AU2020241502B2 - Treatment of hyperglycemia with Solute Carrier Family 39 Member 5 (SLC39A5) inhibitors - Google Patents

Treatment of hyperglycemia with Solute Carrier Family 39 Member 5 (SLC39A5) inhibitors

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Publication number
AU2020241502B2
AU2020241502B2 AU2020241502A AU2020241502A AU2020241502B2 AU 2020241502 B2 AU2020241502 B2 AU 2020241502B2 AU 2020241502 A AU2020241502 A AU 2020241502A AU 2020241502 A AU2020241502 A AU 2020241502A AU 2020241502 B2 AU2020241502 B2 AU 2020241502B2
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slc39a5
seq
hffd
hfd
position corresponding
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AU2020241502A
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AU2020241502A1 (en
Inventor
Anthony MARCKETTA
Lyndon MITNAUL
Harikiran Nistala
Cristopher Van Hout
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/14Hydrolases (3)
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    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818Sequencing of polypeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • G01N2333/575Hormones
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

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AU2020241502A 2019-03-15 2020-03-12 Treatment of hyperglycemia with Solute Carrier Family 39 Member 5 (SLC39A5) inhibitors Active AU2020241502B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962818811P 2019-03-15 2019-03-15
US62/818,811 2019-03-15
US202062976716P 2020-02-14 2020-02-14
US62/976,716 2020-02-14
PCT/US2020/022251 WO2020190608A2 (en) 2019-03-15 2020-03-12 Treatment of hyperglycemia with solute carrier family 39 member 5 (slc39a5) inhibitors

Publications (2)

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AU2020241502A1 AU2020241502A1 (en) 2021-10-21
AU2020241502B2 true AU2020241502B2 (en) 2025-07-31

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AU2020241502A Active AU2020241502B2 (en) 2019-03-15 2020-03-12 Treatment of hyperglycemia with Solute Carrier Family 39 Member 5 (SLC39A5) inhibitors

Country Status (12)

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US (2) US12083141B2 (https=)
EP (1) EP3938513A2 (https=)
JP (1) JP7575396B2 (https=)
KR (1) KR20210139322A (https=)
CN (1) CN113677368A (https=)
AU (1) AU2020241502B2 (https=)
CA (1) CA3132985A1 (https=)
IL (1) IL286308A (https=)
MX (1) MX2021011015A (https=)
NZ (1) NZ780568A (https=)
SG (1) SG11202109711WA (https=)
WO (1) WO2020190608A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200288683A1 (en) * 2019-03-15 2020-09-17 Regeneron Pharmaceuticals, Inc. Loss of function rodent model of solute carrier 39 member 5

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19830770C1 (de) 1998-07-09 2000-05-18 Sueddeutsche Kalkstickstoff Wasserlösliche Zinkpyruvate bzw. deren Hydrate, Verfahren zu ihrer Herstellung und deren Verwendung
JP2001220348A (ja) 1999-11-30 2001-08-14 Japan Science & Technology Corp 亜鉛(ii)有機錯体からなる血糖降下剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUI GUO ET AL: "SLC39A5 mutations interfering with the BMP/TGF-[beta] pathway in non-syndromic high myopia", JOURNAL OF MEDICAL GENETICS, vol. 51, no. 8, 2 June 2014 (2014-06-02), GB, pages 518 - 525 *
QIAN LI ET AL: "Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo", ONCOLOGY RESEARCH., vol. 24, no. 3, 18 July 2016 (2016-07-18), US, pages 205 - 214 *

Also Published As

Publication number Publication date
NZ780568A (en) 2026-02-27
US12083141B2 (en) 2024-09-10
CA3132985A1 (en) 2020-09-24
JP7575396B2 (ja) 2024-10-29
EP3938513A2 (en) 2022-01-19
KR20210139322A (ko) 2021-11-22
SG11202109711WA (en) 2021-10-28
WO2020190608A2 (en) 2020-09-24
AU2020241502A1 (en) 2021-10-21
WO2020190608A3 (en) 2020-10-29
CN113677368A (zh) 2021-11-19
IL286308A (en) 2021-10-31
US20200297751A1 (en) 2020-09-24
US20250032529A1 (en) 2025-01-30
MX2021011015A (es) 2021-12-15
JP2022525456A (ja) 2022-05-16

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