KR20220038068A - Cd3 항원 결합 단편 및 이를 포함하는 조성물 - Google Patents

Cd3 항원 결합 단편 및 이를 포함하는 조성물 Download PDF

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KR20220038068A
KR20220038068A KR1020227002573A KR20227002573A KR20220038068A KR 20220038068 A KR20220038068 A KR 20220038068A KR 1020227002573 A KR1020227002573 A KR 1020227002573A KR 20227002573 A KR20227002573 A KR 20227002573A KR 20220038068 A KR20220038068 A KR 20220038068A
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seq
amino acid
antigen
acid sequence
receptor
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Korean (ko)
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볼커 쉘렌버거
필리페 쿤
안드레 프렌젤
다라흐 맥칸
제임스 맥로이
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아뮤닉스 파마슈티컬스, 인크.
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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    • C07K2319/00—Fusion polypeptide
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020227002573A 2019-06-26 2020-06-25 Cd3 항원 결합 단편 및 이를 포함하는 조성물 Pending KR20220038068A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962866746P 2019-06-26 2019-06-26
US62/866,746 2019-06-26
US202063041059P 2020-06-18 2020-06-18
US63/041,059 2020-06-18
PCT/US2020/039673 WO2020264200A1 (en) 2019-06-26 2020-06-25 Cd3 antigen binding fragments and compositions comprising same

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KR20220038068A true KR20220038068A (ko) 2022-03-25

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US (2) US20230121775A1 (enExample)
EP (1) EP3990497A4 (enExample)
JP (2) JP7651481B2 (enExample)
KR (1) KR20220038068A (enExample)
CN (1) CN115175933A (enExample)
AU (1) AU2020308868A1 (enExample)
BR (1) BR112021026089A2 (enExample)
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WO2019126576A1 (en) * 2017-12-21 2019-06-27 Amunix Pharmaceuticals, Inc. Release segments and binding compositions comprising same
CN116063520A (zh) 2019-01-30 2023-05-05 真和制药有限公司 抗gal3抗体及其用途
EP4337697A4 (en) 2020-04-04 2025-05-14 Janux Therapeutics, Inc. Compositions and methods related to tumor-activated antibodies against EGFR and effector cell antigens
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法
WO2021263058A1 (en) 2020-06-25 2021-12-30 Amunix Pharmaceuticals, Inc. Her-2 targeted bispecific compositions and methods for making and using the same
US11512113B2 (en) 2020-08-11 2022-11-29 Janux Therapeutics, Inc. Cleavable linker compositions and methods
JP7621461B2 (ja) * 2020-08-20 2025-01-24 エー２ バイオセラピューティクス， インコーポレイテッド Ｅｇｆｒ陽性がんを治療するための組成物及び方法
MX2023006817A (es) 2020-12-09 2023-08-14 Janux Therapeutics Inc Composiciones y metodos relacionados con anticuerpos activados por tumores dirigidos a psma y antigenos de celulas efectoras.
WO2022170619A1 (en) * 2021-02-11 2022-08-18 Adagene Pte. Ltd. Anti-cd3 antibodies and methods of use thereof
WO2022240865A1 (en) * 2021-05-11 2022-11-17 Janux Therapeutics, Inc. Antibodies targeting egfr and cd3 and uses thereof
WO2023092099A1 (en) * 2021-11-19 2023-05-25 Ardeagen Corporation Gpc3 binding agents, conjugates thereof and methods of using the same
EP4504257A1 (en) * 2022-04-01 2025-02-12 CytomX Therapeutics, Inc. Activatable multispecific molecules and methods of use thereof
CN116063498A (zh) * 2022-04-27 2023-05-05 博际生物医药科技(杭州)有限公司 单域抗Nectin-4抗体
IL322564A (en) 2023-02-10 2025-10-01 Amunix Pharmaceuticals Inc Prostate-specific membrane antigen (PSMA)-targeting compositions and methods for their preparation and use
KR20250166225A (ko) 2023-04-17 2025-11-27 아뮤닉스 파마슈티컬스, 인크. 표피 성장 인자 수용체를 표적화하는 조성물 및 이의 제조 방법 및 사용 방법
WO2024220870A1 (en) * 2023-04-19 2024-10-24 The University Of Chicago Antibody-targeted enzymatic chemoprotection
WO2025122957A1 (en) 2023-12-08 2025-06-12 Amunix Pharmaceuticals, Inc. Protease activatable cytokines and methods for making and using the same
CN120230203A (zh) * 2023-12-28 2025-07-01 四川思柏沃生物技术有限公司 抗cd3抗体及其用途

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WO2019126576A1 (en) * 2017-12-21 2019-06-27 Amunix Pharmaceuticals, Inc. Release segments and binding compositions comprising same
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PE20220600A1 (es) 2022-04-25
US20210054077A1 (en) 2021-02-25
JP7651481B2 (ja) 2025-03-26
CO2022000406A2 (es) 2022-05-31
CL2021003448A1 (es) 2022-09-09
BR112021026089A2 (pt) 2022-03-22
AU2020308868A1 (en) 2022-01-20
CR20210628A (es) 2022-03-22
US20230121775A1 (en) 2023-04-20
WO2020264200A1 (en) 2020-12-30
DOP2021000264A (es) 2022-05-15
MX2021015880A (es) 2022-03-22
EP3990497A1 (en) 2022-05-04
ECSP22005986A (es) 2022-04-29
JP2025106277A (ja) 2025-07-15
PH12021500051A1 (en) 2023-01-23
CA3143519A1 (en) 2020-12-30
CN115175933A (zh) 2022-10-11
EP3990497A4 (en) 2023-07-19
JP2022537824A (ja) 2022-08-30
IL289102A (en) 2022-02-01

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