KR20210139322A - 용질 운반체 패밀리 39 구성원 5 (slc39a5) 억제제를 사용한 고혈당증의 치료 - Google Patents
용질 운반체 패밀리 39 구성원 5 (slc39a5) 억제제를 사용한 고혈당증의 치료 Download PDFInfo
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- KR20210139322A KR20210139322A KR1020217032315A KR20217032315A KR20210139322A KR 20210139322 A KR20210139322 A KR 20210139322A KR 1020217032315 A KR1020217032315 A KR 1020217032315A KR 20217032315 A KR20217032315 A KR 20217032315A KR 20210139322 A KR20210139322 A KR 20210139322A
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- Prior art keywords
- seq
- slc39a5
- nucleic acid
- nucleotide sequence
- acid molecule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6818—Sequencing of polypeptides
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
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- Hematology (AREA)
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- Biophysics (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Computational Biology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962818811P | 2019-03-15 | 2019-03-15 | |
| US62/818,811 | 2019-03-15 | ||
| US202062976716P | 2020-02-14 | 2020-02-14 | |
| US62/976,716 | 2020-02-14 | ||
| PCT/US2020/022251 WO2020190608A2 (en) | 2019-03-15 | 2020-03-12 | Treatment of hyperglycemia with solute carrier family 39 member 5 (slc39a5) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210139322A true KR20210139322A (ko) | 2021-11-22 |
Family
ID=70190174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217032315A Pending KR20210139322A (ko) | 2019-03-15 | 2020-03-12 | 용질 운반체 패밀리 39 구성원 5 (slc39a5) 억제제를 사용한 고혈당증의 치료 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12083141B2 (https=) |
| EP (1) | EP3938513A2 (https=) |
| JP (1) | JP7575396B2 (https=) |
| KR (1) | KR20210139322A (https=) |
| CN (1) | CN113677368A (https=) |
| AU (1) | AU2020241502B2 (https=) |
| CA (1) | CA3132985A1 (https=) |
| IL (1) | IL286308A (https=) |
| MX (1) | MX2021011015A (https=) |
| NZ (1) | NZ780568A (https=) |
| SG (1) | SG11202109711WA (https=) |
| WO (1) | WO2020190608A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200288683A1 (en) * | 2019-03-15 | 2020-09-17 | Regeneron Pharmaceuticals, Inc. | Loss of function rodent model of solute carrier 39 member 5 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19830770C1 (de) | 1998-07-09 | 2000-05-18 | Sueddeutsche Kalkstickstoff | Wasserlösliche Zinkpyruvate bzw. deren Hydrate, Verfahren zu ihrer Herstellung und deren Verwendung |
| JP2001220348A (ja) | 1999-11-30 | 2001-08-14 | Japan Science & Technology Corp | 亜鉛(ii)有機錯体からなる血糖降下剤 |
-
2020
- 2020-03-12 CA CA3132985A patent/CA3132985A1/en active Pending
- 2020-03-12 SG SG11202109711W patent/SG11202109711WA/en unknown
- 2020-03-12 NZ NZ780568A patent/NZ780568A/en unknown
- 2020-03-12 EP EP20717451.7A patent/EP3938513A2/en active Pending
- 2020-03-12 KR KR1020217032315A patent/KR20210139322A/ko active Pending
- 2020-03-12 WO PCT/US2020/022251 patent/WO2020190608A2/en not_active Ceased
- 2020-03-12 AU AU2020241502A patent/AU2020241502B2/en active Active
- 2020-03-12 CN CN202080027032.4A patent/CN113677368A/zh active Pending
- 2020-03-12 JP JP2021555534A patent/JP7575396B2/ja active Active
- 2020-03-12 MX MX2021011015A patent/MX2021011015A/es unknown
- 2020-03-12 US US16/816,515 patent/US12083141B2/en active Active
-
2021
- 2021-09-12 IL IL286308A patent/IL286308A/en unknown
-
2024
- 2024-08-08 US US18/798,198 patent/US20250032529A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ780568A (en) | 2026-02-27 |
| US12083141B2 (en) | 2024-09-10 |
| CA3132985A1 (en) | 2020-09-24 |
| JP7575396B2 (ja) | 2024-10-29 |
| EP3938513A2 (en) | 2022-01-19 |
| SG11202109711WA (en) | 2021-10-28 |
| WO2020190608A2 (en) | 2020-09-24 |
| AU2020241502A1 (en) | 2021-10-21 |
| WO2020190608A3 (en) | 2020-10-29 |
| CN113677368A (zh) | 2021-11-19 |
| IL286308A (en) | 2021-10-31 |
| US20200297751A1 (en) | 2020-09-24 |
| US20250032529A1 (en) | 2025-01-30 |
| MX2021011015A (es) | 2021-12-15 |
| JP2022525456A (ja) | 2022-05-16 |
| AU2020241502B2 (en) | 2025-07-31 |
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| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |