KR20220102919A - Disinfectant composition with excellent storage stability - Google Patents
Disinfectant composition with excellent storage stability Download PDFInfo
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- KR20220102919A KR20220102919A KR1020210005426A KR20210005426A KR20220102919A KR 20220102919 A KR20220102919 A KR 20220102919A KR 1020210005426 A KR1020210005426 A KR 1020210005426A KR 20210005426 A KR20210005426 A KR 20210005426A KR 20220102919 A KR20220102919 A KR 20220102919A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
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Abstract
Description
본 발명은 보존안정성이 우수한 살균소독제 조성물에 관한 것으로, 더욱 상세하게는 보존안정성이 우수하여 과초산의 농도가 오랜 기간 유지되기 때문에 지속적인 살균효과를 나타내는 보존안정성이 우수한 살균소독제 조성물에 관한 것이다.The present invention relates to a disinfectant composition having excellent storage stability, and more particularly, to a disinfectant composition having excellent storage stability and excellent storage stability, which shows a continuous sterilization effect because the concentration of peracetic acid is maintained for a long period of time.
과초산은 다양한 적용분야에 대해 유용한 살균제 및 소독제로 사용되고 있는데, 미생물에 대해 광범위한 활성 스펙트럼을 가지기 때문에, 내시경과 같은 의료장비의 살균 세척, 냉각탑 용수, 채광 공정 용수, 식품 가공 용수, 펄프 및 제지 공장(paper mill) 용수 등을 포함하는 산업용수의 살균 세척에 유용하게 이용될 뿐만 아니라, 반도체 장비의 에칭제로도 이용되고 있다. Peracetic acid has been used as a useful disinfectant and disinfectant for a variety of applications, and because of its broad spectrum of activity against microorganisms, sterilization cleaning of medical equipment such as endoscopes, cooling tower water, mining process water, food processing water, pulp and paper mills ( It is usefully used for sterilization and cleaning of industrial water including paper mill) water and the like, and is also used as an etchant for semiconductor equipment.
종래에는 의료장비의 살균 세척을 위해, 일반적으로 글루타르알데히드, 차아염소산나트륨, 포르말린 및 초산 등이 사용되었다. 그러나 글루타르알데히드는 자극적인 냄새와 함께, 피부나 눈 등의 인체 조직에 대해 독성을 나타내고, 살균시 오랜 시간을 필요로 하는 단점을 지니고 있다.Conventionally, for sterilization and cleaning of medical equipment, glutaraldehyde, sodium hypochlorite, formalin and acetic acid are generally used. However, glutaraldehyde is toxic to human tissues such as skin and eyes, along with a pungent odor, and has disadvantages in that it requires a long time for sterilization.
또한, 차아염소산나트륨과 초산은 어느 정도의 살균력과 스케일 제거력을 가지고 있으나, 스케일 제거를 목적으로 사용된 고농도의 초산은 차아염소산나트륨과 함께 기기 부식의 주된 원인이 될 뿐 아니라 그로 인한 기기의 잦은 고장을 유발하여 의료기기의 수명을 단축시키는 원인이 되고 있다.In addition, sodium hypochlorite and acetic acid have a certain degree of sterilization and scale removal power, but the high concentration of acetic acid used for the purpose of scale removal is the main cause of device corrosion along with sodium hypochlorite and causes frequent malfunction of the device. As a result, the lifespan of medical devices is shortened.
상기의 문제점을 해결하기 위해 과초산이 의료장비의 세척에 사용되기 시작했으며, 예를 들면 내시경과 같은 의료장비 및 치과용 기구의 살균에 과초산을 이용하는 방법, 과초산, 초산, 과산화수소, 인산, 1,1-디포스폰산, 및 역삼투압수를 혼합하여 의료기기 세척제에 이용하는 방법 등이 알려져 있다.To solve the above problems, peracetic acid started to be used for cleaning medical equipment, for example, a method of using peracetic acid to sterilize medical equipment such as endoscopes and dental instruments, peracetic acid, acetic acid, hydrogen peroxide, phosphoric acid, A method of mixing 1,1-diphosphonic acid and reverse osmosis water for use in a medical device cleaning agent is known.
과초산을 살균제로 사용하는 기술은 고농도의 과초산을 1% 이하의 농도로 희석시킨 후에 사용하는 방법이 주로 이용되었으나, 상기와 같은 종래의 과초산 살균제는 과초산이 빠르게 자연분해되어 사용기간이 지나치게 짧고, 보관 및 관리가 어려운 문제점이 있었다.The technique of using peracetic acid as a disinfectant was mainly used after diluting high-concentration peracetic acid to a concentration of 1% or less. It was too short, and there was a problem that storage and management were difficult.
본 발명의 목적은 보존안정성이 우수하여 과초산의 농도가 오랜 기간 유지되기 때문에 지속적인 살균효과를 나타내는 보존안정성이 우수한 살균소독제 조성물을 제공하는 것이다.It is an object of the present invention to provide a disinfectant composition with excellent storage stability that exhibits a continuous sterilization effect because the concentration of peracetic acid is maintained for a long period of time due to excellent storage stability.
본 발명의 목적은 과초산, 금속이온 봉쇄제, 과황산 화합물 및 정제수로 이루어지는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물을 제공함에 의해 달성된다.An object of the present invention is achieved by providing a disinfectant composition with excellent storage stability, characterized in that it consists of peracetic acid, a sequestering agent, a persulfate compound, and purified water.
본 발명의 바람직한 특징에 따르면, 상기 보존안정성이 우수한 살균소독제 조성물은 과초산 0.01 내지 1 중량%, 금속이온 봉쇄제 0.1 내지 5 중량%, 과황산 화합물 0.1 내지 1 중량% 및 정제수 잔량으로 이루어지는 것으로 한다.According to a preferred feature of the present invention, the disinfectant composition having excellent storage stability is composed of 0.01 to 1% by weight of peracetic acid, 0.1 to 5% by weight of a sequestering agent, 0.1 to 1% by weight of a persulfate compound, and the remaining amount of purified water. .
본 발명의 더 바람직한 특징에 따르면, 상기 금속이온 봉쇄제는 에티드론산, 에티드론산염, 에데트산, 에데트산염, 시트르산, 시트르산 수화물, 에틸렌다이아민테트라아세트산염 및 인계 화합물로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the sequestering agent is selected from the group consisting of etidronic acid, etidronic acid salt, edetic acid, edetic acid salt, citric acid, citric acid hydrate, ethylenediaminetetraacetate and phosphorus-based compounds. It is supposed to consist of one or more.
본 발명의 더욱 바람직한 특징에 따르면, 상기 과황산 화합물은 포타슘퍼옥시모노설페이트로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the persulfate compound is composed of potassium peroxymonosulfate.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 보존안정성이 우수한 살균소독제 조성물에는 산도조절제로 인산염 3 내지 4 중량%가 더 함유되는 것으로 한다.According to an even more preferred feature of the present invention, the antiseptic composition having excellent storage stability further contains 3 to 4% by weight of phosphate as an acidity regulator.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 인산염은 피로인산나트륨수화물, 인산수소나트륨, 인산이수소나트륨, 폴리인산 및 폴리인산나트륨으로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것으로 한다.According to an even more preferred feature of the present invention, the phosphate salt is made of at least one selected from the group consisting of sodium pyrophosphate hydrate, sodium hydrogen phosphate, sodium dihydrogen phosphate, polyphosphoric acid and sodium polyphosphate.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 보존안정성이 우수한 살균소독제 조성물에는 비이온 계면활성제 0.1 내지 2 중량% 및 소포제 0.01 내지 1 중량%가 더 함유되는 것으로 한다.According to an even more preferred feature of the present invention, the antiseptic composition having excellent storage stability further contains 0.1 to 2% by weight of a nonionic surfactant and 0.01 to 1% by weight of an antifoaming agent.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 소포제는 디메치콘으로 이루어지는 것으로 한다.According to an even more preferred feature of the present invention, the antifoaming agent is made of dimethicone.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 보존안정성이 우수한 살균소독제 조성물에는 부식억제제 0.25 내지 2 중량%가 더 함유되는 것으로 한다.According to an even more preferred feature of the present invention, the antiseptic composition having excellent storage stability further contains 0.25 to 2% by weight of a corrosion inhibitor.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 부식억제제는 안식향산나트륨 및 벤조트리아졸로 이루어지는 것으로 한다.According to an even more preferred feature of the present invention, the corrosion inhibitor is to be composed of sodium benzoate and benzotriazole.
본 발명에 따른 보존안정성이 우수한 살균소독제 조성물은 보존안정성이 우수하여 과초산의 농도가 오랜 기간 유지되기 때문에 지속적인 살균효과를 나타내는 살균소독제를 제공하는 탁월한 효과를 나타낸다.The disinfectant composition with excellent storage stability according to the present invention exhibits an excellent effect of providing a disinfectant with a continuous sterilization effect because the concentration of peracetic acid is maintained for a long period of time due to excellent storage stability.
도 1은 실시예 1 및 비교예 1 내지 4를 통해 제조된 살균소독제 조성물을 60℃로 유지한 상태에서 시간의 경과(1시간)에 따른 과초산의 함량을 측정하여 나타낸 그래프이다.
도 2는 실시예 1 및 비교예 1 내지 4를 통해 제조된 살균소독제 조성물을 60℃로 유지한 상태에서 시간의 경과(24시간)에 따른 과초산의 함량을 측정하여 나타낸 그래프이다.1 is a graph showing the measurement of the content of peracetic acid according to the passage of time (1 hour) in a state of maintaining the disinfectant composition prepared in Example 1 and Comparative Examples 1 to 4 at 60 ℃.
2 is a graph showing the measurement of the content of peracetic acid over time (24 hours) while maintaining the disinfectant composition prepared in Examples 1 and 1 to 4 at 60°C.
이하에는, 본 발명의 바람직한 실시예와 각 성분의 물성을 상세하게 설명하되, 이는 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 발명을 용이하게 실시할 수 있을 정도로 상세하게 설명하기 위한 것이지, 이로 인해 본 발명의 기술적인 사상 및 범주가 한정되는 것을 의미하지는 않는다.Hereinafter, a preferred embodiment of the present invention and the physical properties of each component will be described in detail, which is intended to describe in detail enough that a person of ordinary skill in the art to which the present invention pertains can easily carry out the invention, This does not mean that the technical spirit and scope of the present invention is limited.
본 발명에 따른 보존안정성이 우수한 살균소독제 조성물은 과초산, 금속이온 봉쇄제, 과황산 화합물 및 정제수로 이루어지며, 과초산 0.01 내지 1 중량%, 금속이온 봉쇄제 0.1 내지 5 중량%, 과황산 화합물 0.1 내지 1 중량% 및 정제수 잔량으로 이루어지는 것이 바람직하다.The disinfectant composition with excellent storage stability according to the present invention consists of peracetic acid, a sequestering agent, a persulfate compound, and purified water, 0.01 to 1 wt% of peracetic acid, 0.1 to 5 wt% of a sequestering agent, and a persulfate compound It is preferable to consist of 0.1 to 1% by weight and the remaining amount of purified water.
상기 금속이온 봉쇄제와 상기 과황산 화합물은 상기 과초산을 안정화하여 과초산이 자연분해되는 것을 억제하는 역할을 하는데, 상기 금속이온 봉쇄제는 에티드론산, 에티드론산염, 에데트산, 에데트산염, 시트르산, 시트르산 수화물, 에틸렌다이아민테트라아세트산염 및 인계 화합물로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것이 바람직하다.The sequestering agent and the persulfate compound serve to stabilize the peracetic acid to inhibit the natural decomposition of peracetic acid, and the sequestering agent is etidronic acid, etidronic acid salt, edetic acid, edet It is preferably made of at least one selected from the group consisting of acid salts, citric acid, citric acid hydrate, ethylenediaminetetraacetate, and phosphorus-based compounds.
또한, 상기 과황산 화합물은 포타슘퍼옥시모노설페이트로 이루어지는데, 상기와 같이 포타슘퍼옥시모노설페이트로 이루어지는 과황산 화합물은 상기 과초산과 평형을 이루면서, 과초산의 합성에 관여하여 안정성을 향상시키는 역할을 한다.In addition, the persulfate compound is composed of potassium peroxymonosulfate. As described above, the persulfate compound composed of potassium peroxymonosulfate is in equilibrium with the peracetic acid and participates in the synthesis of peracetic acid to improve stability. do
이와 관련하여, 과초산을 안정화시키는 과황산 화합물인 포타슘퍼옥시모노설페이트의 화학적 평형에 대한 반응을 아래 반응식 1에 나타내었다.In this regard, the reaction to the chemical equilibrium of potassium peroxymonosulfate, a persulfate compound that stabilizes peracetic acid, is shown in Scheme 1 below.
<반응식 1><Scheme 1>
또한, 상기 보존안정성이 우수한 살균소독제 조성물에는 산도조절제로 인산염 3 내지 4 중량%가 더 함유될 수 있는데, 상기 인산염은 본 발명에 따른 살균소독제 조성물의 pH를 3 내지 6.5로 조절하는 단계다.In addition, the disinfectant composition having excellent storage stability may further contain 3 to 4% by weight of phosphate as an acidity regulator, wherein the phosphate is a step of adjusting the pH of the disinfectant composition according to the present invention to 3 to 6.5.
이때, 상기 인산염은 피로인산나트륨수화물, 인산수소나트륨, 인산이수소나트륨, 폴리인산 및 폴리인산나트륨으로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것이 바람직하다.In this case, the phosphate salt is preferably made of at least one selected from the group consisting of sodium pyrophosphate hydrate, sodium hydrogen phosphate, sodium dihydrogen phosphate, polyphosphoric acid and sodium polyphosphate.
상기의 성분으로 이루어지는 산도조절제의 함량이 3 중량% 미만이면 살균소독제 조성물의 pH가 3 미만을 나타내어 부식성이 향상되며, 상기 산도조절제의 함량이 4%를 초과하게 되면 살균소독제 조성물의 pH가 6.5를 초과하게 되어 과초산의 안정성이 저하될 뿐만 아니라 살균효과도 저하된다.If the content of the acidity regulator composed of the above components is less than 3% by weight, the pH of the disinfectant composition is less than 3, thereby improving corrosiveness, and when the content of the acidity regulator exceeds 4%, the pH of the disinfectant composition is 6.5. In excess, not only the stability of peracetic acid is lowered, but also the sterilization effect is lowered.
또한, 상기 보존안정성이 우수한 살균소독제 조성물에는 비이온 계면활성제 0.1 내지 2 중량% 및 소포제 0.01 내지 1 중량%가 더 함유될 수도 있는데, 상기 비이온 계면활성제는 살균소독제 조성물에 함유된 과초산을 안정화시키는 역할을 하며, 상기 소포제는 살균소독제의 거품을 제거할 뿐만 아니라, 과초산이 자연분해되는 것을 억제시키는 역할을 한다.In addition, the disinfectant composition having excellent storage stability may further contain 0.1 to 2% by weight of a nonionic surfactant and 0.01 to 1% by weight of an antifoaming agent, wherein the nonionic surfactant stabilizes peracetic acid contained in the disinfectant composition The antifoaming agent not only removes the foam of the disinfectant, but also serves to inhibit the natural decomposition of peracetic acid.
상기 비이온 계면활성제의 함량이 0.1 중량% 미만이면 과초산의 안정화효과가 미미하며, 상기 비이온 계면활성제의 함량이 2 중량%를 초과하게 되면 과초산의 안정화효과는 크게 향상되지 않으면서 거품이 지나치게 발생하게 된다.When the content of the nonionic surfactant is less than 0.1% by weight, the stabilizing effect of peracetic acid is insignificant, and when the content of the nonionic surfactant exceeds 2% by weight, the stabilizing effect of the peracetic acid is not significantly improved and bubbles are formed occurs excessively.
이때, 상기 비이온 계면활성제는 플록사머 계열을 사용하는 것이 바람직하며, 상기 소포제는 디메치콘으로 이루어지는 것이 바람직하다.In this case, the nonionic surfactant is preferably a floxamer series, and the antifoaming agent is preferably made of dimethicone.
또한, 상기 보존안정성이 우수한 살균소독제 조성물에는 부식억제제 0.25 내지 2 중량%가 더 함유될 수도 있는데, 상기 부식억제제는 안식향산나트륨 및 벤조트리아졸로 이루어지는 것이 바람직하다.In addition, the antiseptic composition having excellent storage stability may further contain 0.25 to 2% by weight of a corrosion inhibitor, and the corrosion inhibitor is preferably made of sodium benzoate and benzotriazole.
상기의 성분으로 이루어지는 부식억제제는 본 발명에 따른 보존안정성이 우수한 살균소독제 조성물을 의료기기 등에 적용했을 때, 부식이 발생하는 것을 억제하는 역할을 한다.The corrosion inhibitor composed of the above components serves to inhibit corrosion when the disinfectant composition having excellent storage stability according to the present invention is applied to a medical device or the like.
상기의 성분으로 이루어지는 보존안전성이 우수한 살균소독제 조성물은 상기와 같이 과초산, 금속이온 봉쇄제 및 과황산 화합물을 기본으로 하고, 추가적으로 인산염, 비이온 계면활성제 및 부식억제제 등이 추가로 함유될 수 있으며, 상기의 성분들을 제외한 잔량은 정제수로 이루어진 수용액 상태로 제조된다.The disinfectant composition with excellent storage safety comprising the above components is based on peracetic acid, sequestering agents and persulfate compounds as described above, and additionally phosphates, nonionic surfactants and corrosion inhibitors may be additionally contained. , The remaining amount excluding the above components is prepared in the state of an aqueous solution consisting of purified water.
이하에서는, 본 발명에 따른 보존안정성이 우수한 살균소독제 조성물의 제조방법 및 그 제조방법을 통해 제조된 살균소독제 조성물의 물성을 실시예를 들어 설명하기로 한다.Hereinafter, a method for producing a disinfectant composition having excellent storage stability according to the present invention and physical properties of the disinfectant composition prepared through the method will be described with reference to examples.
<실시예 1><Example 1>
과초산 0.4중량%, 금속이온 봉쇄제(에티드론산) 1.5 중량%, 과황산 화합물(포타슘퍼옥시모노설페이트) 0.5 중량% 및 정제수 잔량으로 하여 보존안정성이 우수한 살균소독제 조성물을 제조하였다.Peracetic acid 0.4% by weight, sequestering agent (ethidronic acid) 1.5% by weight, persulfate compound (potassium peroxymonosulfate) 0.5% by weight, and the remaining amount of purified water to prepare a disinfectant composition with excellent storage stability.
<비교예 1><Comparative Example 1>
과초산 0.4 중량% 및 정제수 잔량으로 하여 살균소독제 조성물을 제조하였다.A disinfectant composition was prepared by using 0.4% by weight of peracetic acid and the remaining amount of purified water.
<비교예 2><Comparative Example 2>
과초산 0.4 중량%, 금속이온 봉쇄제(에티드론산) 1.5 중량% 및 정제수 잔량으로 하여 살균소독제 조성물을 제조하였다.A disinfectant composition was prepared by using 0.4 wt% of peracetic acid, 1.5 wt% of a sequestering agent (ethidronic acid), and the remaining amount of purified water.
<비교예 3><Comparative Example 3>
과초산 0.4 중량%, 금속이온 봉쇄제(에티드론산 1.5 중량%, 시트르산 0.5 중량%) 2.0 중량% 및 정제수 잔량으로 하여 살균소독제 조성물을 제조하였다.Peracetic acid 0.4% by weight, sequestering agent (ethidronic acid 1.5% by weight, citric acid 0.5% by weight) 2.0% by weight, and the remaining amount of purified water to prepare a disinfectant composition.
<비교예 4><Comparative Example 4>
과초산 0.4 중량%, 과황산 화합물(포타슘퍼옥시모노설페이트) 0.5 중량% 및 정제수 잔량으로 하여 살균소독제 조성물을 제조하였다.A disinfectant composition was prepared by using 0.4% by weight of peracetic acid, 0.5% by weight of a persulfate compound (potassium peroxymonosulfate), and the remaining amount of purified water.
상기 실시예 1 및 비교예 1 내지 4를 통해 제조된 살균소독제 조성물을 60℃로 유지한 상태에서 시간의 경과에 따른 과초산의 함량을 측정하여 아래 표 1 및 도 1에 나타내었다.The amount of peracetic acid over time was measured while the disinfectant composition prepared in Example 1 and Comparative Examples 1 to 4 was maintained at 60° C., and is shown in Table 1 and FIG. 1 below.
아래 도 1에서 A는 비교예 1, B는 비교예 2, C는 비교예 3, D는 비교예 4이며, E는 실시예 1이다. 1, A is Comparative Example 1, B is Comparative Example 2, C is Comparative Example 3, D is Comparative Example 4, and E is Example 1.
<표 1><Table 1>
상기 표 1 및 아래 도 1에 나타낸 것처럼, 비교예 1과 같이 일반적인 과초산은 도면1의 A(비교예 1)처럼 하락하는게 일반적이며 금속이온 봉쇄제가 혼합되면 과초산이 안정화되며 과황산 화합물이 투입되면 과초산의 초기 농도가 향상되며 점차적으로 과초산의 함량이 증가하는 것을 알 수 있다.As shown in Table 1 and Figure 1 below, as in Comparative Example 1, general peracetic acid generally falls as in A in Figure 1 (Comparative Example 1), and when a sequestering agent is mixed, peracetic acid is stabilized, and persulfate compound is added It can be seen that the initial concentration of peracetic acid is improved and the content of peracetic acid is gradually increased.
또한, 상기 실시예 1 및 비교예 1 내지 4를 통해 제조된 살균소독제 조성물을 60℃로 유지한 상태에서 24시간 동안 과초산의 함량을 측정하여 아래 표 2 및 도 2에 나타내었다.In addition, the content of peracetic acid was measured for 24 hours while maintaining the disinfectant composition prepared in Example 1 and Comparative Examples 1 to 4 at 60° C., and is shown in Table 2 and FIG. 2 below.
아래 도 2에서 A는 비교예 1, B는 비교예 2, C는 비교예 3, D는 비교예 4이며, E는 실시예 1이다. 2, A is Comparative Example 1, B is Comparative Example 2, C is Comparative Example 3, D is Comparative Example 4, and E is Example 1.
<표 2><Table 2>
상기 표 2 및 아래 도 2에 나타낸 것처럼, 60℃의 온도에서 24시간 보관한 경우 본 발명의 실시예 1의 살균소독제 조성물은 비교예 1에 비해 과초산의 함량이 약 4배를 나타내었으며, 비교예 2 내지 3에 비해서는 약 2배를 나타내었다.As shown in Table 2 and Figure 2 below, when stored at a temperature of 60 ° C. for 24 hours, the disinfectant composition of Example 1 of the present invention exhibited about 4 times the content of peracetic acid compared to Comparative Example 1, Compared to Examples 2 to 3, it exhibited about 2 times.
따라서, 실시예 1과 같이 금속이온 봉쇄제와 과황산 화합물이 함유되면 과초산의 분해억제 효과가 월등하게 향상되는 것을 알 수 있다.Therefore, it can be seen that when the sequestering agent and the persulfate compound are contained as in Example 1, the decomposition inhibitory effect of peracetic acid is significantly improved.
<실시예 2><Example 2>
과초산 0.22 중량%, 금속이온 봉쇄제(에티드론산 0.5 중량%, 시트르산 1.0 중량%) 1.5 중량%, 부식억제제(안식향산나트륨 0.5 중량%, 벤조트리아졸 0.5 중량%) 1 중량%, 산도조절제(인산수소나트륨) 3.5 중량%, 소포제(디메치콘) 0.5 중량%, 비이온 계면활성제(플록사머 184) 1.0 중량%, 과황산 화합물(포타슘퍼옥시모노설페이트) 0.5 중량% 및 정제수 잔량으로 하여 보존안정성이 우수한 살균소독제 조성물을 제조하였다.Peracetic acid 0.22% by weight, sequestering agent (ethidronic acid 0.5% by weight, citric acid 1.0% by weight) 1.5% by weight, corrosion inhibitor (sodium benzoate 0.5% by weight, benzotriazole 0.5% by weight) 1% by weight, acidity regulator ( Sodium hydrogen phosphate) 3.5% by weight, antifoaming agent (dimethicone) 0.5% by weight, nonionic surfactant (Floxamer 184) 1.0% by weight, persulfate compound (potassium peroxymonosulfate) 0.5% by weight, and the remainder of purified water for storage stability This excellent disinfectant composition was prepared.
<실시예 3><Example 3>
상기 실시예 2와 동일하게 진행하되, 과초산을 0.02 중량% 함유하여 보존안정성이 우수한 살균소독제 조성물을 제조하였다.Proceeded in the same manner as in Example 2, but containing 0.02% by weight of peracetic acid to prepare a disinfectant composition with excellent storage stability.
<비교예 5><Comparative Example 5>
과초산 0.27 중량%, 금속이온 봉쇄제(에티드론산 0.5 중량%, 시트르산 1.0 중량%) 1.5 중량%, 부식억제제(안식향산나트륨 0.5 중량%, 벤조트리아졸 0.5 중량%) 1 중량%, 산도조절제(인산수소나트륨) 3.5 중량% 및 정제수 잔량으로 하여 살균소독제 조성물을 제조하였다.Peracetic acid 0.27% by weight, sequestering agent (ethidronic acid 0.5% by weight, citric acid 1.0% by weight) 1.5% by weight, corrosion inhibitor (sodium benzoate 0.5% by weight, benzotriazole 0.5% by weight) 1% by weight, acidity regulator ( Sodium hydrogen phosphate) 3.5% by weight and the remaining amount of purified water to prepare a disinfectant composition.
<비교예 6><Comparative Example 6>
상기 비교예 5와 동일하게 진행하되, 소포제(디메치콘) 0.5 중량% 및 비이온 계면활성제(플록사머 184) 1.0 중량%를 더 혼합하여 살균소독제 조성물을 제조하였다.The same procedure as in Comparative Example 5, except that 0.5 wt% of an antifoaming agent (dimethicone) and 1.0 wt% of a nonionic surfactant (Floxamer 184) were further mixed to prepare a disinfectant composition.
<비교예 7><Comparative Example 7>
과초산 0.22 중량%, 금속이온 봉쇄제(에티드론산 0.5 중량%, 시트르산 1.0 중량%) 1.5 중량%, 부식억제제(안식향산나트륨 0.5 중량%, 벤조트리아졸 0.5 중량%) 1 중량%, 산도조절제(인산수소나트륨) 3.5 중량%, 소포제(디메치콘) 0.5 중량%, 비이온 계면활성제(플록사머 184) 1.0 중량% 및 정제수 잔량으로 하여 살균소독제 조성물을 제조하였다.Peracetic acid 0.22% by weight, sequestering agent (ethidronic acid 0.5% by weight, citric acid 1.0% by weight) 1.5% by weight, corrosion inhibitor (sodium benzoate 0.5% by weight, benzotriazole 0.5% by weight) 1% by weight, acidity regulator ( Sodium hydrogen phosphate) 3.5% by weight, antifoaming agent (dimethicone) 0.5% by weight, nonionic surfactant (Floxamer 184) 1.0% by weight, and the remaining amount of purified water to prepare a disinfectant composition.
<비교예 8><Comparative Example 8>
상기 비교예 7과 동일하게 진행하되, 과초산을 0.02 중량% 함유하여 살균소독제 조성물을 제조하였다.Proceeded in the same manner as in Comparative Example 7, but containing 0.02% by weight of peracetic acid to prepare a disinfectant composition.
상기 비교예 5 내지 6을 통해 제조된 살균소독제 조성물의 과초산 함량과 pH를 시간의 흐름에 따라 측정하여 아래 표 3에 나타내었다.The peracetic acid content and pH of the disinfectant compositions prepared in Comparative Examples 5 to 6 were measured over time and shown in Table 3 below.
<표 3><Table 3>
상기 표 3에 나타낸 것처럼, 소포제와 계면활성제가 더 함유된 비교예 6은 비교예 5에 비해 과초산의 함량이 높게 나타날 뿐만 아니라, 과초산이 오랜 기간 분해되지 않고 유지되는 것을 알 수 있다.As shown in Table 3, Comparative Example 6 containing more antifoaming agent and surfactant not only showed a higher content of peracetic acid compared to Comparative Example 5, but also showed that peracetic acid was maintained without decomposition for a long period of time.
또한, 상기 실시예 2 내지 3 및 비교예 7 내지 8을 통해 제조된 살균소독제 조성물의 초기 과초산 함량을 측정하여 아래 표 4에 나타내었다.In addition, the initial peracetic acid content of the disinfectant compositions prepared in Examples 2 to 3 and Comparative Examples 7 to 8 was measured and shown in Table 4 below.
<표 4><Table 4>
상기 표 4에 나타낸 것처럼, 본 발명의 실시예 2 내지 3과 같이 과황산 화합물이 함유되면 과초산이 평형상태에서 과황산 화합물과 평형을 이루면서 과초산에 함유된 아세트산 성분이 과초산으로 평형이 이동되면서 과초산의 함량을 증가시키는 것을 알 수 있다.As shown in Table 4, when the persulfate compound is contained as in Examples 2 to 3 of the present invention, peracetic acid is in equilibrium with the persulfate compound in the equilibrium state, and the equilibrium of the acetic acid component contained in the peracetic acid is shifted to peracetic acid It can be seen that the content of peracetic acid is increased.
따라서, 본 발명에 따른 보존안정성이 우수한 살균소독제 조성물은 보존안정성이 우수하여 과초산의 농도가 오랜 기간 유지되기 때문에 지속적인 살균효과를 나타내는 살균소독제를 제공하는 탁월한 효과를 나타낸다.Therefore, the disinfectant composition with excellent storage stability according to the present invention exhibits an excellent effect of providing a disinfectant with continuous sterilization effect because the concentration of peracetic acid is maintained for a long period of time due to excellent storage stability.
이상에서 본 발명은 실시예를 중심으로 상세히 설명되었지만 본 발명의 기술사상 범위 내에서 다양한 변형 및 수정이 가능함은 당업자에게 있어서 명백한 것이며, 이러한 변형 및 수정이 첨부된 특허청구범위에 속함은 당연한 것이다.Although the present invention has been described in detail with reference to the embodiments, it is apparent to those skilled in the art that various modifications and variations are possible within the scope of the technical spirit of the present invention, and it is natural that such variations and modifications belong to the appended claims.
Claims (10)
A disinfectant composition with excellent storage stability, characterized in that it consists of peracetic acid, a sequestering agent, a persulfate compound, and purified water.
상기 보존안정성이 우수한 살균소독제 조성물은 과초산 0.01 내지 1 중량%, 금속이온 봉쇄제 0.1 내지 5 중량%, 과황산 화합물 0.1 내지 1 중량% 및 정제수 잔량으로 이루어지는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
The method according to claim 1,
The disinfectant composition having excellent storage stability is a disinfectant with excellent storage stability, characterized in that it consists of 0.01 to 1% by weight of peracetic acid, 0.1 to 5% by weight of a sequestering agent, 0.1 to 1% by weight of a persulfate compound, and the remaining amount of purified water composition.
상기 금속이온 봉쇄제는 에티드론산, 에티드론산염, 에데트산, 에데트산염, 시트르산, 시트르산 수화물, 에틸렌다이아민테트라아세트산염 및 인계 화합물로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
The method according to claim 1 or 2,
The sequestering agent comprises at least one selected from the group consisting of etidronic acid, etidronic acid salt, edetic acid, edetic acid salt, citric acid, citric acid hydrate, ethylenediaminetetraacetate, and phosphorus-based compounds. A disinfectant composition with excellent stability.
상기 과황산 화합물은 포타슘퍼옥시모노설페이트로 이루어지는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
The method according to claim 1 or 2,
The persulfate compound is a disinfectant composition with excellent storage stability, characterized in that consisting of potassium peroxy monosulfate.
상기 보존안정성이 우수한 살균소독제 조성물에는 산도조절제로 인산염 3 내지 4 중량%가 더 함유되는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
The method according to claim 1,
The disinfectant composition having excellent storage stability further comprises 3 to 4% by weight of phosphate as an acidity control agent.
상기 인산염은 피로인산나트륨수화물, 인산수소나트륨, 인산이수소나트륨, 폴리인산 및 폴리인산나트륨으로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
6. The method of claim 5,
The phosphate salt is sodium pyrophosphate hydrate, sodium hydrogen phosphate, sodium dihydrogen phosphate, polyphosphoric acid, and a disinfectant composition with excellent storage stability characterized in that it consists of at least one selected from the group consisting of sodium polyphosphate.
상기 보존안정성이 우수한 살균소독제 조성물에는 비이온 계면활성제 0.1 내지 2 중량% 및 소포제 0.01 내지 1 중량%가 더 함유되는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
The method according to claim 1,
The disinfectant composition having excellent storage stability further comprises 0.1 to 2% by weight of a nonionic surfactant and 0.01 to 1% by weight of an antifoaming agent.
상기 소포제는 디메치콘으로 이루어지는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
8. The method of claim 7,
The antifoaming agent is a disinfectant composition with excellent storage stability, characterized in that consisting of dimethicone.
상기 보존안정성이 우수한 살균소독제 조성물에는 부식억제제 0.25 내지 2 중량%가 더 함유되는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.
The method according to claim 1,
The disinfectant composition having excellent storage stability further comprises 0.25 to 2% by weight of a corrosion inhibitor.
상기 부식억제제는 안식향산나트륨 및 벤조트리아졸로 이루어지는 것을 특징으로 하는 보존안정성이 우수한 살균소독제 조성물.10. The method of claim 9,
The corrosion inhibitor is a disinfectant composition with excellent storage stability, characterized in that consisting of sodium benzoate and benzotriazole.
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