KR20220084527A - Composition for muscle strengthening, physical performance improvement and muscle fatigue recovery - Google Patents

Abstract

The present invention relates to a composition for improving muscle strength, improving athletic performance, and recovering from exercise fatigue, and specifically, a composition for enhancing muscle strength, improving athletic performance, and recovering from exercise fatigue containing a starfish extract, a ginkgo extract and/or a landing extract as an active ingredient is about

Description

Composition for muscle strengthening, exercise ability improvement and exercise fatigue recovery {Composition for muscle strengthening, physical performance improvement and muscle fatigue recovery}

The present invention relates to a composition for improving muscle strength, improving athletic performance, and recovering from exercise fatigue, and specifically, a composition for enhancing muscle strength, improving athletic performance, and recovering from exercise fatigue containing a starfish extract, a ginkgo extract and/or a landing extract as an active ingredient is about

In general, when muscles are not continuously exercised, muscle function deteriorates with aging, and a decrease in muscle mass and muscle nerve junctions occurs. In this case, it is easy to feel fatigued and lethargic, and vitality is reduced, and the quality of life can drop sharply. Here, fatigue refers to a state of deterioration of the body caused by the accumulation of repetitive physical use and mental work. When fatigue is continuously accumulated, complex actions occur in the body. This can eventually lead to damage to the muscles and organs within the body.

To improve the quality of life, regular exercise has become a part of modern people's lives, and the importance of exercise is being emphasized to enjoy leisurely life with the well-being craze, and to prevent and treat various geriatric diseases. With such social interest, not only athletes but also the general public want more energy and endurance in their daily life, and the need for supplements for improving exercise performance and effective recovery from fatigue is increasing.

Recently, research to develop functional supplements using natural products with guaranteed safety, such as plant extracts, is being actively conducted. For example, a research paper on the improvement of exercise performance and anti-fatigue effect of Sanyak (Non-Patent Document 1), a research paper on the effect of beverages containing ginseng mugwort extract on athletes' fatigue recovery substances, heart rate, and serum lipids ( Non-Patent Document 2), research papers on the effect of seaweed extract intake on aerobic ability, exercise fatigue, and concentration (Non-Patent Document 3), etc. exist.

On the other hand, the starfish has a flat, star-shaped body, and is a marine animal that is commonly encountered in coastal areas. It is known that about 30 species of starfish inhabit the coast of the country, and the breeding rate is very high, spawning 2 to 3 million per fish. 47 species of starfish have been reported in Korea, and northern species are more abundant than in the south.

In particular, the Amur starfish ( Asterias amurensis ) is a starfish of the genus Asteraceae, widely distributed in the Pacific Northwest. The diameter is about 30cm and the arm length is around 9cm, and the color variation between individuals is severe from white to indigo purple. It has five arms and forms a large star. The upper part is covered with short spines, and there are one or two crown spines along the tibia.

It lives on the shallow sandy bottom of the coast at a depth of 100m, and is a Korean wave animal from cold regions such as the Kamchatka Peninsula and Hokkaido. Amur starfish are gluttons that eat anything, hence the nickname 'Pirates of the Starfish World'. My favorite food is clams. When it preys on shellfish, it wraps it with its five long arms, then presses it with the countless tube feet attached to its arms to forcefully open the shell. When the shell of the clam opens even a little, the stomach is taken out and turned inside out to secrete digestive enzymes. After a while, the clams melt, leaving only the shell. A mature Amur starfish can easily eat 4 sea urchins, 2 abalone, and 10 mussels a day. Once a shoal of Amur starfish has swept through, there are no surviving shells. Foods include clams, sea urchins, crabs, shrimp, abalone, and mussels. The damage is so great that people are developing ways to use the starfish efficiently. It is mainly used as a fertilizer and recently, it is said that it is also used as a raw material for cosmetics by taking advantage of the fact that Amur starfish contains a lot of collagen.

Star starfish ( Asterina pectinifera ) is a starfish in the family Starfish family, distributed in Korea, Japan, Sakhalin Island, and Primorsky Krai. The arm length is about 6 cm and the body is pentagonal. It has 5 arms by default, but there are cases where it has 4 or 6 arms. The upper side of the body is high, and the lower side is flat. The upper side of the body has a red pattern on a blue background, and the lower side is light orange. As a carnivore, it feeds on aquatic animals such as seashells, midges, and Amur starfish, and lays eggs in May and June. Larvae that hatch from eggs go through the larval stage of non-finnaria, which leads a floating life. Starfish can be found under reefs and sand gravel in shallow waters off the coast of the country.

Spider starfish ( Ophioplocus japonicus ) is an arachnid of the order Arachnid, which refers to all arachnids belonging to the class Arachnid, but also refers to only one species of spider starfish (O. japonicus). It is distributed in East Asia such as Korea, Japan, the Philippines, and Hong Kong, and its habitat is mainly from the intertidal zone to the deep sea. Unlike other types of starfish, they are very active. The diameter of the body is about 2 cm and the arm length is 7 cm. The mouth is in the center of the body, and the mouth is surrounded by teeth. Spider starfish have no excretory organs, or anus, on their legs, so they excrete waste through their mouth. It feeds on small animals and plankton. It is an oviparous male and female separately (hermaphrodite), goes through a larval called 'Opioplutheus' and metamorphoses to become an adult.

The red starfish ( Certonardoa semiregularis ) is a starfish in the family Red starfish family with a typical appearance that comes to mind when thinking of starfish. It lives in Korea, Japan, the Malay Islands, the Philippines, and Indonesia. The color of the body is red and the body is small. It has 5 arms and is about 10cm long. The lower side of the body is orange, and there are two rows of crown feet in a narrow stern groove extending from the mouth to the tip of the arm in the middle. A red starfish parasitizes on its arm and sometimes makes a hump. It reproduces by direct development, and the eggs are large and the yolk is abundant. After the egg comes out of the body, it floats in the water, attaches to another object, and then metamorphoses to become a larva. It inhabits rocks and sandy bottoms of about 10cm deep, eats midges, etc., and is said to be easily caught in shrimp gills.

Ginkgo biloba L. grows mainly in Korea, China, and Japan. Leaves with a length of 5-10 cm are produced alone on old branches and several in clusters on short branches. The leaf body is fan-shaped, and the middle part is often split. The pollination season is May, and two ovules are attached to a 2 cm stalk in a female tree, and the number of spores hangs in a stalk with a length of 3 to 4 cm in a male tree. Ginkgo biloba ripens to yellow in October and has a foul odor. Seeds and leaves are used as herbal medicines, and they are called ginkgo or ginkgo leaves. The seeds have antitussive, expectorant, and heat action, and the leaves or extracts of the leaves are used as thrombolytic agents, treatment of peripheral circulatory disorders, memory recovery, and prevention of high blood pressure.

It is the root of Phytolacca esculenta Houttuyn or Phytolacca americana Linne (Phytolaccaceae). It is also called Jangbulo. It has a cone-shaped root and is branched into several branches. The outer surface is grayish-brown to gray-yellow, and the horizontal pits and vertical grooves are clearly visible. The ones that are in circulation are those that are cut horizontally or vertically, and are not uniform in size or thickness. The slices cut horizontally are bent and not flat, and the edges are wrinkled, 3~9cm in diameter, and 0.2~1cm in thickness. The cut side is light yellowish brown to yellowish white, and it can be seen that the neck is raised to form several concentric rings.

The inventors of the present invention newly confirmed that starfish, ginkgo biloba and/or land extracts do not show toxicity and irritation through numerous experiments and have superior muscle enhancement, exercise ability improvement and exercise fatigue recovery effects compared to conventional products. came to the conclusion of the invention.

Korean Patent No. 1,689,259 (2016.12.19) Korean Patent No. 1,794,607 (2017.11.1) Korean Patent No. 2,050,100 (2019.11.22)

Na-Ri Park, et al., Exercise performance improvement and anti-fatigue effect of Sanyak, Journal of Korean Medicine Rehabilitation Vol. 30 No. 2, (2020) Park Seong-hye et al., Effects of Beverage Containing Injin Mugwort Extract on Fatigue Relief Substances, Heart Rate, and Serum Lipids in University Athletes, Journal of the Korean Society for Food and Nutrition, Vol. 33, No. 5, pp. 839-846, (2004) Jinho Yoon et al., Effects of seaweed extract intake on aerobic ability, exercise fatigue and concentration, Journal of the Korean Sports Association, Vol. 11, No. 2, pp. 287-297, (2013)

In the present invention, it is intended to provide a composition for strengthening muscles, improving athletic performance and/or recovering from exercise fatigue.

Specifically, in the present invention, it is intended to provide a composition capable of rapidly recovering from exercise fatigue while exhibiting the effect of strengthening muscles and improving exercise capacity.

In addition, in the present invention, it is an object of the present invention to provide a composition for strengthening muscles, improving exercise capacity and/or recovering from exercise fatigue without side effects to the human body.

In order to solve the above technical problem, the present invention provides a composition for strengthening muscles, improving athletic performance, or recovering from exercise fatigue containing a starfish extract.

As the starfish, you can use the Amur starfish ( Asterias amurensis ), the star starfish ( Asterina pectinifera ), the spider starfish ( Ophioplocus japonicus ) or the red starfish ( Certonardoa semiregularis ).

In one aspect of the present invention, there is provided a composition for strengthening muscles, improving athletic performance or recovering from exercise fatigue, which further contains a ginkgo extract together with a starfish extract.

Here, Ginkgo biloba L. can use the fruit, leaves, roots, stems, and bark of the ginkgo tree.

In one aspect of the present invention, there is provided a composition for strengthening muscles, improving athletic performance or recovering from exercise fatigue, which further contains a landing extract together with the starfish extract.

Landing here refers to the root of the rhododendron ( Phytolacca esculenta Houttuyn ) or American locust ( Phytolacca americana Linne ).

In another aspect of the present invention, there is provided a composition for strengthening muscles, improving athletic performance or recovering from exercise fatigue, comprising a starfish extract, a ginkgo extract and a landing extract.

In one aspect of the present invention, each of the extracts may be extracted with a solvent selected from the group consisting of water, C _1-4 lower alcohol, and a mixed solvent thereof.

In one embodiment of the present invention, the extract may be formulated in one or more formulations selected from the group consisting of tablets, granules, capsules, pills, liquids, jellies, and gums.

In one aspect of the present invention, the extract may be formulated in one or more formulations selected from the group consisting of creams, gels, lotions, ointments, pastes, tapes and aerosols.

In one aspect of the present invention, the extract is for use by the elderly, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition is provided.

In one aspect of the present invention, the extract is to relieve muscle pain due to muscle fatigue, muscle enhancement, exercise capacity improvement or exercise fatigue recovery composition is provided.

In one aspect of the present invention, the extract is formulated as a cosmetic composition applicable to the skin, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition is provided.

The present invention can provide a composition having an excellent effect on muscle enhancement, improvement of exercise capacity, and recovery from exercise fatigue.

In addition, since the composition according to the present invention is made of natural substances, the risk of side effects is low, and skin toxicity and allergic reactions do not occur, so there is no need for separate rinsing, so it is easy to apply. It can be used widely.

The present invention relates to a composition for strengthening muscles, improving athletic performance, or recovering from exercise fatigue containing a starfish extract.

As the starfish, you can use the Amur starfish ( Asterias amurensis ), the star starfish ( Asterina pectinifera ), the spider starfish ( Ophioplocus japonicus ) or the red starfish ( Certonardoa semiregularis ).

In one aspect of the present invention, there is provided a composition for strengthening muscles, improving athletic performance or recovering from exercise fatigue, which further contains a ginkgo extract together with a starfish extract.

Here, Ginkgo biloba L. can use the fruit, leaves, roots, stems, and bark of the ginkgo tree.

In one aspect of the present invention, there is provided a composition for strengthening muscles, improving athletic performance or recovering from exercise fatigue, which further contains a landing extract together with the starfish extract.

Landing here refers to the root of the rhododendron ( Phytolacca esculenta Houttuyn ) or American locust ( Phytolacca americana Linne ).

In another aspect of the present invention, there is provided a composition for strengthening muscles, improving athletic performance or recovering from exercise fatigue, comprising a starfish extract, a ginkgo extract and a landing extract.

In one aspect of the present invention, each of the extracts may be extracted with a solvent selected from the group consisting of water, C _1-4 lower alcohol, and a mixed solvent thereof.

In one embodiment of the present invention, the extract is formulated in one or more formulations selected from the group consisting of tablets, granules, capsules, pills, liquids, jellies, and gums, muscle enhancement, exercise ability improvement or recovery from exercise fatigue A composition is provided.

In one aspect of the present invention, the extract is formulated in one or more formulations selected from the group consisting of creams, gels, lotions, ointments, pastes, tapes and aerosols, for muscle enhancement, improving athletic performance or recovering from exercise fatigue A composition is provided.

In one aspect of the present invention, the composition of the present invention may further comprise a carrier and a vehicle. Specifically, partial glyceride mixtures of ion exchange resins, alumina, aluminum stearate, lecithin, serum proteins (e.g. human serum albumin), buffers (e.g. various phosphates, glycine, sorbic acid, potassium sorbate, saturated vegetable fatty acids) ), water, salts or electrolytes (e.g. protamine sulfate, disodium hydrogen phosphate, potassium hydrogen phosphate, sodium chloride and zinc salts), colloidal silica, magnesium trisilicate, polyvinylpyrrolidone, cellulosic matrix, polyethylene glycol, sodium carboxy methylcellulose, polyarylate, wax or wool, etc., but is not limited thereto.

The composition comprising a carrier and a vehicle may be in various oral or parenteral dosage forms. In the case of formulation, it can be prepared using a diluent or excipient such as a filler, extender, binder, wetting agent, disintegrant, surfactant, etc. commonly used.

Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and these solid preparations include at least one excipient in the composition according to the present invention, for example, starch, calcium carbonate, water It may be prepared by mixing Sucrose or Lactose, calcium carbonate, gelatin, and the like. In addition to simple excipients, lubricants such as magnesium stearate, talc and the like may also be used.

Liquid preparations for oral administration include suspensions, internal solutions, emulsions, syrups, etc. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have.

Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like can be used.

In one aspect of the present invention, the composition according to the present invention may be commercialized in the form of food. At this time, the foods are beverages, meat, chocolate, cookies, and pizza. There are ramen, noodles, gum, ice cream, vitamin complexes, alcoholic beverages, dairy products, juice, pills, granules, tea bags and sticks, etc., and may include all foods in a conventional sense.

In one aspect of the present invention, a food supplement additive may be additionally added to the food, and various flavoring agents or natural carbohydrates may be used as the food supplement additive. The natural carbohydrates include monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and ertritol. As the sweetener, natural sweeteners such as taumartin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like can be used.

In one aspect of the present invention, the cosmetic composition includes soap, cleansing foam, cleansing cream, cleansing water, bath agent, skin lotion, skin softener, skin toner, lotion, cream, essence, astringent, emulsion, gel, lipstick, spray, shampoo, It may be prepared in any one or more formulations selected from the group consisting of rinse, treatment, body cleanser, pack, massage agent, face powder, compact, foundation, two-way cake, and makeup base, but is not limited thereto.

In one aspect of the present invention, the extract is for use by the elderly, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition is provided.

In one aspect of the present invention, the extract is to relieve muscle pain due to muscle fatigue, muscle enhancement, exercise capacity improvement or exercise fatigue recovery composition is provided.

In one aspect of the present invention, the extract is formulated as a cosmetic composition applicable to the skin, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition is provided.

Hereinafter, the present invention will be described in more detail through the following Examples and Experimental Examples. However, this is intended to help the understanding of the present invention, and is not intended to limit the scope of the present invention.

Example

(1) Preparation of starfish extract

2 L of 70% ethanol was added to 1 kg of the collected starfish (Amur starfish) and extracted at room temperature for 4 weeks. After filtration, the extracted sample was concentrated and dried in a vacuum concentrator at 100 rpm and 40 °C.

(2) Preparation of ginkgo extract

Leaves were collected from female ginkgo trees and washed with ethanol to remove moisture. The washed leaves were freeze-dried for one day, and then the dried leaves were powdered. 1 L of 70% ethanol was added to 500 g of powdered leaves, put in a stirrer at 30° C., and extracted for 24 hours to obtain an extract. This was filtered to prepare a ginkgo leaf extract.

(3) Preparation of landing extract

1 L of water was added to 200 g of landing (obtaining place: Gyeongdong Market), placed in a stirrer at 30° C., and extracted for 24 hours. This was filtered to prepare a landing water extract.

1 L of 70% ethanol was added to 100 g of landing (obtaining place: Gyeongdong Market), placed in a stirrer at 30° C., and extracted for 24 hours. This was filtered to prepare a landing 70% ethanol extract.

Experimental example

(1) Cytotoxicity test

Human fibroblasts were seeded in DMEM medium containing 10% FBS at a concentration of 1 X 10 ⁵ cells/mL in a 24-well plate, and then the medium was replaced 24 hours later. After that, each composition of Example was added at each concentration (10, 40, 70, 100, 130 mg/L), and then cultured at 37° C., 5% CO ₂ incubator for 5 days. After adding 1 mL/well of MTT solution, incubated for about 2 hours at 37 °C, 5% CO ₂ incubator, the medium was removed, 200 μL of DMSO was added thereto, and absorbance was measured at 550 nm. As a result, cell growth inhibition was hardly observed up to a concentration of 100 mg/L, and cell viability was somewhat decreased at a concentration of 130 mg/L.

(2) Affected area application test

After applying to the skin once a day for 1 week to 5 male and female subjects, skin irritation was surveyed and the presence or absence of irritation was followed up. As a result, all 10 subjects responded that they did not feel any skin irritation. Therefore, it was confirmed that the extract had no skin irritation.

(3) forced swimming experiment

After receiving 4-week-old ICR male mice and acclimatizing them for 1 week, the experimental group was divided into 3 groups, 6 animals each, the control group, the exercise group, and the experimental group. In the experimental group, each extract prepared in Example, and a combination extract thereof (starfish extract, ginkgo leaf extract, landing extract, starfish + ginkgo extract, starfish + landing extract, starfish + ginkgo leaf + landing extract) were orally administered once a day for a total of 1 week. was administered, and distilled water was administered to the control group and the exercise group.

A plastic water tank (20 cm in diameter X 20 cm in height) was filled with water at 25° C. and allowed to swim in the water bath. A weight equivalent to 5% of the body weight was hung from the tail. They were allowed to swim for 20 minutes every day for 1 week.

After one week, a forced swimming experiment was conducted with the end of administration of the test substance to measure and compare exercise capacity. The swimming time until exhaustion of the mouse was measured, and when the mouse's nose did not rise for more than 5 seconds after sinking below the surface, it was judged as exhaustion.

As a result, it was confirmed that the exercise group increased swimming time compared to the control group that did not exercise, but it was not statistically significant. In the case of the experimental group, it was confirmed that the exercise time increased statistically significantly compared to the control group.

Claims (10)

A composition for strengthening muscles, improving athletic performance, or recovering from exercise fatigue containing a starfish extract.
According to claim 1,
A composition for improving muscle strength, improving athletic performance or recovering from exercise fatigue, which further contains a ginkgo extract.
According to claim 1,
A composition for improving muscle strength, improving athletic performance or recovering from exercise fatigue, which further contains a landing extract.
A composition for strengthening muscles, improving athletic performance or recovering from exercise fatigue, comprising a starfish extract, a ginkgo extract and a landing extract.
5. The method according to any one of claims 1 to 4,
Wherein the extract is extracted with a solvent selected from the group consisting of water, C _1-4 lower alcohol, and a mixed solvent thereof, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition.
5. The method according to any one of claims 1 to 4,
The extract is formulated in one or more formulations selected from the group consisting of tablets, granules, capsules, pills, liquids, jellies, and gums, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition.
5. The method according to any one of claims 1 to 4,
The extract is formulated in one or more formulations selected from the group consisting of creams, gels, lotions, ointments, pastes, tapes and aerosols, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition.
5. The method according to any one of claims 1 to 4,
The extract is for use by the elderly, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition.
5. The method according to any one of claims 1 to 4,
The extract is to relieve muscle pain caused by muscle fatigue, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition.
5. The method according to any one of claims 1 to 4,
The extract is formulated as a cosmetic composition applicable to the skin, muscle enhancement, athletic performance improvement or exercise fatigue recovery composition.