RU2252011C1 - Tablets for oral hygiene and method for their obtaining - Google Patents

Abstract

FIELD: medicine, hygiene.

SUBSTANCE: the present tablets are designed in solid form and contain the substance of purifying action in the form of finely dispersed insoluble abrasive components, SAS, aromatizing agents, dyestuffs, thickening agents, moreover, the content of water in components should be decreased by 35-37%. The suggested tablets should be prepared due to mixing the components with water to form solid forms out of obtained homogeneous plastic material at the room temperature to be then dried up and packed. Tablets for disposable intake provide great consumer's latitude being very convenient at usage.

EFFECT: higher efficiency of application.

16 cl

Description

The invention relates to dentistry and cosmetology, in particular to the creation of means for oral hygiene.

Currently, there are many options and forms of oral compositions for oral hygiene in the form of toothpastes, gel preparations, tooth powders, mouthwashes and mouthwashes, chewing gums, tablets, lozenges, aerosols, and the like. Oral compositions contain in their recipe components for cleansing the teeth, keeping the teeth and gums in good condition and removing odors.

A new composition with modified physical properties is patented for toothpastes with reduced fluidity (patent RU 2127581), in which the vein with toothpaste easily breaks and does not spread, which improves the dosage of the paste. The desire to improve the physical properties of toothpaste or gel leads to the creation of viscoelastic compositions (patent RU 2089176). There are toothpastes in which the active substance is in dense granules that are crushed by a toothbrush (patent RU 2139034). Solid oral compositions are known in the form of chewing gums, lozenges, lozenges (patents RU 2163480, 2148395, 2097020). The use of oral compositions in the form of chewable or absorbable tablets has long been known and is widely used. Chewable tablets with oral compositions are typically used to rapidly absorb the active therapeutic component through the oral mucosa (US Pat. Nos. 4,820,523, 6,060,878) and the like. Sometimes the technology of incorporating the active substance into microcapsules is used, which are pressed into a filler that hides the taste of the active substance when chewed, or the drug is not intended to be absorbed in the mouth (US Pat.

Oral compositions in absorbable or chewable tablets are widely used in oral hygiene in children. In the USA, tablets containing fluoride and vitamins, for example, Poly-Vi-Flor, are used in children from 6 years of age. (American Academy of Pediatrics, Committee on Nutrition / Fluoride Supplementation for Children: Interim Policy Recommendations / Pediatrics / 1995; 95: 777).

Oral tablets containing calcium and fluorine are also available (US Pat. Nos. 5,476,647, 5,891,448). Types of tablets have been developed that quickly disintegrate in the mouth with a quick release of active substances (US Pat. No. 5,464,632). They can be used as a carrier of various therapeutic substances. Tablets are susceptible to damage and require specially designed packaging for them. This limits their application. The production of these tablets is expensive. They are mainly used in pediatrics. There are recipes for tablets for oral hygiene containing special components for cleaning teeth, for example, it is proposed to melt triclosan into molten sorbitol. After which the mixture is allowed to solidify at room temperature. From this mixture you can form cakes, which are then absorbed in the mouth. Instead of sorbitol, other sugars can be used (patent RU 2097020). There have been attempts to create tablets for oral hygiene, which are part of mannitol.

The closest technical solutions are tablets for the treatment of the oral cavity, described in patents US 3932606 and 4132772. These patents offer a special composition for oral hygiene in the form of tablets with mannitol. A tablet weighing about 0.5 grams needs to be crushed with teeth, and after soaking parts of the tablet with saliva when chewing, mannitol begins to dissolve in the mouth. Further, solid particles in the composition of saliva and mannitol cleanse the teeth. The disadvantage of these developments is that the compositions have a high sugar content (47.3% mannitol) and about 36% water-insoluble cleaning agents. The remainder is made up of inactive additives, flavors and antimicrobials.

The objective of the present invention is to eliminate the above disadvantages when creating means for oral hygiene in tablet form, dosed for single use and having the properties of toothpastes.

A group of inventions is proposed, united by a single inventive concept.

The oral hygiene product in solid form contains a cleaning agent in the form of finely dispersed insoluble abrasive components, surfactants, flavors, sugar if necessary, medicines, colorants, thickeners, while the water content in the components included in the product is reduced 35-75%.

The tool additionally contains glycerin up to 20% of the starting components.

As a cleaning agent, it includes substances selected from the group: calcium carbonate, calcium phosphate, magnesium carbonate, silicon dioxide, titanium dioxide.

As surfactants, it includes substances selected from the group: sodium lauryl acid sulfate, N-methyltaurate, N-lauryl sodium sacrosine.

As a flavoring agent, it includes substances selected from the group: menthol, Equamentol, natural flavors.

As sugars, it includes substances selected from the group: sorbitol, aspartame, mannitol.

As medicines, it includes substances selected from the group: silver, soluble alkali metal fluorides - sodium fluoride, monovalent copper fluoride.

As thickeners, it includes substances selected from the group: cellulose, food glues, for example gelatin.

The tool is made in the form of cakes, tablets.

A method for preparing oral hygiene products in solid form is also proposed, which consists in mixing the components, the water content of which is reduced by 35-75%, with water, forming solid forms from the resulting homogeneous plastic material at room temperature, which are dried and packaged.

Solid forms are made in the form of cakes, tablets.

The solid forms are dried at room temperature, or by gentle heating, or by vacuum.

Solid forms are additionally stained or varnished and sprinkled with colored powder.

The tool in the form of tablets, lozenges is packaged in blisters or in the form of disposable packaging in the form of sweets.

The hardness of tablets and lozenges is regulated by adding up to 20% glycerol to the initial mixture.

On the surface of tablets, lozenges apply drawing or embossing.

The proposed tool for oral hygiene in the initial stages of obtaining resembles the production of conventional toothpastes. The proportions of all components in general correspond to the proportions of toothpastes with the exception of a reduced water content. As a result of reducing the water content in the mass used for the production of toothpaste, it turns out not a liquid paste, but a dense mass from which tablets, lozenges, etc. The water content is selected depending on the composition of the original toothpaste. The criterion for the correct selection of the ratio of water to solid products for a particular mixture is the possibility of obtaining dense objects that retain their shape. The finished product before contact with water is not a paste, but it has all the properties of toothpastes, which are manifested when chewing it in the mouth and in contact with water.

For the manufacture of this tool apply the composition of existing toothpastes. They usually consist of the following components:

water-insoluble, powdery cleaning agents, for example, calcium carbonate, calcium phosphate, magnesium carbonate, silicon dioxide, titanium dioxide or other finely divided insoluble abrasive components;

surfactants, for example, sodium lauryl acid sulfate, N-methyltaurate, N-lauryl sodium sacrosine or other means;

aromatic substances, for example phenolic flavors containing menthol, equamentol or natural flavors;

sugars, for example sorbitol, aspartame, mannitol and the like;

various therapeutic additives, for example silver or soluble alkali metal fluorides: sodium fluoride, monovalent copper fluoride and antibacterial components, for example: N.sup.1- (4-chlorobenzyl) -N.sup.5- (2,4-dichlorobenzyl) biguanide ; p-chlorophenyl biguanide; 4-chlorobenzylhydril biguanide or other non-toxic substances.

Glycerin is also added to the mixture or solutions of sorbitol, propylene glycol or polyethylene glycol are included. Thickeners, for example cellulose, and food glues, for example gelatin, from 0.2 to 10% are added. You can use other components that are widely used in the manufacture of toothpastes. Water is present in all toothpastes. Its content varies depending on the formulation of a particular toothpaste from 35 to 75%. Water can be domestic, water hardness is not limited. Allowed calcium carbonate content up to 500 ppm.

Unlike the finished toothpaste, the finished mixture for the production of tablets resembles dense thick dough or sculpted clay. This mass is not packed in tubes, as is done in the production of toothpastes, but at room temperature tablets or objects of a different shape are formed, which, after final drying at room temperature or accelerated drying when heated, at a temperature of 50-80 degrees or in a vacuum chamber they are packed or, if necessary, undergo further processing: they are painted, varnished, sprinkled with colored powder, etc. They can be painted or embossed. The hardness of the tablets may vary depending on the residual water content. It is possible to use glycerol up to 20% in the initial mixture. Ready-made tablets are not a paste before contact with water. They maintain a stable shape, they are solid, can have different sizes and are already dosed for single use. Unlike known tablets, the claimed tablet has an elastic consistency and is readily soluble in the mouth. After getting into the mouth and chewing with water, the tablet turns into a liquid toothpaste and performs all the functions of a toothpaste. Unlike the known ones, it does not contain fillers that reduce effectiveness: the active components do not mix with molten sugars (mannitol, mannitol, sucrose, etc.), do not melt and are not pressed into them. The sugar content is lower than in known forms.

To test the effectiveness of the claimed funds, tablets and toothpaste were made having the same composition except for the water content. The water content of the tablets was 2-25% lower. The test was carried out with the participation of Global Trials (Clinical Trial Management, 79312 Emmendingen, PB 1263, Germany), which performed technical tasks.

The test toothpaste before vacuum drying contained the following components 100%:

Insoluble sodium metaphosphate 40.0

Sodium lauryl sulfate 3.0

Dicalcium phosphate dehydrate 4.0

Gum tragacant 1.5

Stannous fluoride 0.4

Natural aromatic oil 1.0

Water 30.0

Glycerine (99.3%) 17.9

Antimicrobial agent 0.1

Saccharin Na 0.6

The mass for the preparation of tablets was obtained by placing the test toothpaste in a vacuum chamber at a temperature of 60 degrees Celsius until weight loss of 20%. From the resulting mass, tablets were prepared which, for complete hardening, were again placed in a vacuum chamber. The resulting tablets were compared with reference toothpaste.

The test involved 24 adult subjects. All subjects had healthy teeth. The age ranged from 17 to 23 years. The test lasted 5 days. 12 subjects used reference toothpaste and the remaining 12 used toothpaste tablets. Dental hygiene was carried out 2 times a day. The quality of toothbrushing was carried out using the method of diagnostic staining of teeth with reagent from Diaplague Co. Of Astra Sweden. The test results showed no differences between the consumer properties of the test toothpaste and tablets. All subjects perceived the use of tablets as “convenient” or “interesting”. Negative ratings were not observed. Loss of taste or aroma was not observed when using tablets.

Single-use tablets provide greater freedom of choice for consumers compared to hygiene products in tubes and bottles. For example, during working hours or during a short trip, it is inconvenient to carry standard 75-100 gram tubes or boxes of tooth powder with you. It is enough to take a few tablets of a new product with you. Bright multi-colored pills or figures can be interesting for children. Of particular interest is this tool for hotels. A survey conducted by Global Trials in Germany showed that hotel guests use about 40-60% of the contents of the toothpaste tubes offered at the hotel. Every day, a large number of plastic tubes with the remains of toothpaste are collected, which are taken out with garbage.

You can produce this product in blisters or in paper, in the form of sweets, chocolates.

Claims (16)

1. A means for oral hygiene in solid form, characterized in that it contains a cleaning agent in the form of finely dispersed insoluble abrasive components, surfactants, flavors, if necessary, sugars, drugs, dyes, thickeners, and the water content in the components that make up the tool are reduced by 35-75%. 2. The tool according to claim 1 further comprises glycerin up to 20% of the starting components. 3. The tool according to claim 1, as a cleaning agent, it includes substances selected from the group of calcium carbonate, calcium phosphate, magnesium carbonate, silicon dioxide, titanium dioxide. 4. The tool according to claim 1, as a surfactant, it includes substances selected from the group of sodium sulfate, lauryl acid, N-methyltaurate, N-lauroyl sodium sacrosin. 5. The tool according to claim 1, as a flavoring agent, it includes substances selected from the group of menthol, Equamentol, natural flavors. 6. The tool according to claim 1, as sugars, it includes substances selected from the group of sorbitol, aspartame, mannitol. 7. The tool according to claim 1, as medicines, it includes substances selected from the group of silver, soluble alkali metal fluorides, sodium fluoride, monovalent copper fluoride. 8. The tool according to claim 1, as a thickening agent, it includes substances selected from the group of cellulose, food glues, for example, gelatin. 9. The tool according to claim 1 is made in the form of cakes, tablets. 10. The method of preparation of oral hygiene products in solid form, characterized in that the components, the water content of which is reduced by 35-75%, are mixed with water, solid forms are formed from the obtained homogeneous plastic material at room temperature, which are dried and Packed up. 11. The method according to claim 10, the solid form is made in the form of cakes, tablets. 12. The method according to claim 10, the solid form is dried at room temperature, or by gentle heating, or vacuum. 13. The method according to claim 10, solid forms are additionally stained or varnished and sprinkled with colored powder. 14. The method according to claim 10, the tool in the form of tablets, lozenges is packaged in blisters or in the form of disposable packaging in the form of sweets. 15. The method according to claim 10, the hardness of the tablets, lozenges is regulated by adding up to 20% glycerol in the initial mixture. 16. The method according to claim 10, on the surface of the tablets, lozenges cause drawing or embossing.