CA3132985A1 - Treatment of hyperglycemia with solute carrier family 39 member 5 (slc39a5) inhibitors - Google Patents

Treatment of hyperglycemia with solute carrier family 39 member 5 (slc39a5) inhibitors Download PDF

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Publication number
CA3132985A1
CA3132985A1 CA3132985A CA3132985A CA3132985A1 CA 3132985 A1 CA3132985 A1 CA 3132985A1 CA 3132985 A CA3132985 A CA 3132985A CA 3132985 A CA3132985 A CA 3132985A CA 3132985 A1 CA3132985 A1 CA 3132985A1
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CA
Canada
Prior art keywords
seq
slc39a5
nucleic acid
nucleotide sequence
position corresponding
Prior art date
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Pending
Application number
CA3132985A
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English (en)
French (fr)
Inventor
Harikiran Nistala
Cristopher Van Hout
Lyndon MITNAUL
Anthony MARCKETTA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of CA3132985A1 publication Critical patent/CA3132985A1/en
Pending legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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CA3132985A 2019-03-15 2020-03-12 Treatment of hyperglycemia with solute carrier family 39 member 5 (slc39a5) inhibitors Pending CA3132985A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962818811P 2019-03-15 2019-03-15
US62/818,811 2019-03-15
US202062976716P 2020-02-14 2020-02-14
US62/976,716 2020-02-14
PCT/US2020/022251 WO2020190608A2 (en) 2019-03-15 2020-03-12 Treatment of hyperglycemia with solute carrier family 39 member 5 (slc39a5) inhibitors

Publications (1)

Publication Number Publication Date
CA3132985A1 true CA3132985A1 (en) 2020-09-24

Family

ID=70190174

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3132985A Pending CA3132985A1 (en) 2019-03-15 2020-03-12 Treatment of hyperglycemia with solute carrier family 39 member 5 (slc39a5) inhibitors

Country Status (12)

Country Link
US (2) US12083141B2 (https=)
EP (1) EP3938513A2 (https=)
JP (1) JP7575396B2 (https=)
KR (1) KR20210139322A (https=)
CN (1) CN113677368A (https=)
AU (1) AU2020241502B2 (https=)
CA (1) CA3132985A1 (https=)
IL (1) IL286308A (https=)
MX (1) MX2021011015A (https=)
NZ (1) NZ780568A (https=)
SG (1) SG11202109711WA (https=)
WO (1) WO2020190608A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200288683A1 (en) * 2019-03-15 2020-09-17 Regeneron Pharmaceuticals, Inc. Loss of function rodent model of solute carrier 39 member 5

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19830770C1 (de) 1998-07-09 2000-05-18 Sueddeutsche Kalkstickstoff Wasserlösliche Zinkpyruvate bzw. deren Hydrate, Verfahren zu ihrer Herstellung und deren Verwendung
JP2001220348A (ja) 1999-11-30 2001-08-14 Japan Science & Technology Corp 亜鉛（ｉｉ）有機錯体からなる血糖降下剤

Also Published As

Publication number Publication date
NZ780568A (en) 2026-02-27
US12083141B2 (en) 2024-09-10
JP7575396B2 (ja) 2024-10-29
EP3938513A2 (en) 2022-01-19
KR20210139322A (ko) 2021-11-22
SG11202109711WA (en) 2021-10-28
WO2020190608A2 (en) 2020-09-24
AU2020241502A1 (en) 2021-10-21
WO2020190608A3 (en) 2020-10-29
CN113677368A (zh) 2021-11-19
IL286308A (en) 2021-10-31
US20200297751A1 (en) 2020-09-24
US20250032529A1 (en) 2025-01-30
MX2021011015A (es) 2021-12-15
JP2022525456A (ja) 2022-05-16
AU2020241502B2 (en) 2025-07-31

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