KR20220146979A - A method of producing a pill to improve the effect on rhinitis ring and the pill poduced by using the same as - Google Patents

Abstract

The present invention relates to a method for preparing a pill having efficacy of improving a pill for rhinitis and a pill prepared thereby, wherein swelling and partial texture of glutinous rice flour used as a binder can be improved. The method for preparing a pill having efficacy of improving a pill for rhinitis according to the present invention comprises the steps of: preparing herbal medicines including washed willow bark, horse beans, Chinese bellflower roots, Magnoliae flos, Adenophorae Radix, and mint; grinding the herbal medicines including the willow bark, horse beans, Chinese bellflower roots, Magnoliae flos, Adenophorae Radix, and mint with a grinder; agitating the ground herbal medicine powder with an agitator to prepare a mixture of herbal medicines; putting glutinous rice flour and a decoction of juice or a stem of a sponge prepared at a predetermined weight ratio into a heating container to heat and ferment the mixture to prepare a fermented glutinous rice glue binder; mixing the mixture of the herbal medicines and the fermented glutinous rice glue at a predetermined ratio to prepare a dough; making pills from the dough of the herbal medicines in a predetermined size by using a pill maker; and using a mold to mold the dough of the herbal medicines into a shape of a pill by using a mold.

Description

A method for producing a pill effective in improving rhinitis ring and a pill prepared thereby {A method of producing a pill to improve the effect on rhinitis ring and the pill poduced by using the same as}

The present invention relates to a method for producing a ring effective in improving rhinitis, and a ring prepared thereby, and more particularly, to improve rhinitis containing eugeunpi, green bean, yak bellflower, shin yihwa, sasam, and mint as active ingredients. It relates to a method for producing a ring effective to

In general, pills (丸劑) are one of the herbal medicine formulations, and are a binder in powdered oriental medicine powder or herbal soup concentrate. It is an oral tablet made into a round shape by mixing excipients. Hwanje (丸劑), depending on the type of binder, there are various types such as mil-hwan, su-hwan, compatibility, medicinal juice-hwan, lead-hwan, X-hwan, and hyeol-hwan. Pills are convenient to eat, absorb relatively slowly, and have a long-lasting medicinal effect. Among herbal medicines, it is desirable to make pills for medicines that have weak resistance to high temperatures, are not soluble in water, volatilize easily, and have relatively high toxicity.

Depending on the purpose of use, many types of pills have been developed, such as hangover pills to relieve hangover symptoms, digestive pills to relieve indigestion, diet pills to reduce body fat, and sexual function improvement pills. and are sold.

Among these pills, as an example of a digestive pill for relieving indigestion, Republic of Korea Patent Publication No. 10-1324733 (October 28, 2013) discloses a liver protection function, a liver disease improvement effect, anticancer, antibacterial, diuretic, anthelmintic Disclosed is a health pill using rice straw extract made from rice straw that has detoxification and fermentation effects, excellent digestion of milk products, can be used as a substitute for baby food, and has the effect of preventing adult diseases.

In addition, Republic of Korea Patent Publication No. 10-1965804 (March 29, 2019) discloses an unpleasant odor when fermented by adding a microbial fermenting agent to the dough of the pills in order to solve the phenomenon that the pills harden during storage and have difficulty in digestion. Disclosed are a microbial fermentation agent for improving the physical properties of pills capable of eliminating and preventing hardening, and a method for manufacturing pills for digestion and absorption using the same.

However, since one or more dried and pulverized herbal medicine powders are kneaded using glutinous rice paste or wheat flour paste when making pills in the prior art, no matter how good herbal medicine powder is used, the indigestible material lignin or Since it may contain a large amount of cellulose, etc., there is a problem that the digestion and absorption rate is lowered. Also, the herbal medicine powder or extract is mixed with an extender or excipient to make a pill, and after a certain period of time, the pill becomes hard with evaporation of moisture. When taking the pills, as well as having discomfort, there was a problem that the disintegration was not done well in the stomach of the user.

This problem is that when the pills are stored for a long time, moisture evaporates during storage, and the pills become hardened due to the binder using glutinous rice or wheat flour, which may further deteriorate the degree of disintegration and quick-acting.

Republic of Korea Patent Publication No. 10-1324733 (October 28, 2013) Republic of Korea Patent Publication No. 10-1965804 (March 29, 2019)

The present invention is to solve the problems of the prior art, and a method for producing a ring effective in improving the non-salt ring, which can improve the swelling and partial texture of glutinous rice flour used as a binder, and a method for producing a ring prepared thereby It is to provide a ring.

Another object of the present invention is to reduce the viscosity of glutinous rice flour used as a binder relatively, and a method for producing a ring effective in improving the non-salt ring capable of manufacturing a ring using lactic acid bacteria fermented glutinous rice paste, and a pill manufactured thereby is to provide

Another object of the present invention is to provide a method for producing a ring effective in improving rhinitis, which can suppress deterioration or mold generation even if the pill is stored for a certain period of time or more, and to provide a method for producing a ring prepared thereby.

A method for producing a ring effective in improving rhinitis ring according to the present invention for achieving the above object is to prepare a herbal medicine including washed eugeunpi, green bean, yak bellflower, shin yihwa, ginseng, and mint; pulverizing the oriental medicines including the eugeunpi, green bean, yakdalaji, shin yihwa, sagebrush, and mint using a grinder; preparing a herbal medicine mixture by stirring the pulverized herbal medicine powder through a stirrer; Preparing a fermented glutinous rice paste binder by placing the prepared glutinous rice powder and raw loofah juice or a decoction of the stem in a heating container at a set weight ratio, and then heating and fermenting; preparing a mixture of the herbal medicine mixture and the fermented glutinous rice paste at a set ratio; recirculating the kneaded herbal medicine dough into a shape of a set size using a ventilation machine; It is characterized in that it comprises the step of forming the ring-shaped herbal medicine dough using a molding machine.

Here, the fermented glutinous rice paste binder comprises the steps of: immersing raw glutinous rice in water for a certain period of time, periodically changing water, and then drying; grinding the dried glutinous rice to a predetermined size using a grinder to make glutinous rice powder; Inoculating and culturing a certain amount of Lactococcus lactis in MRS broth medium sterilized at a set temperature for a certain period of time, centrifuging the culture medium aseptically to recover the cells, and diluting it with sterilized water to a set concentration to make a fermentation start solution; heating the glutinous rice powder and raw loofah juice or decoction of loofah stems in a heating container at a set weight ratio, and then gelatinizing and mixing for a certain period of time; Cooling the gelatinized and mixed glutinous rice powder, inoculating a predetermined amount of the lactic acid bacteria fermentation start solution, and culturing at a predetermined temperature for a predetermined time to prepare the fermented glutinous rice paste.

The method for producing a ring effective in improving rhinitis ring according to the present invention and the ring prepared thereby has the following effects.

First, the swelling and partial texture of glutinous rice flour used as a binder can be improved, and the viscosity when making the pills can be relatively lowered. has

In addition, the viscosity of glutinous rice flour used as a binder can be relatively lowered, so that the user can easily disintegrate in the stomach after taking the pill, thereby allowing the user to easily absorb the active ingredients of the herbal medicine constituting the pill. have an effect

In addition, by using fresh loofah juice or decoction of loofah stems instead of water in the glutinous rice paste manufacturing process, it is effective in improving rhinitis, which can suppress deterioration or mold development even if the pills are stored for a certain period of time.

1 is a view showing a manufacturing procedure of a ring effective in improving the rhinitis ring according to a preferred embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, a method for producing a ring effective in improving the nasal ring according to the present invention according to the present invention and a preferred embodiment of the ring prepared thereby will be described in detail.

Hereinafter, before describing the specific manufacturing method, a method for producing a ring effective in improving rhinitis according to the present invention and a medicinal material used in the ring prepared thereby are as follows.

(1) Yugeunpi

Yugeunpi has a slight odor, slightly sweet taste, and has a flat, unbiased nature.

Yugeunpi is used when urinating, pain when urinating, and blood in the urine and swelling. Use for boils, sores, scabies, ringworm, etc.

It has been reported that the pharmacological action is used as a cancer treatment in folklore.

The appearance is tubular or plate-shaped, and the outer surface is dark brown with spots and a cork layer. The cut surface is rough and light brown, and the fine fibrous pattern is distinct, the quality is hard, and there is blackish-yellow powder.

(2) green beans

Soybeans are said to have great effects on hemorrhoids, sinusitis, otitis media, gastritis, and colitis. In the herbal medicine research book 『Bonchogangmok 本草綱目』 published by Chinese herbalist Shijin Li during the Ming Dynasty, it is also recorded as a medicinal herb that protects the intestines and stomach and warms the stomach.

Boiled soybeans can be eaten as a snack or used as an ingredient for soybean paste, or it can be soaked in water and mixed with rice to make rice. You can also grind soybeans into powder and eat them with water or milk, or add them when cooking.

Green soybeans are rich in saponin, which delays the absorption of fat and helps to suppress weight gain. It also contains a lot of dietary fiber, which is effective in preventing constipation. In addition, it contains more vitamins A and C than regular soybeans, so it has beneficial effects such as preventing night blindness, improving eyesight, strengthening immunity, and relieving fatigue.

(3) Schematic

Bellflower grows in mountains and fields, and the roots are thick and the stems are straight. When cut, white sap comes out. The height is 40-100 cm.

Leaves are alternate phyllotaxis, long egg-shaped or broad lanceolate, with serrated edges, without petioles. The tip of the leaf is sharp and the bottom is wide. The front side of the leaf is green and the back side is grayish blue, hairless, 4-7cm long and 1.5-4cm wide.

The flowers are white or purple in July-August, blooming upwards, in the shape of a bell with a spreading tip, 4-5cm in diameter, and the tip is divided into 5 parts. The calyx is also divided into 5, and the fork is lanceolate. 5 stamens, 1 pistil, 5 ovaries, and 5 pistils.

The fruits are capsules, egg-shaped, and ripen with calyx pieces attached. Propagation is good with seeds. Roots are collected in spring and autumn and eaten raw or as greens. The main component of bellflower is saponin. Gilgyeong (桔梗), a herbal medicine, is the root that has been peeled or dried as it is.

(4) Shin Ewha

Magnolia buds that can be seen in early and mid-March are also called "Shinuihwa", and are also called 'North facing flower' because they face the north where the king is. It is also called 'Youngchun' because it produces flower buds in early spring. It is also called 'Mokpil' because the flower buds resemble the tip of a brush. In Gangwon-do, the blooming magnolia is also called 'Hambak Flower'.

Sinuihwa (magnolia) has an excellent effect on allergic rhinitis and sinusitis, which are chronic diseases of modern people. You might think it's ironic that magnolia buds cure pollen allergy. Shinuihwa, which has buds in early spring, has the effect of opening the nose.

(5) four ginseng

The tender parts and roots of ginseng are eaten raw. Whether the roots are edible or medicinal, once canned, wash them in water, peel them, and dry them in the sun for storage. The root (根) of the zandae and the same synergistic plant is called 沙蔘 (Sasam) and is used medicinally.

The roots are collected in the fall, the stems, leaves, and beard roots are removed, the soil is shaken and washed, the cork is scraped off, and the ones that were dried in the sun are dried by exposing them to a fire. The root of the stem contains triterpenoid saponins and starch. It has effects of 補陰 (Boeum), 淸肺 (Cheongpye), 祛痰 (Geodam), and 止咳 (Jihae). It treats 肺熱燥咳 (lung fever), 虛 久咳 (heo guhae), and 陰傷咽乾喉痛 (eumsangin tendon sore throat). lower blood pressure again.

(6) peppermint

Mint is a plant native to temperate regions, and the leaves and stems grown in cool climates have a strong fragrance. It tolerates the summer rainy season better than the Western mint mint type. With strong vitality, it adapts well to any place and can overwinter in winter without any warmth. Soft leaves or shoots sprouting in spring and autumn can be used to enjoy the fragrance. Mint grown as an herbal plant, it has a more intense scent than the scent of pear cloves.

The main component of peppermint oil is menthol, and this menthol is used medicinally as a liniment, analgesic, stimulant, gastric and anthelmintic, or as a refreshing agent or flavoring agent in toothpaste, jam, candy, cosmetics, and cigarettes.

(7) sticky rice

Glutinous rice is a word that corresponds to non-glutinous rice, and is also called nami or jeommi. Non-glutinous rice, which is usually cooked, has a translucent endosperm, whereas glutinous rice is opaque and milky, so it can be distinguished. Also, since the starch of glutinous rice is mostly composed of amylopectin, it is clearly distinguished because the iodine reaction takes on a reddish-brown color.

It has high energy and digests better than non-glutinous rice. It is used to make various types of rice cakes such as glutinous rice cake, injeolmi, dumplings, and danja, and is also used to make sticky rice, yakshik, sikhye, alcohol, and red pepper paste.

Hereinafter, with reference to the accompanying FIG. 1, a description will be given of a procedure for producing a ring effective in improving the preferred rhinitis ring of the present invention.

[Oriental medicine preparation stage: S10 stage]

Prepare oriental medicines including Yugeunpi, green bean, yak radish, shiniihwa, ginseng, and mint, wash them thoroughly in running water, dry them in the shade so that the moisture content is less than 14%, and cut them into pieces suitable for powdering or preparation of herbal extracts. It is preferable to

Here, the moisture content is the amount of moisture contained in the medicinal material, and the moisture content can be measured using a moisture content meter. Although there is no standard for moisture content of herbal medicines, it is known that it is desirable to maintain 14% or less.

[Oriental medicine powdering step: S20 step]

Among the herbal preparations prepared in step S10, 8-12 parts by weight of Yugeunpi, 8-12 parts by weight of green beans, 8-12 parts by weight of yak radish, 2-6 parts by weight of Shin-ihwa, 2-6 parts by weight of ginseng, 2 parts by weight of mint, relative to the total herbal medicine mixture prepared in step S10 After drying ~6 parts by weight in a reduced pressure drying method, pulverize to a size within the range of 0.4 to 1.0 mm using a grinder, and filter through a filter through which 0.4 to 1.0 mm passes to make each herbal medicine powder.

Here, the reason that the content of eugeunpi, green bean, and yellow radish is relatively higher than that of other herbal medicines is to strengthen the active ingredients of herbal medicines that have the effect of preventing nasal congestion, runny nose, and coughing and protecting the bronchial tubes from fine dust. it is for

In addition, in the reduced pressure drying method, herbal medicines including Yugeunpi, green bean, medicinal radish, shiihwa, ginseng, and mint are frozen in a freezer for at least 20 to 28 hours, then crushed using a grinder, and 100% using a reduced pressure dryer. It is a method of drying under reduced pressure in a temperature range of ~140℃.

[Chinese herbal medicine powder stirring step: S30 step]

The herbal medicine mixture in which the herbal medicine powder is mixed is stirred through a stirrer to uniformly stir the herbal medicine mixture consisting of eugeunpi, green bean, yak doraji, shin yihwa, ginseng, and mint to complete the herbal medicine mixture.

[Glutinous rice paste binder manufacturing step: S40 step]

Next, a fermented glutinous rice paste binder is prepared by heating glutinous rice powder and raw juice of loofah or loofah stems, which will be described in detail below.

(1) Step of improving the swelling and texture of raw glutinous rice

Change the water periodically while submerging raw glutinous rice in water for 2 to 14 days, then take it out and dry it. In the water immersion process, various organic acids including lactic acid produced by natural fermenting microorganisms and extracellularly secreted hydrolytic enzymes work to improve the swelling and partial texture of glutinous rice flour.

(2) Glutinous rice powder manufacturing step

Grind the dried glutinous rice with improved bulkiness and texture to a size of 100 mesh using a grinder to make glutinous rice powder. At this time, the powder of glutinous rice contains 26% carbohydrate, 13% protein, 2% fat, and 1% sodium as degree.

(3) Lactic acid strain culture step

On the other hand, for the production of lactic acid bacteria fermented glutinous rice paste, Lactococcus lactis KCCM 40104 strain was received from the Korea Microbial Conservation Center affiliated with the Korea Seed Seed Association and used. Inoculate a certain amount of L. lactis and incubate at 37°C for 36 hours. Then, the culture medium is aseptically centrifuged (3,000 rpm, 30 minutes) to recover the cells, and appropriately diluted with sterile water to a concentration of 1.5 to 2.0 × 107 cells/mL and used as a fermentation start solution.

(4) Fermented glutinous rice paste manufacturing step

Next, glutinous rice powder: fresh loofah juice or decoction of stems is placed in a heating container in a weight ratio of 1: 2.0 to 3.5 (preferably 2.7), and heated until the temperature of the water reaches 90 ° C, respectively, and 5 at 120 rpm. Glaze and mix to disperse evenly for minutes.

Then, the gelatinized and mixed glutinous rice powder is cooled to 37°C, inoculated with 0.7 mL (1.5∼2.0×107 cell/mL) of lactic acid bacteria fermentation start solution, and cultured at 30°C for 15 hours to complete the fermented glutinous rice paste.

Here, the reason for using the decoction of fresh loofah juice or stem is that the loofah produces a component called flavonoid to protect itself from parasites, bacteria, and cell damage. It has the effect of inhibiting the release of histamine that causes allergy while also preventing the occurrence of deterioration or mold that may occur if the pill is stored incorrectly.

[Oriental medicine paste manufacturing step: S50 step]

Next, prepare a herbal medicine paste in which the prepared herbal medicine powder and fermented glutinous rice paste are evenly mixed in a weight ratio of 10: 1.0 to 2.0. At this time, it is preferable that the content of the fermented glutinous rice paste is controlled within the range of 10: 1.0 to 10: 3.0 according to the moisture content of the oriental medicinal product.

[Low-temperature aging stage of herbal medicine dough: S60 stage]

Then, in order to soften the low-temperature aged herbal medicine dough, it is aged at room temperature for a set period of time (18 to 24 hours). When aging at room temperature, the temperature itself cannot be said to be low, but quality can be improved by aging at room temperature to prevent browning that may occur when aging at a high temperature.

[Repurchase stage: S70 stage]

Next, the matured medicinal herb dough is recirculated to 3 to 7 mm using a ventilation machine.

[Pill forming step: S80 step]

Then, the drug mixture is molded into a round shape using a molding machine.

[Phone drying step: S90 step]

Then, the round-shaped ring-shaped product is dried for 16-24 hours at 35-45° C. using a dryer.

The method for producing a ring effective in improving rhinitis according to the present invention will be described in more detail by the following examples, but the scope of the present invention should not be limited thereby.

Example 1

Wash the oriental medicinal herbs including Yugeunpi, green bean, yakdalaji, shinihwa, ginseng, and mint thoroughly under running water and dry in the shade.

Next, 10 parts by weight of Yugeunpi, 10 parts by weight of green beans, 10 parts by weight of yak radish, 4 parts by weight of Shinyihwa, 4 parts by weight of ginseng, and 4 parts by weight of mint were dried by a reduced pressure drying method and then using a pulverizer with respect to the total herbal medicine mixture among the prepared herbal medicines. After grinding to a size within the range of 0.4 to 1.0 mm, each herbal medicine powder is made by filtering it through a filter through which 0.4 to 1.0 mm passes.

Then, the herbal medicine mixture in which the herbal medicine powder is mixed is stirred through a stirrer to uniformly stir the herbal medicine mixture consisting of eugeunpi, green bean, yak bellflower, shin yihwa, ginseng, and mint.

Then, glutinous rice powder and raw juice of loofah or stems are put in a heating container at a set weight ratio, and then heated and fermented to prepare a fermented glutinous rice paste binder.

To explain this in detail, in order to improve the bulkiness and texture of glutinous rice, the raw glutinous rice is immersed in water for 2 to 14 days while periodically changing the water, then taken out and dried. Then, in order to make glutinous rice powder, the dried glutinous rice with improved swelling properties and texture is finely ground using a grinder to make glutinous rice powder. Then, Lactococcus lactis KCCM 40104 lactic acid bacteria culture medium was inoculated with a certain amount of L. lactis in MRS broth (Difco, USA) medium sterilized at 121°C for 15 minutes, and cultured at 37°C for 36 hours. Then, the culture medium is aseptically centrifuged (3,000 rpm, 30 minutes) to recover the cells, and appropriately diluted with sterile water to a concentration of 1.5 to 2.0 × 107 cells/mL to make a fermentation start solution. Next, glutinous rice powder: fresh loofah juice or decoction of stems in a weight ratio of 1:2.7, that is, 72 mL of fresh loofah or decoction of stems and 28 g of glutinous rice powder are placed in a 250 mL heating container, and the water temperature will be After heating until it is gelatinized and mixed so as to be evenly dispersed at 120 rpm for 5 minutes. Then, the gelatinized and mixed glutinous rice powder is cooled to 37°C, inoculated with 0.7 mL (1.5∼2.0×107 cell/mL) of lactic acid bacteria fermentation start solution, and cultured at 30°C for 15 hours to complete the fermented glutinous rice paste.

Next, the herbal medicine powder and fermented glutinous rice paste are mixed in a weight ratio of 10: 1.0, and then kneaded to prepare a herbal medicine paste.

Then, in order to soften the low-temperature aged herbal medicine dough, it is aged for 18 to 24 hours at room temperature.

Then, the aged drug mixture is recirculated to a size of 3 to 7 mm using a ventilation machine.

Then, the drug mixture is molded into a round shape using a molding machine.

Then, the round-shaped ring-shaped product is dried for 16 to 24 hours at a temperature range of 35 to 45° C. using a dryer.

Example 2

The second preferred embodiment of the present invention is the same as the first preferred embodiment of the present invention, except that the herbal medicine powder and fermented glutinous rice paste are mixed in a weight ratio of 10:2.0 and kneaded to prepare a herbal medicine dough.

Example 3

The third preferred embodiment of the present invention is the same as the first preferred embodiment of the present invention, except that the herbal medicine powder and fermented glutinous rice paste are mixed in a weight ratio of 10: 3.0 and kneaded to prepare a herbal medicine dough.

Example 4

In a fourth preferred embodiment of the present invention, it is the same as that of the first preferred embodiment of the present invention, except that, in the fermented glutinous rice paste manufacturing step, glutinous rice powder: fresh loofah juice or decoction of stems is placed in a heating container in a weight ratio of 1:2.0 The difference is that the temperature of the water in the state is heated until it reaches 90°C, respectively.

Example 5

In the fifth preferred embodiment of the present invention, it is the same as the first preferred embodiment of the present invention, except that, in the fermented glutinous rice paste manufacturing step, glutinous rice powder: fresh loofah juice or decoction of stems is put in a heating container in a weight ratio of 1: 3.5 The difference is that the temperature of the water in the state is heated until it reaches 90°C, respectively.

<Comparative example>

Wash the oriental medicinal herbs including Yugeunpi, green bean, yakdalaji, shinihwa, ginseng, and mint thoroughly under running water and dry in the shade.

Next, 10 parts by weight of the prepared Yugeun skin, 10 parts by weight of green beans, 10 parts by weight of yak radish, 4 parts by weight of Shinyihwa, 4 parts by weight of ginseng, and 4 parts by weight of peppermint were dried under reduced pressure and dried using a grinder to a size of 0.4 to 1.0 mm. crush

Then, the herbal medicine powder is stirred through a stirrer to evenly mix the herbal medicine powder consisting of eugeunpi, green bean, yak bellflower, shinihwa, ginseng, and mint.

Then, to prepare a glutinous rice paste binder, glutinous rice is finely ground using a grinder to make glutinous rice powder.

Then, put it in a heating container in a weight ratio of glutinous rice powder: water 10:2, stir it over low heat to make glutinous rice paste, and then cool it down to room temperature.

Next, the herbal medicine powder and glutinous rice paste are mixed in a weight ratio of 10: 1 and kneaded to prepare a herbal medicine paste.

Then, in order to soften the low-temperature aged herbal medicine dough, it is aged for 18 to 24 hours at room temperature.

Next, the aged medicinal herb dough is recirculated to 3 to 7 mm using a ventilation machine.

Then, the drug mixture is molded into a round shape using a molding machine.

Then, the round-shaped ring-shaped product is dried at 35-45° C. and 16-24 hours using a dryer.

<Experimental Example 1> <Evaluation of disintegration degree of ring>

According to Experimental Example 1 below, 0.2 to 0.4 g of the ring effective in improving the non-salt ring prepared according to the first to third preferred embodiments of the present invention and 0.2 to 0.4 g of the ring prepared by the Comparative Example in 2.0 mL of lukewarm water, respectively It was administered and the melting state of the pills and the viscosity were determined accordingly.

division Evaluation items 3 minutes elapsed 5 minutes passed 7 minutes elapsed 10 minutes passed Example 1 start to disintegrate partial disintegration complete disintegration - Example 4 start to disintegrate partial disintegration complete disintegration - Example 5 start to disintegrate partial disintegration mostly disintegrate complete disintegration comparative example start to disintegrate start to disintegrate partial disintegration mostly disintegrate

According to Table 1, it was found that most of the pills effective in improving nasal inflammation prepared according to the first to third preferred embodiments of the present invention disintegrate within 5 to 7 minutes after administration to water, which is fermented While it can be seen that the viscosity of glutinous rice paste is relatively weak compared to the ring of Comparative Example, it was found that the ring prepared by Comparative Example 1 was partially disintegrated after 7 minutes or more.

As described above, the reason why the viscosity of glutinous rice paste according to a preferred embodiment of the present invention is low is judged to be because it is possible to improve the swelling and partial texture of glutinous rice flour used as a binder. It can be easily disintegrated in the, and this can have the advantage that the user can easily absorb the active ingredients of the herbal medicine constituting the pill.

In addition, by using fresh loofah juice or decoction of stems in the manufacturing stage of fermented glutinous rice paste, it has anti-inflammatory, antifungal, analgesic, cardiovascular protection, and hyperlipidemia improvement, and at the same time suppresses the release of histamine that causes allergies. Even if the pill is stored for a long time, it can prevent deterioration or mold.

This efficacy is expected to have a greater difference when fertilizing the state of the pills after long-term storage of the pills.

<Experimental Example 2> <Evaluation of viscosity of fermented glutinous rice paste>

division Evaluation items reconciliation redemption time dry state drying time Example 1 Good 1-3 seconds Good 20 hours Example 4 somewhat good 1-3 seconds Good 18 hours Example 5 shape irregularity 1-3 seconds Good 28 hours

According to Table 2, during the manufacturing process of fermented glutinous rice paste, during the manufacturing process of the ring effective in improving the non-salt ring manufactured according to the first, fourth to fifth preferred embodiments of the present invention, glutinous rice powder: fresh loofah juice or stem In the case of heating the decoction in a weight ratio of 1: 2.0 (Example 4), the moisture is relatively low and the round shape is unbalanced, but the drying time is relatively fast, and glutinous rice powder: fresh loofah juice or decoction of stems In the case of heating at a weight ratio of 1: 3.0 (Example 5), there is a lot of moisture, so the shape is not uniformly formed during ring forming, and it has a disadvantage that it takes a lot of drying time. On the other hand, in the case of heating glutinous rice powder: raw juice of loofah or stem decoction in a weight ratio of 1: 2.7 during the manufacturing process of fermented glutinous rice paste (Example 1), results that relatively satisfy both the ring condition and drying time can be obtained. was able to confirm

<Experimental Example 3> Evaluation of the preference of the ring effective in improving the rhinitis ring

The following sensory experiments were performed to confirm the performance of the ring prepared in Examples 1 to 3 and the ring effective in improving the non-salt ring prepared in Comparative Examples.

The sensory experiment was evaluated using a 9-point hedonic scale method (9 points: very good, 7 points: good, 5 points: average, 3 points: bad, 1 point: very bad ) The evaluation items were flavor, taste, texture, and overall satisfaction. The sensory test subjects were 20 men and women from middle and high school located in Sancheong-gun, and 30 men and women in their 40s and 60s from the village senior citizen center. The average value of is shown in Table 2 below.

division Evaluation items flavor bitter texture overall satisfaction Example 1 7.4 7.6 7.7 7.6 Example 2 7.3 7.4 7.4 7.3 Example 3 7.2 7.7 7.0 6.9 comparative example 5.91 5.6 6.1 6.0

As shown in Table 3, it can be seen that there is no significant difference in the flavor and bitterness of the ring, which is effective in improving the non-salt ring prepared by the first to third preferred embodiments of the present invention. As a result, it was found that the bitter taste had a large difference compared to the comparative example.

On the other hand, it can be seen that the ring prepared by Comparative Example 1 was evaluated relatively poorly in flavor, taste, texture and overall satisfaction compared to Examples 1 to 3 according to the present invention.

According to the method for producing a pill effective in improving nasal inflammation according to a preferred embodiment of the present invention and the pill prepared thereby, since glutinous rice paste used as a binder is fermented and used, the overall uncomfortable and negative image of herbal medicine It is expected that it will be possible to improve the image of herbal medicines through the usefulness of fermented herbal medicines.

The present invention described above is limited to the above-described embodiments and the accompanying drawings, because various substitution modifications and changes are possible without departing from the technical spirit of the present invention for those of ordinary skill in the art to which the invention pertains. it's not going to be

Claims (5)

Preparing a herbal medicine containing the washed eugeunpi, green bean, yak bellflower, shin yihwa, sasam, and mint; pulverizing the herbal medicine containing the eugeunpi, pea bean, yak bellflower, shin yi hwa, sasam, and mint using a grinder; Preparing the herbal medicine mixture by stirring the pulverized herbal medicine powder through a stirrer; Putting glutinous rice powder prepared at a set weight ratio and raw juice of loofah or stems in a heating container, heating and fermentation to prepare a fermented glutinous rice paste binder ; Preparing a mixture of the herbal medicine mixture and the fermented glutinous rice paste in a set ratio; Recirculating the kneaded herbal medicine dough into a shape of a set size using a ventilation machine; A method for producing a ring effective in improving the non-salt ring, characterized in that it comprises the step of molding into a ring shape using a. The method of claim 1, wherein the fermented glutinous rice paste binder comprises: immersing raw glutinous rice in water for a certain period of time and periodically changing water and then drying it; Grinding the dried glutinous rice to a predetermined size using a grinder to make glutinous rice powder ; Inoculating and culturing a certain amount of Lactococcuslactis in a medium sterilized at a set temperature for a certain time, recovering the cells by aseptically centrifuging the culture solution, and diluting it to a concentration set with sterile water to make a fermentation start solution; At a set weight ratio After heating the glutinous rice powder and raw loofah juice or decoction of loofah stem in a heating container, gelatinizing and mixing for a certain time; Cooling the gelatinized and mixed glutinous rice powder and inoculating a certain amount of the lactic acid bacteria fermentation start solution A method of producing a ring effective in improving the non-salt ring, characterized in that it comprises the step of producing the fermented glutinous rice paste by culturing for a certain time at a certain temperature. The method of claim 1, wherein the mixing ratio of the herbal medicine mixture and the glutinous rice paste binder is 10: a method for producing a ring effective in improving the non-salt ring, characterized in that it is mixed in a weight ratio of 1.0 to 2.0. According to claim 1, After the step of preparing the dough, to prevent browning of the herbal medicine mixture, the method further comprises the step of aging the herbal medicine mixture at a low temperature for a set time at room temperature. A method for producing a pill that is effective in improving. [Claim 5] A ring effective in improving the non-inflammatory ring, characterized in that it is prepared according to any one of claims 1 to 4.

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