KR20210139271A - Crispr/cas 융합 단백질 및 시스템 - Google Patents

Crispr/cas 융합 단백질 및 시스템 Download PDF

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KR20210139271A
KR20210139271A KR1020217029732A KR20217029732A KR20210139271A KR 20210139271 A KR20210139271 A KR 20210139271A KR 1020217029732 A KR1020217029732 A KR 1020217029732A KR 20217029732 A KR20217029732 A KR 20217029732A KR 20210139271 A KR20210139271 A KR 20210139271A
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푸치앙 첸
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시그마-알드리치 컴퍼니., 엘엘씨
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    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/00Fusion polypeptide
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020217029732A 2019-02-15 2020-02-13 Crispr/cas 융합 단백질 및 시스템 Ceased KR20210139271A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962806708P 2019-02-15 2019-02-15
US62/806,708 2019-02-15
PCT/US2020/018145 WO2020168102A1 (en) 2019-02-15 2020-02-13 Crispr/cas fusion proteins and systems

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KR20210139271A true KR20210139271A (ko) 2021-11-22

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US (3) US10947517B2 (enExample)
EP (1) EP3924475A1 (enExample)
JP (2) JP2022520104A (enExample)
KR (1) KR20210139271A (enExample)
CN (1) CN113728099A (enExample)
AU (2) AU2020221274B2 (enExample)
BR (1) BR112021016019A2 (enExample)
CA (1) CA3129835A1 (enExample)
IL (1) IL285300A (enExample)
SG (1) SG11202108812SA (enExample)
WO (1) WO2020168102A1 (enExample)

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AU2015330699B2 (en) 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
EP3924475A1 (en) 2019-02-15 2021-12-22 Sigma-Aldrich Co. LLC Crispr/cas fusion proteins and systems
AU2022343268A1 (en) * 2021-09-08 2024-03-28 Flagship Pioneering Innovations Vi, Llc Methods and compositions for modulating a genome
CN116063546A (zh) * 2021-10-29 2023-05-05 深圳先进技术研究院 一种基于共振能量转移的全遗传编码nad+蛋白探针及其制备方法和应用
US20230265405A1 (en) * 2022-02-22 2023-08-24 Massachusetts Institute Of Technology Engineered nucleases and methods of use thereof
WO2025221793A1 (en) * 2024-04-16 2025-10-23 Monsanto Technology Llc Modified cas proteins for nuclear localization and editing activity in plants

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AU2002360424A1 (en) 2001-11-26 2003-06-10 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
MY189533A (en) 2012-05-25 2022-02-16 Univ California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
AU2013355214B2 (en) * 2012-12-06 2017-06-15 Sigma-Aldrich Co. Llc Crispr-based genome modification and regulation
WO2014186686A2 (en) * 2013-05-17 2014-11-20 Two Blades Foundation Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
CN105555317A (zh) * 2013-06-11 2016-05-04 药物运输有限公司 与特异性生物活性货物肽偶联的源自人类的细胞渗透肽的结构、制造和用途
WO2015089486A2 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
JP6605482B2 (ja) * 2014-02-19 2019-11-13 バイオアシス テクノロジーズ インコーポレイテッド P97−ids融合タンパク質
US11242525B2 (en) 2014-03-26 2022-02-08 Editas Medicine, Inc. CRISPR/CAS-related methods and compositions for treating sickle cell disease
KR102630014B1 (ko) 2014-10-01 2024-01-25 더 제너럴 하스피탈 코포레이션 뉴클레아제-유도 상동성-지정 복구의 효율 증가 방법
US20160376610A1 (en) * 2015-06-24 2016-12-29 Sigma-Aldrich Co. Llc Cell cycle dependent genome regulation and modification
JP6867689B2 (ja) * 2016-01-29 2021-05-12 国立大学法人東京工業大学 Cas9−gRNA複合体の細胞核内への導入方法、及び細胞内における標的遺伝子の改変方法
WO2017173004A1 (en) * 2016-03-30 2017-10-05 Mikuni Takayasu A method for in vivo precise genome editing
US11236313B2 (en) 2016-04-13 2022-02-01 Editas Medicine, Inc. Cas9 fusion molecules, gene editing systems, and methods of use thereof
CN107579793A (zh) * 2016-07-04 2018-01-12 中兴通讯股份有限公司 一种通信网络设备间时间同步的优化方法、装置及设备
JP7231935B2 (ja) * 2016-08-03 2023-03-08 プレジデント アンド フェローズ オブ ハーバード カレッジ アデノシン核酸塩基編集因子およびそれらの使用
EP3497214B1 (en) 2016-08-09 2023-06-28 President and Fellows of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
EP3526320A1 (en) * 2016-10-14 2019-08-21 President and Fellows of Harvard College Aav delivery of nucleobase editors
AU2016432443B2 (en) 2016-12-14 2024-04-18 Stichting Voor De Technische Wetenschappen Thermostable Cas9 nucleases
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US20210163910A1 (en) 2021-06-03
EP3924475A1 (en) 2021-12-22
BR112021016019A2 (pt) 2021-10-05
CA3129835A1 (en) 2020-08-20
CN113728099A (zh) 2021-11-30
AU2020221274B2 (en) 2024-02-08
US11965184B2 (en) 2024-04-23
IL285300A (en) 2021-09-30
AU2024202275A1 (en) 2024-05-23
JP2023156365A (ja) 2023-10-24
WO2020168102A1 (en) 2020-08-20
US10947517B2 (en) 2021-03-16
SG11202108812SA (en) 2021-09-29
AU2020221274A1 (en) 2021-08-26
US20230287377A1 (en) 2023-09-14
US20200263155A1 (en) 2020-08-20
JP2022520104A (ja) 2022-03-28

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