KR20220086855A - Antibacterial cream or serum composition based on plant extracts and method for manufacturing the same - Google Patents

Abstract

The present invention provides a hand cream/hand sanitizer in which at least a vegetable extract is blended in a base. In addition, the present invention provides a hand cream / hand sanitizer, wherein the base comprises a water-soluble polymer, an oily mixture, a crosslinking agent, moisture and a skin care component.

Description

Plant extract-based antibacterial cream or antibacterial serum composition and method of manufacturing the composition

The present invention relates to a functional cream/serum showing sufficient antibacterial and antifungal effects by adding a vegetable extract to the base. More specifically, the present invention is a water-soluble polymer, an oily mixture, a crosslinking agent (架橋劑; crosslinking agent), by mixing lemon extract, thyme extract, and tea tree extract in a base containing moisture and skin beauty ingredients to prevent community pneumonia. It relates to a method and composition for preparing a cream/serum with sufficient antibacterial effect.

In general, it contributes greatly to the prevention of infectious diseases by promoting personal hygiene by removing germs or dust present on the hands. In the case of community pneumonia, the mortality rate reaches 12-14% despite antibiotic treatment and is considered one of the most common causes of death among infectious diseases. It is said to be the number one cause of death due to infection among the top 10 causes of death in Korea.

On the other hand, hand creams related to hands refer to creams that prevent roughness of hands by replenishing oil in the hands. They are usually developed and sold focusing on functions such as whitening and skin wrinkle improvement that are not related to hygiene. It has a limitation that it does not help at all for hygiene, which is directly related to health or public health.

In addition, in the case of a general ethyl alcohol (ethyl alcohol, ethanol)-based hand sanitizer, there is a disadvantage in that the skin becomes dry if frequently used. This can make the skin more drier and more irritating in dry weather in autumn and winter, when community pneumonia is predominant. The ethyl alcohol (ethanol) component can make microscopic cracks in the epidermal layer of the skin, making it easier for bacteria to enter during secondary infection.

In addition, the frequent use of ethyl alcohol (ethanol) can lead to irritant contact dermatitis. Some argue that the reason is the frequent use of ethyl alcohol (ethanol)-based hand sanitizers.

A study that ethyl alcohol (ethanol) itself damages the lipid membrane, which plays an important function in skin protection, between the keratinocytes, the outermost layer of the skin, thereby reducing the moisture content of the skin and breaking the pH (hydrogen ion concentration index) balance There are also results. In addition, it is known that it suppresses the inhabitation of normal skin surface bacteria and creates a more vulnerable environment when exposed to external pathogens.

1. Korean Patent Publication 10-2017-0088053. 2. Korean Patent Publication No. 10-2010-0125303. 3. International publication WO 2019/073874.

The present invention is a cream/serum with sufficient antibacterial and antifungal effects, based on natural ingredients (vegetable extracts), not ethyl alcohol-based, that can help personal hand hygiene while satisfying the unique moisturizing function of hand creams. It is an object of the invention to provide

The present invention achieves insecticidal and sterilization and disinfection effects through lemon balm extract and thyme extract, and at the same time relieves skin diseases and heals wounds, and suppresses aging of hand skin with aloe vera gel, ialuronic acid, and purified water. Minimizes the skin drying effect that can occur when using ethanol-based cleaners through hand creams/cleansers.

The present invention provides a hand cream/hand sanitizer in which at least a vegetable extract is blended in a base. In addition, the present invention provides a hand cream / hand sanitizer, wherein the base comprises a water-soluble polymer, an oily mixture, a crosslinking agent, moisture and a skin care component.

The present invention relates to an antibacterial cream/serum in which at least a vegetable extract is blended in a base. In addition, the present invention provides an antibacterial cream/serum, wherein the base includes a water-soluble polymer, an oily mixture, a crosslinking agent, moisture, and a skin care component.

As a preferred embodiment of the water-soluble polymer according to the present invention, deionized (DI)-water, glycerin and carbomer may be used. As a preferred embodiment of the oily mixture according to the present invention, caprylic/capric triglyceride, arachidyl alcohol, and behenyl alcohol may be used.

As a preferred embodiment of the present invention, the oily mixture may include neopentyl glycol diethylhexanoate and caprylic/capric triglyceride.

In addition, as a preferred embodiment of the crosslinking agent according to the present invention, polyacrylate salt and lecithin may be used.

As a moisture and skin cosmetic component according to the present invention, it may include any one or two or more from the set consisting of nylon-12 and glycerin.

As a preferred embodiment of the vegetable extract having an antibacterial and antifungal effect according to the present invention, lemon myrtle, Backhousia citriodora or lemon balm, Melissa officinalis), thyme extract (white thyme, Thyme vulgaris/zygis), tea tree extract (tea tree, Melaleuca alternifolia), peppermint extract (peppermint, Mentha piperita), eucalyptus extract (eucalyptus, Eucalyptus globulus, Eucalyptus camaldulensis, Eucalyptus citriodora), lavender extract (lavender, Lavandula augustifolia) may be included.

As a preferred embodiment of the blending amount of the vegetable extract component according to the present invention, it is preferably composed of 0.001 to 0.4 mass·%.

Hereinafter, the base and composition components used in the present invention will be described. The base that can be used in the cream/serum of the present invention is not particularly limited, but a base containing a water-soluble polymer, an oily mixture, a crosslinking agent, moisture and skin care ingredients is preferred.

As a water-soluble polymer, purified water (deionized(DI)-water), glycerin, trehalose, betaine, allantoin, panthenol, carbomer, niacinamide (niacinamide), sodium hyaluronate (sodium hyaluronate), disodium EDTA, etc. are mentioned, and it is possible to use each individually or by combining two or more types.

As the blending amount of these water-soluble polymers, the adhesiveness and cohesiveness of the formulation, shape retaining properties, absorption capacity, etc., as well as the viscosity during production, uniformity of solids, workability, and From the viewpoint of improving the feeling of use, 50 to 95 mass·%, preferably 70 to 92 mass·%, more preferably 80 to 90 mass·% may be used.

In addition, as a preferred embodiment of the oily mixture according to the present invention, neopentyl glycol diethylhexanoate, caprylic/capric triglyceride, cetearyl glucoside ( cetearyl glucoside), hydrogenated lecithin, macademia ternifolia seed oil, arachidyl alcohol, arachidyl glucoside, behenyl alcohol, vinyldime Chicon (vinyl dimethicone), etc. are mentioned, and it is possible to use each individually or by combining 2 or more types.

The blending amount occupied in the total amount of the base material is 1 to 20 mass %, preferably 1 to 10 mass %, from the viewpoint of adhesion and cohesiveness of the formulation, water retention and shape retention before use, cream uniformity, workability, feeling of use, etc. , more preferably 5 to 8 mass·%.

As a preferred embodiment of the crosslinking agent according to the present invention, sodium acrylates copolymer, hydrogenated polyisobutane, lecithin, polyglyceryl-10 stearate ), and sunflower seed oil (Helianthus annuus (sunflower) seed oil), and it is possible to use each alone or by combining two or more types.

These crosslinking agents, from the viewpoints of cohesiveness, shape retention and stability of the preparation, workability, safety on the skin and feeling of use, etc., furthermore, adhesion, cohesiveness, shape retention, viscosity during manufacture, and uniformity of solids From the standpoint of the above, 0.01 to 3.0 mass·%, preferably 0.02 to 1.0 mass·%, more preferably 0.05 to 0.8 mass·% is used.

Examples of the neutralizing agent according to the present invention include deionized water, arginine, and the like, and can be used individually or by mixing two or more types.

As additional moisturizing, nutritious and skin care ingredients, allantoin, lecithin, amino acids, proteins, sugars, or vitamin A, vitamin C, vitamin D, vitamin E and derivatives thereof, other vitamins or derivatives thereof, nylon-12 (nylon-12), ketotifen, arylsulfatase B; bufexamac, bendazac, butyl flufenamate, ibuprofen piconol, indomethacin, aspirin, flurbiprofen, Ketoprofen, piroxicam, 2-pyridinemethyl mefenamic acid, 5,6-dihydroarachidonic acid, 5,6- methano-LTA ₄ (5,6-methano-LTA ₄ ), esculetin, eupatilin, It is possible to use 4-dimethyleupatilin (4-demethyleupatilin, benzoxaprofen, etc.) individually or by mixing two or more types.

As a preservative, propanediol, 1,2-hexanediol, hydroxyacetophenone, etc. can be used individually or by mixing two or more types.

In addition to the above base components, conventionally known preservatives, moisturizing ingredients, antioxidants, tackifiers, solubilizers, pigments, fragrances, surfactants, ultraviolet absorbers, inorganic fillers, PH adjusters, etc. can be blended in appropriate amounts.

The antibacterial cream or antibacterial serum based on a vegetable extract according to the present invention has the following unique effects.

(a) It is easy to handle.

(b) The antibacterial effect is obtained from plant extracts and is independent of ethyl alcohol.

(c) Nevertheless, the antibacterial activity is excellent and the effect is sustainable for a sufficient period (at least 24 hours).

(d) It has excellent skin safety.

(e) The evaluation of fragrance and feeling of use is excellent.

(f) It moisturizes the skin sufficiently.

(g) Does not cause secondary skin damage and contact dermatitis caused by ethyl alcohol.

1 is a photograph of an antimicrobial activity test according to a first embodiment of the present invention;
2 is a photograph of an antimicrobial activity test according to a second embodiment of the present invention;

Hereinafter, the first, second, and experimental examples of the present invention will be described in more detail. However, the spirit of the present invention is not limited to these examples.

Ingredient name first embodiment
(ingredient %) second embodiment
(ingredient %) antibacterial plant
extract thyme extract
(Thyme vulgaris/zygis) 0.68 0.34 Lemon Balm Extract
(Melissa officinalis) - 0.34 Lemon Myrtle Extract
(Backhousia citriodora) 0.34 - Peppermint Extract
(Mentha piperita) - 0.34 Eucalyptus Extract
(Eucalyptus globulus) - 0.34 lavender extract
(Lavandula augustifolia) - 0.34 tea tree extract
(Melaleuca alternifolia) 0.34 - water-soluble polymer DI-water (purified water) 76,81 76,81 Glycerin (glycerin) 7.00 7.00 Trehalose 0.20 0.20 Betaine 0.20 0.20 Allantoin (Allantoin) 0.10 0.10 Panthenol 0.10 0.10 Carbomer (Carbomer) 0.20 0.20 Niacinamide
(Niacinamide) 0.50 0.50 Sodium hyaluronate
(Sodium Hyaluronate) 0.02 0.02 Disodium EDTA
(Disodium EDIT) 0.02 0.02 oily mixture Neopentyl glycol diethylhexanoate
(Neopentyl glycol
diethylhexanoate) 2.00 2.00 Caprylic/capric triglycerides
(Caplylic/
capric triglyceride) 2.00 2.00 Cetearyl glucoside
(cetearyl glucoside) 0.24 0.24 Hydrogenated lecithin
(hydrogenated lecithin) 0.20 0.20 Macademia ternifolia seed oil
(Macadamia Oil) 1.00 1.00 Arachidyl alcohol
(Arachidyl Alcohol) 0.55 0.55 Behenyl alcohol
(behenyl alcohol) 0.30 0.30 Arachidyl glucoside
(Arachidyl Glucoside) 0.15 0.15 Vinyl dimethicone
(vinyl dimethicone) 0.50 0.50 crosslinking agent Sodium acrylates copolymer
(Sodium acrylate copolymer) 0.31 0.31 Hydrogenated polyisobutane
(hydrogenated
polyisobutene) 0.25 0.25 Lecithin (lecithin) 0.05 0.05 Polyglyceryl-10 stearate
(Polyglyceryl-10 Stearate) 0.05 0.05 Helianthus annuus(sunflower) seed oil 0.04 0.04 corrector Arginine (Arginine) 0.25 0.25 Other (moisturizing) Nylon-12 (Nylon-12) 0.50 0.50 Propanediol (propanediol) 2.00 2.00 antiseptic 1,2-hexanediol (1,2-hexanediol) 1.00 1.00 Hydroxylacetophenone
(Hydroxyacetophenone) 0.50 0.50 fragrance Peony (Peony) 1.64 1.30

■ Example 1 antibacterial activity evaluation

For the composition prepared according to the first embodiment of the present invention, an antibacterial activity test was performed. The strains used were Klebsiella pneumonia, Escherichia coli, Staphylococcus aureus, or Pseudomonas aeruginosa, and the number of bacteria as shown in Table 2 below was inoculated, exposed to the sample for 30 minutes, and left at room temperature for 24 hours to measure the number of bacteria. The reduction rate (%) was calculated as [(initial number of bacteria - number of bacteria after time elapsed)/initial number of bacteria] x 100. 1 is a photograph of an antibacterial activity test according to a first embodiment of the present invention.

Test Items number of inoculum Results (CFU/mL) Decrease rate (%) Klebsiella pneumonia 1.16 x 10 ⁴ CFU/mL 3 99.9 Staphylococcus aureus 1.44 x 10 ⁴ CFU/mL 1,295 91.0 Escherichia coli 1.52 x 10 ⁴ CFU/mL 2,260 85.1 Pseudomonas aeruginosa 1.15 x 10 ⁴ CFU/mL 3,450 70.0

■ 2nd Example Antibacterial activity evaluation

For the composition prepared according to the second embodiment of the present invention, an antibacterial activity test was performed. For the test, 1.87 x 10 ⁴ CFU/mL of the used strain (Klebsiella pneumonia,) was mixed with the sample, exposed for 30 minutes, and left at room temperature for 24 hours to measure the number of bacteria. The reduction rate (%) was calculated as [(initial number of bacteria - number of bacteria after time elapsed)/initial number of bacteria] x 100. 2 is a photograph of an antimicrobial activity test according to a first embodiment of the present invention.

Test Items number of inoculum Results (CFU/mL) decrease rate
(%) Klebsiella pneumonia 1.87 X 10 ⁴ CFU/mL 6.5 99.9

■ Example 1 preservative force test result

For the composition prepared according to Example 1 of the present invention, Escherichia coli and Pseudomonas aeruginosa as bacteria, Bacillus subtilis as endospore, Candida albicans as yeast, and Aspergillus niger as fungus were used as test strains for the composition prepared according to Example 1 of the present invention.

The test standard should show a reduction rate of 99.95 or less (3 Log reduction) for bacteria and 99% (2 Log reduction) for yeast and fungus on the 7th day of inoculation, and there should be no proliferation until the 14th day of inoculation. Endospore bacteria should not proliferate until the 14th day of inoculation.

Viable Cell Count, Aerobic Plate Count (CFU/g or mL) after: laboratory bacteria *0 Time 2 ^nd Day 5 ^th Day 7 ^th Day 14 ^th Day Judgment S. aureus 2 x 10 ⁷ 1 x 10 ² - - - pass E. coli P. aeruginosa B. subtilis 1 x 10 ⁶ 2 x 10 ⁵ 7 x 10 ⁴ 6 x 10 ⁴ 6 x 10 ⁴ C. albicans 6 x 10 ⁵ 2 x 10 ³ 1 x 10 ² 1 x 10 - A. niger 1 x 10 ⁵ 4 x 10 ² 4 x 10 ² 2 x 10 ² -

* Actual number of cells cultured after inoculation- : 1-9 CFU/ g or mL.

■ Example 1 skin stability test result

A skin safety test was conducted with respect to Example 1. In the test, 32 healthy men and women applied this product, observed the degree of skin change after 1 hour and 24 hours, and evaluated the degree of skin irritation according to the following criteria. Table 5 shows the test results.

- : No change in skin

± : small red spots on the skin

+ : clear red spots on the skin

++: Feels like poisoning on the skin

elapsed time ++ + ± - Sum
(Person) Positive rate (%)
± more than 1 hour later first embodiment 0 0 0 32 32 0 after 24 hours first embodiment 0 0 0 32 32 0

As described above, the present invention was found to be excellent in skin antibacterial activity and excellent in skin safety.

■ Usability evaluation test result

The usability evaluation was performed about the 1st Example and 2nd Example. For the test, 80 men and women in their 20s and 40s were asked to skip 1 teaspoon each of both samples of Example 1 and Comparative Example 2 and use them on different days. After that, the subjects were evaluated in five levels with respect to the items of [moisture] [scent] [satisfaction with use]. The test results are shown in Table 6 [Moisture], Table 7 [Fragrance], and Table 8 [Use Satisfaction].

Moisture pretty good good night so so not so good very bad first embodiment 43 25 12 0 0 2nd comparative example 21 21 36 2 0

incense pretty good good night so so not so good very bad first embodiment 30 23 25 2 0 2nd comparative example 26 21 24 9 2

User Satisfaction pretty good good night so so not so good very bad first embodiment 32 25 20 3 0 2nd comparative example 19 23 32 6 0

The present invention has excellent antibacterial activity of 90%-99% against Klebsiella pneumonia and Staphylococcus aureus strains that cause community pneumonia and nosocomial infections, and excellent antibacterial activity of more than 85% against Escherichia coli, which causes enteritis and food poisoning, was confirmed. , the safety of the skin was confirmed. In addition, it gives a moist feeling to the skin and has a sufficient moisturizing effect, can be applied to quasi-drugs or cosmetics for skin and personal hygiene, and is judged to be extremely useful in industry.

Claims (6)

As an antibacterial composition in which a vegetable extract is blended in a base, the vegetable extract is a lemon fragrant extract (Lemon Myrtle, Backhousia Citriodora or Lemon Balm, Melissa Officinalis) or a thyme extract (White Thyme, Thyme Vulgaris/Zygis). An antibacterial composition characterized in that it. The antibacterial composition according to claim 1, wherein the base comprises a water-soluble polymer, an oily mixture, a crosslinking agent, and a skin care component. The antibacterial composition according to claim 2, wherein the water-soluble polymer comprises purified water (DI Water) and glycerin. The antibacterial composition according to claim 2, wherein the oily mixture comprises neopentyl glycol diethylhexanoate and caprylic/capric triglyceride. The antibacterial composition according to claim 2, wherein the crosslinking agent comprises sodium acrylates copolymer and hydrogenated polyisobutane. The antibacterial composition according to claim 2, comprising at least propanediol and nylon-12 as skin cosmetic ingredients.

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