KR20220100239A - Cultured cell remote monitoring system - Google Patents

Abstract

The present invention relates to a cultured cell remote monitoring system configured to control remotely a photographing location, photographing magnification, and focus of a camera module which captures images of cultured cells such that a user uses a user terminal he/she carries to photograph and monitor the cells in culture, without constraints of time and place. In addition, the system further comprises a magnification adjusting means which adjusts distance between an objective lens included in the camera module and the image sensor, thereby allowing the user to readily adjust photographing magnification remotely to observe the cells at more various magnifications. In addition, a liquid lens is included in the camera module such that the liquid lens can adjust focus automatically according to an increase or a decrease in a distance between the objective lens and the image sensor. Therefore, it is possible to solve inconvenience of adjusting the focus every time the magnification is adjusted, and obtain an image whose focus is more accurately adjusted. In addition, a plurality of lightings arranged to emit light with different wavelength in different directions are controlled to be selectively turned on, thereby allowing a plurality of images taken differently to each other according to each of the lightings to be combined into a 3D photo. Therefore, the cultured cell can be observed stereoscopically.

Description

Cultured cell remote monitoring system

The present invention relates to a cultured cell remote monitoring system and method, and more particularly, a cultured cell remote monitoring system capable of remotely monitoring changes in cultured cells by remotely adjusting the photographing position, photographing magnification, and focus of a camera module is about

In general, a microscope is used to enlarge and observe microscopically sized cells that cannot be observed with the naked eye. The microscope includes an objective lens and an eyepiece, puts an observation object on a stage, and observes the real image of the observation object enlarged by the objective lens by further magnifying it with the eyepiece.

However, when continuous observation of cells in culture is required, observation takes a long time and manpower is consumed because an observer must constantly reside and observe while adjusting magnification and focusing according to cell changes.

Korean Patent Registration No. 10-1131678

It is an object of the present invention to provide a cultured cell remote monitoring system capable of remotely monitoring cultured cells.

The remote monitoring system for cultured cells according to the present invention comprises: a cradle on which a culture dish capable of cell culture is placed, which is provided inside the body; a lighting means provided on different surfaces inside the main body, respectively, and including a plurality of lights for illuminating different wavelengths of light toward the culture dish; a camera module including an objective lens provided from the inside of the main body toward the cradle, and an image sensor that converts light entering through the objective lens into an image signal; Y-axis position adjusting means coupled to the camera module inside the main body to horizontally move the camera module in the Y-axis direction to adjust the Y-axis direction shooting position of the camera module; an X-axis positioning means coupled to the Y-axis positioning means inside the main body, and horizontally moving the Y-axis positioning means in the X-axis direction to adjust the X-axis direction shooting position of the camera module; It is coupled to the camera module inside the main body and raises and lowers any one of the objective lens and the image sensor in the Z-axis direction, so that the photographing magnification of the camera module is determined according to the increase or decrease of the distance between the objective lens and the image sensor. a magnification adjustment means for adjusting; a communication unit provided in the main body for wireless communication with the outside; a server for receiving and storing the image captured by the camera module from the communication unit through wireless communication; Wireless communication with the server and the communication unit, and wireless communication of the operation of the lighting means, the camera module, the X-axis position adjustment means, the Y-axis position adjustment means and the magnification adjustment means through a monitoring app provided by the server and a user terminal for remotely controlling it and displaying an image captured by the camera module.

The camera module further includes an auto focus control unit for automatically adjusting a focus for photographing.

The auto-focus control unit is provided in front of the objective lens, and is set to vary the magnitude of the applied voltage according to the increase or decrease in the distance between the objective lens and the image sensor, so that when the distance between the objective lens and the image sensor increases, focus It further includes a liquid lens (Liquid lens) that is automatically adjusted.

The plurality of lights are set to be selectively turned on in a preset order, the monitoring app controls the camera module to operate whenever the lights are turned on, and stereoscopically displays a plurality of images taken whenever the lights are turned on Composite into video

The plurality of lights is installed on the inner upper surface of the main body and illuminates the first wavelength of the upper light, the left side light is installed on the left side of the main body and illuminates the light of the second wavelength, and is installed on the right side of the main body and a right-side illumination illuminating the light of the third wavelength.

The magnification adjusting means includes an elevating nut unit coupled to any one of the objective lens and the image sensor, and a Z-axis screw unit coupled to the elevating nut unit so as to be vertically movable and elongated in the Z-axis direction; and a Z-axis motor for rotating the Z-axis screw unit.

The Y-axis position adjusting means includes a Y-axis screw part coupled to moveably coupled to the first slider provided under the camera module and elongated in the Y-axis direction, and a Y-axis motor for rotating the Y-axis screw part. include

The X-axis positioning means includes an X-axis screw part which is coupled to move a second slider provided under the Y-axis positioning means and is long in the X-axis direction, and an X for rotating the X-axis screw part. Includes shaft motor.

The body includes a case forming an exterior, and a culture dish entrance is formed on the front surface of the case so that the culture dish can be put on the holder.

The main body is provided on the opened lower surface of the case, is disposed at a position spaced apart from the holder by a predetermined distance in the downward direction, and further includes a base panel on which the X-axis positioning means and the Y-axis positioning means are installed. .

The remote monitoring system for cultured cells according to another aspect of the present invention includes: a cradle on which a culture dish capable of cell culture is placed, which is provided inside the main body; a lighting means provided on different surfaces inside the main body, respectively, and including a plurality of lights for illuminating different wavelengths of light toward the culture dish; a camera module including an objective lens provided from the inside of the main body toward the cradle, and an image sensor that converts light entering through the objective lens into an image signal; Y-axis position adjusting means coupled to the camera module inside the main body to horizontally move the camera module in the Y-axis direction to adjust the Y-axis direction shooting position of the camera module; an X-axis positioning means coupled to the Y-axis positioning means inside the main body, and horizontally moving the Y-axis positioning means in the X-axis direction to adjust the X-axis direction shooting position of the camera module; It is coupled to the camera module inside the main body and raises and lowers any one of the objective lens and the image sensor in the Z-axis direction, so that the photographing magnification of the camera module is determined according to the increase or decrease of the distance between the objective lens and the image sensor. a magnification adjustment means for adjusting; a communication unit provided in the main body for wireless communication with the outside; a server for receiving and storing the image captured by the camera module from the communication unit through wireless communication; Wireless communication with the server and the communication unit, and wireless communication of the operation of the lighting means, the camera module, the X-axis position adjustment means, the Y-axis position adjustment means and the magnification adjustment means through a monitoring app provided by the server and a user terminal for remote control through and displaying an image captured by the camera module, wherein the camera module is provided in front of the objective lens, and is applied according to the increase or decrease of the distance between the objective lens and the image sensor It further comprises a liquid lens (Liquid lens) which is set so that the magnitude of the voltage is variable, the focus is automatically adjusted when the distance between the objective lens and the image sensor is increased, wherein the plurality of lights are selectively turned on in a preset order is set, and the monitoring app controls the camera module to operate whenever the lights are turned on, and synthesizes a plurality of images taken whenever the lights are turned on into a stereoscopic image.

The present invention is configured to be able to remotely control the photographing position, photographing magnification and focus of a camera module for photographing cultured cells, so that the user is not restricted by time and place, and using a user terminal possessed by the user There is an advantage in that cells in culture can be photographed and monitored.

In addition, by including a magnification adjusting means for adjusting the distance between the objective lens and the image sensor included in the camera module, there is an advantage that the user can easily adjust the shooting magnification remotely to observe the cells at various magnifications.

In addition, by including the liquid lens in the camera module, the liquid lens can automatically focus according to the increase or decrease of the distance between the objective lens and the image sensor. A tailored image can be obtained.

In addition, by controlling a plurality of lights provided to irradiate light of different wavelengths from different directions to be selectively turned on, a plurality of images photographed differently according to each light are synthesized into a stereoscopic picture, and cultured cells are three-dimensionally turned on. There is an observable advantage.

1 is a diagram showing the configuration of a cultured cell remote monitoring system according to an embodiment of the present invention.
2 is a longitudinal cross-sectional view showing the inside of the main body of the culture cell remote monitoring system according to an embodiment of the present invention.
3 is a cutaway perspective view showing an example of an X-axis positioning means and a Y-axis positioning means according to an embodiment of the present invention.
4 is a plan view showing an example of the Y-axis position adjusting means according to an embodiment of the present invention.
4 is a plan view showing an example of an X-axis position adjusting means according to an embodiment of the present invention.
6 is a view showing a magnification adjusting means according to an embodiment of the present invention.
7 is a diagram schematically showing the configuration of a camera module according to an embodiment of the present invention.
8 shows an image captured by the camera module according to an embodiment of the present invention and an image synthesized into a three-dimensional shape.

Hereinafter, an embodiment of the present invention will be described with reference to the accompanying drawings.

1 is a diagram showing the configuration of a cultured cell remote monitoring system according to an embodiment of the present invention. Figure 2 is a longitudinal cross-sectional view showing the inside of the main body of the culture cell remote monitoring system according to an embodiment of the present invention.

1 and 2 , the culture cell remote monitoring system according to an embodiment of the present invention includes a body 10 in which a culture dish 2 is accommodated and monitoring the cultured cells contained in the culture dish 2 and , and a server 100 and a user terminal 200 that wirelessly communicate with the main body 10 .

The main body 10 is installed in a culture room or laboratory, and is a device for photographing the cultured cells and transmitting the photographed image to the server 100 or the user terminal 200 .

The main body 10 includes a case 11, a base panel 12, a cradle 13, a lighting means 20, a camera module 30, an X-axis positioning means 40, a Y-axis positioning means ( 50), a magnification adjusting means 60, a communication unit (not shown) and a power supply unit (not shown).

The case 11 will be described as an example to form an external appearance and to be formed in a box shape. The case 11 is formed to have at least one surface open. In this embodiment, the lower surface of the case 11 is formed to be opened, and the base panel 12 is provided on the lower surface of the case 11 as an example. However, the present invention is not limited thereto, and at least one of the upper surface, front, rear, left, and right sides of the case 11 may be formed to be openable and openable. In addition, it is of course possible that the case 11 is coupled to the upper and lower cases. In addition, it is of course possible that a temperature and humidity control unit (not shown) for controlling temperature or humidity is provided inside the case 11 to create an appropriate environment for cell culture.

A culture dish entrance 11a is formed on the front surface of the case 11 so that the culture dish 2 can be put on the holder 13 . A door (not shown) may be mounted to the culture dish entrance (11a) to be able to open and close, and when the door (not shown) is mounted, it is preferable to include a transparent window so that the inside can be seen.

The base panel 12 is provided on the lower surface of the case 11 , and the X-axis positioning means 40 and the Y-axis positioning means 50 are installed. However, the present invention is not limited thereto, and of course, the case 11 and the base panel 12 may be provided integrally.

The cradle 13 is installed in a position spaced apart from the base panel 12 upward by a predetermined interval inside the case 11 and is a shelf on which the culture dish 2 capable of cell culture is placed. The cradle 13 is horizontally disposed on the inner upper side of the case 11 . An opening hole 13a is formed in the center of the cradle 13 to facilitate observation of cultured cells through the camera module 30 . In this embodiment, the culture dish 2 is described as an example that the culture dish 2 is placed on the upper side of the opening hole 13a of the holder 13, but is not limited thereto, and the culture dish 2 is placed in the opening hole 13a. It is of course also possible that (2) is fitted and fixed.

The lighting means 20 includes a plurality of lights 21 , 22 , and 23 provided on different surfaces inside the case 11 .

The plurality of lights 21 , 22 , and 23 are color (RGB) LED lights capable of outputting visible light of 380 nm to 760 nm, and illuminating lights of different wavelengths, respectively.

The plurality of lights 21, 22, and 23 are respectively installed on three different surfaces and configured to illuminate different wavelengths of light, so that the internal structure can be clearly observed even in a colorless and transparent sample, and the phase difference Like a microscope, a stereoscopic image can be implemented for cultured cells. The plurality of lights 21, 22, and 23 are configured to be selectively turned on at predetermined time intervals.

The plurality of lights 21 , 22 , and 23 are installed on the inner upper surface of the case 11 and are provided on the left side of the upper light 21 , which illuminates the light of the first wavelength, and the case 11 . A left light 22 installed on the right side of the case 11 and illuminating light of a second wavelength different from the first wavelength, and a right light illuminating light of a third wavelength different from the first and second wavelengths ( 23).

The upper light 21 is an illumination for photographing the shape of the entire cell cultured in the culture dish 2 by illuminating the light from the top of the culture dish 2 .

The left light 22 is a light that serves to create a shadow on the right side of the cell.

The right light 23 is a light that serves to create a shadow on the left side of the cell.

The camera module 30 is disposed under the cradle 13 inside the main body 10 . The camera module 30 is a device for photographing cells in culture in the culture dish 2 through the opening hole 13a of the holder 13 .

In the camera module 30 , the photographing position is adjusted by the X-axis position adjustment means 40 and the Y-axis position adjustment means 50 , and the photographing magnification is adjusted by the magnification adjustment means 60 .

The camera module 30 includes an objective lens 31 , an image sensor 32 , a liquid lens 33 , and a first slider 34 .

The objective lens 31 is provided to face the lower surface of the culture dish 2 placed on the cradle 13 .

The image sensor 32 is provided below the objective lens 31 , and converts light entering through the objective lens 31 into an image signal.

At least one of the objective lens 31 and the image sensor 32 is movable in the vertical direction by the magnification adjusting means 60 so that the distance between the objective lens 31 and the image sensor 32 is adjusted. do. Hereinafter, in the present embodiment, the objective lens 31 is elevated in the vertical direction by the magnification adjusting means 60 as an example.

The liquid lens 33 is provided in front of the objective lens 31 and is an auto-focus function lens whose focus is automatically adjusted. The liquid lens 33, when the voltage applied to the water contained therein is increased, the thickness of the lens is reduced, and when the voltage is increased, the thickness of the lens is increased, and accordingly, the lens is changed into a convex lens, a flat lens and a concave lens shape, and the focus is adjusted. It is a losing principle. In this embodiment, the liquid lens 33 has an electric circuit so that the applied voltage varies according to the increase or decrease of the distance between the objective lens 31 and the image sensor 32, so that the objective lens 31 and When the distance of the image sensor 32 is increased or decreased, a focus may be automatically adjusted.

The first slider 34 is provided under the camera module 30 and coupled to the Y-axis transfer means 50 . The first slider 34 is horizontally moved in the Y-axis direction by the Y-axis transfer means 50 . The first slider 34 includes a nut part coupled to a Y-axis screw part 51 to be described later.

Figure 3 is a cutaway perspective view showing an example of the X-axis position adjustment means and the Y-axis position adjustment means according to an embodiment of the present invention. 4 is a plan view showing an example of the Y-axis position adjusting means according to an embodiment of the present invention.

3 and 4 , the Y-axis positioning means 50 is coupled to the first slider 34 of the camera module 30 to horizontally rotate the camera module 30 in the Y-axis direction. Move to adjust the Y-axis direction shooting position.

The Y-axis positioning means 50 includes a Y-axis screw part 51 and a Y-axis motor 52 .

The Y-axis screw part 51 is disposed to be elongated in the Y-axis direction. The first slider 34 is coupled to the Y-axis screw part 51 . The first slider 34 horizontally moves in the Y-axis direction along the Y-axis screw part 51 when the Y-axis screw part 51 rotates. A cover part 53 covering the Y-axis screw part 51 may be provided outside the Y-axis screw part 51 .

The Y-axis motor 52 rotates the Y-axis screw unit 51 .

The Y-axis positioning means 50 may further include a second slider 54 provided under the cover part 53 and coupled to the X-axis positioning means 40 . The second slider 54 includes a nut coupled to an X-axis screw part 41 to be described later.

In this embodiment, the Y-axis positioning means 50 is described as an example of a motor and a screw structure, but is not limited thereto, and any configuration that can be horizontally moved in the Y-axis direction is applicable.

5 is a view showing an example of an X-axis position adjusting means according to an embodiment of the present invention.

3 and 5 , the X-axis positioning means 40 is coupled to the second slider 54 of the Y-axis positioning means 50 to move the second slider 54 to the X-axis. Move horizontally in the direction to adjust the X-axis direction shooting position.

The X-axis positioning means 40 includes an X-axis screw part 41 and an X-axis motor 42 .

The X-axis screw part 41 is long in the X-axis direction. The second slider 54 is coupled to the X-axis screw part 41 . The second slider 54 horizontally moves in the X-axis direction along the X-axis screw part 42 when the X-axis screw part 42 rotates. A cover part 43 for covering the X-axis screw part 41 may be provided outside the X-axis screw 41 .

The X-axis motor 42 rotates the X-axis screw part 41 .

In this embodiment, the X-axis positioning means 40 is described as an example of a motor and a screw structure, but is not limited thereto, and any configuration that can be horizontally moved in the X-axis direction is applicable.

6 is a view showing a magnification adjusting means according to an embodiment of the present invention.

Referring to FIG. 6 , the magnification adjusting means 60 is coupled to the camera module 30 to raise and lower any one of the objective lens 31 and the image sensor 32 in the Z-axis direction, The photographing magnification of the camera module 30 is adjusted according to the increase or decrease of the distance between the objective lens 31 and the image sensor 32 .

The magnification adjusting means 60 includes an elevating nut part 61 , a Z-axis screw part 62 , and a Z-axis motor 63 .

The elevating nut part 61 may be coupled to any one of the objective lens 31 and the image sensor 32, and in this embodiment, the objective lens 31 and the first connecting rod 65 ) is combined with an example. In addition, the elevating nut part 61 is coupled to the Z-axis screw part 62 and elevates and descends in the Z-axis direction when the Z-axis screw part 62 rotates.

The Z-axis screw part 62 is arranged to be elongated in the Z-axis direction and the elevating nut part 61 is coupled to be movable up and down. The Z-axis motor 63 is coupled to one end of the Z-axis screw part 62 , and the other end is rotatably coupled to the camera module 30 by a second connection rod 64 .

The Z-axis motor 63 is coupled to an end of the Z-axis screw part 62 to rotate the Z-axis screw part 62 .

In this embodiment, the magnification adjusting means 60 is described as an example of a motor and a screw structure, but is not limited thereto, and at least one of the objective lens 31 and the image sensor 32 is raised and lowered. Any configuration that can be moved is possible.

The communication unit (not shown) is provided in the main body 10, and wirelessly communicates with the outside. The communication unit (not shown) wirelessly communicates with the server 100 and the user terminal 200 through a network. The communication unit (not shown) transmits the image captured by the camera module 30 to at least one of the server 100 and the user terminal 200 through wireless communication. In addition, the communication unit (not shown) receives a control signal from at least one of the server 100 and the user terminal 200 .

The power supply unit (not shown) is provided in the main body 10, the camera module 30, the X-axis motor 42, the Y-axis motor 52, the Z-axis motor 63, and the lighting Power supplied from the outside to the means 20 is applied or cut off. The power supply unit (not shown) may be controlled according to a control signal received from the server 100 or the user terminal 200 .

The server 100 receives and stores the image captured by the camera module 30 from the communication unit (not shown) through wireless communication.

The server 100 remotely controls the operation of the camera module 30 , the X-axis motor 42 , the Y-axis motor 52 , the Z-axis motor 63 , and the lighting means 20 . and provides a monitoring app capable of editing, storing, and displaying the image captured by the camera module 30 .

The user terminal 200 is a terminal that is preset to communicate wirelessly with the server 100 and the communication unit (not shown), and the monitoring app is installed therein. The user terminal 200 includes a mobile terminal, a tablet PC, a notebook computer, a desktop computer, and the like.

A method of using the cultured cell remote monitoring system according to an embodiment of the present invention configured as described above will be described as follows.

First, a user who wants to observe changes in cultured cells installs the monitoring app provided by the server 100 in the user terminal 200 possessed by the user, and executes the monitoring app. The monitoring app may be downloaded by accessing the server 100 through the user terminal 200 . A user may receive user permission from the server 100 by inputting user information through the monitoring app.

On the other hand, the user puts the culture dish 2 containing the cultured cells on the holder 13 through the culture dish entrance 11a. At this time, if the user is not in the laboratory where the main body 10 is placed, the operation of putting the culture dish 2 into the main body 10 may be replaced by a person in the laboratory.

Thereafter, the user can remotely photograph the cultured cells by adjusting the photographing position and photographing magnification of the camera module 30 through the user terminal 200 .

The user adjusts the Y-direction shooting position by horizontally moving the camera module 30 in the Y-axis direction by operating the Y-axis motor 52 through the monitoring app, and operating the X-axis motor 42 By horizontally moving the camera module 30 in the X-axis direction, the X-direction shooting position can be adjusted. At this time, it is also possible to move the camera module 30 at a constant speed by inputting a target position through the monitoring app, and the shooting position while controlling the rotational speeds of the X-axis motor 52 and the Y-axis motor 42 . It is of course possible to fine-tune the

When the shooting position of the camera module 30 is adjusted, by operating the Z-axis motor 63 through the monitoring app to adjust the distance between the objective lens 31 and the image sensor 32, the shooting magnification to adjust

When the Z-axis motor 63 is operated, the Z-axis screw part 62 is rotated, and the elevation nut part 61 is raised or lowered. When the elevating nut part 61 moves up and down, the objective lens 31 connected to the elevating nut part 61 moves up and down, and the distance d between the objective lens 31 and the image sensor 32 . ) increases. When the distance d between the objective lens 31 and the image sensor 32 is increased, the angle of view θ is narrowed, so that the photographing area is reduced and the photographing object is enlarged. When the elevating nut unit 61 descends, the objective lens 31 connected to the elevating nut unit 61 descends, so that the distance d between the objective lens 31 and the image sensor 32 . ) is reduced. When the distance d between the objective lens 31 and the image sensor 32 is reduced, the angle of view θ is widened, thereby increasing the photographing area and reducing the photographing object.

At this time, whenever the distance between the objective lens 31 and the image sensor 32 is adjusted, focus should be focused.

The liquid lens 33 is preset so that the voltage applied to the liquid lens 33 is variable according to the distance between the objective lens 31 and the image sensor 32, so that the objective lens 31 and When the distance of the image sensor 32 is adjusted, the focus may be automatically adjusted. That is, the server 100 or the user terminal 200 calculates the distance between the objective lens 31 and the image sensor 32 according to the elevation distance of the elevation nut part 61, and the In the monitoring app, the magnitude of the voltage applied to the liquid lens 33 is preset according to the distance d between the objective lens 31 and the image sensor 32, and when the distance d is changed, the preset The voltage is varied and applied. Therefore, there is no need to manually set the focus, and it is always possible to shoot in a state in which the focus is accurately set. However, the present invention is not limited thereto, and it is of course possible for the user to manually adjust the focus by manually adjusting the magnitude of the voltage applied to the liquid lens 33 .

After the shooting position and the shooting magnification are set as described above, the user controls the shooting of the camera module 30 through the monitoring app.

At this time, the plurality of lights 20 are selectively turned on in a preset order. That is, while any one of the plurality of lights 20 is turned on, the other lights are turned off.

In this embodiment, the upper light 21, the left light 22, and the right light 23 will be described as being turned on at predetermined time intervals in the order as an example. In addition, the camera module 30 is photographed once when the upper light 21 is turned on, photographed once when the left light 22 is turned on, and photographed once when the right light 23 is turned on. will be described as an example. However, the order in which the lights 20 are turned on or the number of times of shooting when the lights are turned on can be variously changed.

The upper light 21, the left light 22, and the right light 23 are provided on different surfaces inside the main body 10 to illuminate the light in different directions, so that the phase difference microscope is used. It has the advantage of being able to shoot three-dimensional shapes together. That is, the upper light 21 serves to illuminate the shape of the entire cell, the left light 22 serves to create a shadow on the right side of the cell, and the right light 23 serves as the cell's It can serve to create a shadow on the left side.

In addition, since the upper light 21 , the left light 22 , and the right light 23 are color (RGB) LEDs and illuminate different wavelengths of light, the internal structure can be clearly observed even with a colorless and transparent sample. have. The difference in refractive index of light according to the wavelength of the lights 20 can be utilized, and it is also effective for photographing surfaces of reflective materials such as glass and flasks.

8a shows an image taken in a state where only the upper light 21 is turned on, FIG. 8b shows an image taken in a state where only the left light 22 is turned on, and FIG. 8c is a state in which only the right light 23 is turned on shows an image taken in , and FIG. 8D shows an image obtained by synthesizing the images of FIGS. 8A to 8C .

The monitoring app synthesizes the images captured by the camera module 30 whenever the lights 20 are selectively turned on through an image processing technique, and displays them after making one stereoscopic image.

Accordingly, in the present invention, a three-dimensional image of the cultured cells can be obtained as shown in FIG. 8D by photographing the plurality of lights 20 by illuminating the plurality of lights 20 from different directions with light of different wavelengths.

On the other hand, the user may set the shooting time in advance through the monitoring app, so that automatic shooting is performed at the set time.

In the culture cell remote monitoring system according to the present invention as described above, even if the user does not reside in a space such as a culture room or laboratory in which the body 10 is located, the photographing position of the camera module 30 through the user terminal 200 Since the and shooting magnification can be adjusted remotely for shooting, ease of use can be improved and manpower consumption and cost can be reduced.

Although the present invention has been described with reference to the embodiment shown in the drawings, which is merely exemplary, it will be understood by those skilled in the art that various modifications and equivalent other embodiments are possible therefrom. Accordingly, the true technical protection scope of the present invention should be determined by the technical spirit of the appended claims.

2: Petri dish 10: body
11: Case 12: Base panel
20: luminaire 21: top light
22: left light 23: right light
30: camera module 31: objective lens
32: image sensor 33: liquid lens
34: first slider 40: X-axis position adjustment means
41: X-axis screw part 42: X-axis motor
50: Y-axis positioning means 51: Y-axis screw part
52: Y-axis motor 54: second slider
60: magnification adjustment means 61: elevating nut part
62: Z-axis screw part 63: Z-axis motor
100: server 200: user terminal

Claims (11)

a cradle provided inside the body and on which a culture dish capable of cell culture is placed;
a lighting means provided on different surfaces inside the main body, respectively, and including a plurality of lights for illuminating light of different wavelengths toward the culture dish;
a camera module including an objective lens provided from the inside of the main body toward the cradle, and an image sensor that converts light entering through the objective lens into an image signal;
Y-axis position adjusting means coupled to the camera module inside the main body to horizontally move the camera module in the Y-axis direction to adjust the Y-axis direction shooting position of the camera module;
X-axis positioning means coupled to the Y-axis positioning means inside the body, horizontally moving the Y-axis positioning means in the X-axis direction to adjust the X-axis direction shooting position of the camera module;
It is coupled to the camera module inside the main body and raises and lowers any one of the objective lens and the image sensor in the Z-axis direction, so that the photographing magnification of the camera module according to the increase or decrease of the distance between the objective lens and the image sensor. a magnification adjustment means for adjusting;
a communication unit provided in the main body for wireless communication with the outside;
a server for receiving and storing the image captured by the camera module from the communication unit through wireless communication;
Wireless communication with the server and the communication unit, and wireless communication of the operation of the lighting means, the camera module, the X-axis position adjustment means, the Y-axis position adjustment means and the magnification adjustment means through a monitoring app provided by the server A culture cell remote monitoring system comprising a user terminal for controlling remotely through and displaying an image captured by the camera module. The method according to claim 1,
The camera module, cultured cell remote monitoring system further comprising an auto-focus control unit for automatically adjusting the focus for photographing. 3. The method according to claim 2,
The auto focus control unit,
A liquid lens that is provided in front of the objective lens and is set to vary the magnitude of the voltage applied according to the increase or decrease in the distance between the objective lens and the image sensor, so that the focus is automatically adjusted when the distance between the objective lens and the image sensor is increased or decreased (Liquid lens) further comprising a cultured cell remote monitoring system. The method according to claim 1,
The plurality of lights are set to be selectively turned on in a preset order,
The monitoring app controls the camera module to operate whenever the lights are turned on, and a culture cell remote monitoring system that synthesizes a plurality of images taken whenever the lights are turned on into a stereoscopic image. 5. The method according to claim 4,
The plurality of lights,
The upper light is installed on the inner upper surface of the main body and illuminates the light of the first wavelength, the left light is installed on the left side of the main body and illuminates the light of the second wavelength, and the light of the third wavelength is installed on the right side of the main body A culture cell remote monitoring system comprising a right-side light illuminating the The method according to claim 1,
The magnification adjustment means,
An elevating nut unit coupled to any one of the objective lens and the image sensor, a Z-axis screw unit coupled to the elevating nut unit so as to be vertically movable, and elongated in the Z-axis direction, and the Z-axis screw unit rotating A remote monitoring system for cultured cells that includes a Z-axis motor. The method according to claim 1,
The Y-axis positioning means,
A culture cell remote monitoring system comprising a Y-axis screw unit coupled to a first slider provided at a lower portion of the camera module so as to be movable, a Y-axis screw part elongated in the Y-axis direction, and a Y-axis motor rotating the Y-axis screw part. The method according to claim 1,
The X-axis positioning means,
A culture cell remote comprising an X-axis screw part long provided in the X-axis direction and an X-axis motor rotating the X-axis screw part coupled so that a second slider provided under the Y-axis positioning means is movable. monitoring system. The method according to claim 1,
The body includes a case forming an exterior,
A culture cell remote monitoring system in which a culture dish entrance is formed on the front side of the case so that the culture dish can be put on the holder. 10. The method of claim 9,
The body is
Remote monitoring of cultured cells provided on the open lower surface of the case, disposed at a position spaced apart from the holder by a predetermined distance in the downward direction, and further comprising a base panel on which the X-axis positioning means and the Y-axis positioning means are installed system. a cradle provided inside the body and on which a culture dish capable of cell culture is placed;
a lighting means provided on different surfaces inside the main body, respectively, and including a plurality of lights for illuminating light of different wavelengths toward the culture dish;
a camera module including an objective lens provided from the inside of the main body toward the cradle, and an image sensor that converts light entering through the objective lens into an image signal;
Y-axis position adjusting means coupled to the camera module inside the main body to horizontally move the camera module in the Y-axis direction to adjust the Y-axis direction shooting position of the camera module;
X-axis positioning means coupled to the Y-axis positioning means inside the body, horizontally moving the Y-axis positioning means in the X-axis direction to adjust the X-axis direction shooting position of the camera module;
It is coupled to the camera module inside the main body and raises and lowers any one of the objective lens and the image sensor in the Z-axis direction, so that the photographing magnification of the camera module according to the increase or decrease of the distance between the objective lens and the image sensor. a magnification adjusting means for adjusting;
a communication unit provided in the main body for wireless communication with the outside;
a server for receiving and storing the image captured by the camera module from the communication unit through wireless communication;
Wireless communication with the server and the communication unit, and wireless communication of the operation of the lighting means, the camera module, the X-axis position adjustment means, the Y-axis position adjustment means and the magnification adjustment means through a monitoring app provided by the server and a user terminal for remotely controlling it and displaying the image captured by the camera module,
The camera module,
A liquid lens that is provided in front of the objective lens and is set to vary the magnitude of the voltage applied according to the increase or decrease in the distance between the objective lens and the image sensor, so that the focus is automatically adjusted when the distance between the objective lens and the image sensor is increased or decreased (Liquid lens) further comprising,
The plurality of lights are set to be selectively turned on in a preset order,
The monitoring app controls the camera module to operate whenever the lights are turned on, and a culture cell remote monitoring system that synthesizes a plurality of images taken whenever the lights are turned on into a stereoscopic image.

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