KR20220032079A - 섬유모세포 활성화 단백질 리간드를 포함하는 화합물 및 그의 용도 - Google Patents
섬유모세포 활성화 단백질 리간드를 포함하는 화합물 및 그의 용도 Download PDFInfo
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- KR20220032079A KR20220032079A KR1020227004043A KR20227004043A KR20220032079A KR 20220032079 A KR20220032079 A KR 20220032079A KR 1020227004043 A KR1020227004043 A KR 1020227004043A KR 20227004043 A KR20227004043 A KR 20227004043A KR 20220032079 A KR20220032079 A KR 20220032079A
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- 0 CCCCCC(N[C@@](CSCc1cc(CSCCNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC([N+]([O-])=O)=O)CC2)=O)cc(CSC[C@@](C(O)=O)*2=C([C@](CCC(NC)=C)NC([C@]([C@@](C)O)NC([C@](CCC3)N3C([C@]3N4CCC3)=O)=O)=C)N[C@@](Cc3ccccc3)C2=O)c1)C4=O)=O Chemical compound CCCCCC(N[C@@](CSCc1cc(CSCCNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC([N+]([O-])=O)=O)CC2)=O)cc(CSC[C@@](C(O)=O)*2=C([C@](CCC(NC)=C)NC([C@]([C@@](C)O)NC([C@](CCC3)N3C([C@]3N4CCC3)=O)=O)=C)N[C@@](Cc3ccccc3)C2=O)c1)C4=O)=O 0.000 description 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19000325.1A EP3763726A1 (en) | 2019-07-08 | 2019-07-08 | Compounds comprising a fibroblast activation protein ligand and use thereof |
| EP19000325.1 | 2019-07-08 | ||
| EP19198813.8 | 2019-09-20 | ||
| EP19198813 | 2019-09-20 | ||
| PCT/EP2020/069298 WO2021005125A1 (en) | 2019-07-08 | 2020-07-08 | Compounds comprising a fibroblast activation protein ligand and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20220032079A true KR20220032079A (ko) | 2022-03-15 |
Family
ID=71409439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227004043A Pending KR20220032079A (ko) | 2019-07-08 | 2020-07-08 | 섬유모세포 활성화 단백질 리간드를 포함하는 화합물 및 그의 용도 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US12427210B2 (https=) |
| EP (2) | EP3997103B9 (https=) |
| JP (3) | JP7608425B2 (https=) |
| KR (1) | KR20220032079A (https=) |
| CN (3) | CN118406106A (https=) |
| AU (1) | AU2020310538B2 (https=) |
| BR (1) | BR112022000122A2 (https=) |
| CA (1) | CA3145340A1 (https=) |
| CL (1) | CL2021003580A1 (https=) |
| DK (1) | DK3997103T3 (https=) |
| ES (1) | ES3012534T3 (https=) |
| FI (1) | FI3997103T3 (https=) |
| HU (1) | HUE070009T2 (https=) |
| IL (2) | IL320543A (https=) |
| LT (1) | LT3997103T (https=) |
| MX (1) | MX2022000252A (https=) |
| PL (1) | PL3997103T3 (https=) |
| RS (1) | RS66480B9 (https=) |
| SI (1) | SI3997103T1 (https=) |
| WO (1) | WO2021005125A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL289673B2 (en) * | 2019-07-08 | 2026-04-01 | 3B Pharmaceuticals Gmbh | Compounds comprising a protein ligand for fibroblast activation and their use |
| CA3176497A1 (en) | 2020-05-07 | 2021-11-11 | Fatima MECHTA-GRIGORIOU | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| EP4251639A1 (en) * | 2020-11-30 | 2023-10-04 | Rayzebio, Inc. | Radiopharmaceutical conjugate compositions and uses thereof |
| US20240139350A1 (en) * | 2021-02-01 | 2024-05-02 | Five Eleven Pharma, Inc | Radioactively labeled ligand for fibroblast activation protein-alpha imaging agent and preparation method therefor |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| NZ803235A (en) | 2021-02-10 | 2026-01-30 | Yantai Lannacheng Biotechnology Co Ltd | Truncated evans blue modified fibroblast activation protein inhibitor, preparation method therefor, and application thereof |
| GB202109922D0 (en) | 2021-07-09 | 2021-08-25 | Blue Earth Diagnostics Ltd | Radiotracers and therapeutics binding to fibroblast activation protein (fap) |
| EP4475900A1 (en) | 2022-02-09 | 2024-12-18 | Novartis AG | Pharmaceutical compositions comprising a 225-actinium-labelled complex and a bismuth sequestering agent |
| EP4282439A1 (en) | 2022-05-23 | 2023-11-29 | Erasmus University Rotterdam Medical Center | Radioisotope labeled sstr2-agonists with linkers |
| CN115304582B (zh) * | 2022-07-20 | 2023-05-12 | 北京法伯新天医药科技有限公司 | FAP-α特异性肿瘤诊断显像剂 |
| EP4311557A1 (en) * | 2022-07-26 | 2024-01-31 | Oncomatryx Biopharma, S.L. | Fap-targeted antibody-drug conjugates |
| JP2025530229A (ja) * | 2022-09-07 | 2025-09-11 | ３ベー ファーマシューティカルズ ゲーエムベーハー | 前立腺特異的膜抗原（ｐｓｍａ）リガンドおよびその使用 |
| EP4342890A1 (en) | 2022-09-21 | 2024-03-27 | Erasmus University Rotterdam Medical Center | Platform and scaffold for fap targeting agents |
| WO2024198838A1 (zh) * | 2023-03-27 | 2024-10-03 | 晶核生物医药科技(南京)有限公司 | 环状多肽类化合物及其应用 |
| KR20260009883A (ko) | 2023-05-24 | 2026-01-20 | 베이징 창핑 래보러토리 | 신규 삼관능 화합물 및 이의 용도 |
| TW202502800A (zh) * | 2023-07-11 | 2025-01-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種成纖維細胞活化蛋白配體及其用途 |
| CN121752300A (zh) | 2023-08-31 | 2026-03-27 | 荷兰拉德堡德大学学术医学中心 | 子宫内膜异位症示踪剂 |
| WO2025063849A2 (en) | 2023-09-21 | 2025-03-27 | Erasmus University Medical Center Rotterdam | Dimeric fap targeting agents |
| WO2025082283A1 (zh) * | 2023-10-16 | 2025-04-24 | 四川科伦博泰生物医药股份有限公司 | 环肽结构的配体化合物及其核素标记物、药物组合物及应用 |
| TW202532108A (zh) | 2024-02-01 | 2025-08-16 | 瑞士商諾華公司 | 治療癌症的方法 |
| CN121045338A (zh) * | 2025-11-05 | 2025-12-02 | 原子高科股份有限公司 | 一种靶向caix的环肽及其制备方法与应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2304206A1 (en) | 1997-09-29 | 1999-04-08 | Point Therapeutics, Inc. | Stimulation of hematopoietic cells in vitro |
| EP0953639A1 (en) | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| JP2003530092A (ja) | 2000-03-17 | 2003-10-14 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | ヒトＦＡＰ−α−特異抗体 |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| US7374898B2 (en) | 2004-10-12 | 2008-05-20 | The Research Foundation Of State University Of New York | Peptide inhibitors against seprase |
| EP1943257A2 (en) | 2005-05-19 | 2008-07-16 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| US8933201B2 (en) | 2006-06-07 | 2015-01-13 | The Board Of Regents Of The University Of Oklahoma | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use |
| WO2008116054A1 (en) | 2007-03-20 | 2008-09-25 | Trustees Of Tufts College | Inhibitors of fibroblast activation protein, and methods of use thereof |
| WO2010036814A1 (en) | 2008-09-25 | 2010-04-01 | Molecular Insight Pharmaceuticals, Inc. | Selective seprase inhibitors |
| WO2010071894A2 (en) | 2008-12-19 | 2010-06-24 | Baxter International Inc. | Tfpi inhibitors and methods of use |
| EP2483316A1 (en) | 2009-10-02 | 2012-08-08 | Ludwig Institute for Cancer Research Ltd. | Anti-fibroblast activation protein antibodies and methods and uses thereof |
| AU2011227714B2 (en) | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| HUE036077T2 (hu) | 2010-08-13 | 2018-06-28 | Roche Glycart Ag | Anti-FAP ellenanyagok és alkalmazásukra szolgáló eljárások |
| WO2013107820A1 (en) | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| WO2013141965A1 (en) | 2012-03-21 | 2013-09-26 | Baxter International Inc. | Tfpi inhibitors and methods of use |
| EP2740726A1 (en) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin receptor ligands |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| GB201402006D0 (en) | 2014-02-06 | 2014-03-26 | Oncomatryx Biopharma S L | Antibody-drug conjugates and immunotoxins |
| CN106794264B (zh) | 2014-06-10 | 2021-03-23 | 3B制药有限公司 | 包含神经降压肽受体配体的缀合物及其用途 |
| EP2954933A1 (en) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand |
| WO2016146174A1 (en) | 2015-03-17 | 2016-09-22 | Biontech Ag | Compositions and methods for diagnosis and treatment of cancer |
| EP3405476B1 (en) | 2016-01-20 | 2022-05-18 | Polypeptide Laboratories Holding (PPL) AB | METHOD FOR PREPARATION OF PEPTIDES WITH psWANG LINKER |
| WO2017211809A1 (en) | 2016-06-10 | 2017-12-14 | Bayer Pharma Aktiengesellschaft | Radio-pharmaceutical complexes |
| CN106046121B (zh) | 2016-06-20 | 2020-06-16 | 郑州大学 | 一种靶向fap的抗血管生成肽z-gp-v1及其应用 |
| CN105949282B (zh) | 2016-06-20 | 2020-06-16 | 郑州大学 | 一种靶向fap的抗血管生成肽z-gp-v2及其应用 |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| EA202090776A1 (ru) | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| IL289673B2 (en) | 2019-07-08 | 2026-04-01 | 3B Pharmaceuticals Gmbh | Compounds comprising a protein ligand for fibroblast activation and their use |
| KR20230129261A (ko) | 2021-01-07 | 2023-09-07 | 쓰리비 파마슈티컬스 게엠베하 | 섬유모세포 활성화 단백질 리간드를 포함하는 화합물및 그의 용도 |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
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2020
- 2020-07-08 CN CN202410413792.9A patent/CN118406106A/zh active Pending
- 2020-07-08 FI FIEP20735646.0T patent/FI3997103T3/fi active
- 2020-07-08 WO PCT/EP2020/069298 patent/WO2021005125A1/en not_active Ceased
- 2020-07-08 EP EP20735646.0A patent/EP3997103B9/en active Active
- 2020-07-08 RS RS20250117A patent/RS66480B9/sr unknown
- 2020-07-08 IL IL320543A patent/IL320543A/en unknown
- 2020-07-08 PL PL20735646.0T patent/PL3997103T3/pl unknown
- 2020-07-08 LT LTEPPCT/EP2020/069298T patent/LT3997103T/lt unknown
- 2020-07-08 IL IL289675A patent/IL289675B2/en unknown
- 2020-07-08 HU HUE20735646A patent/HUE070009T2/hu unknown
- 2020-07-08 DK DK20735646.0T patent/DK3997103T3/da active
- 2020-07-08 SI SI202030573T patent/SI3997103T1/sl unknown
- 2020-07-08 US US17/625,139 patent/US12427210B2/en active Active
- 2020-07-08 BR BR112022000122A patent/BR112022000122A2/pt unknown
- 2020-07-08 CN CN202080062650.2A patent/CN114341159B/zh active Active
- 2020-07-08 ES ES20735646T patent/ES3012534T3/es active Active
- 2020-07-08 JP JP2022501192A patent/JP7608425B2/ja active Active
- 2020-07-08 MX MX2022000252A patent/MX2022000252A/es unknown
- 2020-07-08 EP EP24213879.0A patent/EP4517326A3/en active Pending
- 2020-07-08 AU AU2020310538A patent/AU2020310538B2/en active Active
- 2020-07-08 KR KR1020227004043A patent/KR20220032079A/ko active Pending
- 2020-07-08 CA CA3145340A patent/CA3145340A1/en active Pending
- 2020-07-08 CN CN202410413789.7A patent/CN118388588A/zh active Pending
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2021
- 2021-12-30 CL CL2021003580A patent/CL2021003580A1/es unknown
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2024
- 2024-12-18 JP JP2024221293A patent/JP7783396B2/ja active Active
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2025
- 2025-11-18 US US19/392,245 patent/US20260061086A1/en active Pending
- 2025-11-26 JP JP2025203677A patent/JP2026035703A/ja active Pending
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| US20230212549A1 (en) | Compounds comprising a fibroblast activation protein ligand and use thereof | |
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| RU2836270C2 (ru) | Соединения, содержащие лиганд белка активации фибробластов, и их применение | |
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