KR20220165679A - System for intraperitoneal gas provision comprising twin-fluid nozzle - Google Patents

Abstract

A system for intraperitoneal gas provision according to the present invention includes a medicine and gas spraying device, and the medicine and gas spraying device includes: a medicine syringe supplying medicine; a medicine and gas injector receiving gas, receiving the medicine from the medicine syringe, and injecting the medicine and gas into the peritoneal cavity of an individual by being inserted into the peritoneal cavity; and a nozzle disposed at the end of the medicine and gas injector and spraying the medicine and gas together into the peritoneal cavity. The present invention is to provide a system including a medicine and gas spraying device capable of more effectively delivering medicine such as anticancer medicine into the peritoneal cavity.

Description

Intraperitoneal gas provision system including two-fluid nozzle {SYSTEM FOR INTRAPERITONEAL GAS PROVISION COMPRISING TWIN-FLUID NOZZLE}

The present invention relates to a system for providing intraperitoneal gas including a two-fluid nozzle, and more particularly, to providing intraperitoneal gas including a two-fluid nozzle for effectively injecting a drug such as an anticancer drug into the abdominal cavity in order to treat a patient's cancer. It relates to a system, particularly an intraperitoneal hot pressurized gas circulation system.

Recently, intraperitoneal chemotherapy (IPC) has been implemented as a method for solving the low efficiency of drugs administered orally or intravascularly to metastasized cancer cells in the peritoneal cavity.

In the case of pressurized intraperitoneal aerosol chemotherapy (PIPAC), the micronized drug is directly sprayed on cancer cells, allowing anticancer treatment with about 10% of the dose of anticancer drugs used in Hyperthermic Intraperitoneal Chemotherapy (HIPEC). Although the therapeutic effect can be seen, there is a problem in that it is difficult to maintain the intra-abdominal temperature at a temperature of about 42 ° C at which cancer cells die due to the body's temperature homeostasis (36 ° C).

In addition, in the case of HIPEC, it is possible to maintain a temperature of about 42 ° C., but there is a problem in that it is easy to cause side effects of chemotherapy due to a large amount of anticancer drugs and extensive surgery.

In addition, in the case of the existing method, there is a problem that it is difficult to evenly spray the anticancer drug in the abdominal cavity and it is difficult to control the spray direction.

Korean Patent No. 1866455

In order to solve the above problems, the present invention is to provide a system including a drug and a gas injection device capable of more effectively delivering drugs such as anticancer drugs to the lesion into the abdominal cavity. In addition, an object of the present invention is to provide a gas circulation system capable of circulating gas at a constant temperature and pressure in the abdominal cavity and a temperature control device to increase the therapeutic effect.

In order to achieve this object, a system for providing intraperitoneal gas according to an embodiment of the present invention includes a drug and gas injection device, wherein the drug and gas injection device includes: a drug syringe for supplying a drug; a medicament and gas dispenser for receiving gas, receiving medicaments from the medicament syringe, and administering the medicament and gas into the abdominal cavity of the subject by being crowned in the abdominal cavity; and a two-fluid nozzle disposed at an end of the drug and gas dispenser and injecting both the drug and the gas into the abdominal cavity.

In addition, the system may be a system for circulating hot pressurized gas in the abdominal cavity, particularly a system for intraperitoneal thermal chemotherapy.

Such a system includes a gas circulation device that circulates gas expelled from the abdominal cavity back to the abdominal cavity, including a gas hose connected to the abdominal cavity of the subject and a pump connected to the gas hose and circulating the gas; and a temperature control device for controlling the gas temperature of the gas circulation device so that the gas inside the abdominal cavity has a constant temperature. Here, the above-described drug and gas injection device is included as the intraperitoneal gas injection unit of the gas circulation device.

By the system of the present invention, a gas for expanding the abdominal cavity of a subject, for example, carbon dioxide, and an atomized drug, for example, an anticancer drug, are sprayed together by a two-fluid nozzle into the expanded abdominal cavity, thereby injecting an anticancer agent at a high pressure. can be atomized to a higher level to be evenly sprayed into the abdominal cavity, and it is very easy to control the direction of spraying. As such, the micronized anticancer agent can be evenly spread in the expanded abdominal cavity, so that it can effectively act on the peritoneum where cancer cells have metastasized, thereby maximizing the anticancer treatment effect. Furthermore, it is possible to maintain the temperature inside the abdominal cavity by heating the gas inside the abdominal cavity while circulating it with a circulation pump of the circulation unit.

1 is a schematic diagram showing a system device configuration according to a first embodiment of the present invention.
FIG. 2 is an enlarged partial cross-sectional view of part A in the system shown in FIG. 1 .
Figure 3 is a schematic diagram of the system arrangement shown in Figure 1 together with the medicament and gas flow.
4 is a schematic diagram showing a system device configuration according to a second embodiment of the present invention.
Figure 5 is a schematic diagram of the system arrangement shown in Figure 4 together with the medicament and gas flow.
6 is a schematic diagram showing a system device configuration according to a third embodiment of the present invention.
Figure 7 is a schematic diagram of the system arrangement shown in Figure 6 together with the medicament and gas flow.
8 is a schematic diagram showing a system device configuration according to a fourth embodiment of the present invention.
Figure 9 is a schematic diagram of the system arrangement shown in Figure 8 together with the medicament and gas flow.
10 is a schematic diagram showing the configuration of a system device according to a fifth embodiment of the present invention.
FIG. 11 is a schematic diagram illustrating the system arrangement shown in FIG. 10 with drug and gas flow.

Hereinafter, embodiments of the present invention will be described in detail.

A system (device) according to embodiments of the present invention is an intraperitoneal gas providing system including a drug and a gas injection device, particularly a system for circulating hot pressurized gas in the abdominal cavity, particularly a system for intraperitoneal thermal chemotherapy.

The system may include a gas circulation device including the drug and the gas injection device and a temperature control device. Each is described in detail below.

The gas circulation device includes a gas hose connected to the abdominal cavity of the subject and one or more pumps connected to the gas hose to circulate and pressurize gas, and circulate the gas discharged from the abdominal cavity back to the abdominal cavity.

In one embodiment, the gas circulation device, the intraperitoneal gas input unit into which pressurized gas is injected into the abdominal cavity, and the circulation unit for discharging gas from the abdominal cavity to the outside, circulating the gas from the outside of the abdominal cavity, and injecting it back into the abdominal cavity. can include

In one embodiment, the intraperitoneal gas injection unit may include one or more of the above-described drug and gas injection devices for injecting the gas together with the drug when the gas is injected into the abdominal cavity of the subject. In addition, one or more gas trocars (gas supply trocar) may be further included to supply gas separately from the drug and gas injection device.

In one embodiment, the medicament and gas injection device is connected to a medicament syringe for supplying medicament and a gas hose to receive pressurized gas, receives the medicament from the medicament injector, and is projected into the abdominal cavity to enter the abdominal cavity of the subject. It may include a medicine and gas dispenser for administering medicine and gas. At the distal end of the drug and gas dispenser, a two-fluid nozzle for injecting the drug and gas into the abdominal cavity may be disposed.

In one embodiment, the drug and gas dispenser may be configured to include, for example, a head, a body portion extending from the head, and an abdominal cavity tube below the body portion. A gas hose may be connected to at least one of the head and body to supply gas. In addition, as will be described later, a temperature sensor may be mounted on one side of the torso.

In one embodiment, the two-fluid nozzle has a structure in which the drug and the gas are administered together. For example, the two-fluid nozzle may include one or more drug lines through which drugs are supplied, one or more gas lines serving as gas supply passages, and optionally have one or more mixing chambers in which gases and drugs are mixed. In addition, the two-fluid nozzle may include one or more outlets that are fine holes located in front of the nozzle.

In one embodiment, the pressure upon injection from the two-fluid nozzle is such that the pressure is less than intra-abdominal pressure, such as 6-14 mmHg or 6-15 mmHg. The injection pressure can be adjusted through the size of each line, the size of the fine holes, and the presence or absence of a mixing chamber.

In this way, when the two-fluid nozzle is used, the high-pressure drug and the pressurized gas are injected into the abdominal cavity, and the degree of atomization is excellent. In addition, in the case of a hydraulic nozzle that provides only drugs, it is difficult to spray to a desired lesion in the abdominal cavity and it is difficult to control the spray direction. very suitable

In one embodiment, the gas circulation unit may include a circulation hose that is a gas hose of the circulation unit, and one or more circulation pumps connected to the circulation hose and increasing the pressure of the circulation gas.

The circulating gas of the gas circulation unit may be discharged from the gas discharge unit, circulate through the circulation unit by a pump, heat and/or pressurized through a temperature controller as will be described later, and then supplied back to the gas input unit into the abdominal cavity.

Here, the circulating gas of the gas circulation unit may be supplied to the drug and gas dispenser, to a gas inlet trocar tubed in the abdominal cavity, or to the drug and gas dispenser and the gas inlet trocar, respectively.

In one embodiment, the gas circulation device may further include a gas supply unit for supplying gas. The gas supply unit may be configured to be connected to one or more of the intraperitoneal gas input unit and the gas circulation unit of the gas circulation device.

For example, in one embodiment, the gas supply unit may be connected so that gas is supplied to the drug and the gas injection device of the intraperitoneal gas input unit. The gas supply unit may include a gas injector for generating gas and a gas hose (first hose) through which the gas flows from the gas injector and connected to the medicine and the gas injection device. In addition, the gas supply unit may further include a pump that increases the pressure of the gas flowing through the gas hose.

In one embodiment, the gas hose of the gas supply unit may further include one or more branched gas hoses (second hose). The branched hose may be connected to the circulation unit.

In addition, in one embodiment, a gas supply unit for supplying gas to the circulation unit may be directly connected. The gas supply unit may include a gas injector for generating gas and a gas hose (third hose) (not shown) through which gas flows from the gas injector and is connected to a circulation unit.

In one embodiment, the gas circulation unit may include one or more valves connecting two or more gas hoses.

For example, the circulation unit may include a valve (first valve) that connects a circulation hose and a hose (second hose) branched from the gas hose (first hose) of the above-described gas supply unit and discharges gas into the medicine and gas dispenser. can

In addition, the circulation unit may include a valve (second valve) connecting the third hose and the circulation hose and discharging gas to the circulation pump.

In addition, the circulation unit may further include a valve (third valve) through which gas flows from the circulation pump and supplies gas to the drug and gas dispenser. One or more gas hoses from the third valve may be connected to the medicine and gas dispenser. For example, two gas hoses from the third valve are connected to different positions of the medicine and gas dispenser, or one gas hose is connected to the medicine and gas dispenser from the third valve and the other gas hose is connected to different positions. It may be connected to the second trocar.

On the other hand, the temperature control device controls the gas temperature of the gas circulation device so that the gas inside the abdominal cavity has a constant temperature. To this end, the temperature control device may measure the gas temperature of one or more of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, and then control the gas temperature in the abdominal cavity based on this.

Specifically, in one embodiment, the temperature control device, one or more temperature sensors for measuring the gas temperature of one or more of the gas temperature of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, of the gas hose of the gas circulation device It may include a heating device that provides heat to at least a part, for example, a heating coil, and a temperature control unit (controller) connected to the heating device and a temperature sensor.

The temperature control unit (controller) may control the temperature of the heating device so that the gas temperature inside the abdominal cavity is maintained at a constant temperature, for example, 38°C to 42°C based on the measured value of the temperature sensor.

The temperature sensor may be provided in plurality. That is, the system of the present invention may include at least a first temperature sensor for measuring the temperature of the gas injected into the abdominal cavity, and may additionally include one or more sensors for measuring the temperature of the gas hose of the gas circulation device. For example, one or more of a second temperature sensor for measuring the temperature of the circulating hose gas of the circulation unit and a third temperature sensor for measuring the temperature of the gas supplied from the circulation unit to the medicine and gas dispenser may be further included.

In one embodiment, a gas supply amount from each gas hose may be adjusted based on a measured value of one or more of the second temperature sensor and the third temperature sensor. That is, since the temperature of the gas flowing through the gas hoses such as the mild hose, the first hose, and the second hose may be different, each temperature measurement value of one or more of the above-described second temperature and third temperature sensors is used. The temperature of the gas injected into the abdominal cavity can be adjusted by adjusting the gas flow rate of the gas hose.

In one embodiment, the system is specifically for intraperitoneal hyperthermia chemotherapy, the drug may be an anti-cancer drug, and the gas may be carbon dioxide.

In performing intraperitoneal thermal chemotherapy by using the above-described system, it is possible to effectively maintain the temperature and pressure of the gas inside the abdominal cavity and evenly spray the drug into the abdominal cavity, thereby maximizing the anticancer treatment effect.

Hereinafter, an embodiment of a system according to an embodiment of the present invention will be described in more detail with reference to the drawings. In the following, the present invention will be described with reference to the embodiments shown in the drawings, but this will be described as one embodiment, and accordingly, it will be understood that the technical spirit of the present invention and its core configuration and operation are not limited.

Descriptions of overlapping configurations and operations in each of the following embodiments will be omitted. For example, the nozzle of FIG. 2 may be commonly used in all embodiments.

Example 1

1 is a schematic diagram showing the configuration of a system 1 (hereinafter, referred to as 'system 1') including a gas circulation device and a temperature control device for maintaining intraperitoneal temperature according to an embodiment of the present invention.

FIG. 2 is an enlarged partial cross-sectional view of part A in the system shown in FIG. 1 .

Figure 3 is a schematic diagram of the system arrangement shown in Figure 1 together with the medicament and gas flow.

1 to 3, the system (1) (device) injects pressurized gas for expanding the space inside the abdominal cavity (2) of the subject into the abdominal cavity, discharges it to the outside of the abdominal cavity, heats and/or It includes a gas circulation device that pressurizes and puts the gas back into the abdominal cavity, and a temperature control device that controls the temperature of the gas circulation device. Accordingly, the expanded abdominal cavity inside (2) space to maintain a constant temperature and pressure.

The gas circulation device is an intraperitoneal gas injection unit for injecting pressurized gas into the abdominal cavity, and includes a drug and gas injection device 20 for micro-injecting gas and drugs into the abdominal cavity 2, and the drug and gas injection device It may include a gas supply unit 10 for supplying pressurized gas to (20). In addition, the gas circulation device may include a circulation unit 30 for circulating gas.

First, the gas supply unit 10 includes a gas injector 11 for generating gas for expanding the inside of the abdominal cavity 2 of the subject, a pump 12 for supplying the generated gas to the drug injector 20, and a gas injector. It is connected from (11) to the drug injector (20) and may include a first hose (13) for transporting gas.

The gas injector 11 supplies gas at a pressure of, for example, 12 to 14 bar, and the pump 12 supplies the gas to the drug and gas injection device 20 at a pressure of, for example, about 3 bar. In this case, the gas may be, for example, carbon dioxide.

The drug and gas injection device 20 is a device that atomizes the drug injected at high pressure together with the gas and evenly injects it into the abdominal cavity 2, a drug (eg, anticancer drug) syringe 21, a drug and gas dispenser connected thereto (22) and a nozzle (23) at the end of the medicament and gas dispenser.

The medicine injector 21 supplies the medicine to be administered into the abdominal cavity 2 onto the medicine and gas dispenser 22 at high pressure. At this time, the medicine on the medicine injector 21 may be supplied onto the medicine and gas dispenser 22 at a pressure of about 1500 kPa or less.

The drug and gas dispenser 22 receives the pressurized gas from the gas supply unit 10 and the drug from the drug injector 21 and discharges the gas and drug into the abdominal cavity 2 of the subject. At this time, a nozzle 23 is installed at the end of the drug and gas dispenser 22 to atomize and spray the drug.

Here, preferably, the nozzle 23 may be a two-fluid nozzle 23', as shown in FIG. 2 shows a cross-sectional view of the double-fluid nozzle 23', and gas and medicine are injected together through the double-fluid nozzle 23'. Specifically, the medicine supplied through the medicine line 231 and the gas supplied through the gas line 232 are mixed in the mixing chamber 233 and finely injected through the outlet 234 .

As described above, since the system 1 according to a preferred embodiment of the present invention atomizes the drug using the principle of a two-fluid nozzle, the degree of atomization is superior to that of the hydraulic nozzle used in the existing PIPAC, and the level of atomization is excellent. It is easy to adjust the spray direction. In the case of the micronized anticancer agent, it spreads evenly in the expanded abdominal cavity (2) and effectively acts on the peritoneum where cancer cells have metastasized.

In addition, a first temperature sensor 42 for measuring the temperature of the gas injected into the abdominal cavity 2 may be disposed at the nozzle end of the drug and gas injection device 20 . As will be described later, by measuring the temperature of the gas with the first temperature sensor 42, the temperature of the gas discharged into the abdominal cavity of the subject is set to 38 to 42 °C, preferably 41 to 42 °C, more preferably 42 °C. can be maintained Accordingly, the anticancer treatment effect can be maximized by increasing the penetration of the anticancer drug into the patient's peritoneal carcinomatosis.

On the other hand, the gas injected into the abdominal cavity 2 of the object presses the inner wall of the abdominal cavity of the object to expand the abdominal cavity, and discharges the gas to circulate.

To this end, the circulation unit 30 discharges gas from the abdominal cavity to the outside, recovers the gas in the system 1, circulates it outside the abdominal cavity, and introduces it into the abdominal cavity again.

Specifically, the circulation unit 30 includes a trocar (gas discharge trocar; hereinafter referred to as a first trocar) 31 that is tubed in the abdominal cavity to discharge gas, a circulation pump 32, a circulation hose 33, and a circulation valve ( 34) may be included. That is, the first trocar 31 is inserted into the abdominal cavity 2 as an intra-abdominal gas recovery device to recover gas in the abdominal cavity 2 . The recovered gas is supplied to the circulation valve 34 through the circulation hose 33. At this time, the circulation pump 32 pressurizes the gas so that the recovered gas can be circulated.

On the other hand, loss may occur in the process of recovering the gas circulated in the abdominal cavity (2) on the system (1). An amount of gas corresponding to the lost gas may be supplied to the circulation valve 34 through the second hose 35 branched between the gas injector 11 and the pump 12 .

The circulation valve 34 may re-supply or shut off the gas recovered from the inside of the abdominal cavity 2 and/or the gas supplied by the second hose 35 to the drug and gas dispenser 22 through opening and closing of the valve. there is.

The temperature control device controls the temperature sensor for measuring the temperature of the gas, the heating coil (heating device) for heating the gas hose, and the heating coil based on the measured value of the temperature sensor to control the temperature of the gas at a constant temperature. A temperature controller (controller) 40 may be included.

The temperature control device includes a heating coil 41 wound around the first hose 13, the second hose 35, and the circulation hose 33, the first temperature sensor 42, the second temperature sensor 43, and the first temperature sensor 42. 3 temperature sensors 44 may be included. For reference, for convenience, the heating coils 41 wound around the first hose 13, the second hose 35, and the circulation hose 33 may be referred to as a first heating coil, a second heating coil, and a third heating coil, respectively. can

The temperature controller (controller) 40 controls the voltage applied to the heating wire coil 41 and the degree of heat generation of the heating wire coil 41 based on the temperature measured by each of the temperature sensors 42, 43, and 44. By doing so, the gas temperature can be set to a constant temperature. Therefore, the temperature of the gas discharged into the abdominal cavity 2 of the subject can be maintained at a constant temperature.

Hereinafter, with reference to FIG. 3 , drug injection and intra-abdominal temperature maintenance will be described.

When the drug and gas are discharged into the abdominal cavity 2 of the subject, the circulation valve 34 may be closed. Accordingly, the gas supplied to the drug dispenser 22 is the gas supplied from the gas supply unit 10, and the gas supply through the circulation valve 34 connected to the circulation hose 33 and the second hose 35 is Closed. The temperature of the medicine and gas discharged into the abdominal cavity 2 of the subject is measured by the first temperature sensor 42, and the temperature controller 40 based on the measured value of the first temperature sensor 42, the abdominal cavity The heating device is controlled so that the temperature of the inside 2 is maintained at 38 to 42°C or preferably 41 to 42°C, more preferably 42°C as described above.

Specifically, the temperature controller 40 adjusts the temperature of the heating wire coil 41 wound around the first hose 13 between the gas supply unit 10 and the medicine dispenser 22, and supplies the gas through the gas supply unit 10. The temperature of the gas can be adjusted.

Next, after all the drugs on the drug injector 21 are administered to the inside of the subject's abdominal cavity 2, the gas in the abdominal cavity is circulated. At this time, the gas recovered on the circulation unit 30 is in a state in which the temperature is lowered by heat transfer in the abdominal cavity (2). Accordingly, the temperature of the recovered gas is raised by the heating wire coil 41 wound on the circulation hose 33. The temperature of the gas in the circulation hose 33 is measured by the second temperature sensor 43 and can be maintained at a predetermined set value.

Meanwhile, the gas lost in the abdominal cavity 2 of the subject may be replenished through the second hose 35, and the temperature of the gas in the second hose 35 may be lower than the temperature of the gas in the circulation hose 33. there is. Therefore, the temperature of the gas in the circulation hose 33 can be maintained at 42° C. or higher, and the set value of the temperature of the gas in the circulation hose 33 is adjusted according to the amount of gas supplied through the second hose 35. It can be.

The circulation valve 34 mixes the gas recovered from the inside of the abdominal cavity 2 and supplied by the circulation hose 33 and/or the gas supplied by the second hose 35. A third temperature sensor 44 is disposed between the circulation valve 34 and the medicine dispenser 22 . Accordingly, the third temperature sensor 44 measures the temperature when the gas supplied by the circulation hose 33 and/or the gas supplied by the second hose 35 are mixed. The temperature controller 40 may adjust the temperature of the coil wound around the circulation hose 33 and/or the coil wound around the second hose 35 based on the temperature of the gas measured by the third temperature sensor 44 .

In addition, the first temperature sensor 42 measures the temperature of the gas discharged into the abdominal cavity 2 of the subject. The temperature control unit 40 adjusts the temperature of the gas measured by the third temperature sensor 44 based on the measured value of the first temperature sensor 42 to adjust the temperature of the inside of the abdominal cavity 2 as described above. Similarly, it can be adjusted to maintain at 38 to 42 ° C or preferably 41 to 42 ° C, more preferably 42 ° C.

As such, the system 1 of the present invention includes a plurality of temperature sensors 42, 43, 44, a heating coil 41, and a temperature control unit 40 for controlling them, thereby controlling the temperature inside the abdominal cavity 2 in advance. It can be kept constant at a predetermined value set.

Second embodiment

4 is a schematic diagram showing a system device configuration according to a second embodiment of the present invention. Figure 5 is a schematic diagram of the system arrangement shown in Figure 4 together with the medicament and gas flow.

Referring to FIGS. 4 and 5 , the system 1 (device) of this embodiment is similar in configuration to that of the first embodiment, except that the gas supply unit is directly connected to the circulation unit.

That is, the circulation unit 30 further includes a gas supply unit 10 supplying gas to the circulation unit, wherein the gas supply unit has a gas injector 11 generating gas and the gas from the gas injector 11 It flows and includes a gas hose (third hose) connected to the circulation unit 30. The gas injector 11 may supply gas at a pressure of, for example, 12 to 14 bar, as in the first embodiment, and the gas pressure may be adjusted while passing through the circulation pump 32.

In addition, the circulation unit 30 may further include a three-way valve (second valve) 34 through which the gas of the third hose and the gas of the circulation hose are introduced and the gas is discharged to the circulation pump 32. . In addition, a three-way valve (third valve) 34 through which gas is introduced from the circulation pump 32 and gas is supplied to the drug and gas dispenser 22 may be further included.

From the third valve, one or more gas hoses, for example, two gas hoses may be connected to different locations of the medicine and gas dispenser 22, for example, a head part and a body part, respectively.

It is the same as in the case of the first embodiment that a temperature sensor (third temperature sensor) 44 for measuring the gas temperature of the gas hose connected to the dream port can be provided, and other configurations and operations of the first embodiment Same as

Third embodiment

6 is a schematic diagram showing a system device configuration according to a third embodiment of the present invention. Figure 7 is a schematic diagram of the system arrangement shown in Figure 6 together with the medicament and gas flow.

6 and 7, the system 1 (device) of this embodiment is similar in configuration to that of the second embodiment, but from the three-way valve (third valve) 34 of the circulation part 30. One gas hose is connected to the drug and gas dispenser 22, and the other gas hose is connected to the gas inlet trocar (hereinafter referred to as the second trocar) 37, which is a gas injector for injecting gas into the abdominal cavity. There is a difference being

Accordingly, the drug and gas may be injected into the abdominal cavity together in the drug and gas dispenser 22, and the gas may be injected into the abdominal cavity through a separate second trocar. Other configurations and operations are the same as those of the second embodiment.

4th embodiment

8 is a schematic diagram showing a system device configuration according to a fourth embodiment of the present invention. Figure 9 is a schematic diagram of the system arrangement shown in Figure 8 together with the medicament and gas flow.

8 and 9, the system 1 (device) of the present embodiment is similar in configuration to the first embodiment, except that the gas injector 11 of the gas supply unit is configured to supply drugs and drugs without a separate branch hose or pump. It is connected to the head of the gas dispenser 22.

In addition, in the circulation unit 30, the circulation hose 33 is connected to the body of the drug and gas dispenser 22, and a second temperature sensor is mounted thereto to measure the temperature. Other configurations and operations are the same as those of the first embodiment.

Example 5

10 is a schematic diagram showing a system device configuration according to a fifth embodiment of the present invention. FIG. 11 is a schematic diagram illustrating the system arrangement shown in FIG. 10 with drug and gas flows.

10 and 11, the system 1 (device) of this embodiment is similar in configuration to that of the fourth embodiment, except that in the circulation part 30, the circulation hose 33 is a medicine and gas dispenser ( 22), but connected to the second trocar 37, which is a separate gas injection chamber.

It is the same as the first embodiment that the gas hose of the circulation unit 30 is provided with the second temperature sensor 43 for measuring the gas temperature. Other configurations and operations are the same as those of the first embodiment.

Although the embodiments of the present invention have been described in more detail with reference to the accompanying drawings, the present invention is not necessarily limited to these embodiments, and may be variously modified and implemented without departing from the technical spirit of the present invention. there is. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention, but to explain, and the scope of the technical idea of the present invention is not limited by these embodiments. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The protection scope of the present invention should be construed according to the claims below, and all technical ideas within the equivalent range should be construed as being included in the scope of the present invention.

1: system 2: intraperitoneal cavity
10: gas supply unit 11: gas injector
12: pump 13: first hose
20: drug injector 21: drug syringe
22: drug dispenser 23 (23'): nozzle (two-fluid nozzle)
30: circulation unit 31: first trocar
32: circulation pump 33: circulation hose
34: circulation valve 35: second hose
37: second trocar 40: temperature controller
41: hot wire coil 42: first temperature sensor
43: second temperature sensor 44: third temperature sensor
231: drug line 232: gas line
233: mixing chamber 234: outlet

Claims (8)

A system for circulating hot pressurized gas in the abdominal cavity,
A gas circulation device comprising a gas hose connected to the abdominal cavity of the subject and a pump connected to the gas hose and circulating gas, and circulating the gas discharged from the abdominal cavity back to the abdominal cavity; and
A temperature control device for controlling the gas temperature of the gas circulation device so that the gas inside the abdominal cavity is at a constant temperature;
The gas circulation device includes: an intraperitoneal gas inlet unit through which gas is introduced into the abdominal cavity; and a circulation unit that discharges gas from the abdominal cavity to the outside, circulates the gas outside the abdominal cavity, and injects the gas back into the abdominal cavity,
The intraperitoneal gas injection unit includes a drug and gas injection device for injecting drugs and gas when gas is injected into the abdominal cavity of the subject,
The temperature control device includes a temperature sensor for measuring at least one gas temperature of a gas temperature inside the abdominal cavity and a gas temperature of a gas circulation device outside the abdominal cavity; a heating device providing heat to at least a portion of the gas hose of the gas circulation device; And a temperature controller connected to the heating device and the temperature sensor;
The system, characterized in that the temperature control unit controls the temperature of the heating device so that the temperature of the gas inside the abdominal cavity is a constant temperature based on the measured value of the temperature sensor.
A system for providing intraperitoneal gas, comprising:
The system includes a drug and gas injection device;
The drug and gas injection device includes a drug syringe for supplying the drug; And a drug and gas dispenser that receives gas, receives the drug from the drug syringe, and is tubed in the abdominal cavity to administer the drug and gas into the abdominal cavity of the subject,
The system includes a gas circulation device including a gas hose connected to the abdominal cavity and a pump connected to the gas hose and circulating the gas, and circulating the gas discharged from the abdominal cavity back to the abdominal cavity,
The gas circulation device includes the drug and the gas injection device,
The gas circulation device includes: an intraperitoneal gas inlet unit through which gas is introduced into the abdominal cavity; and a circulation unit that discharges gas from the abdominal cavity to the outside, circulates the gas outside the abdominal cavity, and injects the gas back into the abdominal cavity,
The circulation part includes a first trocar that is crowned in the abdominal cavity and discharges gas, a circulation hose that is a gas hose connected to the first trocar, and a circulation pump that is connected to the circulation hose and increases the pressure of the circulating gas,
The system, characterized in that the circulating gas of the circulation portion is provided to the drug and gas dispenser, to the second trocar tubed in the abdominal cavity, or to the drug and gas dispenser and the second trocar.
According to claim 2,
The intraperitoneal gas injection unit further includes a gas supply unit for supplying gas to the drug and the gas injection device,
The gas supply unit may include a gas injector generating gas; and
and a first hose through which the gas from the gas injector flows and is connected to a medicine and a gas injection device.
According to claim 3,
The gas supply unit, a pump for increasing the pressure of the gas flowing through the first hose; And a second hose branched from the first hose; further comprising,
The circulation unit further comprises a first valve through which the gas of the circulation hose and the second hose is introduced and the gas is discharged into the medicine and gas dispenser.
According to claim 2,
The circulation unit further includes a gas supply unit supplying gas to the circulation unit,
The gas supply unit may include a gas injector generating gas; and
A third hose through which the gas from the gas injector flows and is connected to the circulation unit;
The circulation unit includes a second valve through which the gas of the third hose and the gas of the circulation hose are introduced and the gas is discharged to the circulation pump; And a third valve through which gas is introduced from the circulation pump and provides gas to the medicine and gas dispenser; further comprising;
Two gas hoses from the third valve are connected to different locations of the medicament and gas dispensers, or
A system according to claim 1 , wherein one gas hose from the third valve is connected to the medicament and gas dispenser and the other gas hose is connected to the second trocar.
According to claim 1,
The heating device is a heating wire coil surrounding at least a portion of the gas hose,
The temperature control device includes a first temperature sensor for measuring the temperature of the gas injected into the abdominal cavity;
The system characterized in that for controlling the temperature of the heating coil so that the temperature of the gas inside the abdominal cavity is maintained at 38 ℃ to 42 ℃ based on the measured value of the first temperature sensor.
According to claim 1,
The temperature control device may include a second temperature sensor for measuring the temperature of the gas of the circulation unit; and a third temperature sensor for measuring the temperature of the gas supplied from the circulation unit to the medicine and gas dispenser. contains one or more of
and adjusting the amount of gas flow to the gas hose based on the measured values of at least one of the second temperature sensor and the third temperature sensor.
According to any one of claims 1 to 7,
The system is a system for intraperitoneal thermal anticancer chemotherapy, the drug is an anticancer drug, and the gas is carbon dioxide.

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