KR20210154312A - Combination Extract for improving or treating diabetes comprising Rehmanniae Radix Recens, and preparation method thereof - Google Patents

Abstract

The present invention provides a composition for preventing, alleviating or treating diabetes, including a complex extract. The complex extract of Rehmannia glutinosa, Scrophularia ningpoensis, Trichosanthes kirilowii seeds, Paeonia suffruticosa root bark, Gardenia jasminoides fruits, Lonicera japonica, and glue obtained by boiling down Pelodiscus sinensis shells according to the present invention significantly lowers the blood insulin concentration, reduces blood sugar and urine sugar, alleviates glycated hemoglobin, and stabilizes the level of ketonuria, thereby exhibiting an excellent effect on type 2 diabetes. Accordingly, the composition can be usefully used as a pharmaceutical composition or health functional food.

Description

Herbal medicine combination extract for improving and treating diabetes, including Saengjihwang, a manufacturing method thereof {Combination Extract for improving or treating diabetes comprising Rehmanniae Radix Recens, and preparation method thereof}

The present invention relates to a composition for preventing or treating diabetes comprising a complex extract.

Diabetes mellitus is a type of metabolic disease caused by abnormal action of insulin, and is characterized by hyperglycemia in which the concentration of glucose in the blood increases.

Diabetes mellitus is divided into type 1 and type 2, type 1 diabetes is caused by a failure to produce insulin, and type 2 diabetes mellitus insulin is secreted but the function of insulin is poor, causing cells to become resistant to insulin (insulin resistance) is caused by having For example, insulin resistance occurs due to hyperinsulinemia, a condition in which the amount of insulin in the blood is higher than that which is considered normal, and the mechanism of action of making and replenishing more insulin accordingly causes hyperinsulinemia to type 2 diabetes mellitus. may develop In addition, the above hyperinsulinemia is a state of high blood insulin level, and has an additional problem of promoting sympathetic nerve activity enhancement or sodium absorption in the kidneys.

As a substance for treating type 2 diabetes, PPAR-γ activator, GLP-1 derivative, DPP-IV inhibitor, PTP1B inhibitor, etc. have been developed as major antidiabetic drugs, but these conventional drugs show side effects due to each mechanism. have. For example, toxicity to the liver, kidney, muscle, and heart, along with weight gain, are typical side effects. In particular, when sulfonylurea or biguanide, which are mainly used as oral hypoglycemic agents, are administered, the blood sugar level increases rapidly after eating, whereas the blood sugar level of insulin caused by the administered drug is administered. Because my appearance is relatively slow, the problems of postprandial hyperglycemia and hyperinsulinemia between meals cannot be addressed.

Under this background, there is an urgent need for research and development on a composition for preventing, improving or treating diabetes and hyperinsulinemia using natural materials that can be easily used as materials for food or pharmaceuticals.

Korean Patent Application No. 10-1679117 Korean Patent Application No. 10-1095467

The present invention provides a pharmaceutical composition for the prevention or treatment of diabetes comprising Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo complex extract as active ingredients.

In addition, the present invention provides a food composition for preventing or improving diabetes, comprising the extract of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo complex extract.

The present inventors have made diligent efforts to find substances that can prevent, improve, and treat diabetes using natural plant materials with excellent safety. Surprisingly, saengjihwang, ginseng, gwaruin, mokdanpi, gardenia, indongdeung, and byeogapgyo complex extract are diabetic. , in particular, confirmed that it effectively prevents, improves and treats diabetes mellitus related to hyperinsulinemia, and completed the present invention.

The present invention provides a pharmaceutical composition for the prevention or treatment of diabetes comprising Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo complex extract as active ingredients.

The pharmaceutical composition for preventing or treating diabetes of the present invention significantly lowers the level of insulin, improves blood sugar and urine sugar, as well as improves glycated hemoglobin, thereby exhibiting an excellent effect in preventing and treating diabetes.

In the present invention, "diabetes" is a disease that occurs due to the abnormal action of insulin. In the present invention, diabetes includes all types of diabetes, for example, type 1 diabetes or type 2 diabetes. Preferably, the diabetes to be prevented or treated by the composition of the present invention is type 2 diabetes.

Type 2 diabetes can be caused by developing insulin resistance due to hyperinsulinemia in which blood insulin levels remain high. The composition according to the present invention shows an excellent effect on type 2 diabetes by significantly lowering the blood insulin concentration in a hyperinsulinemic state, reducing blood sugar and urine sugar, improving glycated hemoglobin, and stabilizing the level of ketonuria.

In the present invention, Saengjihwang (Rehmanniae Radix Recens) is a fresh root of the ginseng family, collected in autumn to remove outcrops, root hairs, and soil sand, and uses fresh or red-dried ones to dry up to 80%. It forms a cylindrical-fusiform shape, with a length of 5-15cm and a diameter of 0.8-2cm, and some are bent or bent. The outer surface is yellowish-red to yellow-reddish-brown, and has horizontally deep grooves. The quality is very soft and bends easily. The cut surface is flat, the neck is white, and the skin is light yellowish red. It has a characteristic odour, and the taste is sweet and slightly bitter.

In the present invention, Hyun ginseng ( Scrophularia buergeriana ) is also called middle (weight) · modern (玄臺) · gwijang (鬼藏) · chukhor (逐 horse). It grows in mountainous areas. The root is thick and 80?m high, and the cross section is square and there are no branches. The leaves are opposite, long ovate, pointed at the end, and sawtooth on the edge, and the petiole is short. Flowers bloom in August-September and are yellow-green in color and hang on inflorescences. The calyx is divided into 5 pieces, and the corolla is shaped like a crushed jar, and the edge is divided into 5 pieces. Among the 4 stamens, 2 are long and capsules are ovate. In oriental medicine, the root is generally called Hyeonsam.

In the present invention, Gwaruin ( Trichosanthes kirilowii ) refers to the seeds of Cucumber serrata and yellow haremaceae, which are vines, and the Guara (果), which is a combination of the fruit on a tree and the fruit that grows on the ground, changes the sound and changes the tone.樓) is said to have been This medicine is odorless, tastes sweet and bitter, and has a cold nature.

Mokdanpi in the present invention ( Paeonia suffruticosa ) is a medicinal material made from the root bark of the peony family (Paeonia suffruticosa Andrews) (Korea). China and Japan are the same as Korea. This medicine has a characteristic odor, and the taste is slightly bitter and very cold in nature.

Gardenia (Gardenia jasminoides ) in the present invention is a dried fruit of the gardenia tree. The ripe fruits are picked and dried in autumn, and the taste is bitter and the nature is cold.

In the present invention, Lonicera japonica ) is the dried stem and leaves of honeysuckle. It grows in the foothills and fields of various places. The stems are harvested between late summer and autumn and dried in the sun. The taste is sweet and the nature is cold.

In the present invention, byeolgapgyo is washed cleanly the carapace of the larvae, put in a kiln, put in water, and then thoroughly decocted and filtered 3 to 5 times. It refers to a product that combines the filtered liquid, boils it to become a glue, cools it, cuts it into small pieces, and then dried it in the shade.

The complex extract according to the present invention may further include additional herbal ingredients. One or more of these additional ingredients can be added in consideration of the patient's oriental medical condition, and the diabetes improvement effect of the complex extract can be further enhanced.

Specifically, it may further include any one or more selected from the group consisting of gypsum, moryeo, hyeonggae, windbreak, ganghwal, dokhwal, jeonho, phalanx and moktong.

In the present invention, gypsum is cold in nature, spicy in taste, and non-toxic. In Donguibogam, it cures headache and body fever due to dolrimbyeong, fever in 3 seconds, skin fever, dry mouth, burning tongue, and sore throat. It is also said to relieve thirst, make you sweat, and relieve stomach upset.

In the present invention, Moryae is the shell of Crassostrea gigas, Ostera rivularis, Ostrea gigas, Ostrea rivularis, and Ostrea talienwhanensis, which converges yin and yang, stops the wall, and purifies the body. It is a medicinal agent that has the effect of astringent and removing phlegm.

Hyeonggae in the present invention ( Schizonepeta tenuifolia ) is Hyeonggae (list price) Schizonepeta tenuifolia Briq. Or Nepeta japonica Maxim. is dried out of the planted everywhere. When the flowers bloom in the summer, cut the outpost and dry it in the shade with good ventilation. The taste is spicy and bitter, and the nature is warm.

Windbreak in the present invention ( Saposhnikovia divaricata Sc) is Saposhnikovia It is the root of divaricata Schischkin (Umbelliferae). It is also known as Guanbangpung (關防wind) or Eastern Bangpung (東防wind), and according to records, it is an item mainly used as a genuine windbreaker in China. It has a long, conical shape with a root, and becomes progressively thinner as it goes down, and is 15-20 cm long and 0.7-1.5 cm in diameter. The outer surface is light brown, and there are many vertical wrinkles, and there are also thin root marks. The bizarre parts that remain on the head are in the shape of a broom, and the ones with the bizarre parts removed have a dense ring pattern on the head of the root and look like the head of an earthworm. The body is light, the quality is soft, and it is easy to cut. On the cut side, the skin is light brown, there are several gaps, the neck is light yellow, and it looks like round eyes as a whole. It has a characteristic odor and the taste is slightly sweet.

In the present invention, Ganghwal ( Ostericum praeteritum ) is a dried root of Ganghori Ostericum praeteritum Kitag. It grows in the deep valleys of Gangwon-do, especially in the central and northern parts of our country, and is also planted in various places. Dig up the roots in autumn or spring, wash them in water and dry them in the sun. The taste is bitter and bitter, and the nature is slightly warm.

In the present invention, poisoning ( Aralia continentalis ) is a herbaceous perennial plant belonging to the family Araliaceae, with a height of 1.5 m and sparsely short hairs throughout except for flowers. The leaves are alternate phyllotaxis, 50 ~ 100 cm long, and are bipolar right-sided bi-lobed leaves. The small leaves are ovate or oval with a sharp tip. It is 5-30cm long and 3-20cm wide, with sparse hairs on both sides. In July and August, large panicles (conical inflorescences) grow on branches and at the tip or upper leaf veins of main stems. The flowers are light green as a single flower (one family flower: male and female flowers bloom on one branch). The fruits ripen in September and October.

In the present invention, Jeonho ( Anthriscus sylvestris ) is a herbaceous perennial plant belonging to the family Buttercup. Grows well in forests or slightly damp places. Flowers bloom white in May-May and bear fruit in July-June. The fruit has a yellowish color, and the hairy sagebrush is also wild. Jeonho is particularly well-developed with roots and is widely used as a medicine. The medicinal ingredients are known as nodakenin, which is a furocumarin, and spongesterone, mannitol, and essential oil. Weakness is slightly cold and non-toxic, and the taste is bitter and spicy.

In the present invention, the phalanx ( Lycium) chinense ) is the root bark of Goji berry. The root bark is cylindrical-semi-cylindrical or fragmented, 3-10 cm long, 0.5-1.5 cm wide, and 0.1-0.3 cm thick. The outer surface is gray-yellow to orange-yellow, rough, irregularly with vertical torn patterns, and the bark is scaly and easy to peel off. The inner surface is yellowish-white to gray-yellow, relatively flat, with thin vertical patterns. The cut side is grayish white to yellowish brown, not fibrous, and the quality is light and rough. It has a characteristic odour, and the taste is slightly sweet and bitter later.

In the present invention, the neck tube ( Akebiae Caulis ) is a stem of the creeper family with the bark removed. A stem with bark removed, cylindrical, usually twisted, and 30-70 cm long and 0.5-2 cm in diameter. The outside is yellowish-white to yellowish-brown, and there are many vertical troughs, and the places where there are nodes are enlarged and there are also traces of cutting of side branches. What remains is grayish-brown and has a round or vertically long oval bark. The quality is light, firm, and difficult to cut. On both sides of the cut side, the skin is dark grayish-brown, and the neck has a light brown conduit and a grayish-white waterline alternately arranged radially. The numbers are pale grayish-yellow and distinct. There is almost no odor and the taste is slightly bitter.

As used herein, the term "extract" refers to an extract obtained by extracting and processing the flowers, herbs, leaves, stems, seeds, fruits, roots, and/or pulverized products of the above-mentioned natural products, dilutions or concentrates of the extracts, and the extracts. It includes extracts of all formulations that can be formed using the extract itself and the extract, such as a dried product obtained by drying, a prepared product or purified product of the extract, or a mixture thereof.

The complex extract may be prepared by extracting from the above-mentioned natural product or a drug processing it according to a conventional extract preparation method.

For example, about 1 to 20 times, preferably about 3 to 10 times the weight of the aforementioned natural product or a processed drug thereof, the primary extraction solvent, preferably water, C ₁ to C ₄ lower alcohol ( For example, extraction with methanol, ethanol, propanol, isopropanol, butanol, etc.) or a mixed solvent thereof can be carried out. Extraction may be performed by an extraction method known in the art, for example, cold extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, etc., but is not limited thereto. The extraction temperature may be adopted by those skilled in the art in various temperature ranges suitable for the extraction method, for example, it may be carried out at 20 ℃ to 100 ℃, etc., but is not limited thereto. In addition, the extraction time varies depending on the extraction method, and a person skilled in the art may adopt an appropriate extraction time, but is not limited thereto, but may be performed single or multiple times in the range of about 1 hour to 10 days. The extract obtained by performing extraction with the primary extraction solvent is obtained in a liquid form from which impurities are removed by filtration according to a conventional method, or the obtained liquid extract is concentrated and/or dried under reduced pressure according to a conventional method to obtain a powder form can be obtained

In addition, the extraction process may further include, if necessary, obtaining a fraction having a high content of the active ingredient. That is, after dispersing the extract obtained by extraction with the primary extraction solvent in water, extraction with an appropriate secondary extraction solvent, for example, saturated C ₁ -C ₄ alcohol, to enhance the content of the active ingredient. can

In addition, the complex extract according to the present invention may be obtained by extracting each natural product or each of the processed medicines and mixing them, or may be extracted by applying an extraction method to each natural product or after mixing the processed medicines. .

According to one embodiment of the present invention, it may be prepared through a bath in a yaktanggi at 80 to 100 ℃ after putting the above-mentioned natural product or a processed medicine thereof into water.

In addition, the compound extract drug prepared by the bath may be concentrated by heating by lowering the pressure through a low-pressure concentrator to evaporate water.

Accordingly, according to the present invention, (a) Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indong, etc. and Byeolgapgyo are put in water and extracted by heating at 80 to 100° C. for 1 to 5 hours; A manufacturing method is provided.

The method for producing a complex extract according to the present invention may further include (b) concentrating the complex extract of step (a) by heating and evaporating water by lowering the pressure through a low-pressure concentrator. Concentration using the low pressure concentrator may be extraction while evaporating water by lowering the pressure at 60 to 80 ℃.

The preparation of the complex extract of step (a) according to the present invention is, in addition to Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdeung and Byeolgapgyo, gypsum, Moryeo, Hyeonggae, Bangpung, Ganghwal, Dokhwal, Jeonho, Jigolpi and It may further include one or more selected from the group consisting of the neck.

As used herein, the term “prevention” refers to any action of inhibiting or delaying diabetes by administering the composition of the present invention to an individual.

As used herein, the term “treatment” refers to any action for improving or benefiting diabetic symptoms by administering the composition of the present invention to an individual.

The complex extract according to the present invention contains 1 to 5 parts by weight of Saengjihwang, 1 to 5 parts by weight of Hyeonsam, 0.5 to 4 parts by weight of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdang and Byeolgapgyo with respect to 100 parts by weight of water, respectively. It may be preferable to include it in an amount of 0.5 to 3 parts by weight, 0.5 to 3 parts by weight of mulberry skin, 0.3 to 3 parts by weight of gardenia, 0.3 to 3 parts by weight of ginseng, etc., and 0.1 to 2 parts by weight of byeolgap bridge.

More preferably, about 100 parts by weight of water, about 2.5 parts by weight of saengjihwang, 2.25 parts by weight of ginseng, 1.75 parts by weight of gwaruin, 1.25 parts by weight of mulberry skin, 0.94 parts by weight of gardenia, 0.94 parts by weight of ginseng, etc., 0.38 parts by weight of byeolgap bridge.

In addition, it may further include one or more selected from the group consisting of gypsum, moryeo, hyeonggae, windbreak, ganghwal, dokhwal, jeonho, phalanx and moktong, each of the components 0.2 to 6 parts by weight based on 100 parts by weight of water. It is preferable to include as much as a part. Each of these components may be included at an appropriate level according to the condition of the oriental medicine patient.

It is preferable to include the complex extract in an amount of 0.1 to 95% by weight based on the total weight of the composition containing the complex extract of the present invention as an active ingredient, but is not limited thereto.

The pharmaceutical composition of the present invention may include a pharmaceutically acceptable carrier, and each of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, etc., oral dosage forms, external preparations, suppositories, and It may be formulated in the form of a sterile injectable solution.

The pharmaceutically acceptable carriers include those commonly used in the art, such as lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In addition, the pharmaceutical composition of the present invention includes a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, and other pharmaceutically acceptable additives.

When the pharmaceutical composition of the present invention is formulated as a solid preparation for oral use, it includes tablets, pills, powders, granules, capsules, etc., and these solid preparations include at least one or more excipients, for example, starch, calcium carbonate, It may include sucrose or lactose, gelatin, and the like, and includes, but is not limited to, lubricants such as magnesium stearate and talc.

When the pharmaceutical composition of the present invention is formulated as a liquid formulation for oral use, it includes suspensions, solutions, emulsions, syrups, and the like, and includes, but is not limited to, water, diluents such as liquid paraffin, wetting agents, sweeteners, fragrances, preservatives, and the like.

When the pharmaceutical composition of the present invention is formulated for parenteral use, it includes sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations, and suppositories, and non-aqueous solvents and suspensions include propylene glycol, polyethylene glycol, olive. vegetable oils such as oils, injectable esters such as ethyl oleate, and the like. As a base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, etc. may be used, but are not limited thereto.

The dosage of the complex extract contained in the pharmaceutical composition of the present invention varies depending on the patient's condition and weight, age, degree of disease, drug form, administration route and period, but may be appropriately selected by those skilled in the art. For example, the complex extract may be administered at a dose of 0.0001 to 100 mg/kg per day, preferably 0.001 to 10 mg/kg, and the administration may be administered once or in several divided doses per day.

The pharmaceutical composition of the present invention may be administered to mammals such as rats, mice, livestock, and humans by various routes, for example, oral, intraperitoneal or intravenous, intramuscular, subcutaneous, intrauterine intrathecal or intracerebrovascular injection. .

The present invention also includes a food composition for preventing or improving diabetes, comprising Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo complex extract as active ingredients.

The food composition of the present invention can be used as a health functional food. The term "health functional food" means a food manufactured and processed using raw materials or ingredients useful for the human body in accordance with the Health Functional Food Act, and "functionality" refers to the structure and function of the human body. It refers to ingestion for the purpose of obtaining useful effects for health purposes such as regulating nutrients or physiological effects.

The food composition of the present invention may contain conventional food additives, and the suitability as the "food additive" is determined according to the general rules and general test methods of food additives approved by the Ministry of Food and Drug Safety, unless otherwise specified. It is judged according to the standards and standards related to the item.

The items listed in the "Food Additives Code" include, for example, chemical compounds such as ketones, glycine, potassium citrate, nicotinic acid, and cinnamic acid; Mixed preparations such as sodium L-glutamate preparation, noodle-added alkali agent, preservative agent, and tar color agent can be mentioned.

The food composition of the present invention may include 0.01 to 95% by weight of the complex extract, preferably 1 to 80% by weight, based on the total weight of the composition. The complex extract contained in the food composition of the present invention can be obtained by the same method as the extraction method mentioned in the preparation of the pharmaceutical composition.

In addition, the food composition of the present invention may be manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, etc. for the purpose of preventing and/or improving diabetes.

For example, the health functional food in the form of a tablet is granulated by a mixture with a complex extract, excipients, binders, disintegrants, and other additives in a conventional manner, and then a lubricant is added to compression molding, or the mixture is Direct compression molding is possible. In addition, the health functional food in the form of tablets may contain a mating agent, etc., if necessary, and may be coated with a suitable skinning agent if necessary.

Among health functional foods in the form of capsules, hard capsules can be prepared by filling conventional hard capsules with a mixture of complex extracts and additives such as excipients, or their granules or coated granules, and soft capsules are complex extracts. And it can be prepared by filling a mixture with additives such as excipients in a capsule base such as gelatin. The soft capsule formulation may contain a plasticizer such as glycerin or sorbitol, a colorant, a preservative, and the like, if necessary.

A health functional food in the form of a ring can be prepared by molding a mixture of complex extracts, excipients, binders, disintegrants, etc. in an appropriate way, and if necessary, the skin is coated with sucrose or other suitable skinning agent, or starch, talc, or a suitable material. You can also dress up.

The health functional food in the form of granules may be prepared in granular form by an appropriate method of a mixture of complex extracts, excipients, binders, disintegrants, and the like, and may contain flavoring agents, flavoring agents, etc. as necessary. For health functional foods in granular form, use No. 12 (1680 μm), No. 14 (1410 μm), and No. 45 (350 μm) sieves to pass all the sieves in the next particle size test, and the remaining amount in No. 14 sieves 5.0% or less and passing through No. 45 may be less than 15.0% of the total amount.

The term definitions for the excipients, binders, disintegrants, lubricants, flavoring agents, flavoring agents, etc. are described in documents known in the art and include those having the same or similar functions (Explanation of the Korean Pharmacopoeia, Moonseongsa, Korea) Association of Colleges of Pharmacy, 5th ed., p33-48, 1989).

There is no particular limitation on the type of the food. Examples of foods to which the extract of the present invention can be added include beverages, gums, vitamin complexes, drinks, and the like, and include all health functional foods in a conventional sense.

The present invention provides a method for treating diabetes, comprising administering to a subject a complex extract of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo.

In the present invention, terms such as "saengjihwang, ginseng, gwaruin, mokdanpi, gardenia, indongdeung and byeolgapgyo complex extract", "diabetes" and "administration" are the same as described above.

The subject refers to an animal, and typically may be a mammal that can exhibit beneficial effects by treatment using the complex extract of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdeung and Byeolgapgyo of the present invention. Preferred examples of such subjects may include primates such as humans. Also, such subjects may include all subjects with or at risk of having symptoms of diabetes.

The present invention also provides the use of the complex extract of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo in the manufacture of a medicament for the treatment of diabetes.

The present invention also provides a composition comprising the extract of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo complex extract for use in the treatment of diabetes.

The present invention also provides the use of the complex extract of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo for the treatment of diabetes.

The complex extract of Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo according to the present invention significantly lowers the blood insulin concentration, reduces blood sugar and urine sugar, improves glycated hemoglobin, and stabilizes the level of ketonuria for diabetes. It shows an excellent effect. Accordingly, it can be usefully used as a pharmaceutical composition or health functional food.

Hereinafter, the present invention will be described in more detail through examples. However, these Examples and Test Examples are for illustrating the present invention, and the scope of the present invention is not limited to these Examples and Test Examples.

Example 1. Preparation of complex extract

In the case of all herbal medicine materials, those purchased through an herbal medicine vendor in Gyeongdong Market were used. 200 g of raw ginseng, 180 g of ginseng, 140 g of ginseng, 100 g of mulberry skin, 75 g of gardenia, 75 g of ginseng root, and 30 g of byeolgap bridge were put in 8,000 ml of water, put in a water heater (no pressure or pressure) at 80-100 ° C, and boiled for 2-3 hours. Then, after the bath, 120ml each was packed in a pack so that the patient could take it conveniently.

Example 2. Preparation of complex extracts

In addition to the components of the complex extract of Example 1, 40 g of any one or more selected from the group consisting of stone (gypsum), 牡蠣 (moryeo), Put it in water and put it in a water heater (no pressure or pressure) at 80-100° C., and boil it for 2-3 hours. These additional ingredients are ingredients that can be added to one or more in consideration of the patient's oriental medical condition, and correspond to ingredients that can exhibit an additional synergistic effect in improving diabetes.

After the bath, 120ml each was packed in a pack so that the patient could take it conveniently.

Example 3. Preparation of complex extracts

In addition to the complex extract component of Example 2, 40 g each of at least one selected from the group consisting of In addition, it was put in 10,000ml water, put in a water heater (no pressure or pressure) at 80-100°C, and bathed for 2-3 hours. These additional ingredients are ingredients that can be added to one or more in consideration of the patient's oriental medical condition, and correspond to ingredients that can exhibit an additional synergistic effect in improving diabetes.

After the bath, 120ml each was packed in a pack so that the patient could take it conveniently.

Example 4. Preparation of concentrated extract of complex extract

When the herbal medicine blend extract prepared in Examples 1 to 3 is heated by lowering the pressure through a "low pressure concentrator" to boil and evaporate water at 60 ° C. , was concentrated up to 3 liters of water evaporation per hour on average). Then, the concentrate was packaged in 20 ml each so that the patient could take it conveniently.

Example 5. Confirmation of diabetes improvement effect

To the diabetic patient group, the above-prepared complex extract or concentrated extract was prescribed to confirm its therapeutic effect.

Specifically, from July 1, 2018 to November 30, 2018, the study was conducted retrospectively through chart review for registered patients.

As for the condition, adult men and women over 30 years of age and having type 2 diabetes, the changes in the patient group who took the concentrated extract of the complex extract containing the components of Example 1 above for 3 months or more were confirmed.

Among these adult men and women over 30 years of age, pregnant or lactating women were excluded from the clinical target group, and those who arbitrarily stopped the above prescription were also excluded from this clinical target group.

90 packs (20ml) each of the concentrated extract of the complex extract containing the components of Example 1 above was provided to the patient, and was to be taken before meals, between meals, and at any time after meals. As a precaution, try to go to bed at 10 or 11 o'clock if possible, and be careful about instant food.

(1) General characteristics of clinical subjects

[Table 1] General characteristics of clinical subjects

SY: So-Yang, DM medication: patients on western medication for diabetes mellitus (DM).

A total of 5 patients as above were selected as the clinical target group. There were 3 males and 2 females, all of whom were diagnosed with diabetic disease, and they corresponded to patients with the constitution of Soyangin.

(2) History and medical history of the clinical target group

The duration of diabetes mellitus of 5 subjects was from 3 months to as long as 12 years, and 2 patients were not taking diabetic medications, and the rest were taking them.

[Table 2] History and medical history of clinical subjects

(3) Changes in glycated hemoglobin (HbA1c)

After taking the concentrated extract of the complex extract containing the components of Example 1 according to the present invention, the change in glycated hemoglobin was confirmed in units of one month.

The results are shown in Table 3.

[Table 3] Changes in glycated hemoglobin

As can be seen in Table 3, a significant improvement in glycated hemoglobin was shown in the Soyangin group. Specifically, the Soyangin group, corresponding to the above five, showed a significant improvement effect in terms of glycated hemoglobin over time.

(4) changes in urine sugar

After taking the concentrated extract of the complex extract containing the components of Example 1 according to the present invention, the change in glycated hemoglobin was confirmed in units of one month.

The results are shown in Table 4.

[Table 4] Confirmation of changes in urine sugar

As can be seen in Table 4, urine sugar significantly decreased in all 5 clinical subjects.

As can be seen from Tables 3 and 4, administration of the complex extract according to the present invention improved glycated hemoglobin and urine sugar in the clinical subject group, thereby exhibiting a therapeutic effect on diabetes. These results indicate clinically significant results in that they confirmed the direct treatment effect in the actual patient group.

Moreover, it is thought that better results can be achieved if the active life guidance of an oriental doctor is used in parallel with the treatment of these diseases in terms of the result of only administering herbal medicines during the course of normal life without any special life management guidance to the patient.

Example 6. Case study results for confirming the diabetes improvement effect

For individual patients suffering from diabetes, the therapeutic effect of the complex extract prescription according to the present invention was individually confirmed, and the results were summarized as follows.

(1) Case study 1 (KJS (male/30) case log)

1. address card

口乾, 夜間頻尿, 体重減少 (116Kg -> 99Kg; occurred in the summer of 2016)

2. Past history: no specifics

3. Current military history

The person mentioned above is a 30-year-old male with a strong body type (182 cm / 99.4 kg) who is a freight driver by profession. The usual food was eating out, eating out a lot of instant food and drinking 6 times a week, but recently it was reduced to once a week due to concerns about diabetes complications.

When I visited the hospital for neck disc surgery in December 2015, I was diagnosed with diabetes, and after taking the diabetes medication for 3 to 4 days, I stopped taking it because of discomfort in my stomach. The fasting blood glucose level was 250 mg/dl 4 days ago, and the oral and nasal symptoms lasted more than 1 year, and on April 18, 2017, he visited this oriental clinic.

4 Major findings

1) April 18, 2017 Inspection at the hospital

Blood pressure: 132/90mmHg, postprandial blood sugar: 130mg/dl (6 hours and 40 minutes after a meal), HbA1c: 9.0%

Urine sugar positive (+)

5. First visit

1) 消化器系;消化良好, heart lower(+)

2) 飮酒: 1 day/week, 2 bottles/time of soju (drinking about 6 times a week until a few months ago)

3) 睡眠: I am a cargo driver, so I have irregular sleeping hours, and the amount of sleep is 5 hours a day.

入眠難, go to urinate 1-2 times during sleep.

4) 汗: Sweat a lot all over the body

5) 大便: 2-3 times/day

6) 舌診: 舌大, 質裂, no 苔

7) 脈診 : 沈滑, 84 times/min

8) Lifestyle: Working as a freight driver, there is a lot of work and a lot of stress.

I used to eat out often, but I've been trying to eat at home lately.

6 Herbal medicine prescription and daily life management

6-1 Herbal medicine

[Table 5] Prescription herbal medicine

6-2 Living management guidance

1) sleep; go to bed by 11 o'clock

The brain and retina use only glucose for energy. In order to reduce the amount of sugar, which is an energy source for the brain and retina, it was decided to go to bed before 11 p.m. in the judgment that a good sleep habit is important.

2) food; Avoid instant foods that are refined carbohydrates (bread, ramen, soda, etc.). In general, eat enough Korean food, but chew it slowly.

3) exercise; Because exercise was difficult due to working conditions, they were instructed to stretch in the middle to recover from eye fatigue while driving, and to take a 15-minute break after driving for 2 hours.

7 Progress

1) May 1 (13 days after treatment) - Weight 99.7 kg

Blood sugar 121㎎/㎗ (5 hours 40 minutes after meals), urine sugar (-)

Reduced urination.

2) May 24 (37 days after treatment) - Weight 99.5 kg

Blood sugar 126mg/dl (5 hours after meals) Urine sugar (-)

Do not wake up in the middle of sleep

3) June 14 (1 month and 26 days after treatment) - Weight 99.5 kg

Blood sugar 125㎎/㎗ (3 hours 30 minutes after meals) Urine sugar (-)

They said that they were comfortable because the frequency of urination was reduced and that there were no discomfort symptoms.

It was said that Umju drinks excessively once a week. Exercise: I play badminton 3-4 times a week.

4) June 28 (2 months and 10 days after treatment) - Weight 96.9 kg

Blood sugar 102 mg/dl (5 hours 40 minutes after meals) HbA1c 7.3%, urine sugar (-)

There is no 口乾, 頻尿 has disappeared, and he is sleeping soundly.

Late-night meals 1-2 times a week, drinking alcohol once/week, exercise 3-4 times/week

5) July 19th (3 months after treatment) - Weight 97.9kg

Blood sugar 121mg/dl (5 hours 30 minutes after meals), HbA1c 6.2%, urine sugar (-)

I couldn't exercise, I drank 2 times/week (3~4 bottles of soju/time)

He said he was tired because he slept 5 hours a day.

6) July 19th ~ September 26th (phone consultation)

It was difficult to come to the hospital due to the change in the cargo operation area, so I prescribed it after consulting by phone.

It is said that postprandial blood sugar is about 110mg/dl, and he is in good health

[Table 6] Changes in blood sugar, urine sugar, and glycated hemoglobin in patients

As can be seen from the above table, it can be confirmed that after drug prescription, urine sugar disappeared and blood sugar and glycated hemoglobin were significantly improved.

(2) Case study 2 (KCS (male/51) case log)

1 address card

渴症, 夜間頻尿, 疲勞, skin itching,

2 past history

I have been taking blood pressure medicine and aspirin since 4 years ago, and cholesterol medicine since 3 months ago.

3 current military

On November 16, 2013, he visited the hospital with symptoms of sleep disturbance due to 口乾, 渴症, 体重減少, numbness in the legs, and 夜間頻尿. After receiving herbal medicine and acupuncture treatment, fatigue was improved, but he wanted to receive additional treatment for active oriental treatment of diabetes.

On November 16, 2013, when he visited the hospital for the first time, he complained of many complaints of discomfort in the mouth, numbness in the legs, skin irritation, and itching of the skin.

4. Major inspection findings

1) November 16, 2013 Inspection at the hospital

Blood sugar: 499mg/dl (3 hours 50 minutes after meals), HbA1c: 12% urine sugar positive (++++)

5 First visit

1) 消化器系

There is no 消化不良(+), heartburn(-), 心下(+), no hunger.

Eat fast, eat 3 meals a day regularly.

2) 飮酒: 2~3 times a month (2 bottles of soju at a time), until 3 years ago, I drank a lot.

3) 睡眠 : Irregular but the last 10 ~ 5 o'clock

4) 汗 : When the weather is hot, it sheds a lot, especially from the head.

5) 大便: 1 time/day, no discomfort

6) 舌診: 舌大, 質燥, no 苔

7) 脈診 : 沈滑數, 81 times/min

8) Lifestyle: I am an executive at my organization, and I had a lot of things to worry about since 45 days ago.

6. Herbal medicine prescription and daily life management

6-1 Life management

1) sleep; go to bed by 11 o'clock

The brain and retina use only glucose for energy. In order to reduce the amount of sugar, which is an energy source for the brain and retina, it was decided to go to bed before 11 p.m. in the judgment that a good sleep habit is important.

2) food; Avoid instant foods that are refined carbohydrates (bread, ramen, soda, etc.). In general, eat enough Korean food, but chew it slowly.

3) exercise; Climb once a week (2 hour round trip course) with an intensity of about the same.

6-2 Herbal medicine prescription

[Table 7] Prescription herbal medicine

7. Progress

1) December 7, 2013 - Weight 63Kg

Loss of lethargy, fatigue, edema, numbness in the legs

2) January 4, 2014 - Weight 67.2Kg

The weight I lost has increased slightly. I take a half-bath for about 30-40 minutes every day, and I go to bed after 12 o'clock.

3) February 4th - Weight 66Kg

I feel drowsy and tired after lunch. Condition is good.

Sleep (10:30-5:30, waking up at around 3 am)

4) March 21st - Weight 67Kg

It has been 1 month since I stopped taking blood pressure medicine, cholesterol medicine, and aspirin.

Blood pressure 121/86, blood sugar 110mg/dl (2 hours after meals), HbA1c 6.5%

Stiffness when clenching fists when waking up in the morning. Complaining that the body feels swollen when waking up

5) April 18 - Weight 67 Kg

Sleeping late again. Drinking 3 times in 2 weeks

脈沈緩 There is some swelling in the fingers. Reduced the amount of food by 2/3 (from 1 week ago)

6) June 2nd - Weight 68.2 Kg

Tired of overdoing hiking on the weekend. No drinking and no western medicine

Edema no longer complains.

7) August 30th - Weight 68.1Kg

From August 20, changing the prescription from decoction to pills to maintain and manage physical condition

The pill was taken 3 times a day (25 pills/1 time) when the body was tired.

8) October 18 - Weight 67.5Kg

Tired of being busy with work, I stopped taking Tibetan mushrooms

9) April 4, 2015 - Weight 67.5Kg

I was taking the pill twice a day in the morning and evening (20 pills at a time), and there were many family problems.

10) September 19th - Weight 67.5Kg

I ate Western medicine for esophagitis 3 days ago, and there was redness in the face and red eyes.

HbA1c 7.3%

11) April 13, 2016 - Weight 67.5Kg

Daily life is busy and stressful. A feeling of sweetness in the mouth, complaints of chest pain

Blood pressure 157/98 (2 years after stopping blood pressure medication)

The stool has recently become thin, and the symptoms of esophagitis are still there, and bloating occurs. Good digestion after eating

The herbal medicine Hyeongbangdojeoksan was administered by recommending the re-administration of the decoction.

12) June 24 - Weight 67.7Kg

Blood pressure 130/80, no symptoms of esophagitis. No sweet taste in the mouth

HbA1c 6.6%

13) July 18 - Weight 68 Kg

Blood pressure 160/95, HbA1c 6.9%

He said that it was difficult to take decoctions and that he would live by managing his own life.

He wants to take Hyeongbang-hwang-tang pills.

12) February 10, 2017 - Weight 67.5Kg

I did a lot of long-distance driving and had trouble sleeping because I was taking care of my grandchildren.

No Western medicines and health functional foods are taken. HbA1c 6.3%

[Table 8] Changes in blood sugar, urine sugar and glycated hemoglobin in patients

After diagnosis of diabetes due to hyperglycemia, active treatment with herbal medicines without taking Western medicines. At the first visit (November 26, 2013), the blood sugar level of 499mg/dl HbA1c 12% after 7 months (June 2, 2014), the blood sugar 95mg/dl HbA1c 5.9 % confirmed. In addition, as of February 10, 2017, the blood glucose level was confirmed to be 145 mg/dl HbA1c 6.3% and is being maintained.

(3) Case study 3 (PTY(M/57) case log

1. address card

口乾, 疲勞感, type 2 diabetes, soyangin 消渴

2. History: On November 30, 2016, Samsung Medical Center performed coronary artery bypass surgery for myocardial infarction.

3. Current military history

The person mentioned above is a 57-year-old male with a normal body type (170 cm/78.1 kg) and his occupation is a principal.

I was told that I usually drink a lot, and as a result of the workplace examination, I had high liver levels, and that there was a lot of work-related stress. On November 30, 2016, he visited a local hospital due to an abnormal condition and was diagnosed with myocardial infarction.

On May 10, 2017, after being tested at the hospital and the results of blood sugar 276mg/dl and HbA1c 10.0% came out, he was diagnosed with diabetes and was prescribed diabetes medication (Diabex, Posigagat).

With the sudden increase in Western medicine, worries about diabetes complications and fatigue persisted, so I came to the hospital on May 27, 2017 for herbal treatment while taking diabetes medicine.

4 Major findings

1) May 10, 2017 (Inspection at Pohang 00 Hospital)

Blood sugar: 270㎎/㎗ , HbA1c: 10.0%

2) May 27, 2017 (Prosecutor at this oriental clinic)

Diabetes drug (diabex 500mg 1 tablet, Forsiga 10mg 1 tablet) 1 time/day, 15 days taking

Blood sugar 109 mg/dl (5 hours 30 minutes after meals), HbA1c: 9.3 %, urine sugar (++)

Blood pressure 129/83 mmHg

5. First visit

1) 消化器系;消化良好, heart lower(+)

2) 飮酒: I drank a lot before heart surgery, but I rarely drink after that.

3) 睡眠: 12 pm to 5 am, the amount of sleep is small.

4) 汗 : 多, burns a lot of heat

5) 大便: 1 time/day, no inconvenience

6) 舌診: 舌質裂甚, 白苔有, lip color is black.

7) 脈診 : 沈滑, 66 times/min

8) Lifestyle: Before the heart surgery, there was a lot of stress and a lot of drinking.

Recently, for breakfast, I am eating fried egg + vegetable juice.

6 Herbal medicine prescription and daily life management

6-1 Herbal medicine

[Table 9] Prescription herbal medicine

6-2 Living management guidance

1) sleep; go to bed by 11 o'clock

The brain and retina use only glucose for energy. In order to reduce the amount of sugar, which is an energy source for the brain and retina, it was decided to go to bed before 11 p.m. in the judgment that a good sleep habit is important.

2) food; Avoid instant foods that are refined carbohydrates (bread, ramen, soda, etc.).

In general, eat enough Korean food, but chew it slowly.

3) exercise; Teach a walk that can relax the mind and body rather than strenuous exercise.

7 Progress

1) June 24 (27 days after treatment) - Weight 77.5 kg

Blood sugar 115㎎/㎗ (6 hours 30 minutes after meals), urine sugar (-) blood pressure 128/82 mmHg

Diabetes drug Diabex 500mg taking 1 tablet (stop taking Posiga after taking herbal medicine)

Trying to sleep within 11 o'clock, the dark red lip color is improving.

(June 20 public health center test result) HbA1c 7.6%

2) July 22 (1 month and 25 days after treatment) - Weight 77.5 kg

Blood sugar 91mg/dl (3 hours 40 minutes after meals) Urine sugar (+), HbA1c 7.3%

Diabetes drug Diabex 500mg 1 tablet in the evening (I did not take it twice last week)

He said that his body felt lighter and that he felt good. no inconvenience

3) August 19th (2 months and 22 days after treatment) - Weight 77.1kg

Blood sugar 105mg/dl (5 hours 20 minutes after meals) Urine sugar (-) Blood pressure 124/80 mmHg

Do not take diabetes medication (Stop taking Diabex from July 22)

There is no discomfort, but it is said that he is concerned about a lot of foam in the urine.

4) September 16 (3 months and 19 days after treatment) - Weight 76.4 kg

Blood sugar 111mg/dl (6 hours after a meal) Urine sugar (-) HbA1c 6.8%,

I wake up around 2-3 am during sleep and go to urinate, there is a lot of foam in the urine

1 hour and 20 minute walks in the morning and evening.

(Pohang 00 Hospital September 13th test result) HbA1c 7.0% Blood sugar 129 ㎎/㎗

5) November 18th (5 months and 21 days after treatment) - Weight 77.2kg

Blood sugar 105 mg/dl (5 hours 20 minutes after meals), urine sugar (-) HbA1c 7.0%, blood pressure 115/75 mmHg

I drink 1-2 cups of black coffee every day. 1 drink in November. walking every day

6) January 29, 2018 (8 months after treatment) - Weight 78.4 Kg

Blood sugar 125 mg/dl (2 hours after meals), urine sugar (-) HbA1c 6.6%,

The condition is good, and the lip color is red without noticeably black. A lot of white spots are gone.

[Table 10] Changes in blood sugar, urine sugar and glycated hemoglobin in patients

As can be seen above, the patient's urine sugar, blood sugar, and glycated hemoglobin showed excellent improvement effects.

(4) Case study 4 LDS (M/45) case log

1. address card

渴症, 夜間頻尿, 心煩, 疲勞,

2. History: Cataract surgery in 2011 (right)

3. Current military history

The above person is a 45-year-old male with a strong body type (180 cm / 83.7 kg), and in May-June 2016, weight loss (88 kg → kg), thirst, and fatigue occurred. diagnosed He was recommended for hospitalization and insulin pump surgery because his blood sugar was very high at the hospital, but he came to the hospital to receive oriental medical treatment. At the time of admission, ketones (++) and proteinuria (++) were both positive, along with severe fatigue, fatigue, and fatigue. Symptoms related to upper and middle arms were confirmed, and over the past two months, he had been working overtime and under a lot of stress, and he had proteinuria.

4 Major findings

1) Inspection at the hospital on June 21, 2016

Blood pressure: 148/105mmHg, postprandial blood sugar: 322mg/dl (5 hours and 32 minutes after meals), HbA1c: 11.3%

Urine sugar positive (++), ketone positive (++), proteinuria positive (++)

5. First visit

1) 消化器系

消化不良(+), heartburn(-), 心下(+)

Eat food early, breakfast; bread, lunch; restaurant, dinner; eat late at home

2) 飮酒: 1 day/week, 1 bottle of soju/time

3) 睡眠: 12 pm to 6 pm (Wake up to urinate 2 to 3 am)

4) 汗 : I usually sweat a lot.

5) 大便: 1 time/day, no discomfort

6) 舌診: 舌大, 質淡紅微燥, 苔

7) 脈診 : 沈滑數, 91 times/min

8) Lifestyle: Working as a food researcher, over the past 2 months (9-10 p.m.) continued and increased stress caused severe chest discomfort. I don't exercise.

6 Herbal medicine prescription and daily life management

6-1 Herbal medicine

[Table 11] Herbal medicine prescription

6-2 Life management

1) sleep; go to bed by 11 o'clock

The brain and retina use only glucose for energy. In order to reduce the amount of sugar, which is an energy source for the brain and retina, it was decided to go to bed before 11 p.m. in the judgment that a good sleep habit is important.

2) food; Avoid instant foods that are refined carbohydrates (bread, ramen, soda, etc.). In general, eat enough Korean food, but chew it slowly.

3) exercise; Exercise was already sufficient, and it was judged that the patient's physical strength was too high, so he was instructed not to do more than 1 hour and 30 minutes a day.

7 Progress

1) July 5th (14 days after treatment) - Weight 83.7kg

Blood pressure: 145/100 mmHg, 脈沈遲 (pulse rate 67/min)

Digestion is better than before, sleep is maintained at 11 o'clock to 6 o'clock (wake up from urination is reduced), and he exercised for 20 minutes on an indoor bicycle every day.

2) July 19 (28 days after treatment) - Weight 81 kg

Blood pressure 130/90mmHg

There was no digestive problem, but it was confirmed that he ate a lot of fruit recently (peach, plum, cherry, banana). Sleeping 11 o'clock to 6 o'clock wake up (sometimes waking up due to urination) was maintained, and stress due to overwork was still there. The amount of exercise was walking for 30 minutes to 1 hour every day.

3) August 16th (1 month and 25 days after treatment) - Weight 80.7kg

Blood pressure 120/75 mmHg, 脈沈遲 (pulse rate 67/min)

Good digestion, thirst quenched. I ate mainly Korean food, went to bed between 11 and 12 o'clock and woke up at 6 o'clock (I woke up once because it was hot without urinating).

For exercise, indoor cycling and walking were exercised every day, and hiking was performed for 1 hour on weekends.

4) September 27 (3 months after treatment) - Weight 78.6 kg

Dry mouth, thirst, and frequent urination disappeared.

5) October 24 (4 months after treatment) - Weight 78.3 kg

On October 19th, he came to the hospital with the results of the medical examination conducted at Seoul Mo Hospital. The resulting figures were as follows. HbA1c 6.5%, blood sugar 105mg/dl, blood pressure: 117/74mmHg ECG normal, cholesterol level improved 248mg/dl →210mg/dl

6) November 22 (5 months after treatment) - Weight 78.4 kg

Sleep was maintained between 12 o'clock to 6 o'clock (no waking up in the middle), and exercise was performed by indoor cycling or walking 3 times a week.

8) January 4, 2017 (6 months and 15 days after treatment) - Weight 78.7kg

He went to bed after 12 o'clock, but woke up without waking up in the middle.

[Table 12] Changes in blood sugar, urine, and glycated hemoglobin in patients

As can be seen in the table above, after diagnosis of diabetes due to high blood sugar, fatigue increased after taking Western medicines, so without taking Western medicines, active treatment only with herbal medicines and lifestyle management resulted in the disappearance of all physical symptoms and reduced blood sugar, glycated hemoglobin, urine sugar, and ketonuria. All values were stabilized.

(5) Case study 5 CBH (M/39) case log

1 address card

Fatigue, high blood sugar, fatty liver

2 past history

I have been taking neuropsychiatric medication for 3 years for mixed anxiety-depressant disorder.

Psychological counseling in Daegu once every 1-2 weeks (General Psychological Counseling Center)

Taking antihypertensive drugs (Salotan 50mg, from 4 years ago),

I am taking a fatty liver treatment in the morning and evening (from 4 years ago)

In February 2009, he started taking diabetes medication because his blood sugar was about 600mg/dl and his weight loss was severe.

3 current military

On June 24, 2016, I came to the hospital because I was taking diabetes medication (Zemamet Seo-Release Tablet 2550 morning 1, evening 1) with the above dyslexia and wanted to receive oriental treatment at the same time as my blood sugar could not be controlled.

At the time of admission, he came with the test result sheet that was performed on April 27 at the mother's internal medicine department, who is currently taking diabetes medication.

4. Major inspection findings

1) April 27, 2016 Seoul Medical Examination

Fasting blood sugar: 161mg/dl, HbA1c 7.8%

GOT: 82 IU/L, GPT: 51 IU/L, triglycerides: 156 mg/dl

2) Inspection at the hospital on June 24, 2016

blood pressure 130/90 mmHg blood sugar; 363 mg/dl (2 hours 23 minutes after meals) HbA1c 10%

5 First visit

1) 消化器系

I eat quickly due to working conditions, and meal times are irregular.

Sometimes there is no heartburn (+), 心下 (+), or hunger.

2) 飮酒: I do not drink from the beginning.

3) 睡眠: Irregular with 2 shifts, the total amount of sleep is 6-8 hours.

4) 汗: A lot of shed from the body.

5) 大便: 1 time/day, no discomfort

6) 舌診: 舌大, 質燥, 白苔有

7) 脈診 : 沈緊數, 102 times/min

8) Lifestyle: As a prison guard at Cheongsong Prison, there is a lot of tension and stress and irregular life patterns due to working in two shifts.

6. Herbal medicine prescription and daily life management

6-1 Herbal medicine

[Table 13] Herbal medicine prescription

6-2 Life management 1) Sleep; Although it is difficult to have a consistent sleep pattern due to working conditions, instruct them to get enough sleep as much as possible.

2) food; Avoid instant foods that are refined carbohydrates (bread, ramen, soda, etc.). In general, eat enough Korean food, but chew it slowly.

3) exercise; Exercise for the purpose of psychological stability and mood change through walking.

7. Progress

1) July 27, 2016 (one month after treatment) - Weight 75.3 Kg

blood pressure 120/85 mmHg blood sugar; 183 mg/dl (2 hours 10 minutes after meals)

He said that the number of times he wakes up during sleep is reduced.

Instruct them to take blood tests to check liver levels

On July 29th, blood test results are sent by fax (liver level is normal, triglyceride level rises)

GOT: 27 IU/L, GPT: 25 IU/L, triglycerides: 309 mg/dl

2) September 1st - Weight 73.5 Kg

blood pressure 112/98 mmHg blood sugar; 269 mg/dl (1 hour and 10 minutes after meals)

I lost 2 kg of weight and my energy improved.

3) September 21 - Weight 73.4 Kg

There was a lot of stress because the work department moved

4) October 24 - Weight 72.9 Kg

When visiting an oriental clinic, blood sugar was found to be 149 mg/dl, and blood sugar dropped significantly.

Before visiting the oriental medicine clinic, he visited a medical department in Seoul and came (additionally prescribed diabetic drug Glimel).

5) November 25 - Weight 75.5 Kg

Blood sugar: 140 mg/dL (1 hour and 12 minutes after a meal), HbA1c 8.6% level continues to improve

Glimel tablets, an additional diabetes drug prescribed by the internal medicine clinic on October 24, are being taken 3 to 4 times a week.

There are no complaints, but he said that he seems to have gained weight after taking Glimel tablets.

On November 21st, I had a rectal examination and my blood pressure was 110/70mmHg, fasting blood sugar 128 mg/dl.

GOT: 24 IU/L, GPT: 40 IU/L, triglyceride: 229 mg/dl were confirmed.

6) December 26 - Weight 77.5 Kg

After taking Glimel, he experienced weight gain, increased fatigue, and symptoms of hypoglycemia, so he stopped taking it. As for diabetes medication, I am taking only Zemamet.

脈沈緊數, 舌苔無, stool once a day

7) January 16, 2017 - Weight 79.1Kg

He said that he reduced his drug intake.

For diabetes, take 1 tablet of Zemamet 2550 each in the morning and evening, and take 1 tablet each in the evening.

Glimel was taken 1/2 tablet in the morning of Monday, Wednesday, and Friday.

I am taking the blood pressure medicine by reducing it by 1/2.

Nerve sedatives are not taken on night shift days.

8) February 24 - Weight 80Kg

Blood sugar 134 mg/dl (1 hour after meal)

Diabetes prescription has changed in internal medicine, so the pattern of taking Western medicine has changed

Glimel tablet 1mg is taking 1/2 tablet once every 2 days in the morning

Zemiglo 50mg is taking 1 tablet every morning

Diabex 500 is taking 1 in the morning and 1 in the evening.

Posiga 10mg was also prescribed, but not taken. My blood sugar has recently gone down, but the internal medicine doctor has prescribed more diabetes drugs, so when the patient searched for it, he was concerned about the side effects of Forxiga, so he didn't take it.

[Table 14] Changes in blood sugar, urine sugar, and glycated hemoglobin in patients

As can be seen above, significantly improved values were shown in terms of blood sugar, urine sugar, and glycated hemoglobin. In particular, it is a case in which blood sugar is not controlled at some point during the course of taking Western medicines, and the medication is helping to control blood sugar through herbal treatment to a patient who continues to increase, and helps to improve the condition and symptoms of the body.

The results of the initial high liver level returning to normal after herbal medicine administration shows that active herbal medicine treatment can play a big role in improving the body as well as controlling the patient's blood sugar.

(6) Case study 6 LHJ (F/50) case log

1. Address card;足痺症, 疲勞, 糖尿

2. History : After cataract diagnosis 5 years ago, regular ophthalmology examination

After diagnosis of overactive cystitis in 2016, taking Western medicine for 1 year

I was taking painkillers with the diagnosis that the water bag in my ankle was pressing on the nerve since a year ago, and I stopped taking it for the last 1 month (due to concerns about side effects of Western medicine)

3. Current military history

The person mentioned above is a 50-year-old woman (160cm/85.1kg) who works in the church.

In the process of taking painkillers for ankle pain, he visited a rheumatologist with his thumb 屈伸不利 and performed a blood test along with treatment for the patient's discomfort symptoms such as thirst and frequent urination.

On April 4, 2018, as a result of the internal medicine blood test, blood sugar 392 mg/dl, HbA1c 13.5%, and urine sugar positive (++) were diagnosed, and three types of diabetes drugs were started.

Hypoglycemia occurred while taking the diabetes medicine, so I reduced the diabetes medicine by one tablet, but I arbitrarily stopped the diabetes medicine for 10 days due to fatigue, numbness in my legs, and worries that I would have to take diabetes medicine for the rest of my life.

4 Major findings

1) Results of rheumatology examination on April 4, 2018

Postprandial blood sugar 392 mg/dL, HbA1c 13.5 %, urine sugar positive (++),

2) June 18, 2018 inspection results

Postprandial blood glucose 136 mg/dl (3 hours 30 minutes after meals), HbA1c 7.0%, urine glucose negative (-),

5. First visit

1) 消化器系; Recent change of heart (+)

2) 飮酒: Almost never.

3) 睡眠: 11am to 12pm, bedtime to 5pm (worship service at 5:20pm)

4) 汗: sweating profusely on the face

5) 大便: Once/day I was constipated and it was hard, but I got better after eating lactic acid bacteria.

6) 舌診 : 舌大, 白裂有 sticky saliva

7) 脈診 : 沈緊, 數 91 times/1 min

8) menstruation; I had my period 3 years ago, and I had my period once in April of this year.

9) Lifestyle: There is a lot of stress in human relationships.

I ate bread often, but after my diabetes diagnosis, I cut down on bread a lot.

Food management is difficult.

6 Herbal medicine prescription and daily life management

6-1 Herbal medicine

[Table 15] Herbal medicine prescription

6-2 Living management guidance

1) sleep; go to bed by 11 o'clock

The brain and retina use only glucose for energy. In order to reduce the amount of sugar, which is an energy source for the brain and retina, it was decided to go to bed before 11 p.m. in the judgment that a good sleep habit is important.

2) food; Avoid instant foods that are refined carbohydrates (bread, ramen, soda, etc.). In general, eat enough Korean food, but chew it slowly.

3) exercise; In the middle of looking at the monitor, stretch often, and teach them to take a walk when they have time.

4) Western medicine; He continued to stop taking herbal medicine because he had a strong will not to take it.

7 Progress

1) July 2nd (14 days after treatment) - Weight 86.4kg

Blood sugar 139㎎/㎗ (3 hours 7 minutes after meals), urine sugar negative (-),

No diabetic or painkillers have been taking since June 10th

Efforts to improve sleep time (go to bed around 11 am; go to sleep at 12 pm)

I received acupuncture treatment at a local oriental clinic related to sciatica.

2) July 31 (1 month and 13 days of treatment) - Weight 83.7kg

Blood sugar 101mg/dl (2 hours after meals) Urine glucose negative (-)

足痺症 almost none. No need to wake up wkadf and urinate because it's hot during sleep.

Received acupuncture treatment once at a local oriental clinic related to sciatica.

3) August 27 (2 months and 9 days after treatment) - Weight 83.4 kg

Blood sugar 139mg/㎗ (2 hours 30 minutes after a meal), urine sugar negative (-)

From August 13th to August 21st, I went on an overseas trip.

After a blood test at the public health center on August 23, I brought the test result today.

Postprandial blood glucose 153mg/dL, HbA1c 6.5%

4) September 11 (2 months and 23 days of treatment) - Weight 84.2kg

Blood sugar 169㎎/㎗ (2 hours 30 minutes after meals) Urine sugar negative (-),

I have had cold symptoms since 1 week ago, but I am not taking any medications.

5) October 4th (3 months and 16 days after treatment) - Weight 83.7kg

Blood sugar 126 mg/dl (4 hours after meals), urine glucose negative (-) HbA1c 6.4 %

I have menopausal symptoms with a fever on my face.

There is a feeling of discomfort on the bladder side in the early stages of being diagnosed with cystitis in the past

He was in good condition and had no symptoms related to diabetes.

[Table 16] Changes in blood glucose, urine glucose and glycated hemoglobin in patients

As can be seen, significant improvement in blood sugar, urine sugar, and glycated hemoglobin was achieved only by discontinuing the Western medicine and prescribing the herbal medicine.

In particular, it showed an excellent effect in the case of controlling the blood sugar of a female patient with a strong sense of reluctance to diabetic drugs by taking oriental medicine and managing daily life, and controlling various symptoms of the body.

As can be seen from the above case cases, the complex extract according to the present invention exhibited an excellent diabetes improvement effect in all patient groups showing various clinical findings. This improvement effect shows excellent treatment and improvement effects of the complex extract according to the present invention.

Claims (10)

A pharmaceutical composition for the prevention or treatment of diabetes comprising Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indongdung and Byeolgapgyo complex extract as an active ingredient. The pharmaceutical composition for preventing or treating diabetes according to claim 1, wherein the diabetes is type 1 diabetes or type 2 diabetes. The pharmaceutical composition for preventing or treating diabetes according to claim 2, wherein the complex extract further comprises one or more selected from the group consisting of gypsum, moryeo, hyeonggae, windbreak, ganghwal, dokhwal, jeonho, phalanx and moktong. The pharmaceutical composition for preventing or treating diabetes according to any one of claims 1 to 3, wherein the complex extract is an extract of water, a C ₁ to C ₄ lower alcohol or a mixed solvent thereof. The method according to claim 1, wherein the saengjihwang, ginseng, gwaruin, mokdanpi, gardenia, indongdang, and byeolgapgyo complex extract is 1 to 5 parts by weight of saengjihwang, 1 to 5 parts by weight of ginseng, 0.5 to 4 parts by weight of ginseng based on 100 parts by weight of water. A pharmaceutical composition for the prevention or treatment of diabetes, which comprises 0.5 to 3 parts by weight of mokdanpi, 0.3 to 3 gardenia, 0.3 to 3 parts by weight, and 0.1 to 2 parts by weight of byeolgap bridge. A food composition for preventing or improving diabetes, comprising Saengjihwang, Hyeonsam, Gwaruin, Mokdanpi, Gardenia, Indong, and Byeolgapgyo complex extract as active ingredients. The food composition for preventing or improving diabetes according to claim 6, wherein the diabetes is type 1 diabetes or type 2 diabetes. The food composition for preventing or improving diabetes according to claim 6, wherein the complex extract further comprises one or more selected from the group consisting of gypsum, moryeo, hyeonggae, windbreak, ganghwal, dokhwal, jeonho, phalangeal skin and moktong. The food composition for preventing or improving diabetes according to any one of claims 6 to 8, wherein the complex extract is an extract of water, a C ₁ to C ₄ lower alcohol or a mixed solvent thereof. The method of claim 6, wherein the saengjihwang, ginseng, gwaruin, mokdanpi, gardenia, indongdang, and byeolgapgyo complex extract is 1 to 5 parts by weight of saengjihwang, 1 to 5 parts by weight of ginseng, 0.5 to 4 parts by weight of ginseng based on 100 parts by weight of water. A food composition for the prevention or improvement of diabetes comprising 0.5 to 3 parts by weight of mulberry skin, 0.3 to 3 parts by weight of gardenia, 0.3 to 3 parts by weight of ginseng, and 0.1 to 2 parts by weight of byeolgap bridge.