KR20220033726A - Hand sanitizer composition - Google Patents

Abstract

The present invention relates to a hand sanitizer composition which minimizes harm to the human body by including a material derived from a natural substance. The composition includes hypochlorous acid, acetic acid, and an excipient.

Description

Hand sanitizer composition

The present invention relates to a hand sanitizer composition, characterized in that it minimizes harm to the human body, including materials derived from natural products.

Masks and hand sanitizers for personal hygiene in accordance with the 2020 pandemic of Coronavirus Infectious Disease-19 (COVID-19), a respiratory infectious disease caused by a new type of coronavirus that first emerged in Wuhan, China in December 2019 and is spreading worldwide The importance of products for personal hygiene such as etc. is increasing.

Hand sanitizer, also called hand sanitizer or hand sanitizer, is a broad concept that not only refers to a substitute for washing hands with water, but also includes a substitute for washing hands with water after use. Na-gel type disinfectants are the mainstay.

Alcohol-containing hand sanitizers can actually exacerbate the problem in subjects with eczema by promoting the autoimmune response that causes the eczema. When exposed to alcohol, Staphylococcus aureus and other surviving bacteria respond by creating a protective biofilm. Biofilms are known to attenuate skin wound healing and reduce local antibacterial efficacy, which can also spread bacteria into the air. On the other hand, antibiotic-resistant bacteria such as MRSA can proliferate within the biofilm, leading to many serious and fatal nosocomial infections.

In order to solve the above problems, the present invention uses hypochlorous acid (HOCl) and acetic acid rather than alcohol as disinfectants. HOCl has a high oxidation ability and shows excellent disinfection ability, but there is a limitation that HOCl is an unstable compound.

It is provided in a spray type or gel type to the user's hand, and the user rubs his hand to provide a hand sanitizer composition with enhanced sterilization power so that the PLA capsule type disinfectant and ingredients harmful to the human body can be sequentially provided.

In addition, the present invention is to provide a hand sanitizer composition for preventing infectious diseases that not only safely provides non-acidic hypochlorous acid water with strong sterilization power as an eco-friendly material together with ethanol, but also provides beneficial effects to the human body through an extract derived from natural products. .

However, the objects of the present invention are not limited to the above-mentioned objects, and other objects not mentioned will be clearly understood by those skilled in the art from the following description.

The present invention for achieving the above object is hypochlorous acid (HOCl), acetic acid (HAc), water; and an excipient.

The pH of the composition is from about 3.7 to about 5.8, preferably about 4.76. The pH is achieved by titrating the composition with NaOH and HAc. The composition is usually prepared by mixing in an air-free environment, such as an environment formed by evacuating through reduced pressure.

Hand sanitizer composition for preventing infectious diseases according to another embodiment may be characterized by comprising 38 to 39 parts by weight of the first PLA coating type non-acidic hypochlorous acid water with respect to 100 parts by weight of ethanol.

The hand sanitizer composition according to an embodiment of the present invention provides a highly effective but stable HOCl and acetic acid composition. The hypochlorous acid composition of the present invention is substantially free of metal ions. The composition of the present invention has a stable pH within the range of about 3.7 to 5.8. The disclosed composition provides a stable HOCl based skin disinfectant with a long shelf life not hitherto available in the art. Other additives and excipients may be included in the composition to further enhance stability.

In addition, the hand sanitizer composition according to another embodiment of the present invention may include an extract that not only safely provides non-acidic hypochlorous acid water with strong sterilizing power as an eco-friendly material together with ethanol, but also provides beneficial effects to the human body. .

Hereinafter, a detailed description of a preferred embodiment of the present invention will be described with reference to the accompanying drawings. In the following description of the present invention, if it is determined that a detailed description of a related well-known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted.

The compositions and methods of the present invention take advantage of the protonation of hypochlorite ions (OCl ⁻ ). Using HCl and NaOCl as examples, protonation is effected by introducing an acid (such as HCl) into the solution resulting in the following reaction: HCl (aq) + NaOCl (aq) ↔ HOCl (aq) + NaCl ( aq).

In aqueous solution, hypochlorous acid partially dissociates into the anion hypochlorite (OCl ⁻ ). Accordingly, there is always an equilibrium between hypochlorous acid and the anion (OCl ⁻ ) in an aqueous solution. Such an equilibrium is pH dependent, where at higher pH the anions dominate. In aqueous solution, hypochlorous acid is also in equilibrium with other chlorine species, especially chlorine gas Cl2 and various chlorine oxides. At acidic pH, chlorine gas becomes increasingly dominant, while at neutral pH, hypochlorous acid dominates in solution. Therefore, it is desirable to control exposure to air and pH in the production of hypochlorous acid.

Any compound that generates a hypochlorite anion (OCl ⁻ ) in water can be used with the method of the present invention.

Representative compounds include NaOCl and Ca(OCl)2. In certain embodiments, the compound is NaOCl. Any compound that generates a proton (H ⁺ ) in water can be used with the method of the present invention. Representative compounds are acetic acid, HCl and acids such as H2SO4. In certain embodiments, the compound is HCl. In a preferred embodiment, the compound is acetic acid. Acetic acid is a weaker acid compared to HCl and has a desirable pKa. It is better able to maintain the desired pH level.

The pipe and mixing device may be interconnected using a sealant such that all air is purged from the system so that the method of the present invention can be performed in an air-free environment. In certain embodiments, the methods of the present invention are also carried out under pressure. Carrying out the process of the present invention under an air-free environment and pressure allows for the production of HOCl that does not interact with gases in the air (such as oxygen and CO2) that can destabilize the produced HOCl.

The hand sanitizer composition with enhanced sterilization power according to an embodiment of the present invention contains 38 to 39 parts by weight of the first PLA coating type non-acidic hypochlorous acid water and 14.7 to 21.3 parts by weight of the second PLA coating type Moringa extract based on 100 parts by weight of ethanol. , 0.7 to 0.8 parts by weight of anionic surfactant, 0.3 to 0.6 parts by weight of nonionic surfactant, and when used as a spray-type hand sanitizer, 95 to 99 parts by weight of deep sea water is additionally mixed with 100 parts by weight of ethanol or gel-type hand sanitizer When used, it may be prepared by additionally mixing 75 to 87 parts by weight of water-soluble cellulose.

Here, the deep sea water has excellent low temperature stability as the water temperature is less than about 5℃ and there is little change throughout the year. Compared to surface water, sunlight does not reach, so photosynthesis does not occur, It contains a lot of salt, and contains essential trace elements and various minerals in a balanced way. Looking at the effectiveness of deep sea water in detail, it contains zinc (Zn), selenium (Se), manganese (Mn), etc. in addition to the four essential minerals magnesium (Mg), calcium (Ca), potassium (K), and sodium (Na). It contains more minerals and is more balanced than surface water or groundwater that we use as drinking water. That is, deep sea water contains many mineral components. Among them, the main component of deep sea water is magnesium, and magnesium is one of the important nutrients for the human body. It can be provided as a substance that has a catalytic activity essential for cell activity along with it.

Here, the concentration of ethanol used in the present invention may be 90 to 100% (v/v), more preferably 85% (v/v). Ethanol may be edible grain fermented alcohol. Ethanol not only has the effect of coagulating proteins and removing the lipid layer of cells, but it can also be consumed as a component of alcohol. Since silver contains ethanol, which is harmless to the human body, distribution and storage are easy, and there is no toxicity, so it has excellent biosafety properties.

Although ethanol has an excellent sterilization effect, when included in excess in the composition, usability may be reduced by causing excessive irritation or unpleasant odor to the skin, whereas when contained in a small amount, the sterilization effect may not be sufficiently implemented, In the hand sanitizer composition for preventing infectious diseases, non-acidic hypochlorous acid water is additionally added as an auxiliary disinfectant to increase the sterilization effect, but by adding 28 to 29 parts by weight of the first PLA coating type non-acidic hypochlorous acid water with respect to 100 parts by weight of ethanol, Compared to the content of ethanol, it is possible to significantly reduce the amount used.

The non-acidic hypochlorous acid water used in the present invention has a pH of 5.0 to 6.5 and an effective chlorine concentration of 20 to 30 ppm, and is completely harmless to the human body to the extent that it can be used for sterilization of food raw materials and foods.

Such non-acidic hypochlorous acid water can be obtained by electrolyzing 3 to 7% of dilute hydrochloric acid for food addition, sea salt, and tap water in a non-diaphragm electrolyzer.

Non-acidic hypochlorous acid water is added to compensate for the disadvantage of low sterilization power due to the side effect of lowering the content of ethanol. will have

Here, the slightly acidic hypochlorous acid water used in the present invention is weakly acidic with a pH of 5.0 to 6.5, but when the pH is less than 5 strongly acidic, as the molecularly effective chlorine component, hypochlorous acid, is volatilized into chlorine, the effectiveness of the slightly acidic hypochlorous acid water There are problems such as lowering the chlorine concentration to reduce storage safety, causing irritating chlorine smell and metal corrosion.

In addition, the non-acidic hypochlorous acid water according to the present invention should have an effective chlorine concentration of 20 to 30 ppm. If the effective chlorine concentration is less than 20 ppm, effective sterilization and disinfection effects cannot be expected despite the ethanol content, and the effective chlorine concentration is 30 ppm If it exceeds the ethanol content, there is a problem such as unnecessarily high sterilization power and significantly lower economic efficiency.

The improved stability of HOCl achieved by the present invention makes it even more useful as a disinfectant than was previously possible. The disinfectant properties of HOCl are generally known. HOCl is a weak acid known to rapidly inactivate bacteria, spores, viruses, algae, fungi and other organisms, making it an effective agent across a wide range of microorganisms. Humans produce certain compounds, such as taurine, that make it possible for them to tolerate hypochlorous acid, thus making it a safe disinfectant for use on the skin. However, HOCl prepared by conventional methods is highly unstable, and hypochlorous acid is decomposed even for a short period of time (eg, several hours to two weeks). Thus, although it is an effective biocide, the use of hypochlorous acid has hitherto been limited by the need for on-site production and the challenge of maintaining storage stability.

However, the compositions and methods of the present invention provide a stable HOCl-based hand sanitizer. A preferred embodiment of the formulation comprises HOCl, acetic acid (HAc), water and excipients. The formulation can be titrated with NaOH and HAc to obtain a pH of about 4.6-4.7.

In addition to buffering the product during storage and after application, acetic acid also has the advantage of improving the sporicidal effect by 40% compared to other acids used for protonation of HOCl.

As discussed above, pH is an important factor that is controlled throughout the manufacturing process of the present invention. If the pH is too low, chlorine gas is generated, which is undesirable. If the pH is too high (as is the case with most other HOCl products on the market), the less potent OCl- ions dominate in the product equilibrium. Although the formulations of the present invention may have a pH in the range of 3.0 to 8.0, formulations at the higher limit of this range are much less potent than formulations at the preferred pH of 4.0 to 5.0, even more preferably 4.76. will be done Acetic acid has a buffering capacity of approximately 3.7 to 5.8.

The formulations of the present invention contain additives or excipients. Excipients provide the final product with other properties, such as viscosity, which are desirable for pumping and handling. Excipients may include thickening and/or chelating agents. Excipients may include, for example, inorganic thickeners such as colloidal silica, synthetic clay materials, or the products marketed under the trademark Laponite by BYK Additives, Cheshire, UK. Additionally or alternatively, excipients may include EDTA, polyethylene glycol, polysorbates, glycerol, acrylate copolymers, essential oils, buffers, cellulose derivatives or xanthan gum.

Additives may be added to the topical product for desirable hydration. Additives may also be added to improve fragrance, cleaning, preservation, or to impart other properties to the final product, and may be in the form of a cream, gel, lotion, balm or other topical ointment.

Below, many additives commonly used in hand sanitizer products known in the art are discussed. Since HOCl is an oxidizing species, the choice of additives is not trivial. Some additives should not be used with HOCl at the desired pH level. The list of additives discussed below is a non-exhaustive list of additives for use with the present invention, including conventional excipients used in hand sanitizer products or other similar product types.

Some of the excipients discussed are more desirable than others, in part based on their susceptibility to oxidation, which affects shelf life. This depends in part on other factors such as molecular variability (eg cross-linkers in some polymers), presence of metal ions (especially glycerol) and chemical origin (eg polyethylene glycol-based surfactants or sugar-based surfactants). Thus, even less desirable excipients can still be used.

In other words, xeronin activates more than 1500 enzymes in the human body, combines with vitamins, minerals, antioxidants, and serotonin in the body to regenerate damaged cells into normal cells, restore cellular functions, and deliver oxygen and nutrients into the blood. It is a substance that catalyzes essential cellular activity for transport.

In the present invention, the term "extract" is an active ingredient contained in the extraction raw material by contacting the solvent and the extraction raw material under specific conditions, and if it is a substance that separates the ingredient contained in the raw material from the natural product, it is included regardless of the extraction method or the type of the ingredient can do.

For example, extracts of components soluble in solvents from natural products using water or organic solvents, specific components of natural products, for example, products obtained by extracting only specific components such as oil may be included. The extract may be powdered after drying, or obtained by various conventionally known extraction methods such as hot water extraction and ethanol extraction.

The extract is selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, petroleum ether, ethyl acetate, butyl acetate, trichloromethane, dichloromethane, chloroform, hexane and 1,3-butylene glycol It may be extracted with one or more solvents, specifically, it may be extracted with ethanol at a concentration of 60 to 80% (v/v).

As described above, preferred embodiments of the present invention have been disclosed in the present specification and drawings, and although specific terms are used, these are only used in a general sense to easily explain the technical content of the present invention and help the understanding of the present invention. , it is not intended to limit the scope of the present invention. It will be apparent to those of ordinary skill in the art to which the present invention pertains that other modifications based on the technical spirit of the present invention can be implemented in addition to the embodiments disclosed herein.

Claims (1)

In the composition comprising hypochlorous acid, acetic acid and an excipient,
The composition has a pH of 3.7 to 5.6, and is prepared by mixing in a vacuum, hand sanitizer composition.