KR20220041057A - Solid tablets toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate - Google Patents

Abstract

Disclosed is a solid toothpaste tablet containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride, and sodium pyrophosphate to increase a tooth whitening effect, a tooth decay and tartar prevention effect, and safety. According to the present invention, the solid toothpaste tablet is manufactured by mixing 50 to 95 wt% of a binder containing one or more selected from sugar alcohols or cellulose derivatives, 1 to 50 wt% of silicon dioxide, 0.001 to 5 wt% of sodium fluoride, 0.001 to 5 wt% of pyridoxine hydrochloride, and 0.001 to 5% by weight of sodium pyrophosphate, and 0.4 to 45 wt% of other additives, and using a wet granulation, dry granulation, or direct tablet forming methods.

Description

{Solid tablets toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate}

The present invention relates to a toothpaste, and more particularly, to a solid tablet-type toothpaste comprising silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate.

Toothpaste is a drug compound used to clean the inside of the teeth and oral cavity, and has various uses, such as whitening teeth, preventing tartar deposition, and removing bad breath, and is used as a daily necessities.

Conventional toothpaste is made in the form of cream or gel, and it is common to put the toothpaste in a tube with a lid and use the toothpaste pushed out through the tube entrance by applying pressure to the tube whenever it is used.

However, the tube container of toothpaste increases the production cost, and the tube container remaining after using up the toothpaste is not recycled, which causes environmental pollution.

In addition, in the case of infants or children of lower grades, it is not easy to squeeze toothpaste alone and put it on the toothbrush, and if the tube is left open, it may be exposed to various bacteria.

To solve this problem, the present applicant has developed a tablet-type toothpaste in the form of a tablet (Patent Application No. 10-2011-0083295, "tablet toothpaste").

The solid tablet-type toothpaste does not require a tube container, so production cost is reduced, storage and use are easy, exposure to various bacteria can be prevented, and it is easy to carry.

However, since the solid tablet-type toothpaste is a solid preparation in the form of a final product, unlike the conventional general tube toothpaste, the manufacturing method is different from that of the general tube toothpaste, and the ingredients must also be different.

In particular, in order to sufficiently exhibit the original functions of toothpaste such as whitening teeth, preventing tartar deposition, and removing bad breath as a solid agent, an optimal combination of ingredients different from that of general tube toothpaste is absolutely necessary.

Document 1. Korean Intellectual Property Office, Patent Application No. 10-2011-0083295, "Tablet toothpaste"

The present invention has been devised to solve the above problems, and by manufacturing a solid tablet-type toothpaste using silicon dioxide as an abrasive, sodium fluoride as a fluorine compound, pyridoxine hydrochloride as an antioxidant, and sodium pyrophosphate as a tartar deposition inhibitor The purpose of this is to improve the tooth whitening effect, caries and tartar prevention effect and safety of toothpaste.

The solid tablet toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate for achieving the object of the present invention as described above is a binder in which one or two or more selected from sugar alcohols or cellulose derivatives are combined. 50 to 95% by weight, 1 to 50% by weight of silicon dioxide, 0.001 to 5% by weight of sodium fluoride, 0.001 to 5% by weight of pyridoxine hydrochloride, 0.001 to 5% by weight of sodium pyrophosphate, 0.4 to 45% by weight of other additives It can be prepared in wet granulation type.

Here, the toothpaste may be prepared by a wet granulation method including the steps of mixing, kneading, granulating, drying, sizing, and tableting.

In addition, 50 to 95% by weight of a binder containing one or more selected from sugar alcohols or cellulose derivatives, 1 to 50% by weight of silicon dioxide, 0.001 to 5% by weight of sodium fluoride, 0.001 to 5% by weight of pyridoxine hydrochloride , 0.001 to 5% by weight of sodium pyrophosphate, and 0.4 to 45% by weight of other additives may be mixed to form dry granules.

Here, the toothpaste may be prepared by a dry granulation method including the steps of mixing, kneading, granulating, sizing, and tableting.

In addition, 50 to 95% by weight of a binder containing one or more selected from sugar alcohols or cellulose derivatives, 1 to 50% by weight of silicon dioxide, 0.001 to 5% by weight of sodium fluoride, 0.001 to 5% by weight of pyridoxine hydrochloride , 0.001 to 5% by weight of sodium pyrophosphate, and 0.4 to 45% by weight of other additives may be mixed to form direct tableting.

Here, the toothpaste may be manufactured by a direct tableting manufacturing method including the steps of mixing and tableting.

In addition, as other additives, one or more foaming agents selected from among anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants and zwitterionic surfactants may be further added.

In addition, as other additives, one or two or more types of sweeteners selected from natural sweeteners and artificial sweeteners may be further added.

In addition, as other additives, one or two or more of mint types such as peppermint and spearmint and fragrances such as menthol, eucalyptus, anise, thymol, lemon, lime, coffee, green tea, rosemary, and jasmine are selected and mixed. It can be prepared by adding more.

In addition, as other additives, a lubricant selected from calcium stearate, magnesium stearate, sodium stearate, and stearic acid may be further added.

The solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate according to the present invention is a solid tablet-type toothpaste, and has the advantage of being convenient to carry and convenient to use.

In addition, by using silicon dioxide as an abrasive, there is an effect of less irritation to teeth and oral cavity.

In addition, as an antioxidant, pyridoxine hydrochloride has the effect of preventing stomatitis or glossitis and improving oral health.

In addition, sodium pyrophosphate as a tartar deposition inhibitor has an effect of preventing tartar from sticking to the teeth.

In addition, by using sodium fluoride as a fluorine compound, the caries prevention efficacy is maintained, and there is an advantage in that the functionality and safety of the toothpaste can be secured at the same time.

1 is a view showing a state in which the solid tablet-type toothpaste according to the present invention is contained in a container and used.

Hereinafter, the present invention will be described in detail with reference to a preferred embodiment of the present invention and the accompanying drawings, but the same reference numerals in the drawings will be described on the premise that they refer to the same components.

When it is said that any one component "includes" another component in the detailed description or claims of the invention, it is not construed as being limited to only the component, unless otherwise stated, other components It should be understood that more may be included.

Hereinafter, an example in which a solid tablet toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate is implemented will be described through specific examples.

1 is a view showing a solid tablet-type toothpaste prepared by the present invention.

As shown in the drawing, the toothpaste 10 according to the present invention is prepared in the form of a tablet and put in the container 1, and then taken out one by one and chewed in the oral cavity to create bubbles. You can brush your teeth by brushing your teeth with a toothbrush.

Therefore, there is an advantage of being easy to carry and easy to use compared to the tube-type toothpaste.

The toothpaste according to the present invention can improve the functions of the toothpaste, such as tooth whitening effect, caries and tartar prevention effect, and bad breath removal, by including the components described below while maintaining the convenience of use of the solid tablet-type toothpaste as described above.

As basic ingredients for the manufacture of solid tablet-type toothpaste, binders, abrasives, and foaming agents are required. Additives according to functions such as fluorine compounds, antioxidants, and tartar deposit removers, as well as additives according to the user's preference such as sweeteners and flavoring agents, etc. It can be prepared by adding more.

Abrasives play a role in removing tartar and plaque from teeth together with brushing, and the stronger the abrasive, the higher the effect of removing tartar and plaque.

In the present invention, it is most preferable to use silicon dioxide as an abrasive.

Silicon dioxide has no salty taste and has a neutral pH, so it does not irritate the mucous membranes in the oral cavity, so it has the advantage that anyone, regardless of age or gender, can use it safely.

However, replace with calcium pyrophosphate, aluminum hydroxide, precipitated silica, hydrous silicic acid, hydrous alumina, insoluble sodium metaphosphate, zirconium silicate, sodium bicarbonate, aluminosilicate, tricalcium phosphate, calcium diphosphate dihydrate and anhydrous, calcium carbonate It is possible to manufacture the product even if it is used.

In addition, natural fiber abrasives such as cellulose and its derivatives, and natural material pulverized powders such as egg shells and seashells pulverized powder can also be used as abrasives.

One or two of the above materials are selected and included as an abrasive, but the content is 1 to 50% by weight, preferably 5 to 30% by weight, based on the total weight of the solid tablet-type toothpaste according to the present invention.

On the other hand, the binder serves to maintain the shape of the toothpaste by preventing each component from being separated in preparing a toothpaste as a solid formulation.

Sugar alcohol or cellulose derivatives can be used as the binder in the toothpaste according to the present invention.

Sugar alcohol refers to an alcohol having two or more hydroxyl groups formed by reducing the carbonyl group of a monosaccharide, or a compound belonging to the same family.

Because the chemical composition is different from that of ordinary sugar, the properties are quite different from that of ordinary sugar, and it is suitable as a binder for toothpaste because it has lower calories than regular sugar and does not cause tooth decay.

Sugar alcohol includes substances such as sorbitol, xylitol, maltitol, erythritol, reduced palatinose, mannitol, and lactitol, and these substances can be used as binders.

In addition to the sugar alcohol, dextrin, maltodextrin, cellulose derivatives (crystalline cellulose, microcrystalline cellulose, etc.) may also be used as a binder.

One or two or more selected from the above sugar alcohols or binders other than sugar alcohols are mixed and used as a binder, but the content is 50 to 95 wt%, preferably 60 to 85 wt%, of the total weight of the toothpaste according to the present invention %am.

The foaming agent creates bubbles inside the oral cavity when brushing with toothpaste to clean tartar, etc.

In the toothpaste according to the present invention, the foaming agent includes anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, zwitterionic surfactants, and the like.

The most representative anionic surfactants are sodium lauryl sulfate (SLS) and sodium coconut monoglyceride sulfonate.

Other suitable anionic surfactants include sarcosinates such as sodium lauroyl sarcosinate, taurates, sodium lauryl sulfoacetate, sodium lauroyl isethionate, sodium laureth carboxylate and sodium dodecyl benzenesulfonate. etc.

In addition, cocamidopropyl betaine, poloxamer, sorbitan mono oleate, PEG-40 sorbitan isostearate, or a mixture thereof may also be used.

One or two or more of the above substances are selected and used as a foaming agent, but the content is about 0.1 to 15% by weight, preferably 1 to 10% by weight, based on the total weight of the toothpaste according to the present invention.

On the other hand, it may contain a fluorine compound to improve the functionality of the toothpaste, the fluorine compound is formulated in the toothpaste to increase the acid resistance of the tooth has an effect of preventing tooth decay.

It is most preferable to use sodium fluoride as the fluorine compound in the toothpaste according to the present invention.

Fluorine, commonly known as fluorine, is a highly toxic substance. Sodium fluoride is a substance recomposed into a compound by neutralizing it with sodium.

The material has the advantage of being able to secure the functionality and safety of toothpaste at the same time by minimizing the toxicity of fluorine while maintaining the efficacy of preventing tooth decay.

However, sodium monofluorophosphate, fluoride stone, fluorinated amine, etc. can also be used as fluorine compounds.

One or two or more of the above substances are selected and used as the fluorine compound, but the content is 0.001 to 5% by weight, preferably 0.1 to 1% by weight, based on the total weight of the toothpaste according to the present invention.

On the other hand, antioxidants block the generation of free radicals in the body or have the ability to remove active oxygen by reacting with already generated free radicals, that is, a substance having antioxidant activity. plays a role in maintaining health.

It is most preferable to use pyridoxine hydrochloride as an antioxidant of the toothpaste according to the present invention.

Pyridoxine hydrochloride is a substance known as vitamin B6, and has excellent antioxidant action. In particular, its deficiency is known to cause periodontitis, stomatitis, glossitis, etc. in the oral cavity.

Therefore, when the toothpaste contains the above component as an antioxidant, there is an effect of preventing the inflammation and improving oral health.

However, vitamins such as sodium ascorbate, tocopheryl acetate, nicotinic acid amide, and calcium pantothenate can also be used as antioxidants.

One or two or more of the above substances are selected and used as antioxidants, but the content is 0.001 to 5% by weight, preferably 0.1 to 2% by weight, based on the total weight of the toothpaste according to the present invention.

On the other hand, the tartar deposition inhibitor serves to prevent tartar from sticking to the teeth.

It is most preferable to use sodium pyrophosphate as the tartar deposition inhibitor of the toothpaste according to the present invention.

However, acid sodium pyrophosphate, potassium pyrophosphate, sodium metaphosphate, etc. can also be used as tartar deposition inhibitors.

One or two or more of the above substances are selected and used as a tartar deposition inhibitor, but the content is 0.001 to 1% by weight, preferably 0.1 to 2% by weight, based on the total weight of the toothpaste according to the present invention.

In the manufacture of solid tablet-type toothpaste, silicon dioxide is used as an abrasive, but sodium fluoride as a fluorine compound, pyridoxine hydrochloride as an antioxidant, and sodium pyrophosphate as a tartar deposition inhibitor are used. It was confirmed that the effect of increasing the acid resistance of teeth and inhibiting the deposition of tartar was maximized.

That is, by mixing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate in a predetermined binder, and then preparing a solid tablet-type toothpaste having a predetermined shape by dry granulation, wet granulation or direct tableting, It can maximize the original functionality of toothpaste, such as whitening teeth, preventing tartar deposition, and removing bad breath.

In addition, it can be prepared by further including the following components.

First, the sweetener hides the original bitter taste of toothpaste so that you can brush your teeth more easily.

Natural sweeteners and artificial sweeteners can be used as sweeteners, and xylitol, stevioside, erythritol, saccharin, sucralose, sugar, lactose, mannitol, maltitol, aspartame, taurine, saccharin salt, D - Tryptophan, etc. can be used.

One or two or more of the above substances are selected and used as a sweetener, but the content is 0.1 to 10% by weight, preferably 1 to 5% by weight, based on the total weight of the toothpaste according to the present invention.

On the other hand, the flavoring agent is a means for reinforcing, modifying, or suppressing the smell of toothpaste, and serves to help users brush their teeth with a refreshing feeling without feeling repulsed when brushing.

As the flavoring agent, mint such as peppermint and spearmint and flavorings such as menthol, eucalyptus, anise, thymol, lemon, lime, coffee, green tea, rosemary, and jasmine can be used.

One or a mixture of two or more of the above substances is used as a flavoring agent, but the content is 0.1 to 10% by weight, preferably 1 to 5% by weight, based on the total weight of the toothpaste according to the present invention.

On the other hand, the toothpaste according to the present invention may further contain a gelling agent, a medicinal agent, a thickener, a viscosity modifier, a preservative, a pigment, and the like, in addition to the above-mentioned ingredients.

On the other hand, the toothpaste according to the present invention is a solid tablet type, and a process of purifying the mixture of the components is compressed into a solid form is required.

For the preparation of the solid tablet-type toothpaste according to the present invention, three methods can be used: a dry granulation method, a wet granulation method, and a direct tableting method.

When explaining each method, the wet granulation method goes through the steps of mixing, kneading, granulating, drying and sizing.

In the mixing step, the materials are mixed and mixed with a mechanical powder mixer until each component is evenly mixed and distributed.

The kneading step is a step to make granules by mixing the binder solution and excipients.

The granulation step is a step of extruding the mixture through a sieve (granulator) to make granules.

The granulation step may be performed by hand, or a special device for extruding through a hole in the device may be used.

The granules formed through the above process are evenly spread on a shallow tray, etc. and dried.

In the drying step, drying is performed using a dryer such as a temperature-controlled constant temperature dryer, a hot air dryer, or an electric heating dryer.

In the sizing step, the granules are aligned by passing the granules through a finer sieve than the sieve used in the assembling step.

This allows the granules to be quickly filled in the tableting machine during tableting.

Thereafter, a lubricant can be added to the granules, and the lubricant serves to impart fluidity and gloss to the granules during the tableting process of the granules, and to allow the compressed tablets to easily come out of the frame of the tableting machine.

On the other hand, the dry granulation method is similar to the wet granulation method, but it is a method utilized when using pre-dried materials.

This is used to make granules without using a binder when the components of toothpaste are sensitive to moisture or heat.

Except for the drying step, the remaining steps are the same as the wet granulation method.

On the other hand, the direct tableting method is a method of making tablets by mixing each component and putting it directly into a tableting machine and tableting.

This method is used when there is no need to make granules because the raw material has free-flowing and cohesive properties. Since the granule manufacturing step is unnecessary, it has the advantage of rapidly manufacturing complete tablets without changing any components.

The technical idea of the present invention has been reviewed through the above several embodiments.

It is apparent that those of ordinary skill in the art to which the present invention pertains can variously modify or change the above-described embodiments from the description of the present invention. In addition, even if not explicitly shown or described, a person of ordinary skill in the art to which the present invention pertains may make various modifications including the technical idea according to the present invention from the description of the present invention. is self-evident, which still falls within the scope of the present invention. The above embodiments described with reference to the accompanying drawings have been described for the purpose of explaining the present invention, and the scope of the present invention is not limited to these embodiments.

1: Courage
10: solid tablet type toothpaste

Claims (10)

50 to 95% by weight of a binder containing one or more selected from sugar alcohols or cellulose derivatives, 1 to 50% by weight of silicon dioxide, 0.001 to 5% by weight of sodium fluoride, 0.001 to 5% by weight of pyridoxine hydrochloride; A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared in a wet granular form by mixing 0.001 to 5% by weight of sodium pyrophosphate and 0.4 to 45% by weight of other additives. The method of claim 1,
A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared by a wet granulation method comprising the steps of mixing, kneading, granulating, drying, sizing and tableting. 50 to 95 wt% of a binder containing one or more selected from sugar alcohols or cellulose derivatives, 1 to 50 wt% of silicon dioxide, 0.001 to 5 wt% of sodium fluoride, 0.001 to 5 wt% of pyridoxine hydrochloride, fatigue A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared in a dry granular form by mixing 0.001 to 5% by weight of sodium phosphate and 0.4 to 45% by weight of other additives. 4. The method of claim 3,
A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared by a dry granulation method comprising the steps of mixing, kneading, granulating, sizing and tableting. 50 to 95 wt% of a binder containing one or more selected from sugar alcohols or cellulose derivatives, 1 to 50 wt% of silicon dioxide, 0.001 to 5 wt% of sodium fluoride, 0.001 to 5 wt% of pyridoxine hydrochloride, fatigue A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared by direct injection by mixing 0.001 to 5% by weight of sodium phosphate and 0.4 to 45% by weight of other additives. 6. The method of claim 5,
A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared by a direct tableting method comprising the steps of mixing and tableting. 7. The method according to any one of claims 1 to 6,
Silicon dioxide, characterized in that it is prepared by adding one or more foaming agents selected from anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants and zwitterionic surfactants as other additives; A solid tablet toothpaste containing sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate. 7. The method according to any one of claims 1 to 6,
A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared by further adding one or two or more types of sweeteners selected from natural and artificial sweeteners as other additives. 7. The method according to any one of claims 1 to 6,
Other additives, such as peppermint and spearmint, and menthol, eucalyptus, anise, thymol, lemon, lime, coffee, green tea, rosemary, jasmine, etc. A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is manufactured by 7. The method according to any one of claims 1 to 6,
A solid tablet-type toothpaste containing silicon dioxide, sodium fluoride, pyridoxine hydrochloride and sodium pyrophosphate, characterized in that it is prepared by further adding a lubricant selected from calcium stearate, magnesium stearate, sodium stearate, and stearic acid as other additives.

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