KR20220069989A - 펩티드 링커를 갖는 헤테로 2작용성 단분산 폴리에틸렌글리콜 - Google Patents

펩티드 링커를 갖는 헤테로 2작용성 단분산 폴리에틸렌글리콜 Download PDF

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KR20220069989A
KR20220069989A KR1020227013431A KR20227013431A KR20220069989A KR 20220069989 A KR20220069989 A KR 20220069989A KR 1020227013431 A KR1020227013431 A KR 1020227013431A KR 20227013431 A KR20227013431 A KR 20227013431A KR 20220069989 A KR20220069989 A KR 20220069989A
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group
formula
bond
drug
antibody
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KR1020227013431A
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Korean (ko)
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유키 마츠노
히로키 요시오카
아키라 스즈키
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니치유 가부시키가이샤
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
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    • C07—ORGANIC CHEMISTRY
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KR1020227013431A 2019-09-26 2020-09-25 펩티드 링커를 갖는 헤테로 2작용성 단분산 폴리에틸렌글리콜 KR20220069989A (ko)

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JPJP-P-2019-176066 2019-09-26
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PCT/JP2020/036195 WO2021060439A1 (ja) 2019-09-26 2020-09-25 ペプチドリンカーを有するヘテロ二官能性単分散ポリエチレングリコール

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015057699A (ja) 2009-10-21 2015-03-26 ディール、アーカーオー、シュティフトゥング、ウント、コンパニー、コマンディトゲゼルシャフトＤｉｅｈｌ ＡＫＯ Ｓｔｉｆｔｕｎｇ ＆ ＣＯ．ＫＧ 建物自動化および建物情報システム
JP2016063006A (ja) 2014-09-17 2016-04-25 トヨタ紡織株式会社 柱状集合体
WO2018181059A1 (ja) 2017-03-30 2018-10-04 日油株式会社 ヘテロ二官能性単分散ポリエチレングリコール及びそれを用いた複合体

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0247730A3 (en) 1986-04-28 1989-04-12 Antibody Technology Limited Antibodies, their preparation and use and products containing them
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
DE68921982T4 (de) 1988-06-14 1996-04-25 Cetus Oncology Corp Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
JP3068180B2 (ja) 1990-01-12 2000-07-24 アブジェニックス インコーポレイテッド 異種抗体の生成
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US7063845B2 (en) 2000-04-28 2006-06-20 Gemini Science, Inc. Human anti-CD40 antibodies
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
NZ534174A (en) 2002-01-09 2007-03-30 Medarex Inc An isolated human monoclonal antibody which binds to human CD30
ES2544527T3 (es) 2002-07-31 2015-09-01 Seattle Genetics, Inc. Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
ZA200603619B (en) 2003-11-06 2008-10-29 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
WO2005058367A2 (en) 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules
US8562965B2 (en) * 2004-05-03 2013-10-22 Nektar Therapeutics Polymer derivatives comprising an acetal or ketal branching point
NZ550934A (en) 2004-05-19 2010-05-28 Medarex Inc Chemical linkers and conjugates thereof
KR20120064120A (ko) 2004-06-01 2012-06-18 제넨테크, 인크. 항체 약물 접합체 및 방법
CN100475837C (zh) * 2004-06-11 2009-04-08 北京键凯科技有限公司 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物
AU2005254736B2 (en) * 2004-06-18 2011-08-18 Ipf Pharmaceuticals Gmbh Oligomeric peptides and their use for the treatment of HIV infections
JP2008521828A (ja) 2004-11-29 2008-06-26 シアトル ジェネティックス， インコーポレイテッド 操作された抗体およびイムノコンジュゲート
WO2006088248A1 (ja) * 2005-02-18 2006-08-24 Nof Corporation ポリオキシアルキレン誘導体
CN101168594B (zh) * 2006-10-24 2011-07-27 北京键凯科技有限公司 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
FR2949469A1 (fr) 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
JP5825507B2 (ja) * 2010-06-25 2015-12-02 日油株式会社 分岐型ヘテロポリエチレングリコール
AU2012301793A1 (en) * 2011-08-30 2014-03-20 Quanta Biodesign, Ltd. Branched discrette PEG constructs
WO2014177042A1 (zh) * 2013-04-28 2014-11-06 Qin Gang 一种新型的连接子及其制备方法和用途
CN104448295B (zh) * 2013-12-02 2018-01-23 北京键凯科技股份有限公司 聚乙二醇‑多爪寡肽键合的雷帕霉素衍生物
CN104109235B (zh) * 2014-05-30 2017-07-18 厦门赛诺邦格生物科技股份有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN108530617B (zh) * 2017-03-05 2020-11-27 厦门赛诺邦格生物科技股份有限公司 一种支化聚乙二醇异双官能化衍生物、其制备方法及其双组份生物相关物质缀合物
JP7204078B2 (ja) * 2018-03-13 2023-01-16 日油株式会社 主鎖および側鎖に単分散ポリエチレングリコールを有するヘテロ二官能性化合物
JP6630390B2 (ja) 2018-03-29 2020-01-15 アオイ電子株式会社 半導体装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015057699A (ja) 2009-10-21 2015-03-26 ディール、アーカーオー、シュティフトゥング、ウント、コンパニー、コマンディトゲゼルシャフトＤｉｅｈｌ ＡＫＯ Ｓｔｉｆｔｕｎｇ ＆ ＣＯ．ＫＧ 建物自動化および建物情報システム
JP2016063006A (ja) 2014-09-17 2016-04-25 トヨタ紡織株式会社 柱状集合体
WO2018181059A1 (ja) 2017-03-30 2018-10-04 日油株式会社 ヘテロ二官能性単分散ポリエチレングリコール及びそれを用いた複合体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nature Biotechnology, 2015, 33, 733-735

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