KR20220157392A - 알파-2-아드레날린성 수용체 효능제의 약제학적 조성물 및 시력 개선을 위한 이의 용도 - Google Patents

알파-2-아드레날린성 수용체 효능제의 약제학적 조성물 및 시력 개선을 위한 이의 용도 Download PDF

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KR20220157392A
KR20220157392A KR1020227032439A KR20227032439A KR20220157392A KR 20220157392 A KR20220157392 A KR 20220157392A KR 1020227032439 A KR1020227032439 A KR 1020227032439A KR 20227032439 A KR20227032439 A KR 20227032439A KR 20220157392 A KR20220157392 A KR 20220157392A
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South Korea
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pharmaceutical composition
improvement
subject
reduction
amount
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English (en)
Korean (ko)
Inventor
리차드 그레이엄
케 우
마수드 파히드
모하메드 디바스
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알러간, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020227032439A 2020-02-20 2021-02-19 알파-2-아드레날린성 수용체 효능제의 약제학적 조성물 및 시력 개선을 위한 이의 용도 Withdrawn KR20220157392A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062979214P 2020-02-20 2020-02-20
US62/979,214 2020-02-20
PCT/US2021/018906 WO2021168349A1 (en) 2020-02-20 2021-02-19 Pharmaceutical compositions of alpha-2-adrenergic receptor agonists and their use for improving vision

Publications (1)

Publication Number Publication Date
KR20220157392A true KR20220157392A (ko) 2022-11-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227032439A Withdrawn KR20220157392A (ko) 2020-02-20 2021-02-19 알파-2-아드레날린성 수용체 효능제의 약제학적 조성물 및 시력 개선을 위한 이의 용도

Country Status (12)

Country Link
US (2) US20210260041A1 (enExample)
EP (1) EP4106728A1 (enExample)
JP (1) JP2023514732A (enExample)
KR (1) KR20220157392A (enExample)
CN (1) CN115443125A (enExample)
AU (1) AU2021224232A1 (enExample)
BR (1) BR112022016730A2 (enExample)
CA (1) CA3168767A1 (enExample)
IL (1) IL295782A (enExample)
MX (1) MX2022010317A (enExample)
TW (1) TW202139998A (enExample)
WO (1) WO2021168349A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022182740A1 (en) 2021-02-24 2022-09-01 Ocular Therapeutix, Inc. Intracanalicular depot inserter device

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
KR102337046B1 (ko) 2010-01-22 2021-12-08 알러간, 인코포레이티드 전방내 서방성 치료제 이식물
WO2014159576A1 (en) * 2013-03-14 2014-10-02 Allergan, Inc. Alpha-2 adrenergic agonist for treating intraocular pressure and ocular diseases through intravitreal and intracameral routes
ES2751681T3 (es) 2013-03-15 2020-04-01 Allergan Inc Implante intraocular que contiene prostamida
EP2978406A1 (en) 2013-03-27 2016-02-03 Forsight Vision5, Inc. Bimatoprost ocular silicone inserts and methods of use thereof
WO2014165308A2 (en) 2013-04-01 2014-10-09 Allergan, Inc. Microsphere drug delivery system for sustained intraocular release
EP3283004A4 (en) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
EP3840750A1 (en) * 2018-08-21 2021-06-30 Allergan, Inc. The use of alpha-2-adrenergic receptor agonists for improving vision

Also Published As

Publication number Publication date
AU2021224232A1 (en) 2022-10-13
JP2023514732A (ja) 2023-04-07
CA3168767A1 (en) 2021-08-26
TW202139998A (zh) 2021-11-01
US20210260041A1 (en) 2021-08-26
BR112022016730A2 (pt) 2022-11-08
EP4106728A1 (en) 2022-12-28
WO2021168349A1 (en) 2021-08-26
US20240335425A1 (en) 2024-10-10
MX2022010317A (es) 2023-01-24
CN115443125A (zh) 2022-12-06
IL295782A (en) 2022-10-01

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