KR20220160423A - Coating composition for teeth - Google Patents

Abstract

The present invention provides a composition for coating teeth, in which two or more materials selected from the group consisting of polyvinyl acetate, rosin, and a methacrylic acid copolymer are included as a base material for tooth attachment. The composition of the present invention has excellent heat resistance and is advantageous in dispersing inorganic substances, and thus is advantageous to prepare a formulation suitable for users.

Description

Composition for coating teeth {Coating composition for teeth}

The present invention relates to a composition for coating teeth, and more particularly, to a composition for coating teeth capable of temporarily changing the color of teeth.

Since most people currently prefer white teeth, a number of studies/inventions have been conducted on permanent or continuous whitening treatment or management methods. However, a tooth coating product capable of exerting a temporary tooth whitening effect is being developed for consumers who have consumption or needs that want to make their teeth white, but cannot receive treatment due to tooth condition or time leeway.

Since a tooth coating product providing a temporary tooth whitening effect must be maintained without change in quality for a long time in an oral environment, the required quality is implemented using a water-insoluble resin. In particular, although shellac, which is applied in many products, is used as the water-insoluble resin, it is not possible to maintain the coating state when exposed to moisture for a long time, and the initial state of the coating is not maintained and the problem of turning white occurs. I found out.

In addition, it was confirmed that the water resistance of the coating composition is poor due to the dispersant, emulsifier, etc. used for dispersing the inorganic material used to impart a temporary whitening effect.

The inventors of the present invention have completed the present invention in order to solve the above problems with the tooth coating composition applied to the tooth surface.

Therefore, the problem to be solved by the present invention is to provide a composition for coating teeth with improved durability.

In addition, the present invention is to provide a novel tooth coating composition, more preferably a combination of tooth whitening agents, with improved durability and stability while uniformly dispersing inorganic particles included to impart a tooth whitening effect.

In order to solve the above problems, the present invention provides a composition for coating the tooth surface. The inventors of the present invention completed the present invention by confirming that a composition obtained by including at least two selected from the group consisting of polyvinyl acetate, rosin, and methacrylic acid copolymer as a base material for tooth attachment is preferable for the purpose of the present invention I came to do it. A tooth coating composition according to an embodiment of the present invention is a tooth coating composition comprising at least one inorganic particle dispersed in a tooth attachment base, wherein the tooth attachment base is polyvinyl acetate, rosin, and a methacrylic acid copolymer It may include two or more selected from the group consisting of.

The tooth coating composition can be used for various purposes capable of forming a film on the tooth surface, for example, for re-strengthening teeth, for forming an anti-calculus film, for forming an antibacterial film on teeth, for tooth whitening, Preferably, it can be used as a composition for tooth whitening that can make the tooth surface look white.

In one embodiment, the tooth coating composition may include one or more inorganic particles, and preferably, the inorganic particles may be provided while being dispersed in a tooth attachment base.

As used herein, "a base for tooth attachment" may be used to refer to a component capable of providing adhesion to a tooth surface. "Inorganic particle" is widely known in the industry as a pigment-grade inorganic powder having a size of micrometers and usually having light scattering properties. The size of the inorganic particles is not particularly limited, and the size of the inorganic particles is not particularly limited as long as the inorganic particles are included in the present composition and have a size sufficient to reflect light or emit color themselves. The inorganic particles may be replaced with terms such as inorganic material and inorganic powder. The inorganic particles may include inorganic pigments. The inorganic particles are, for example, titanium oxide, titanate mica, pearl, mica titanium (mica), hydroxyapatite, silica, bentonite, zeolite, calcium carbonate, dicalcium phosphate, calcium pyrophosphate, and alumina oxide. It may include one or more selected from the group consisting of, and may preferably include titanium oxide and / or pearl. When the inorganic particles are or contain titanium oxide and/or pearl, dispersion in the base material for tooth attachment may be excellent, and the whitening effect may be excellent.

The inorganic particles may be included in an amount of 0.1 to 20% by weight, preferably 1 to 10% by weight, more preferably 3 to 8% by weight, based on the total weight of the composition. While the inorganic particles are stably dispersed in the above content range, the tooth whitening effect may be remarkable, or it is preferable in terms of usability.

It was confirmed that the composition of the present invention can provide a tooth coating composition having excellent physical properties while stably dispersing inorganic particles without using a generally used dispersant or emulsifier when the tooth attachment base is used. . In particular, it was confirmed that the water resistance and heat resistance properties of the composition can be rapidly deteriorated when a dispersant is used. In one embodiment, the composition of the present invention may be substantially free of a dispersant. The dispersant that is not substantially included may include a dispersant generally used when mixing with a polymer in the industry, for example, SLS (sodium lauryl sulfate), SPAN 80, Poloxamer 407, cocamidopropyl betaine (Cocamidopropyl betaine (CAPB)) and the like may be included. The meaning of substantially not containing means that it contains 0.05% by weight or less based on the total weight of the composition, preferably 0.01% by weight or less, and more preferably means that it does not contain at all.

A tooth attachment base according to an embodiment of the present invention will be described in detail.

The tooth attachment base may include two selected from the group consisting of polyvinyl acetate, rosin, and methacrylic acid copolymer.

The polyvinyl acetate (or polyvinyl acetate, PVAc) is a thermoplastic resin made by polymerizing vinyl acetate monomers. The composition of the present invention has, for example, a weight average molecular weight (Mw, g/mol) of 15,000 to 100,000 Phosphorus polyvinyl acetate may be included.

The rosin may include gum rosin, which is a resin obtained by removing terrapin oil by distilling raw rosin collected from pine tree trunks, and the type of rosin is not particularly limited.

The (meth)acrylic copolymer may include EVONIK's Eudragit ^® . Although Eudragit is a trade name, it is already commonly understood and recognized in the industry, and is commonly used in the industry to the extent that it is mentioned as an enteric base in the list of pharmaceutical additives of the Korea Food and Drug Administration. The Eudragit can be used as a tooth coating agent in RL, RS, and E grades, but may include RL grade, which is advantageous for dispersing inorganic particles. Eudragit RL grade is a copolymer of polyethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate, and polyethyl acrylate, methyl methacrylate, and trimethylammonioethyl methacrylate, respectively, in a composition of 1:2:0.2. The trade names are RL 100, RL PO, RL 30D, and RL 12.5, which are divided into product types (ex. solution, granule, powder). In the present invention, RL 100 (granule type) can be used, and the Eudragit RL 100 has an ionic moiety in the polymer structure, so it behaves in the form of a dispersant and can advantageously act on the dispersibility of inorganic substances such as titanium oxide.

One embodiment of the present invention may provide a preferred mixing ratio of the attachment base included in the composition.

The tooth coating composition may include (a) rosin, polyvinyl acetate or a mixture thereof and (b) a methacrylate copolymer as a base for tooth attachment. The composition comprises a weight ratio of 10:0 to 5:5 as a mixing ratio of (a) and (b), preferably 9:1 to 5:5, more preferably 8:2 to 6:4, most preferably may include a weight ratio of 7.5 to 5.5: 2.5 to 3.5.

When the base material for tooth attachment is included in the mixing ratio, water resistance or heat resistance of the tooth coating composition may be excellent. When the tooth coating composition includes a mixture of rosin and polyvinyl acetate, the mixing ratio of the rosin and polyvinyl acetate is 1:9 to 9:1 in weight ratio, preferably 2:8 to 7:3, more More preferably, it may be included in a weight ratio of 3:7 to 6:4, most preferably 4.5 to 5.5:4.5 to 5.5. In the above range, the heat resistance (sustainability at high temperature) was excellent, the degree of uniform application (applicability) and the degree of rapid hardening (quick drying) were excellent, and the dyeing phenomenon could be reduced.

The term 'water resistance' means that when the coating composition is applied to the tooth surface to form a film on the surface, and then the composition or tooth whitening agent of the present invention absorbs moisture in the oral environment, the color does not change to white, and the tooth surface It can be understood as meaning including maintaining the shape without peeling off. The term 'heat resistance' can be understood as including the property that the coating composition is applied to the surface of a tooth to form a film on the surface and then, when treated at a temperature of 50° C. or higher, the coating composition does not melt and lasts. have. The 'dispersibility' may be understood as a meaning including a characteristic that inorganic particles are evenly mixed. The 'staining phenomenon' may be understood to mean a phenomenon in which the composition of the present invention is colored.

In one embodiment of the present invention, the coating composition may not include shellac as a base material for tooth attachment. A tooth coating composition that does not contain the shellac as a base material for tooth attachment has a significantly reduced degree of whitening of the coating composition by moisture, and thus may be highly preferred in terms of aesthetics. In addition, a composition not containing shellac may not be easily peeled off from the tooth surface even when exposed to moisture for a long time and may have excellent shape retention.

One embodiment of the present invention provides an instant tooth whitening agent or composition for instant tooth whitening. The instant tooth whitening agent may be provided by dispersing one or more inorganic particles for tooth whitening in a mixture in which two or more tooth attachment bases selected from the group consisting of polyvinyl acetate, rosin, and (meth)acrylate copolymer are mixed. .

As used herein, “instant” may be understood to make an object appear white or bright instantly, temporarily, or temporarily. The instant tooth whitening agent can be distinguished from the action of removing or removing stains on the tooth surface by treatment with hydrogen peroxide, etc., and the instant tooth whitening agent means to temporarily make teeth look white by covering stains on teeth.

The instant tooth whitening agent may include all components included in the tooth coating composition mentioned in this specification. For example, all descriptions of the tooth attachment base included in the tooth coating composition may be applied to the instant tooth whitening agent.

The instant tooth whitening agent is from the group consisting of titanium oxide, titanate mica, pearl, mica titanium (mica), hydroxyapatite, silica, bentonite, zeolite, calcium carbonate, dicalcium phosphate, calcium pyrophosphate, and alumina oxide At least one selected inorganic particle for tooth whitening may be included, and preferably when titanium oxide and/or titanated mica are included, it has good compatibility with the adhesive base material of the present invention and excellent dispersion stability, resulting in tooth whitening. The effect can be particularly good.

In one embodiment of the present invention, the instant tooth whitening agent may not contain shellac.

The instant tooth whitening agent attached to the tooth surface to make the tooth surface look white may include components used in the tooth whitening agent without limitation within a range that does not impair the object of the present invention. The tooth whitening agent may be prepared in any form such as gel, paste, liquid, solid, semi-solid, etc. The tooth whitening agent may be provided in the form of dental nail polish, dental varnish, dental crayons, lipstick, and the like.

The solvent included in the tooth coating composition according to the present invention may include a volatile solvent. When the solvent is volatilized after the tooth coating composition is applied to the teeth, a water-resistant film may be formed on the teeth. The volatile solvent generally used in the industry for mixing polymers may be used without limitation, and may preferably include a lower alcohol having 4 or less carbon atoms, and more preferably ethanol. In one embodiment, the content of the volatile solvent in the composition may be appropriately adjusted to control the volatilization rate. For example, the composition according to the present invention may include 50% by weight or more, preferably 60% by weight or more, more preferably 70% by weight or more, and 90% by weight or less, preferably volatile solvent, based on the total weight of the composition. Preferably it may contain 85% by weight or less, and even more preferably 80% by weight or less.

One embodiment of the present invention is an instant product in which one or more inorganic particles for tooth whitening are dispersed in a mixture in which two or more tooth attachment bases selected from the group consisting of polyvinyl acetate, rosin, and (meth)acrylate copolymer are mixed. Provided is an instant tooth whitening kit including a tooth whitening agent and instructions for using the instant tooth whitening agent. The instructions for use may include information on how to apply the tooth whitening agent, how much to use, and how often to use the whitening agent. The tooth whitening agent may be applied before bedtime, but is not limited thereto and may be used during the day. In addition, due to the excellent water resistance or heat resistance of the present invention, it can be applied before meals and used during meals. The tooth whitening agent may be applied to about 4 to 12 teeth when applied once. The tooth whitening agent may be applied in a thickness of 1 to 20 micrometers (㎛), and the average application amount per unit area (1 cm ² ) is 0.001 g to 1 g, preferably 0.003 to 0.5 g, and more preferably 0.005 g ( 5 mg) to 0.2 g (200 mg).

It can be used several times a day and repeatedly whenever necessary. The kit may further include a tool for applying the instant tooth whitening agent to the tooth surface, if necessary. For example, it may include an applicator such as a sponge, brush, or tip. The tooth whitening agent may be prepared in a gel or liquid form and applied with a brush. In another example, a tooth whitening agent may be stored in a tube and discharged to the outside through an end of the tube to be applied to the tooth surface.

One embodiment of the present invention provides a temporary tooth whitening method. One embodiment of the present invention is an instant product in which one or more inorganic particles for tooth whitening are dispersed in a mixture in which two or more tooth attachment bases selected from the group consisting of polyvinyl acetate, rosin, and (meth)acrylate copolymer are mixed. It may include applying a tooth whitening agent to the tooth surface. The temporary tooth whitening method may further include drying after applying the instant tooth whitening agent.

The tooth coating composition of the present invention exhibits water resistance even during long-term exposure and can solve the problem of staining by coffee or juice. In addition, since the film is not affected by hot or cold water, the durability of the film is excellent. An embodiment of the present invention is advantageous in dispersing inorganic substances such as titanium oxide and can appropriately control the viscosity, so that a formulation suitable for the user can be prepared.

The following drawings attached to this specification illustrate preferred embodiments of the present invention, and serve to further understand the technical idea of the present invention together with the contents of the above-described invention, so the present invention is limited to those described in the drawings. It should not be construed as limiting.
1 is a photograph showing the state change of the composition for coating according to the composition of the present invention. This is the result observed after drying for about 1 minute after application.
Fig. 2 shows the dispersion results of titanium oxide depending on the components of the base for adhesion used.

Hereinafter, examples and the like will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention can be modified in many different forms, and the scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

<Example 1. Confirmation of physical properties according to the type and formulation of tooth attachment base>

1. Preparation of coating composition

Compositions for tooth surface coating having compositions of TC-1 to TC-6 were prepared. The composition was added in a weight ratio and prepared to be filled with ethanol to 100. Each value is expressed in % by weight.

2. Application method

The coating composition was applied to the artificial tooth specimen by the following method, and the following physical properties were confirmed.

A matte black tile (2.5cm x 2.5cm) made of porcelain was used as a substrate, and as a treatment method before sample treatment, it was washed with distilled water more than once and dried at 50℃ / 1hr or more. After subdividing more than 3g of the composition for coating the tooth surface in a 5mL nail polish bottle, it was applied to the tile using a brush pen. It was applied to a thickness of about 10 μm in one direction so as not to clump during application, and then dried at a temperature of 22 to 25 ° C and a humidity of 45 to 50% for 1 minute. By checking the tile weight before application and the change in tile weight after application, a sample coated with 0.5±0.1g of the composition for coating the tooth surface was selected and used for the following evaluation.

3. Check physical properties

A composition for tooth surface coating having the composition shown in Table 1 below was prepared and water resistance, heat resistance, dyeability, etc. of the composition were evaluated.

(1) Check water resistance

After drying the tooth whitening agent for 1 minute, it was soaked in distilled water at 37° C. for 12 hours, and then the change in the tooth whitening agent was confirmed.

(2) Check dyeability

After soaking in 37 ℃ coffee for 30 minutes, the color change of the tooth whitening agent was observed. The color change was confirmed through a color difference meter, and the change in the initial color and the color after treatment was confirmed. The ΔE is a general measurement value used to observe a change in brightness of a tooth, and is a change value representing the degree of change by integrating changes in the results of L*, a*, and b*.

(3) Check heat resistance

After soaking in 50 ℃ distilled water for 10 minutes, the change was confirmed.

At the bottom of Table 1 below, the results of confirming water resistance, dyeability, and heat resistance for each sample are described, and the confirmation results are shown in FIG.

composition/sample TC-1 TC-2 TC-3 TC-4 TC-5 TC-6 shellac 10 rosin 15 10 12.5 Eudragit RL100 25 12.5 12.5 5 ethyl cellulose 12.5 Poly(vinyl acetate) 12.5 10 12.5 Inorganic particles (titanium oxide) 2.5 2.5 2.5 2.5 2.5 2.5 ethanol 72.5 72.5 72.5 72.5 72.5 72.5 result content - Turns white by moisture
- Less staining - No change due to moisture
- Occurrence of dyeing phenomenon (ΔE = 25.2)
- Easy to disperse/re-disperse inorganic matter
- No abnormality of persistence at room temperature/oral environment (37℃) temperature of water
- Hot water over 50℃
recorded in - No change due to moisture
- Less staining
- Easy to disperse/re-disperse inorganic matter
- Brittle and fall off in dry environment - No change due to moisture
- Less staining
- Easy to disperse/re-disperse inorganic matter
- No abnormality of persistence at room temperature/oral environment (37℃) temperature of water - No change due to moisture
- Less staining
- Easy to disperse/re-disperse inorganic matter
- No abnormality of persistence at room temperature/oral environment (37℃) temperature of water
- The film is maintained even at high temperature (100 degrees) - No change due to moisture
- No staining phenomenon (ΔE = 5.4)
- No abnormality of persistence at room temperature/oral environment (37℃) temperature of water
- Even at high temperature (100℃)
Encapsulated

As can be seen in Table 1 and FIG. 1, in the case of TC-4 to 6, it was possible to provide excellent tooth surface coating compositions that met all measurement criteria.

<Example 2. Confirmation of dispersibility according to the type and formulation of tooth attachment base>

The degree of dispersion of titanium oxide was confirmed with the composition shown in Table 2 below. After sufficiently stirring for 1 minute or more using a voltax mixer, the degree of precipitation of titanium oxide was confirmed after 30 minutes. The result is shown in a photograph in FIG. 2 . Table 2 below shows the inorganic dispersion results according to each composition.

*Excellent: In the above test method, when checking the degree of precipitation after 30 minutes, the titanium oxide that has settled is not visible.

*Normal: Titanium oxide is partially precipitated after 30 min in the above test method,

*Bad: Titanium oxide is all settled after 30 min in the above test method (all precipitated)

Image in Figure 2 A B C A+B A+C B+C A+B+C polymer Eudragit RL100 rosin polyvinyl acetate (PVAc) Eudragit RL100
+
polyvinyl acetate Eudragit RL100
+
rosin polyvinyl acetate
+
rosin Eudragit RL100
+
polyvinyl acetate
+
rosin composition ratio eudragit RL100 25% titanium oxide 2.5%
Ethanol 72.5% 25% rosin
Titanium oxide 2.5%
Ethanol 72.5% 25% PVAc
Titanium oxide 2.5%
Ethanol 72.5% Eudragit RL100
7.5%
PVAc 17.5%
Titanium oxide 2.5%
Ethanol 72.5% Eudragit RL100
7.5%
rosin 17.5%
Titanium oxide 2.5%
Ethanol 72.5% 12.5% PVAc
rosin 12.5
Titanium oxide 2.5%
Ethanol 72.5% Eudragit RL100
7.5%
PVAc 8.5%
rosin 8.5%
Titanium oxide 2.5%
Ethanol 72.5% Inorganic Dispersion Results (O: Excellent / △: Normal / X: Poor) - O X △ O O △ O

As can be seen from Table 2 above, dispersibility can be improved when Eudragit is included.

<Example 3. Confirmation of the effect according to the mixing ratio of the tooth attachment base>

In order to confirm that a composition made by mixing two or more kinds of vinyl acetate resin (A), rosin (B), and (meth)acrylic copolymer (c) may have different water resistance, dyeability, and heat resistance depending on the mixing ratio, the following Additional experiments were conducted with the same composition as A description of the results is shown at the bottom of Table 3.

R3P7 has a rosin:polyvinyl acetate weight ratio of 3:7, R5P5 has a rosin:polyvinyl acetate weight ratio of 5:5, and R3.5P3.5A3 has a rosin:polyginyl acetate:Eudragit RL100 weight ratio of 3.5. :3.5:3.

composition ratio R10 P10 R3P7 R5P5 R3.5
P3.5
A3 rosin 25 7.5 12.5 8.75 polyvinyl acetate 25 17.5 12.5 8.75 Eudragit RL100 ¹ 7.5 mineral 2.5 2.5 2.5 2.5 2.5 ethanol 72.5 72.5 72.5 72.5 72.5 water resistance X O O O O Dyeing X X O O O heat resistance X X O O O

1: acrylates copolymer

- When evaluating water resistance, O: lasts for a long time without changing color, △: the film partially falls off or the color changes, X: the film is not maintained

- When evaluating dyeability, O: There is no change in color to the naked eye, △: A little color change is seen, X: The color is completely changed

- When evaluating heat resistance, O: The film is maintained, △: The film partially falls off, X: The film is not maintained

As can be seen in Table 3, when two or more types of vinyl acetate resin (A), rosin (B), and (meth)acrylic copolymer (c) were included, heat resistance or dyeability was superior to that when only one type was included. .

Claims (10)

A tooth coating composition comprising at least one inorganic particle dispersed in a base material for tooth attachment,
The base for the tooth attachment comprising at least two selected from the group consisting of polyvinyl acetate, rosin, and methacrylic acid copolymer, tooth coating composition. The method of claim 1, wherein the inorganic particles are titanium oxide, titanate mica, pearl, mica titanium (mica), hydroxyapatite, silica, bentonite, zeolite, calcium carbonate, dicalcium phosphate, calcium pyrophosphate, and Characterized in that at least one selected from the group consisting of alumina oxide, tooth coating composition. According to claim 1, wherein the inorganic particles are tooth coating composition containing 0.1 to 20% by weight relative to the total weight of the composition. The composition for coating teeth according to claim 1, wherein the composition is substantially free of a dispersant. According to claim 1, wherein the methacrylic acid copolymer is polyethyl acrylate methyl methacrylate trimethylammonioethyl methacrylate chloride copolymer for tooth coating composition comprising. According to claim 1, wherein the tooth coating composition is a base material for tooth attachment
(a) rosin, polyvinyl acetate or a mixture thereof; and
(b) a composition for coating teeth comprising a methacrylate copolymer. According to claim 6, wherein the composition (a) and (b) of the mixing ratio of 10: 0 to 5: tooth coating composition characterized in that having a weight ratio of 5. According to claim 1, The tooth coating composition comprising a mixture of rosin and polyvinyl acetate, tooth coating composition. According to claim 8, wherein the mixing ratio of the rosin and polyvinyl acetate is 2: 8 to 7: tooth coating composition characterized in that having a weight ratio of 3. An instant tooth whitening agent comprising the tooth coating composition according to any one of claims 1 to 9.

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