KR20220106998A - 시클로알킬 우레아 유도체 - Google Patents

시클로알킬 우레아 유도체 Download PDF

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KR20220106998A
KR20220106998A KR1020227021008A KR20227021008A KR20220106998A KR 20220106998 A KR20220106998 A KR 20220106998A KR 1020227021008 A KR1020227021008 A KR 1020227021008A KR 20227021008 A KR20227021008 A KR 20227021008A KR 20220106998 A KR20220106998 A KR 20220106998A
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South Korea
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alkyl
alkoxy
substituted
halogen atoms
oxadiazol
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Korean (ko)
Inventor
에이지 이데우에
마사후미 고미야
쇼코 이
슌이치로 우에스기
šœ이치로 우에스기
유타 후나코시
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스미토모 파마 가부시키가이샤
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Publication of KR20220106998A publication Critical patent/KR20220106998A/ko
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Publication number Priority date Publication date Assignee Title
US12503475B2 (en) 2020-09-03 2025-12-23 Centessa Pharmaceuticals (Uk) Limited Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists
CN114014747B (zh) * 2021-08-30 2023-12-08 海南师范大学 一种多羟基环己烯类化合物及其制备方法与应用
CA3248959A1 (en) 2022-04-22 2025-02-03 Sumitomo Pharma Co., Ltd. BICYCLOAMINE CARBOXAMIDE DERIVATIVE
AR130709A1 (es) * 2022-10-07 2025-01-08 Kissei Pharmaceutical Compuesto de ciclopentano
WO2024095158A1 (en) 2022-10-31 2024-05-10 Takeda Pharmaceutical Company Limited Dosing of orexin type 2 receptor agonists
TW202430169A (zh) 2022-12-16 2024-08-01 日商第一三共股份有限公司 2-氮雜雙環[3.1.1]庚烷化合物
JP2026501630A (ja) 2022-12-30 2026-01-16 エクソン、ラブズ、インコーポレイテッド ジヒドロ－キナゾリン、－ベンゾチアジンおよび－ベンズオキサジン誘導体ならびに神経疾患を治療または予防するためのオレキシン受容体作動薬としてのそれらの使用
WO2024168004A1 (en) * 2023-02-08 2024-08-15 Vertex Pharmaceuticals Incorporated Biaryl amide-containing agonists of orexin receptor type 2
TW202502342A (zh) 2023-06-02 2025-01-16 日商武田藥品工業股份有限公司 食慾素２受體促效劑用於改善睡眠期間之呼吸功能的用途
WO2025010314A1 (en) * 2023-07-05 2025-01-09 Vertex Pharmaceuticals Incorporated Urea-containing agonists of orexin receptor type 2
WO2025124698A1 (en) 2023-12-12 2025-06-19 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
TW202542165A (zh) 2023-12-19 2025-11-01 瑞士商愛杜西亞製藥有限公司 大環食慾素激動劑
WO2025224168A1 (en) 2024-04-24 2025-10-30 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
WO2025229493A1 (en) 2024-04-29 2025-11-06 Takeda Pharmaceutical Company Limited Dosing of orexin type 2 receptor agonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017135306A1 (en) 2016-02-04 2017-08-10 Takeda Pharmaceutical Company Limited Substituted piperidine compound and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849922A (en) * 1996-05-31 1998-12-15 Eli Lilly And Company Preparation of substituted alkenoic acids
AU2004231087B2 (en) 2003-04-15 2007-01-04 Merck Sharp & Dohme Corp. Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
KR20070015598A (ko) 2004-04-28 2007-02-05 다케다 야쿠힌 고교 가부시키가이샤 융합 퀴놀린 유도체 및 이의 용도
US20090111805A1 (en) 2005-02-24 2009-04-30 Pfizer Inc. Bicyclic heteroaromatic derivatives useful as anticancer agents
JP2010155827A (ja) * 2008-12-04 2010-07-15 Takeda Chem Ind Ltd スピロ環化合物
EP2604601B1 (en) 2010-08-10 2016-02-24 Astellas Pharma Inc. Hetero ring compound
GB201318222D0 (en) * 2013-10-15 2013-11-27 Takeda Pharmaceutical Novel compounds
TW201627299A (zh) 2014-10-29 2016-08-01 美國禮來大藥廠 用於抑制微粒體前列腺素ｅ合成酶１之新穎羧酸化合物
EP3029024A1 (en) * 2014-12-02 2016-06-08 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
US20200207734A1 (en) 2017-08-03 2020-07-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017135306A1 (en) 2016-02-04 2017-08-10 Takeda Pharmaceutical Company Limited Substituted piperidine compound and use thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Brain, Vol.130, 1577-1585, 2007
Cell, Vol. 92, pp. 573-585, 1998
Cell, Vol.98, 365-376, 1999
Cell, Vol.98, 437-451, 1999
Neuron, Vol.38, 715-730, 2003
Neuroscience Letters, Vol.569, 68-73, 2014
Proc. Natl. Acad. Sci. USA, Vol.101, 4649-4654, 2004
THE LANCET, Vol.355, 39-40, 2000

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