KR20220143867A - G12d 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 - Google Patents

G12d 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 Download PDF

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KR20220143867A
KR20220143867A KR1020227031175A KR20227031175A KR20220143867A KR 20220143867 A KR20220143867 A KR 20220143867A KR 1020227031175 A KR1020227031175 A KR 1020227031175A KR 20227031175 A KR20227031175 A KR 20227031175A KR 20220143867 A KR20220143867 A KR 20220143867A
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노암 레빈
라미 요셉
비맨 씨 파리아
스티븐 에이 로젠버그
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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KR1020227031175A 2020-02-12 2021-02-12 G12d 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 Pending KR20220143867A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062975544P 2020-02-12 2020-02-12
US62/975,544 2020-02-12
PCT/US2021/017794 WO2021163434A1 (en) 2020-02-12 2021-02-12 Hla class i-restricted t cell receptors against ras with g12d mutation

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KR20220143867A true KR20220143867A (ko) 2022-10-25

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KR1020227031175A Pending KR20220143867A (ko) 2020-02-12 2021-02-12 G12d 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체

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US (1) US20230080742A1 (https=)
EP (1) EP4103597A1 (https=)
JP (1) JP7832111B2 (https=)
KR (1) KR20220143867A (https=)
CN (1) CN115279784A (https=)
AU (1) AU2021221138A1 (https=)
BR (1) BR112022015888A2 (https=)
CA (1) CA3168015A1 (https=)
CL (1) CL2022002208A1 (https=)
CO (1) CO2022012922A2 (https=)
CU (1) CU20220044A7 (https=)
GB (1) GB2609760B (https=)
IL (1) IL295252A (https=)
MX (1) MX2022009654A (https=)
TW (1) TWI900528B (https=)
WO (1) WO2021163434A1 (https=)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
TW202540156A (zh) * 2020-10-02 2025-10-16 美國衛生與公眾服務部 針對含有g13d突變之ras之hla第ii類限制性dq t細胞受體
IL305393A (en) 2021-02-25 2023-10-01 Alaunos Therapeutics Inc Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
EP4673167A1 (en) * 2023-02-27 2026-01-07 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d
CN118812698A (zh) * 2023-04-19 2024-10-22 香雪生命科学技术（广东）有限公司 一种识别kras突变的高亲和力t细胞受体及其应用
CN118852403A (zh) * 2023-04-26 2024-10-29 北京鼎成肽源生物技术有限公司 靶向kras突变的tcr分子和细胞及其应用
WO2025006196A1 (en) 2023-06-28 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation
WO2026057812A1 (en) * 2024-09-12 2026-03-19 Medigene Immunotherapies Gmbh T-cell receptor variant against mkras 7-16 g12d

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
WO2007017201A1 (en) * 2005-08-05 2007-02-15 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt Gmbh Generation of antigen specific t cells
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
MX384919B (es) 2014-11-26 2025-03-14 Us Health Receptores de células t de kras anti-mutado.
CN108395479B (zh) * 2017-02-06 2021-07-16 高军 一种有关kras基因突变的t细胞受体
EP3720478A1 (en) * 2017-12-04 2020-10-14 The United States of America, as represented by the Secretary, Department of Health and Human Services Hla class i-restricted t cell receptors against mutated ras

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CU20220044A7 (es) 2023-06-13
CL2022002208A1 (es) 2023-06-02
CN115279784A (zh) 2022-11-01
CA3168015A1 (en) 2021-08-19
CO2022012922A2 (es) 2022-10-21
GB2609760A (en) 2023-02-15
JP2023528112A (ja) 2023-07-04
TW202140536A (zh) 2021-11-01
GB202211733D0 (en) 2022-09-28
JP7832111B2 (ja) 2026-03-17
WO2021163434A1 (en) 2021-08-19
AU2021221138A1 (en) 2022-09-01
MX2022009654A (es) 2022-10-20
TWI900528B (zh) 2025-10-11
IL295252A (en) 2022-10-01
GB2609760B (en) 2026-02-04
US20230080742A1 (en) 2023-03-16
BR112022015888A2 (pt) 2022-10-11
EP4103597A1 (en) 2022-12-21
WO2021163434A8 (en) 2022-09-01

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