KR20220002796A - Composition for improving dry eyes and preventing tear pigmentation for pets - Google Patents

Abstract

The present invention relates to a composition for mitigating dry eyes and preventing tear staining of pets. According to the present invention, the composition comprises omega-3 fatty acids, a milk thistle extract, and propolis as active ingredients. The composition includes omega-3 fatty acids to help mitigation of dry eye syndrome and inflammation, a milk thistle extract (silymarin) which strengthens liver function to help in discharging waste products, such as porphyrin which is a substance causing tear staining, from the body, and propolis having excellent natural antibacterial and anti-inflammatory properties as active ingredients, thereby relieving fatigue of a pet's eyes to relax the pet's eyes, lowering acidity of tears to naturally suppress browning (discoloration of coat color) by tears and the smell of tears, and preventing secondary infection of the skin around the eyes, which can be caused by excessively secreted tears.

Description

Composition for improving dry eyes and preventing tear pigmentation for companion animals

The present invention relates to a composition for improving dry eyes and preventing tear pigmentation for companion animals, and more particularly, omega-3 fatty acids that help improve dry eye syndrome and inflammation, porphyrin, a substance that causes tears by enhancing liver function, etc. By containing milk thistle extract (silymarin), which helps to dispose of waste products from the body, and propolis, which has excellent natural antibacterial and anti-inflammatory properties, as active ingredients, it can relieve the fatigue of the eyes of companion animals and make their eyes comfortable. By lowering the acidity, it can naturally suppress browning (discoloration of coat color) and the smell of tears caused by tears, and improve eye dryness for companion animals that can prevent secondary infection of the skin around the eyes that can occur due to excessive tears And it relates to a composition for preventing tear staining.

Recently, the family type has rapidly changed due to the nuclear family, and as the number of people living alone increases, interest in companion animals is increasing. This is being released in a variety of ways.

For example, the concept of companion animals has been changed according to the trend of becoming more and more common in an environment where people feel like a family by not only providing medical benefits to companion animals but also funerals in the event of death.

In other words, from the concept of animals bred for pleasure by humans, the perception of animals that live together with humans has changed, meaning that they are not toys for humans by respecting the various benefits that animals provide to humans. , it can be said that it clearly shows the relationship between humans and animals in modern society.

As if reflecting such a change in consciousness about companion animals, the number of individuals has increased sharply in recent years, and the industry related to cats and dogs is also continuing to grow rapidly. , Recently, commercial feed has been developed, and it is common to feed commercial feed for most companion animals.

In addition, these companion animals are being bred in general households, and in particular, dogs and cats, etc., are moving beyond the concept of animals and are becoming family members and companions in life. House, food, and other tools are essential, and in the case of food and animal cages, various types of feed and cages are widely distributed and used according to the characteristics of animals.

Meanwhile, as the global aging society and fertility rate decrease, the number of households with companion animals has reached 6 million and the number of population has reached 10 million, and the average lifespan of representative companion animals, dogs and cats, is now about As the age of 15-20 years increases, the demand for systematic nutritional supplementation to improve the health of elderly animals is also increasing rapidly.

Among the various diseases of companion animals, tear marks (or tear stains), which are common in small dog breeds such as Maltese, Pekingese, Chihuahua and Yorkshire terriers, are the most problematic disease for owners of pets. Not only is it a structural problem that occurs in cases, but it is known that the causes are diverse, such as an unbalanced diet, dust, facial hair that irritates the eyes, secondary irritation caused by other ophthalmic diseases such as allergies, conjunctivitis, keratitis, uveitis, and dry eye syndrome. have.

Specifically, porphyrins present in mammalian blood are waste products containing iron components that appear due to the breakdown of red blood cells. Unlike humans, which are excreted in feces, dogs are excreted together with tears and saliva. At this time, porphyrins react with sunlight and air It turns red, and the hair around the eyes is colored, causing tear marks.

Another cause is that there are many nutrients in tears. These nutrients cause the growth of red yeast and bacteria around the eyes, resulting in brown tear marks, and the skin around the eyes is easy to scorch and causes a bad odor. becomes this If the tear marks become severe, skin diseases such as itching around the eyes or hair loss may accompany it, and it may lead to secondary diseases, such as a series of serious eye diseases due to physical stimuli such as scratching by a dog due to itching.

In order to solve this problem, methods of injecting a tear stain remover or eye drops to a dog or cat or mixing it with feed, etc. have been proposed, and there is also a method of radical treatment with a surgical operation.

However, these drugs are only a temporary expedient, and there is a problem that recurs when taking them is stopped. have. In addition, it has been reported that post-operative complications such as damage to the nasal mucosa, sinusitis, obstruction of the tear duct, keratoconjunctivitis sicca, conjunctival edema and hyperemia, eyelid edema, and keratitis occur.

Also, in the past, supplements containing antibiotic component tylosin tartrate (inhibits pigmentation by binding with iron (Fe) contained in porphyrin pigments) were distributed for the purpose of erasing tear marks, but side effects such as tolerance occurred when taking for a long time For safety reasons, dogs and their mothers are banned or warned against use, but a safe and steady management method is needed to improve the dry eyes of companion animals and fundamentally improve the prevention of tear staining.

Domestic Patent Publication No. 10-2018-0065640 (published on June 18, 2018) Domestic Patent Publication No. 10-2014-0127703 (published on November 04, 2014) Domestic Patent Publication No. 10-2017-0084520 (published on July 20, 2017)

The present invention provides a milk thistle extract (silymarin) that helps to discharge waste products from the body, such as omega-3 fatty acids that help improve dry eye syndrome and inflammation, porphyrin, a substance that causes tears by strengthening liver function, and natural antibacterial and anti-inflammatory functions By containing this excellent propolis as an active ingredient, it can relieve the eye fatigue of companion animals and make their eyes comfortable, and lower the acidity of tears to naturally suppress browning (discoloration of coat color) and the smell of tears caused by tears. It is to provide a composition for improving eye dryness and preventing tear staining for companion animals that can prevent secondary infection of the skin around the eyes that may be caused by excessively secreted tears.

In addition, the present invention is to provide a composition for improving eye dryness and preventing tear staining for companion animals, which can be safely ingested without side effects such as antibiotic resistance even during long-term feeding and can be manufactured in a tablet type with high convenience and palatability.

Various problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

The composition for improving dry eyes and preventing tear staining for companion animals according to the present invention includes omega-3 fatty acids, milk thistle extract and propolis as active ingredients.

It may be included in a weight ratio of 0.1 to 4 parts by weight of the omega-3 fatty acid, 2 to 10 parts by weight of milk thistle extract, and 0.1 to 4 parts by weight of propolis.

In addition to the omega-3 fatty acids, milk thistle extract and propolis, meat protein, potato starch, tapioca starch, pea powder, olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate, purple sweet potato, vitamin C and It may further contain vitamin A.

0.1 to 4 parts by weight of the omega-3 fatty acid, 2 to 10 parts by weight of milk thistle extract, 0.1 to 4 parts by weight of propolis, 25 to 35 parts by weight of meat protein, 12 to 18 parts by weight of potato starch, 20 to 25 parts by weight of tapioca starch parts by weight, 5 to 10 parts by weight of pea powder, 3 to 7 parts by weight of olive oil, 3 to 7 parts by weight of fructooligosaccharide, 2 to 6 parts by weight of vegetable glycerin, 1 to 3 parts by weight of lutein, 0.5 to 3 parts by weight of cheese, mixed It may be included in a weight ratio of 0.1 to 2 parts by weight of berry concentrate, 0.1 to 2 parts by weight of purple sweet potato, 0.1 to 1 part by weight of vitamin C, and 0.1 to 1 part by weight of vitamin A.

In addition to the composition consisting of the omega-3 fatty acid, milk thistle extract, propolis, meat protein, potato starch, tapioca starch, pea powder, olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate and purple sweet potato, Cujippong It may further include fermented broth, fermented mushroom broth and silkworm matured powdered oil.

The omega-3 fatty acids, milk thistle extract, propolis, meat protein, potato starch, tapioca starch, pea powder, olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate, purple sweet potato, vitamin C and vitamins It may be further included in a weight ratio of 1 to 3 parts by weight of Cujipon fermented broth, 0.1 to 2 parts by weight of Sanghwang mushroom broth, and 2 to 4 parts by weight of fermented silkworm powder based on 100 parts by weight of the total composition consisting of A.

The meat protein may include chicken and duck meat, and the meat protein may be included in a weight ratio of 20 to 30 parts by weight of chicken and 1 to 10 parts by weight of duck.

In addition to the chicken and duck meat, a salmon and tuna mixture is further included as a meat protein, and the salmon and tuna mixture is further included in a weight ratio of 30 to 70 parts by weight based on 100 parts by weight of the chicken and duck meat, and the salmon and tuna The mixture may be included in a weight ratio of 32 to 36 parts by weight of salmon and 15 to 19 parts by weight of tuna.

Specific details of other embodiments are included in the detailed description.

The composition for improving dry eyes and preventing tear pigmentation for companion animals according to the present invention helps to discharge waste products from the body, such as omega-3 fatty acids that help improve dry eye syndrome and inflammation, and porphyrin, a substance that causes tears by strengthening liver function. By containing milk thistle extract (silymarin) and propolis with natural antibacterial and anti-inflammatory properties as active ingredients, it can relieve the eyestrain of companion animals and make their eyes comfortable. It can naturally suppress browning (discoloration of coat color) and the smell of tears, and it can prevent secondary infection of the skin around the eyes that can occur due to excessively secreted tears.

In addition, the composition for improving eye dryness and preventing tear staining for companion animals according to the present invention can be safely ingested without side effects such as antibiotic resistance even after long-term feeding, and can be prepared in a tablet type with high convenience and palatability.

It will be fully understood that embodiments of the technical idea of the present invention may provide various effects not specifically mentioned.

1A is a photograph showing the tear marks of a dog before feeding a composition for improving eye dryness and preventing tear staining for companion animals according to an embodiment, and FIG. It is a photograph showing the tear marks of a dog after feeding the composition for

Advantages and features of the present invention, and methods for achieving them, will become apparent with reference to the embodiments described below in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosed subject matter may be thorough and complete, and that the spirit of the present invention may be sufficiently conveyed to those skilled in the art.

The terms used in the present application are only used to describe specific embodiments, and are not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in a commonly used dictionary should be interpreted as having a meaning consistent with the meaning in the context of the related art, and should not be interpreted in an ideal or excessively formal meaning unless explicitly defined in the present application. does not

The composition for improving dry eyes and preventing tear staining for companion animals according to the present invention includes substances that protect the eyes themselves as well as substances that can improve liver function. It is an important organ where the vitality of the five organs and organs gathers. If there is an eye problem, it may be a problem with the eye itself, but it may also be a problem caused by a decrease in organs, especially the liver. He explains that strengthening the liver function is important for eye health .

The liver is an important organ responsible for detoxification of harmful substances, especially drugs, damaged red blood cells, microorganisms, and toxins. The more you drink, the less bile in the liver, which leads to aging of the eyes.

Hereinafter, the composition for improving dry eyes and preventing tear staining for companion animals according to the present invention will be described in detail with reference to preferred examples.

The composition for improving dry eyes and preventing tear staining for companion animals according to the present invention includes omega-3 fatty acids, milk thistle extract (silymarin) and propolis as active ingredients.

In addition, the composition for improving dry eyes and preventing tear staining for companion animals according to the present invention contains 0.1 to 4 parts by weight of the omega-3 fatty acid, 2 to 10 parts by weight of milk thistle extract (silymarin), and 0.1 to 4 parts by weight of propolis. It may be included in a weight ratio of parts.

In addition, the composition for improving eye dryness and preventing tear staining for companion animals according to the present invention includes, in addition to the omega-3 fatty acids, milk thistle extract (silymarin) and propolis, meat protein, potato starch, tapioca starch, pea powder, Olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate, purple sweet potato, vitamin C and vitamin A may be further included.

In addition, the composition for improving dry eyes and preventing tear staining for companion animals according to the present invention contains 0.1 to 4 parts by weight of the omega-3 fatty acid, 2 to 10 parts by weight of milk thistle extract (silymarin), and 0.1 to 4 parts by weight of propolis. parts, 25 to 35 parts by weight of meat protein, 12 to 18 parts by weight of potato starch, 20 to 25 parts by weight of tapioca starch, 5 to 10 parts by weight of pea powder, 3 to 7 parts by weight of olive oil, 3 to 7 parts by weight of fructooligosaccharide, Vegetable glycerin 2 to 6 parts by weight, lutein 1 to 3 parts by weight, cheese 0.5 to 3 parts by weight, mixed berry concentrate 0.1 to 2 parts by weight, purple sweet potato 0.1 to 2 parts by weight, vitamin C 0.1 to 1 parts by weight, and vitamin A 0.1 It may be further included in a weight ratio of 1 to 1 part by weight.

In addition, in the composition for improving eye dryness and preventing tear staining for companion animals according to the present invention, the meat protein may be included in a weight ratio of 20 to 30 parts by weight of chicken and 1 to 10 parts by weight of duck meat (loin), and the chicken And a mixture of salmon and tuna as meat protein in addition to duck meat may be further included.

In addition, in the composition for improving eye dryness and preventing tear staining for companion animals according to the present invention, the salmon and tuna mixture is further included in a weight ratio of 30 to 70 parts by weight based on 100 parts by weight of the chicken and duck meat, and the salmon and The tuna mixture may be included in a weight ratio of 32 to 36 parts by weight of salmon and 15 to 19 parts by weight of tuna.

The omega-3 fatty acid (Omega-3 fatty acid) is distributed in the nerve cell membrane and the retina, and serves to transfer electrical stimulation from the cell membrane to the next cell at a high speed. It protects cells in the human body, maintains the structure of cells, and helps smooth metabolism. In addition, there is an effect of inhibiting the formation of a blood film, and promoting and strengthening the bone formation.

Examples of the omega-3 fatty acids include alpha-linolenic acid (LNA), docosahexaenoic acid known as DHA, eicosapentaenoic acid known as EPA, and stearidonic acid (SDA). , and ETA (eicosatetraenoic acid).

The recommended daily amount of the omega-3 fatty acids is 0.6 to 1 g, and it contains a lot of fish oil, plankton, seafood, soybean oil, breast milk, and the like. In particular, in the case of newborns and adolescents, a larger amount is needed to help normal tissue development. Deficiency is known to cause depression, schizophrenia, attention deficit/hyperactivity disorder, blurred vision, heart disease, etc., and may increase stress.

The docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are omega-3 fatty acids and are known as the most essential fatty acids among polyunsaturated fatty acids (PUFA). . These fatty acids are distributed in large amounts in animals such as blue-backed fish (mackerel, herring, salmon, tuna) and seal oil in nature, and are also present in small amounts in some plants. DHA is an essential component of nerve cells and is widely known to be important for maintaining brain and eye health. According to an epidemiological study of Greenlanders, EPA has a strong anti-cardiovascular disease function.

The omega-3 fatty acids are known to exhibit beneficial effects on arteriosclerosis by removing risk factors for circulatory disease or changing serum lipid composition or platelet aggregation function. In particular, DHA is tested as a component of retina and brain phospholipids It is said to contribute to the improvement of brain functions including learning ability in animals.

The milk thistle extract is a material extracted from a milk thistle plant, which is a useful part of the whole herb, roots, leaves, seeds, and husks, and thistle seeds contain a flavonoid compound known as silymarin. Milk thistle extract contains 70-80% silymarin, which activates hepatocyte protein synthesis to promote hepatocyte regeneration and metabolism, and has the ability to remove active oxygen, thereby preventing hepatocyte damage from toxicity.

Recently, it has been reported that inhibition of the expression of inflammation-related factors by inhibition of the activity of macrophages present in liver tissue is related to the hepatoprotective action of silymarin. Formulations containing silymarin as an active ingredient have already been widely used clinically for the treatment of liver disease, but the active ingredient silymarin is a poorly soluble substance that is hardly soluble in water. There is a problem that it is only ~40%, so it is important to develop a formulation with improved bioavailability while maintaining pharmacological activity. I need this.

In particular, the milk thistle extract can greatly affect the palatability of companion animals because of its bitter taste and goes beyond the limit of the range of use mostly used for the prevention and improvement of liver disease, and the omega used together in the present invention -3 It was confirmed that it had a positive effect on the prevention and improvement of tear pigmentation when fed continuously for 12 weeks to animals together with ingredients such as fatty acids and propolis.

The propolis is a substance made by mixing its saliva and enzymes with a resin-like substance extracted from various plants by bees for their own survival and reproduction, and contains the most organic substances and minerals (inorganic salts). Among the components, minerals, vitamins, amino acids, fats, organic acids and flavonoids play an important role in cellular metabolism, and overall have anti-inflammatory, antioxidant and antibacterial effects, and in the present invention, the propolis is a known liquid propolis. can be used.

In relation to the immune-enhancing effect of propolis, the most important substance among the components of propolis is flavonoids. In the propolis, there are 18 types of flavonoids, and it is this flavonoid that can maintain the sterile state in the honeycomb. It's because of the ingredients.

When the flavonoid is absorbed into the body of an animal, it acts as an antioxidant by inhibiting the reaction of a specific enzyme. Propolis not only regenerates skin cells by strengthening cell membranes, but also has anti-allergic effects. In addition, it improves the resistance to infection by regulating the immunity of body tissues and promoting the immune function of the whole body. Propolis is known not only as a natural antibiotic, but also as an antiviral and antifungal agent to protect the beehive from various microorganisms and fungi and keep it clean. It is a functional material whose function has been proven through various studies.

In particular, the flavonoids are safe natural materials used to improve the eyesight of cats and dogs suffering from blepharitis, infectious conjunctivitis, corneal edema, tear duct obstruction, corneal conjunctivitis, corneal ulcers, glaucoma, etc. Through several clinical studies, ophthalmic problems without side effects It is reported to be excellent for effectively improving

The chicken, unlike red meat or fish such as pork or beef, has a low fat content and calories, so it is an animal protein source suitable for people who need weight control, patients in recovery period, the elderly with little physical activity, and modern people who lack exercise. The calories of lean meat with the chicken skin removed are only 100~110kcal/100g, so it is a low-calorie, high-protein food than red meat, mackerel (183kcal/100g), or saury (165kcal/100g).

In addition, the chicken meat is characterized by thinner and softer muscle fibers than beef, and because fat is not mixed with muscle fibers like beef, it has a light taste and is easily digested and absorbed. It has a higher content than beef and is rich in nutrients such as calcium, phosphorus, thiamine, riboflavin, niacin, retinol and unsaturated fatty acids that are converted into vitamins in the body. It is known as an excellent nutritious food that has the effect of protecting the liver and alleviating muscle atrophy, fatigue, and deterioration of eyesight caused by liver dysfunction.

In addition, the chicken is largely divided into white meat and red meat depending on the part. The breast meat is white and low in fat, so it is light, and the leg meat part is red and has a unique flavor. do.

The duck meat is a good source of iron, phosphorus, and vitamin B compared to other meat, has a higher content of unsaturated fatty acids than beef or pork, and contains abundant essential amino acids such as lysine, valine, threonine, leucine, and methionine. It is nutritionally excellent and low in calories, so it has the advantage of being suitable as a diet for weight control, a diet for patients during convalescence, and a diet for the elderly with little physical activity.

In addition, while most other meats are acidic foods, duck meat is slightly alkaline suitable for the human body. Due to its strong sodium, calcium, lecidin, and serenium components, it reduces cholesterol in blood vessels and helps prevent stroke, arteriosclerosis, and high blood pressure. It is also known as a food that helps prevent osteoporosis, diabetes, neuralgia, and cancer cell development.

The duck meat is a good source of iron, phosphorus, and vitamin B compared to other meat, has a higher content of unsaturated fatty acids than beef or pork, and contains abundant essential amino acids such as lysine, valine, threonine, leucine, and methionine. It is nutritionally excellent and low in calories, so it has the advantage of being suitable as a diet for weight control, a diet for patients during convalescence, and a diet for the elderly with little physical activity.

In addition, while most other meats are acidic foods, duck meat is slightly alkaline suitable for the human body. Due to its strong sodium, calcium, lecidin, and serenium components, it reduces cholesterol in blood vessels and helps prevent stroke, arteriosclerosis, and high blood pressure. It is also known as a food that helps prevent osteoporosis, diabetes, neuralgia, and cancer cell development.

In addition, since duck meat oil is unsaturated fat, it contains linoleic acid and linoleic acid, which are fatty acids necessary for our body, to suppress the formation of cholesterol and facilitate blood circulation. It is significantly higher than beef, pork, and chicken, and is rich in essential amino acids and various vitamins. In particular, it has a high content of vitamin C, vitamin B1, and vitamin B2, which improves endurance, prevents loss of concentration, and eliminates chronic fatigue.

In the present invention, known hydrolyzed duck meat (or hydrolyzate of duck meat) may be used as the duck meat in the present invention.

The salmon is rich in high-quality protein and fat compared to meat, and in particular, contains a large amount of omega-3 fatty acids such as DHA and EPA, so it is effective in preventing cardiovascular diseases. The omega-3 fatty acid has various effects such as wrinkle prevention, adult disease prevention, arthritis, moisturizing effect, vision protection, colorectal cancer, or osteoporosis prevention, and thus people's preference is increasing. Among the proteins of salmon, lysine and arginine, which are amino acids, and glutamic acid, which give a umami taste, are contained a lot, giving a fresh and cool feeling.

In addition, salmon is rich in vitamin A compared to other fish species, so it is good for preventing eye diseases and colds, and contains a lot of vitamin B group, so it is effective in promoting growth and alleviating gastrointestinal disorders. In addition, astaxanthin, a red pigment component of salmon, is effective in anti-aging and wrinkle improvement due to its powerful antioxidant action that removes oxygen, and vitamin D and calcium contained in salmon are good for bone health.

The tuna is a high-protein food, and as a low-fat, low-calorie fish species, it is nutritionally excellent as well as ω-3 polyunsaturated fatty acid (PUFA) elcosapentaenoeic acid (EPA, C20:5 ω-3) and docosahexaenoic acid (DHA). , C22:6 ω-3) as well as various vitamins, minerals, and amino acids such as histidine and anseline, including selenium, which has anticancer action, is a high-protein, low-calorie food with very high nutritional value.

In addition, DHA and EPA, which are unsaturated fatty acids contained in tuna, decompose cholesterol, thereby lowering serum cholesterol levels, lowering blood pressure, preventing restenosis of blood vessels, anti-inflammatory effects, relieving arthritis, inhibiting malignant tumors (anticancer effect) and heart disease, It has a preventive effect on diseases such as cirrhosis of the liver, stomach cancer, pancreatic cancer, cervical cancer, cholelithiasis, and Alzheimer's disease.

In addition, DHA contained in tuna is contained in the gray matter of the frontal lobe of the human brain and the phospholipids present in the retina. It has the effect of preventing anemia.

The potato starch can function as a carbohydrate source by being included in the composition for improving dry eyes and preventing tear staining for companion animals. The potato starch has large starch particles, high purity, relatively long amylose and amylopectin chain lengths, The presence of phosphate ester groups, the ability to exchange certain cations affecting the viscous behavior, and the ability to form a thick, viscoelastic gel upon heating and cooling. In addition, the potato starch has high viscosity, excellent film-forming ability, and low gelatinization temperature. Softness and elasticity are good when forming a gel, but the gel strength is weak. It tends to break more easily by heating and stirring.

In general, potatoes are a food resource that has been used by humans for a long time and contain a lot of starch, high-quality protein, vitamin C, vitamin B6, vitamin B8, potassium, phosphorus, magnesium, iron, dietary fiber, and phenol. It is a food with high nutritional value.

The tapioca starch is included in the composition for improving eye dryness and preventing tear staining for companion animals and serves to form a carbohydrate source and viscosity. Raw roots contain 20-30% of starch, and crushed to make tapioca by washing and precipitating the starch with water.

The potency of tapioca is close to zero sugar, fat and protein calories with 26 grams of carbohydrates per 100 calories. Additionally, tapioca is unsweetened and gluten-free, products made from cassava are easy to digest and are often recommended for people with digestive issues such as IBS or IBD, and can be consumed by people with sensitive digestive systems or those who have difficulty eating wheat. have.

The pea powder is produced by pulverizing peas and included in a composition for improving eye dryness and preventing tear staining for companion animals to function as a carbohydrate source, the pea ( Pisum sativum ) is a legume annual plant It is widely cultivated all over the world, including Korea. The peas reinforce the digestive function, lower the energy that rises upward, make the urine flow well, and treat muscle spasms, beriberi, and swelling.

The peas of the pea powder contain a large amount of vitamins and minerals such as carbohydrates, proteins, lipids, and the like, and unlike other beans, the protein content is low and the carbohydrate content is high. In addition, the peas of the pea powder are good for preventing constipation by facilitating intestinal activity and helping to reduce LLD cholesterol, which is unhealthy for the body, as dietary fiber rich in soybeans contains.

The olive oil can be included in the composition for improving dry eyes and preventing tear staining for companion animals to enhance palatability, and monounsaturated monounsaturated acids such as oleic acid play an important role in the formation of human cells and all organs in the body. Fatty acid (mono-unsaturated fatty acid) contains about 55-83% of the total fatty acid, and contains 40 kinds of enzymes including vitamins A, B, C, D, E, F, K It is known to have an excellent effect in preventing arteriosclerosis, cardiovascular-related diseases, diabetes, and obesity.

The fructooligosaccharide refers to a mixture of ingredients in which 1 to 3 fructose are bonded to sugar using a fructose transferase using sugar as a substrate. The fructooligosaccharide is included in the composition for improving eye dryness and preventing tear staining for companion animals, and it is known that it has the effect of intestinal function that helps the growth of beneficial intestinal bacteria, suppresses harmful bacteria and discharges waste, and helps smooth bowel movements. .

The vegetable glycerin may be used as a binder for formulation stability by being included in a composition for improving dry eyes and preventing tear staining for companion animals.

The lutein may be included in the composition for improving eye dryness and preventing tear staining for companion animals to protect eye tissue and prevent aging, wherein the lutein is a yellow pigment hormone in the corpus luteum cells It is abundant in the chloroplasts of plants. The lutein is a component that helps the health of the eyes by maintaining the macular pigment density although the macular pigment density decreases due to aging.

The cheese may be included in a composition for improving eye dryness and preventing tear staining for companion animals and used to enhance palatability, and the cheese is a food prepared mainly from curd, a semi-solid material formed when milk is coagulated. As a result, when the curd is formed, fat particles are wrapped in proteins and coagulated and precipitated together. Therefore, it can be seen that cheese is concentrated to about 1/10 of protein and fat in milk, and in general, cheese contains 20-30% of protein and fat.

In the present invention, the cheese is not specifically limited, and various types of known cheese can be used to enhance the palatability of dogs and cats.

The mixed berry concentrate is included in the composition for improving eye dryness and preventing tear staining for companion animals to supply anthocyanins that help prevent eye aging. It refers to natural plant pigments that show purple, red, and blue colors depending on the acid concentration of the dye compound, the chemical structure of the dye compound, and the bonding state with various metal ions.

Recently, it is known that anthocyanins have various physiological activities, and for example, anti-aging, antibacterial, mutagenic, cholesterol-lowering, visual acuity, blood vessel protection, and anti-ulcer functions have been identified.

In the present invention, the mixed berry concentrate may be at least one selected from the group consisting of blackberry concentrate, blackcurrant concentrate, blueberry concentrate, strawberry concentrate, raspberry concentrate, cranberry concentrate, and acai berry concentrate.

The purple sweet potato can be included in the composition for improving eye dryness and preventing tear staining for companion animals to provide anthocyanins that enhance palatability and help prevent eye aging. As it contains a large amount of anthocyanin, a water-soluble pigment, it is attracting attention as a natural food color source.

In addition, since the purple sweet potato contains a large amount of active plant ingredients such as starch, calcium, iron, potassium, minerals, and dietary fiber, it not only has a nutritional replenishment effect, but is also rich in vitamin C, so that an antioxidant effect can be expected.

The vitamin C is included in the composition for improving dry eyes and preventing tear pigmentation for companion animals and can function as an antioxidant or antioxidant. The vitamin C (Vitamin C) is called ascorbic acid, and as a strong reducing agent, As one of the essential components in the human body, such as activating synthetic enzymes, vitamin C deficiency in the human body causes scurvy. Therefore, the human body cannot make its own vitamin C, so it must be consumed through vegetables or fruits.

In addition, the vitamin C is a water-soluble antioxidant that protects the body from free radicals and prevents cancer, arteriosclerosis, rheumatism, etc. protects In other words, as vitamin C prevents oxidation of cells, papers have been published that prevent cancer and various chronic diseases and inhibit aging.

The vitamin A is included in the composition for improving eye dryness and preventing tear staining for companion animals to help improve eyesight and recover from eye fatigue. The vitamin A is also known as retinol and helps to increase the body's immunity It can keep the eyes and skin moist.

In addition, the composition for improving dry eyes and preventing tear staining for companion animals according to the present invention is the omega-3 fatty acid, milk thistle extract (silymarin), propolis, duck meat, potato starch, tapioca starch, pea powder, olive oil , fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate and purple sweet potato in addition to the composition consisting of purple sweet potato fermented cucurbita fermented broth, Sanghwang mushroom broth and silkworm matured powdered oil, the omega-3 fatty acid, milk thistle Total 100 composition consisting of extract (silymarin), propolis, duck meat, potato starch, tapioca starch, pea powder, olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate, purple sweet potato, vitamin C and vitamin A It may be further included in a weight ratio of 1 to 3 parts by weight of Cujippong fermented broth, 0.1 to 2 parts by weight of turmeric water, and 2 to 4 parts by weight of fermented silkworm powder.

The kkujippong fermented broth may be used kkujippong fermented broth prepared by the following method.

First, eoseongcho can be prepared and washed.

The eoseongcho (Houttuynia cordata thunb) is an outpost of Yakmomil, a plant of the Saururaceae family, and inhabits southeast Asia and, in particular, Japan and Korea. The Eoseongcho is also called ten medicine because it has ten medicinal effects, and the stem is like a sweet potato leaf, and it is also called Eoseongcho because it is derived from the strong fishy smell when touched. Eoseongcho can be used medicinally and edible, and it is classified as an animal and plant that can be used only in a minimum amount as an auxiliary material in the Food Ingredients Classification of the Food Standards Code. It is used as a cosmetic and health functional food to help with detoxification and beauty.

Next, the washed eoseongcho can be steamed with steam.

In the above step, the steaming may be performed by heating the washed eoseongcho with steam at a temperature of 110 to 130° C. at a pressure ^{of 3 to 4 kgf/cm 2 for 40 to 60 minutes.}

Next, the steamed eoseongcho can be dried.

In the above step, in order to prevent the chlorophyll of the eoseongcho from being destroyed and the useful components volatilized during drying in sunlight, the eoseongcho is dried at a temperature of 15 to 20 ℃ and a humidity of 55 to 60% for 20 to 30 hours. can

Then, the dried fishwort can be heated and roasted and then cooled, and the roasting is the first roasting for 5 to 10 minutes at a temperature of 70 to 75° C. after putting the dried fishwort into a heating container, and The second roasted eoseongcho is second roasted at a temperature of 130 to 140 ° C. for 10 to 30 seconds, and the second roasted eoseongcho is cooled at a temperature of 25 to 35 ° C. for 2 to 4 hours. It may proceed.

Next, you can prepare the Cudrania fruit and wash it.

The Cuji mulberry fruit is cultivated in autumn, and has a taste of bitterness and sweetness. Its efficacy is to lower fever, remove residual heat from blood, relax muscles and tendons, and allow meridians to flow well. It is also used as a stamina food as well as supplementing the yang energy.

Next, the washed Cuji mulberry fruit may be steamed with steam.

In the above step, the steaming may be performed by heating the washed mulberry fruit with steam at a temperature of 140 to 160° C. at a pressure ^{of 3 to 5 kgf/cm 2 for 20 to 40 minutes.}

Next, the steamed Cuji mulberry fruit may be first dried.

In the above step, the moisture contained in the inside of the cucurbita fruit is rapidly evaporated when the sunlight is dried, and it can be carried out in a well-ventilated shady place to prevent the inherent flavor from disappearing, for example, the steamed cucurbita mulberry tree. The first drying of the fruit may be performed at a temperature of 18 to 22° C. and a humidity of 60 to 70% for 30 to 50 hours.

Subsequently, the first dried Cuji mulberry fruit may be dried a second time.

In the above step, the second drying may be performed by irradiating microwaves to the first dried Cucurbita mulberry fruit, and the second drying is at a pressure of 60 to 80 mbar, a temperature of 40 to 45 ℃ for 10 to 30 minutes. It can be carried out by irradiating microwaves of 2.3 to 2.5 GHz to the first dried Cuji mulberry fruit.

In the above step, the microwave penetrates to the inside of the Curcuma mulberry fruit and can exhibit a volumetric heating effect of heating the entire Curcuma mulberry fruit. Accordingly, it vibrates or rotates, and such polarization vibration may lead to friction between molecules, which may cause heat generation.

In the above step, by irradiating a microwave of 2.3 to 2.5GHz to the first dried Cucurbita mulberry fruit at a pressure of 60 to 80mbar, a temperature of 40 to 45° C. for 10 to 30 minutes, Heating efficiency can be improved because it penetrates into the inside of the mulberry fruit in a short time without heat conduction and is converted into heat due to friction caused by polarity change.

Next, by mixing the second dried Cuji mulberry fruit and Eoseongcho after the roasting to prepare a Cujippong mixture, it can be mixed by spraying the lactic acid bacteria culture solution to the Cujippong mixture.

In the above step, the cucurbita mixture is mixed in a weight ratio of 80 to 90% by weight of the second dried cucurbita fruit and 10 to 20% by weight of Eoseongcho cooled after roasting, and lactic acid bacteria culture medium 3 to 7 with respect to 100 parts by weight of the Cujippong mixture It can be mixed by spraying in a weight ratio of parts by weight.

In addition, in the above step, the lactic acid bacteria can use a lactic acid strain isolated from kimchi, a fermented food, specifically, as the lactic acid strain, Lactobacillus curvatus ( Lactobacillus curvatus ) , Weissella viridescens ) , Lactobacillus plantarum ( Lactobacillus plantarum ) and Any one or more known lactic acid strains selected from the group consisting of Leuconostoc lactis may be used.

For example, in the step, the pH of the medium is adjusted to 2.8-3.2 using 1.2N HCl to prepare a lactic acid bacteria culture solution from kimchi, and then the lactic acid strain is separated from the kimchi, and the separated lactic acid strain is used in MRS broth (Oxoid). , England) for 20 to 25 hours at 37-39 ° C, ^{diluted to 1×1.0 8} to 5×1.0 ⁸ CFU/mL, and then centrifuged at 10,000 to 15,000 rpm for 10 to 15 minutes to obtain the supernatant. After separating only (supernatant), and filtering the supernatant with a 0.45㎛ syringe filter, sterile distilled water with respect to 100 parts by weight of the filtered supernatant by mixing and diluting in a weight ratio of 1,000 to 2,000 parts by weight of lactic acid bacteria A culture solution can be prepared.

Next, the lactic acid bacteria culture medium can be fermented kkujippong mixture is mixed.

In the above step, after the kkujippong mixture mixed with the lactic acid bacteria culture medium is maintained at a temperature of 40 to 43 ℃ and a humidity of 60 to 62%, it can be fermented for 5 to 10 days, the fermentation of the kkujippong mixture is the above-mentioned lower limit If it is carried out less than the range, the problem that the kkujippong mixture is not sufficiently fermented may occur, and when it is performed in excess of the above-described upper limit range, there may be a problem that the physical properties of the fermented kkujippong mixture are lowered.

Then, the fermented kkujippong mixture may be dried in cold air.

Cold air drying of the fermented kkujippong mixture in the above step is carried out by drying the fermented kkujippong mixture with cold air at a temperature of 5 to 8 ℃ for 5 to 10 hours, and maintaining it for 2 to 4 days at a temperature of 55 to 60 ℃ can

Next, by extracting the cold-air dried kkujippong mixture can be prepared kkujippong fermentation broth.

In the above step, the cold-air dried kkujippong mixture can be extracted using various extraction methods such as hot water extraction, organic solvent extraction, ultrasonic extraction, supercritical extraction, and the like.

For example, the ultrasonic extraction method refers to the extraction of at least one solvent selected from the group consisting of distilled water, ethanol, methanol, butanol, acetone, ethyl acetate, hexane, propanol, hydrous butylene glycol, and hydrous propylene glycol as an extraction solvent in the sample by 10 times. It refers to an extraction method carried out using an ultrasonic extraction method for 1 hour to 10 hours, preferably 1 hour to 4 hours after adding in an amount of to 20 times by volume.

In addition, in the supercritical extraction method, 500-700 mL of ethanol (99.5%) as a dry and crushed sample and an auxiliary solvent are put into a supercritical fluid extraction reactor (Natex, Autstria), the temperature in the reactor is 65 ℃, the pressure is 450 bar, S It refers to the method of extraction under the condition that /F ratio (supercritical fluid kg/Feed kg) becomes 35.

The Sanghwang mushroom broth refers to boiled water from which the useful components of the Sanghwang mushroom are extracted by heating the Sanghwang mushroom.

The Sanghwang mushroom has an excellent effect in preventing the growth of early cancer, and has an excellent blood pressure lowering effect on hypertension, and is also excellent in preventing recurrence after cancer surgery. Unlike anticancer chemotherapy, it does not have a toxic effect on normal cells, and by further strengthening the immune function, it raises the immune antibody to a normal level, greatly increasing the resistance to cancer.

In addition, the Sanghwang mushroom improves immune function when combined with chemotherapy after resection of liver cancer, including gastric cancer, esophageal cancer, duodenal cancer, colon cancer, and rectal cancer, which are cancers of the digestive system. It is known to activate and detoxify.

As for the situation mushroom broth, the situation mushroom broth prepared by the following method may be used.

First, it is possible to remove foreign substances attached to the surface of the situation mushroom by washing the collected situation mushroom.

In the above step, after immersing the collected Sanghwang mushroom in a mixed solution consisting of lemon juice and salt solution for 3 to 5 minutes, the Sanghwang mushroom can be washed with purified water in which _{sodium bicarbonate (NaHCO 3 ) is dissolved.} Lemon juice and salt solution may be mixed in a weight ratio of 1:2.

The lemon juice and salt solution can sterilize the Sangha mushroom and prevent easy spoilage at the same time, and the salt solution can use a salt solution having a concentration of 0.5 to 0.8 wt%, and 100 weight of the collected Sanghwang mushroom It can be immersed by mixing in a weight ratio of 80 to 120 parts by weight of a mixed solution consisting of lemon juice and salt solution with respect to parts.

The purified water in which the sodium bicarbonate (NaHCO ₃ ) is dissolved may have a concentration range of 1 to 3 (w/w)%, and the sodium bicarbonate is also used as a food additive, has no toxicity, and penetrates, diffuses, expands have functions such as In the present invention, by washing the surface of the Sangha mushroom using purified water in which sodium bicarbonate is dissolved, the cell wall of the fungus is expanded to sterilize and wash the Sanghwang mushroom at the same time.

Next, it is possible to remove the moisture contained in the condition mushroom by naturally drying the washed condition mushroom.

In the above step, the washed situation mushrooms can be dried at a temperature of 23 to 27° C. for 2 to 4 days. By drying the situation mushrooms in the above range, the nutrition and flavor of the situation mushrooms can be subtly alive.

Next, the naturally-dried Shanghai mushroom can be vacuum-dried by irradiating microwaves in a reduced pressure atmosphere.

In the above step, it can be carried out by irradiating microwaves to the naturally dried Sangha mushroom under a pressure of 55 to 65 mbar, wherein the step is performed at a temperature of 40 to 45° C. for 1 to 2 minutes, and on the naturally dried Sangha mushroom This can be done by irradiating a 2.15 GHz microwave to

The microwave can exhibit a volumetric heating effect that penetrates to the inside of the Sangha mushroom and heats it. When the microwave is irradiated, the water molecules inside the Sanghwang mushroom vibrate or rotate according to the polarity change of the microwave, such as The polarization vibration leads to friction between molecules, which can cause heat generation. If the Sanghang mushroom is dried by irradiating with microwaves under reduced pressure, swelling occurs due to the heating inside the Sangha mushroom, and by this instantaneous internal heating and expansion As the cell membrane inside the Sangha mushroom is destroyed, a sterilization effect is also generated, and the active ingredient of the Sangha mushroom can be effectively leached out during broth production later by the expansion by heating inside the Sangha mushroom.

Subsequently, the vacuum-dried Sanghwang mushroom can be aged. In the above step, the vacuum-dried Sanghwang mushroom is stored at a temperature of 10 to 15° C. for 30 to 40 hours, thereby stabilizing the physical properties of the Sanghwang mushroom later. This can double the flavor and taste of our water.

Next, purified water is mixed with the aged Sanghwang mushroom and heated to prepare Sanghwang mushroom broth infused with useful ingredients of the Sanghwang mushroom, which is 300 Sanghwang mushroom per 20 to 30 liters (L) of purified water. After mixing in a weight ratio of to 500 g, primary heating at a temperature of 95 to 100 ° C. for 60 to 80 minutes, and secondary heating at a temperature of 70 to 75 ° C. for 300 to 400 minutes can be prepared. .

If the above step is performed below the lower limit range, there may be a problem that the flavor and useful ingredients of the Sangha mushroom are not sufficiently developed. There may be a problem that the flavor of the boiled water is lowered.

As the mature silkworm powder oil, the silkworm ripened powdered oil prepared by the following method may be used.

First, in order to prepare the mature silkworm powder oil, silkworm larvae mature powder and silkworm pupa matured powder may be prepared.

The silkworm (Bombyx mori L) is a larva of the Bombycidae family, and it is also recorded in ancient books such as Donguibogam and Bonchogangmok, and has been used as folk medicine for malnutrition, pulmonary tuberculosis, windswept, ikjeong, and stroke. In the past, it was mainly used only in the silk yarn industry, but with the recent development of the domestic functional food market and life science technology, it is also treated as a cosmetic, food, medical material, etc.

In addition, silkworm has a high nutritional value because it is rich in protein, free amino acids, monounsaturated or polyunsaturated fatty acids, minerals, fiber and deoxynojirimycin, and inhibits active oxygen, improves hyperlipidemia, and liver toxicity Prevention and blood sugar lowering studies have been reported.

The mature silkworm larvae powder may use the silkworm larvae aged powder prepared by the following manufacturing method.

First, after preparing the silkworm larvae, the silkworm larvae may be washed.

In the above step, the silkworm larvae may be larvae before pupation, for example, the silkworm larvae may be the silkworm larvae of the 3rd day of the fifth instar, and the washing of the silkworm larvae is the prepared silkworm larvae at 45 to 50 ° C. By immersing the prepared silkworm larvae in a solution of 1 to 3 (w/w)% sodium bicarbonate (NaHCO ₃ ) maintained at a temperature for 10 to 30 minutes, the surface of the prepared silkworm larvae can be washed.

In the above step, by washing the prepared silkworm larvae to remove foreign substances or mulberry leaves, etc. remaining on the surface of the silkworm larvae, the taste of the prepared silkworm-aged powdered oil is improved, and it is prevented from easily decaying or denatured by foreign substances. can do.

Next, the washed silkworm larvae may be first dried.

In the first drying of the washed silkworm larvae in the above step, the washed silkworm larvae are dried at a temperature of 45 to 50° C. for 10 to 20 hours to first remove moisture remaining in the washed silkworm larvae.

Next, the first dried silkworm larvae may be second dried with hot air.

In the above step, the first dried silkworm larvae may be performed by applying hot air at a temperature of 135 to 140° C. for 50 to 100 minutes.

Then, the second dried silkworm larvae can be pulverized and then aged to prepare a powdered silkworm larvae aged.

The grinding of the second dried silkworm larvae in the step is pulverized by grinding the dried silkworm larvae to a particle size of 5 to 10mm, and the aging of the powdered silkworm larvae is 5 to 7 of the powdered silkworm larvae. It can be carried out by storing for 20 to 30 hours at a temperature of ℃.

The aged silkworm pupa powder may use the silkworm pupa aged powder prepared by the following manufacturing method.

First, the silkworm pupae can be prepared and washed and then heated in a bath.

The washing of the silkworm pupa in the above step is by immersing the silkworm pupa in a _{sodium bicarbonate (NaHCO 3} ) solution at a concentration of 1 to 3 (w/w)% maintained at a temperature of 40 to 45 ° C. for 20 to 40 minutes, The surface of the silkworm pupa can be washed, and the hot water heating of the silkworm pupa is sterilized by immersing the washed pupa in 1 to 1.5% by weight of bamboo salt water heated to a temperature of 90 to 95 ° C. You can keep it clean.

Next, by drying the silkworm pupa heated in the bath, moisture remaining in the silkworm pupa heated in the bath may be removed.

The drying of the silkworm pupae heated in the bath in the above step may be performed by drying the steamed silkworm pupa heated in the bath at a temperature of 70 to 75° C. for 20 to 30 hours.

Next, the dried silkworm pupae can be pulverized and powdered.

The pulverization of the dried silkworm pupae in the above step may be pulverized to a particle diameter of 5 to 10 mm using a known pulverizer.

Subsequently, a mixture can be prepared by mixing the lactic acid bacteria culture solution with the silkworm pupa powder.

In the above step, 10 to 15 parts by weight of the lactic acid bacteria culture solution may be blended and mixed with respect to 100 parts by weight of the silkworm pupa powder.

In addition, in the above step, the lactic acid bacteria can use a lactic acid strain isolated from kimchi, a fermented food, specifically, as the lactic acid strain, Lactobacillus curvatus ( Lactobacillus curvatus ) , Weissella viridescens ) , Lactobacillus plantarum ( Lactobacillus plantarum ) and Any one or more known lactic acid strains selected from the group consisting of Leuconostoc lactis may be used.

More specifically, in the step, the pH of the medium is adjusted to 2.8~3.2 using 1.2N HCl to prepare a lactic acid bacteria culture solution using the lactic acid strain isolated from kimchi, and then the lactic acid strain is separated from the kimchi, and the separated After culturing the lactic acid strain at 37-39° C. for 20 to 25 hours using MRS broth (Oxoid, England), ^{it is diluted to 1×1.0 8} to 5×1.0 ⁸ CFU/mL, and then 10 at 10,000 to 15,000 rpm. Separate the supernatant by centrifugation for ~15 minutes, filter the supernatant with a 0.45 μm syringe filter, and then sterilize 1,000 to 2,000 parts by weight of distilled water with respect to 100 parts by weight of the filtered supernatant By mixing and diluting in a ratio, it is possible to prepare a lactic acid bacteria culture solution.

Next, by aging the mixture consisting of the silkworm pupa powder and lactic acid bacteria culture medium, it is possible to prepare a silkworm pupa ripening powder.

In the above step, the silkworm pupa ripening powder can be prepared by storing and aging the mixture consisting of the silkworm pupa powder and the lactic acid bacteria culture solution at a temperature of 15 to 17° C. for 20 to 30 hours.

Next, by mixing the prepared silkworm larvae mature powder and silkworm pupa matured powder, it is possible to prepare a silkworm aged powder.

In the above step, the aged silkworm powder may be mixed in a weight ratio of 40 to 60% by weight of the matured silkworm larvae powder and 40 to 60% by weight of the matured silkworm pupa powder.

Next, a mixture may be prepared by mixing the aged silkworm powder and avocado oil.

In the above step, 1000 to 2000 parts by weight of avocado oil may be mixed with respect to 100 parts by weight of the mature silkworm powder.

Subsequently, the mixture of the aged silkworm powder and avocado oil may be heated and then aged.

In the above step, the mixture of the aged silkworm powder and avocado oil is heated at a temperature of 70 to 75° C. for 50 to 100 minutes, and then stored and aged at a temperature of 10 to 15° C. for 5 to 10 days, thereby adding to the aged silkworm powder. It can be made so that the nutrients contained in it are sufficiently leached out.

Next, the mature silkworm powder can be prepared by filtering the mixture of the aged silkworm powder and avocado oil.

In the above step, the mature silkworm powder can be prepared by filtering the mixture of the aged silkworm powder and avocado oil with a filter to remove solids such as the aged silkworm powder. For the sake of convenience of description and clarity of the technical idea of the present invention, a detailed description thereof will be omitted.

As the avocado oil, avocado oil extracted from the flesh of avocado ripened can be used, and the avocado oil contains a large amount of unsaturated fatty acids, which greatly reduces the incidence of heart disease, cancer, and diabetes, and is also consumed with green and yellow vegetables. It can increase the absorption rate of beta-carotene by 15.3 times.

The avocado is rich in vitamins and minerals, and can prevent various adult diseases and vascular diseases by effectively decomposing cholesterol.

In addition, the avocado contains important antioxidants such as vitamin C and vitamin E, so it can fight inflammation and relieve the symptoms of arthritis. can prevent

For example, the avocado oil is an avocado oil extracted from aged avocado flesh, and a commercially known avocado oil may be used, or an avocado oil prepared by the following method may be used.

First, you can prepare the avocado and wash it thoroughly in water.

Next, the washed avocado may be immersed in a rancidity inhibitor to prevent discoloration or rancidity of the avocado oil produced by immersing the avocado in the rancid inhibitor.

The immersion of the washed avocado may be performed by immersing the avocado in a rancidity inhibitor, which may be prepared by mixing vitamin C and a salt solution in a weight ratio of 1:1.

The salt solution used as the rancidity inhibitor may be a salt solution having a concentration of 1 to 2% by weight, and after being immersed in a weight ratio of 100 to 120 parts by weight of the rancidity inhibitor to 100 parts by weight of the washed avocado, for 10 to 40 minutes It can be kept going.

Next, the avocado immersed in the mixed solution of the rancidity inhibitor may be taken out to allow the component of the rancidity inhibitor to penetrate into the avocado.

In the above step, it is possible to prevent discoloration or rancidity of the avocado oil produced even after a long period of time by allowing the active ingredient of the rancidity inhibitor to penetrate the surface of the avocado. It can be carried out by storing for 60 to 100 minutes at a temperature of 28 to 32 °C.

Subsequently, the avocado permeated with the component of the rancidity inhibitor may be steamed.

The steaming of the avocado may be performed by steaming the avocado impregnated with the component of the rancidity inhibitor for 50 to 100 minutes with steam. There is a problem that does not occur, and when it is performed in excess of the upper limit range, the difference in the effect according to the increase of the steaming time may be insignificant.

Next, the steamed avocado may be dried.

Drying of the steamed avocado may be performed for 10 to 20 hours at a temperature of 45 to 50° C. for the steamed avocado. In order to maintain a constant drying temperature of the avocado, mechanical drying using a dryer may be used. have.

Next, the dried avocado may be washed with any one or more acids of acetic acid or citric acid. The washing of the dried avocado is performed by washing the surface of the dried avocado with any one or more acids of acetic acid or citric acid. It has the effect of improving the flavor and color of avocado oil to be manufactured through the fermentation process.

Then, the washed avocado may be sprayed with a culture solution and a fermentation broth composed of lactic acid bacteria.

As the lactic acid bacteria, any one known lactic acid bacteria selected from the group consisting of Lactobacillales , Streptococcus thermophiles and Bifidobacterium longum may be used, and the culture medium is peptone. , malt extract, sodium citrate, potassium phosphate dibasic, glucose and distilled water, and the culture medium is 15 to 25 parts by weight of peptone, 5 to 15 malt extract It may be made by mixing in a weight ratio of 0.5 to 1.5 parts by weight of sodium citrate, 0.1 to 0.3 parts by weight of potassium dibasic, 1-3 parts by weight of glucose, and 100 to 200 parts by weight of distilled water.

In the culture medium, the peptone is a nitrogen source that supplies proteins and supplies proteins necessary for the growth of microorganisms, and the malt extract contains various minerals, vitamin B group, and amino acids to help microorganisms grow, Silver is a mineral that maintains an optimized state for the growth of microorganisms by adjusting the pH of the culture medium, and can supply nutrients, and the glucose can function as an important component for lactic acid bacteria to metabolize sugar to produce organic acids.

Next, the avocado sprayed with the fermentation broth can be fermented, and the fermentation of the avocado is 3 to 6 days in a storage container that maintains the avocado sprayed with the fermentation broth at a temperature of 45 to 50° C. and a humidity of 60 to 65%. It can be stored and fermented for a while.

Next, the fermented avocado may be dried in cold air.

Cold air drying of the fermented avocado may be performed by drying the fermented avocado with cold air at a temperature of 3 to 6° C. for 5 to 10 hours, and maintaining the fermented avocado at a temperature of 55 to 60° C. for 1 to 3 days.

Then, by separating the oil after pressing the cold air dried avocado at a humidity of 70 to 80%, a temperature of 120 to 150 ℃, and 20 to 25 kgf / cm ² , avocado oil can be prepared.

Hereinafter, examples of the composition for improving dry eyes and preventing tear staining for companion animals according to the present invention will be described in more detail.

<Example>

Omega-3 fatty acid 2 parts by weight, milk thistle extract 6 parts by weight, propolis 2 parts by weight, duck meat 27.03 parts by weight, potato starch 15.47 parts by weight, tapioca starch 23.17 parts by weight, pea powder 7.72 parts by weight, olive oil 4.63 parts by weight , 4.63 parts by weight of fructooligosaccharide, 3.87 parts by weight of vegetable glycerin, 2.17 parts by weight of lutein, 1.55 parts by weight of cheese, 1 part by weight of mixed berry concentrate, 1 part by weight of purple sweet potato, 0.38 parts by weight of vitamin C and 0.38 parts by weight of vitamin A A composition for improving dry eyes and preventing tear staining for companion animals was prepared.

< Comparative Example >

A composition for improving eye dryness and preventing tear staining for companion animals was prepared using the same composition as in Example, but in Comparative Example, omega-3 fatty acids, milk thistle extract, and propolis were not included, and in Comparative Example, companion animals were not included. A composition for improving dry eyes and preventing tear staining was prepared.

< Experimental Example 1 >

Experiments to measure whether or not tear browning and odor reduction in dogs fed the composition for improving dry eyes and preventing tear staining for companion animals according to Examples and Comparative Examples

(1) Composition for improving eye dryness and preventing tear staining for companion animals according to the Examples and Comparative Examples for 16 dogs (10 females, 6 males) observed with tear staining syndrome (TSS) After feeding twice a day for 12 weeks, it was measured whether the dog's tear browning and odor reduction were reduced.

(2) As for the browning of tears in the dog in Experimental Example 1, three professional veterinarians observed whether the browning due to tears disappeared after examining the dog's eyes, and the results are shown in [Table 1] below using a 3-point scale method indicated as

(3) In Experimental Example 1, whether the dog's tear odor was reduced or not, 3 professional veterinarians looked at the dog's eyes and observed whether the odor from the tears disappeared, and the result was 3 points in [Table 2] below It is expressed by a scale method.

Reduced browning due to tears division Example (Marie) Comparative Example (Marie) 1 point - 13 2 points One 3 3 points 15 -

(Here, 1 point: browning is intact, 2 points: browning is slightly gone, 3 points: browning is not seen at all)

Reduces tear odor division Example (Marie) Comparative Example (Marie) 1 point - 13 2 points One 3 3 points 15 -

(Here, 1 point: the stench of tears is intact, 2 points: the stench of tears slightly disappears, 3 points: the stench of tears disappears)

Referring to [Table 1] and [Table 2] above, when the composition for improving dry eyes and preventing tear staining for companion animals according to the Example was fed twice a day for 12 weeks, tear browning and bad smell in dogs It was confirmed that it was significantly reduced.

<Experimental Example 2>

Test for measuring the amount of tears in dogs fed the composition for improving eye dryness and preventing tear staining for companion animals according to Examples

(1) For 16 dogs (10 females, 6 males) observed with tear staining syndrome (TSS), the composition for improvement of dry eyes and prevention of tear staining for companion animals according to the above example was administered. The effects on dry eye and tear pigmentation were observed.

(2) In Experimental Example 2, the average age of the dogs observed was 8.5 years and the average weight was 4.2 kg. Physical examination, ophthalmic examination (visual examination, Schirmer tear test (STT)), fluorescence staining, blood test There were no specific health problems, but 5 subjects with a tear volume lower than the normal range (15-23) were identified.

(3) The composition for improving eye dryness and preventing tear staining for companion animals according to the above example was fed twice a day for 12 weeks, before feeding, at 4 week intervals after feeding, up to 12 weeks, and after the end of administration 16 The condition was evaluated through various tests a total of 5 times during the week.

(4) Changes in coat coloration, off-flavor, and secretions were scored through subjective evaluation, and tears were recorded by STT test results.

(5) Results

After 12 weeks had elapsed after feeding the composition for improving eye dryness and preventing tear staining for companion animals according to the above example, all 16 small adult dogs with TSS had no side effects, and in the test group fed the composition according to the example Skin pigmentation and odor, which are clinical symptoms of tear pigmentation syndrome, were significantly reduced compared to before ingestion.

In addition, there was a statistically significant difference in the average tear volume before and after ingestion after 12 weeks of feeding the composition for improving eye dryness and preventing tear staining for companion animals according to the above example, and the tear volume of subjects with low tear volume was within the normal range. was confirmed as the difference as it increased.

<Experimental Example 3>

Test for investigating tear marks in dogs fed with a composition for improving dry eyes and preventing tear staining for companion animals according to Examples

(1) Tears and tears of dogs after feeding the composition for improving dry eyes and preventing tear staining for companion animals according to the embodiment to dogs with tear staining syndrome (TSS) twice a day for 12 weeks Whether or not the marks were reduced was measured.

1A is a photograph showing the tear marks of a dog before feeding a composition for improving eye dryness and preventing tear staining for companion animals according to an embodiment, and FIG. It is a photograph showing the tear marks of a dog after feeding the composition for

1a and 1b, after feeding the composition for improving dry eyes and preventing tear staining for companion animals according to the embodiment, tear staining syndrome (TSS) is observed in dogs with significantly reduced tear marks was able to confirm that

In the above, a preferred embodiment of the present invention has been described, but those of ordinary skill in the art to which the present invention pertains will understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential features thereof. will be able Therefore, it should be understood that the embodiment described above is illustrative in all respects and not restrictive.

Claims (8)

A composition for improving dry eyes and preventing tear pigmentation for companion animals, comprising omega-3 fatty acids, milk thistle extract and propolis as active ingredients.
The method of claim 1,
Composition for improving eye dryness and preventing tear pigmentation for companion animals, characterized in that it contains 0.1 to 4 parts by weight of the omega-3 fatty acid, 2 to 10 parts by weight of milk thistle extract, and 0.1 to 4 parts by weight of propolis .
3. The method of claim 2,
In addition to the above omega-3 fatty acids, milk thistle extract and propolis, meat protein, potato starch, tapioca starch, pea powder, olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate, purple sweet potato, vitamin C and A composition for improving dry eyes and preventing tear pigmentation for companion animals, which further comprises vitamin A.
4. The method of claim 3,
0.1 to 4 parts by weight of the omega-3 fatty acid, 2 to 10 parts by weight of milk thistle extract, 0.1 to 4 parts by weight of propolis, 25 to 35 parts by weight of meat protein, 12 to 18 parts by weight of potato starch, 20 to 25 parts by weight of tapioca starch parts by weight, 5 to 10 parts by weight of pea powder, 3 to 7 parts by weight of olive oil, 3 to 7 parts by weight of fructooligosaccharide, 2 to 6 parts by weight of vegetable glycerin, 1 to 3 parts by weight of lutein, 0.5 to 3 parts by weight of cheese, mixed Berry concentrate 0.1 to 2 parts by weight, purple sweet potato 0.1 to 2 parts by weight, vitamin C 0.1 to 1 parts by weight, and vitamin A 0.1 to 1 parts by weight. composition for
5. The method of claim 4,
The omega-3 fatty acid, milk thistle extract, propolis, meat protein, potato starch, tapioca starch, pea powder, olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate and purple sweet potato in addition to the composition consisting of A composition for improving dry eyes and preventing tear staining for companion animals, characterized in that it further comprises fermented broth, broth of Sanghwang mushroom and powdered silkworm powder.
6. The method of claim 5,
The omega-3 fatty acids, milk thistle extract, propolis, meat protein, potato starch, tapioca starch, pea powder, olive oil, fructooligosaccharide, vegetable glycerin, lutein, cheese, mixed berry concentrate, purple sweet potato, vitamin C and vitamins For companion animals, characterized in that it is further included in a weight ratio of 1-3 parts by weight of Cujipon fermented broth, 0.1-2 parts by weight of Sangha mushroom broth, and 2-4 parts by weight of fermented silkworm powder based on 100 parts by weight of the total composition consisting of A. A composition for improving eye dryness and preventing tear pigmentation.
7. The method of claim 6,
The meat protein consists of chicken and duck meat, and the meat protein is included in a weight ratio of 20 to 30 parts by weight of chicken and 1 to 10 parts by weight of duck meat. composition for.
8. The method of claim 7,
In addition to the chicken and duck meat, a salmon and tuna mixture is further included as a meat protein, and the salmon and tuna mixture is further included in a weight ratio of 30 to 70 parts by weight based on 100 parts by weight of the chicken and duck meat, and the salmon and tuna The mixture is 32 to 36 parts by weight of salmon and 15 to 19 parts by weight of tuna A composition for improving dry eyes and preventing tear staining for companion animals, characterized in that it is included in a weight ratio.

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