bee venom peptide, a solution in which 0.1% (1000 ppm) of the bee venom peptide was dissolved in a solvent containing purified water, butylene glycol, and phenoxyethanol was used. The sh-oligopeptide-1 is synthetic human epidermal growth factor-1 (Synthetic Human Epidermal Growth Factor, sh-EGF) and is prepared in a solvent containing glycerin, 1,3-butylene glycol, and 1,2-hexanediol. A solution in which the sh-EGF was dissolved at 0.0001% was used. As the low molecular weight sodium hyaluronate (oligo-Sodium Hyaluronic acid), a solution having a molecular weight of 10 KDa or less and dissolved in a solvent containing purified water, butylene glycol, and 1,2-hexanediol at 1 wt% was used. The aqueous phase active ingredient was used after being dissolved in a solvent containing purified water, glycerin, and butylene glycol.

In the present invention, horse oil, emu oil, and lanolin, which are animal oils, were used as oily components, and vegetable oils, Rexpil Oil and MCT Oil, were used.

In the present invention, emulsifying wax, olive oil wax, cetearyl alcohol and ethylhexane were used as emulsion stabilizers for smooth emulsification of aqueous and oil components, and 1,2-hexanediol was used as a preservative.

2. Manufacturing method of moisturizing and nourishing cream

An aqueous mixed solution was prepared by mixing 30 g of purified water, 2 g of glycerin, and 3 g of butylene glycol. 1g of 1% sh-Oligopeptide-1 (1% OLIGO-HA (HD)), 1g of soybean phytoplacenta extract, 0.1% bee venom peptide (Bee Venom Extract) and 1% sodium hyaluronate (Sodium Hyaluronate) 1g was added and stirred at 100 rpm for 3 minutes to prepare a water phase active ingredient mixture.

Horse Oil 4g, Emu Oil 4g, Emulsifying Wax 3.5g. Cetearyl Alcohol, 3.8g, Olive Oil Wax 4g, Lanolin 2g, Lexfeel Oil (Heptyl Undecylenate) 2g, Medium Chain Triglycerides (MCT) Oil 3g, Ethylhexyl An oily mixed solution was prepared by mixing 0.2 g of glycerin (Ethylhexylglycerin) and 1.5 g of 1,2-hexanediol.

The aqueous phase active ingredient mixture and the oil phase mixture were heated to 70 ° C. and stirred at 100 rpm for 1 minute, so that the components of the aqueous phase active ingredient mixture and the oil phase mixture were completely dissolved and further mixed while maintaining the temperature at 65 ° C.

An emulsion was prepared by mixing the aqueous phase active ingredient mixture and the oil phase mixture solution maintained at 65° C., first stirring at 5000 rpm for 1 minute, and then secondarily stirring at 200 rpm for 2 minutes to emulsify.

The emulsion was rapidly cooled to 40° C. and then aged at 120 rpm for 30 minutes.

After cooling the emulsion aged at 40 ° C to 30 ° C, additional additives were added, and then mixed at 200 rpm for 1 minute to prepare a moisturizing and nourishing cream. The additives are yam root extract, aloe vera leaf extract, Portulaca extract, Houttuynia cordata extract, Sambaekcho extract, centella asiatica extract, lavender essential oil, strip root extract (mperata Cylindrica root extract), D-panthenol, and natural antifoaming agent (BST-AF) was used. After mixing the additives, when the cooling and mixing temperature is set to 30° C. or higher, the decomposition and decay of the extract may proceed rapidly.

The moisturizing and nutritious cream contains 1% sh-Oligopeptide-1 (1% OLIGO-HA (HD)), soybean-derived phytoplacenta extract, 0.1 It was prepared as follows by varying the amount of % Bee Venom Extract and 1% Sodium Hyakuronate.

Example 1 Example 2 Example 3 Example 4 note Purified water 30g 30g 30g 30g water component glycerin 2g 2g 2g 2g water component butylene glycol 3g 3g 3g 3g water component sh-Oligopeptide-1 1g 2g 3g 4g water active ingredient Phytoplacenta Extract 1g 2g 3g 4g water active ingredient bee venom peptide 1g 2g 3g 4g water active ingredient sodium hyraluronate 1g 2g 3g 4g water active ingredient Mayu 4g 4g 4g 4g animal oil emu oil 4g 4g 4g 4g animal oil Emulsifying Wax 3.5g 3.5g 3.5g 3.5g emulsion stabilizer Cetearyl Alcohol 3.8g 3.8g 3.8g 3.8g emulsion stabilizer olive oil wax 4g 4g 4g 4g emulsion stabilizer lanolin 2g 2g 2g 2g animal oil Rex Peel Oil 2g 2g 2g 2g vegetable oil MCT Oil 3g 3g 3g 3g vegetable oil ethylhexyl 0.2g 0.2g 0.2g 0.2g emulsion stabilizer 1,2 Hexanediol 1.5g 1.5g 1.5g 1.5g antiseptic total 67g 71g 75g 79g

Experimental Example 1: Infrared spectrum analysis

Infrared spectrum analysis (TENSOR27, Bruker) was performed on the moisturizing and nourishing cream of the present invention to confirm whether the active ingredient of the present invention was manufactured as an O/W type (Oil In Water). The infrared spectrum analysis was scanned up to 4500 nm. As a result, two peaks in the 1500 to 1800 nm region and peaks around 3000 nm and 3300 nm were confirmed, respectively, confirming that the moisturizing and nourishing cream containing the active ingredient was prepared in an O / W type (see FIG. 1).

Experimental Example 2: Evaluation of viscosity and moisture-moisturization

The viscosity of the moisturizing and nourishing creams of Examples 1, 2, 3, and 4 prepared above was measured using a VT-60 viscometer (25° C.). In addition, moisture and moisturizing tests were performed using a JASKEY skin oil and moisture meter.

The skin oil and moisture measurement was performed on 4 experienced test subjects (1 female in her 30s, 1 male in her 30s, 1 female in her 60s, and 1 female in her 40s). First, the test subjects washed their face with water before applying each product, and after 1 minute of washing, the oil and moisture content was measured. After that, the moisturizing and nourishing cream of the present invention was applied evenly, and the oil and moisture content was measured every 1 hour, 6 hours, and 12 hours, and the average value was calculated.

Viscosity
(VT-06) Moisture content (%) Before application right after application 1 hour after application 6 hours after application 12 hours after application Example 1 26000 dPa S 37.8 59.5 53.5 51.3 46.5 Example 2 22000 dPa S 34.0 60.3 58.0 56.3 52.5 Example 3 20100 dPa S 33.8 61 54.8 51.0 47.3 Example 4 14400 dPa S 35.7 60.0 54.3 53.0 46.3

As a result of the experiment, it was confirmed that the creams of Examples 2 and 3 had the best spreadability, and the viscosity was 2000 to 22000 dPa·S. The cream of Example 1 was confirmed to have a strong tendency to crumbly when applied, and the cream of Example 4 was confirmed to have a tendency to flow when applied due to its too watery properties.

As a result of evaluation of moisture retention, in Examples 1, 3, and 4, the moisture content, which increased due to the application of the cream, decreased by about 13% when 12 hours elapsed after application, whereas in Example 2, even after 12 hours after application, the moisture content A reduction of less than 10% was found. In addition, in the case of Examples 1, 3, and 4, when 1 hour elapsed after application, the moisture content rapidly decreased (reduction by 8% or more) and then gradually decreased with time, but in the case of Example 2, regardless of time It was confirmed that there was a gradual decrease in moisture.

The above results show that in Example 2 of the present invention, the proportions of oil phase components, aqueous phase components, and emulsion stabilizers are optimized, as well as the emulsification method, so that animal and vegetable oil components present in the cream and active ingredients in the water phase are very homogeneous. It is determined that it is the result of maintaining a constant rate of reduction of moisture because it is dispersed (see FIG. 2).

Experimental Example 3: Product Satisfaction Evaluation

Among the examples of the present invention, the evaluation of satisfaction with product performance was performed for Example 2, which had the best spreadability and moisture moisturizing effect. For this purpose, 8 male and female testers were selected. When the experimenters were classified according to age, there were 2 people in their 20s, 12 people in their 30s, 1 person in their 50s, and 1 person in their 60s. When classified according to skin characteristics, there were 5 dry skin types, 3 oily skin types, and combination skin types. It was a composition of 8 people.

Product performance evaluation was performed by subjectively evaluating moisture and moisturizing performance, skin stability performance, skin nutrition performance, absorption performance, texture performance and satisfaction items while the experimenter directly used it for a total of 4 weeks.

The moisture and moisture performance means that the moisture and moisture effect is excellent, so that the moisture of the skin is maintained for a long time, and when the experimenter is very satisfied with the performance according to subjective use while using it for 4 weeks, 5 points are satisfied. 4 points for good, 3 points for moderate, 2 points for poor, and 1 point for very poor.

The skin care performance means that skin troubles, including dermatitis, acne, purulent acne, and site-specific acne, due to the use of the cream do not occur or that the skin troubles are reduced, and the experimenter uses the cream for 4 weeks. Performance was rated 5 points for very satisfied, 4 points for satisfactory, 3 points for average, 2 points for poor performance, and 1 point for very poor performance.

Bee venom plant placenta, the main active ingredient of the nourishing cream of the present invention, has wrinkle improvement effect, external stimulation protection effect, soothing effect, skin elasticity maintenance effect, skin blood circulation promotion effect, skin waste removal effect, nutrient supply effect, and skin moisture There is a maintenance effect. Therefore, the skin nutrition performance was 5 points if the experimenter was very satisfied with the effect of the active ingredient while using it for 4 weeks, 4 points if satisfied, 3 points if normal, 2 points if insufficient, and very 1 point was given if it was insufficient.

The absorptivity performance means that the cream is well absorbed into the skin and has excellent spreadability when using the cream, and for the above performance, 5 points for very satisfied, 4 points for satisfactory, 3 points for average, A score of 2 was given for poor and 1 point for very poor.

The texture performance refers to the texture of the surface state such as fine irregularities when the cream is applied to the skin, and if the texture is excellent because it is well applied and absorbed into the skin, 5 points if the cream is very satisfied according to the subjective, Satisfied 4 points for good, 3 points for average, 2 points for poor, and 1 point for very poor

The satisfaction is about how satisfied you are when considering the moisture and moisturizing performance, skin stability performance, skin nutrition performance, absorption performance, and texture performance as a whole, 5 points for very satisfied, 4 points for satisfactory, and average. 3 points, 2 points for poor, and 1 point for very poor.

The moisture and moisturizing performance, skin stability performance, skin nutrition performance, absorption performance, texture performance, and satisfaction evaluation results for the nutritional cream of the present invention are shown in Table 3 below.

division Number of experimenters by satisfaction score satisfaction score 5 4 3 2 One total score Average Excellent Percentage ^* Moisture and moisturizing performance 8 people 6 people 2 people 0 people 0 people 70 points 4.4 points 87.5% skin stability performance 6 people 7 people 2 people 1 person 0 people 66 points 4.1 points 82.5% skin nutrition performance 6 people 7 people 3 people 0 people 0 people 67 points 4.2 points 83.8% absorbency performance 5 people 5 people 5 people 1 person 0 people 62 points 3.9 points 77.5% texture performance 9 people 4 people 3 people 0 people 0 people 70 points 4.4 points 87.5% overall satisfaction 5 people 10 people 1 person 0 people 0 people 68 points 4.3 points 85.0% - Excellent percentage ^* means the percentage of experimenters with a satisfaction score of 4 or higher.

As a result of the satisfaction evaluation, it was confirmed that the overall satisfaction was 4.3 points on average, showing excellent satisfaction beyond the excellent satisfaction standard of 4 points. Satisfaction with moisture and moisturizing performance and texture performance was the highest at 4.4 points, and the satisfaction score for absorption performance was the lowest at 3.9 points. was judged to be absent.

Specific examples described in this specification are meant to represent preferred embodiments or examples of the present invention, and the scope of the present invention is not limited thereby. It will be apparent to those skilled in the art that variations and other uses of the present invention do not depart from the scope of the invention described in the claims.

Claims (6)

Oil in Water (O/W) type containing Bee Venom Extract, Vegetable Placenta, sh-Oligopeptide-1 and Hyaluronic acid - moisturizing nutrition Cream cosmetic composition.
The oil in water (O/W) type of claim 1, wherein the oil-in-water (O/W) type-moisturizing nourishing cream is prepared by mixing water-phase components and oil-phase components in a weight ratio of 2.7 to 3.0: 1. Type - Moisturizing and nourishing cream cosmetic composition.
The oil in water (O/W) type moisturizing nutrient cream according to claim 2, wherein the water-phase component consisting of bee venom extract, vegetable placenta, sh-oligopeptide-1, hyaluronic acid, purified water, glycerin, and butylene glycol and ; An oily component composed of animal oils such as horse oil, emu oil, and lanolin, and vegetable oils such as Rexpil Oil and MCT Oil; An Oil in Water (O/W) type-moisturizing nutritious cream cosmetic composition, characterized in that it is prepared by mixing emulsifying wax, cetearyl alcohol, olive oil wax and an emulsion stabilizer composed of ethylhexane.
4. The method of claim 3, wherein the aqueous phase component includes bee venom extract, vegetable placenta, sh-oligopeptide-1, and hyaluronic acid in a ratio of 1:1:1:1, and the oil phase component contains animal oil and vegetable oil in a ratio of 1.8 to 2.2:1. Oil in Water (O / W) type - moisturizing nutritious cream cosmetic composition, characterized in that contained in a weight ratio of.
The oil in water according to claim 3, characterized in that the aqueous phase component of bee venom extract, vegetable placenta, sh-oligopeptide-1 and hyaluronic acid and the oil phase component of animal oil are included in a weight ratio of 0.6 to 1:1 ( O/W) type-moisturizing nourishing cream cosmetic composition.
The Oil in Water (O/W) type-moisturizing nourishing cream according to claim 1, wherein the viscosity is 21000 to 24000 dPa S and the moisture content is 50 to 55% after 12 hours of application. W) A type-moisturizing nourishing cream cosmetic composition.

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