KR20210137302A - Composition for anti-virus using antioxidant saponin extracted from wild-simulated ginseng - Google Patents

Composition for anti-virus using antioxidant saponin extracted from wild-simulated ginseng Download PDF

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KR20210137302A
KR20210137302A KR1020200054697A KR20200054697A KR20210137302A KR 20210137302 A KR20210137302 A KR 20210137302A KR 1020200054697 A KR1020200054697 A KR 1020200054697A KR 20200054697 A KR20200054697 A KR 20200054697A KR 20210137302 A KR20210137302 A KR 20210137302A
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권태용
추명호
선형곤
조성휘
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테이블바이오(주)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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Abstract

The present invention provides a composition for anti-virus using an anti-oxidant saponin component extracted from wild-simulated ginseng, which contains 64 to 72 parts by weight of wild-simulated ginseng (ginsenoside), and 19 to 24 parts by weight of garlic (allicin), onion (quercetin), and ginger (gingerol) as a combined weight.

Description

산양삼에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물{Composition for anti-virus using antioxidant saponin extracted from wild-simulated ginseng}Antiviral composition using antioxidant saponin extracted from wild ginseng {Composition for anti-virus using antioxidant saponin extracted from wild-simulated ginseng}

본 발명은 산양삼에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물에 관한 것으로서, 보다 상세하게는 항산화 사포닌 성분의 조성물로서 인공향료, 인공색소 등 합성 화학성 물질을 포함하지 않는 천연 조성물을 제공한다.The present invention relates to an antiviral composition using an antioxidant saponin component extracted from wild ginseng, and more particularly, it provides a natural composition comprising an antioxidant saponin component that does not contain synthetic chemicals such as artificial flavorings and artificial colors.

화장품, 코팅제 등에는 항균 조성물이 원료로서 첨가되는 다양한 제품들이 출시되고 있다. 그러나, 식물로부터 추출된 항산화 성분을 포함하는 원료 첨가제는 매우 적으며, 통상 인공 화학 물질을 포함하므로 인체에 유해한 경우가 많다. 즉, 인삼 성분의 파낙스, 홍삼 성분의 사포닌, 산양삼 열매 다당체 추출물 등을 함유하는 조성물이 출시되어 있으나, 이들에 인공 화학 물질이 포함되어 있는 경우가 매우 많다. 이러한 인공 화학 물질을 첨가제로 사용하게 되면, 신체 노화를 촉진하는 과산화 지질이 축적되어 각종 과민성 증상, 질병 등이 유발되고, 피부에는 각질이 생성되어 탄력성이 저하되며, 면역력이 저하되는 문제점이 있다. 왜냐하면, 이러한 합성 화학물질들은 유용한 성분을 함유함에도 불구하고, 합성 원료, 첨가제, 인공 향료, 인공 색소, 합성 보존제, 방부제, 점증제 등 인체에 자극성을 유발할 수 있는 성분들도 병행하여 함유하고 있기 때문이다. 이러한 성분들은 오히려 인체 노화 치료 기능이 있는 원료들의 고유한 기능을 상쇄시키는 결과를 초래할 가능성이 높다.Various products to which an antibacterial composition is added as a raw material are being marketed in cosmetics, coatings, and the like. However, there are very few raw material additives including antioxidants extracted from plants, and since they usually contain artificial chemicals, they are often harmful to the human body. That is, a composition containing Panax of ginseng component, saponin of red ginseng component, polysaccharide extract of wild ginseng fruit, etc. has been released, but there are very many cases in which artificial chemicals are included in these. When such an artificial chemical is used as an additive, lipid peroxide that accelerates aging in the body is accumulated, causing various hypersensitivity symptoms and diseases, keratin is generated on the skin, elasticity is lowered, and immunity is lowered. Because these synthetic chemicals contain useful ingredients, they also contain ingredients that can cause irritation to the human body, such as synthetic raw materials, additives, artificial fragrances, artificial colors, synthetic preservatives, preservatives, and thickeners. am. Rather, these ingredients are more likely to result in offsetting the unique functions of raw materials that have the ability to treat aging of the human body.

세균(1 ㎛ 내외)은 숙주가 없어도 증식이 가능하며, 숙주 균주(0.1~0.2 ㎛)는 숙주가 되는 세균이 있어야 증식이 가능하다. 체내에서 불포화 지방산이 산화되면 면역력이 저하되며, 따라서, 숙주가 되는 세균과 숙주 균주가 잘 자랄 수 있는 환경이 된다. 아울러, 피부 탄력을 주는 섬유질 분해요소인 엘라스라제의 활성이 증가함에 따라서, 피부 건강을 해치게 된다. Bacteria (around 1 μm) can proliferate without a host, and host strains (0.1 to 0.2 μm) can proliferate only when there is a host bacterium. When unsaturated fatty acids are oxidized in the body, immunity is lowered, and thus, it becomes an environment in which bacteria and host strains that become hosts can grow well. In addition, as the activity of elastase, a fibrous decomposing factor that gives skin elasticity, increases, skin health is impaired.

또한, 원료의 주성분이 생약재 등 자연계 재료 또는 인체에 무해한 화합물을 사용한 기존 제품의 경우에도, 영양 성분을 촉진하는 성분의 항산화 및 항 바이러스 생성 기능이 결여되어 있어서, 인체에는 무해할지라도 유해한 바이러스 등 병원균의 충분한 억제 및 완화에는 한계가 있다.In addition, even in the case of existing products using natural ingredients such as herbal medicines or compounds harmless to the human body as the main ingredients of the raw materials, the antioxidant and antiviral production functions of the ingredients that promote nutrients are lacking. There are limits to sufficient suppression and mitigation of

본 발명은 전술한 문제점을 해결하기 위하여 안출된 것으로서, 본 발명은 항산화 및 항 바이러스 성분의 조성물을 제조하기 위하여 진세노사이드를 활용하였으며, 이의 유효 성분으로부터 인체에 미치는 항산화 및 항 바이러스 억제 및 방어 효과를 구현하여 면역력 강화와 혈액 순환 개선에 도움을 줄 수 있는 진세노사이드에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물을 제공하는 것을 목적으로 한다. The present invention has been devised to solve the above problems, and the present invention utilizes ginsenoside to prepare a composition of antioxidant and antiviral components, and antioxidant and antiviral effects on the human body from its active ingredients deterrence and defense An object of the present invention is to provide an antiviral composition using an antioxidant saponin component extracted from ginsenoside that can help strengthen immunity and improve blood circulation by realizing the effect.

또한, 본 발명은 일체의 인공 화학 성분이 포함되지 않으므로, 유익한 조성물의 효과를 저감시키지 않고, 장기간 저장성이 우수하여, 인체에서의 흡수력이 우수한 진세노사이드에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물을 제공하는 것을 다른 목적으로 한다. In addition, since the present invention does not contain any artificial chemical components, it does not reduce the effect of the beneficial composition, has excellent long-term storage, and is an antiviral composition using antioxidant saponin components extracted from ginsenosides, which have excellent absorption in the human body. provide for a different purpose.

본 발명은 전술한 목적을 달성하기 위하여, 산양삼(진세노사이드) 64~72 중량부, 마늘(알리신), 양파(케르세틴), 생강(진저롤) 합산 중량으로 19~24 중량부를 포함하는 것을 특징으로 하는 산양삼에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물을 제공한다.In order to achieve the above object, the present invention comprises 19 to 24 parts by weight of wild ginseng (ginsenoside) 64 to 72 parts by weight, garlic (alicin), onion (quercetin), and ginger (gingerol) by weight. It provides an antiviral composition using antioxidant saponin components extracted from wild ginseng.

상기 조성물에는 보존제로서 식물성 소듐클로라이드 9~12 중량부가 더 포함되는 것이 바람직하다.The composition preferably further contains 9 to 12 parts by weight of vegetable sodium chloride as a preservative.

상기 추출은 용매에 상기 성분들을 침잠하여 수행하며, 용매온도가 50~70℃인 경우, 20시간 내지 24시간으로 하고, 용매온도가 5.5~6℃인 경우 10일 내지 30일인 것이 바람직하다.The extraction is performed by immersing the components in a solvent, and when the solvent temperature is 50 to 70° C., it is 20 hours to 24 hours, and when the solvent temperature is 5.5 to 6° C., it is preferably 10 days to 30 days.

이상과 같은 본 발명에 따르면, 인체에 미치는 유해 바이러스 세균 균주의 억제, 혈액순환 개선, 지방질 생성 억제, 체중 조절, 고지혈증 개선, 항염증을 위한 면역력 개선, 염증 해소 등의 효과가 기대된다. According to the present invention as described above, effects such as inhibition of harmful virus and bacterial strains on the human body, improvement of blood circulation, inhibition of lipid production, weight control, improvement of hyperlipidemia, improvement of immunity for anti-inflammatory, relief of inflammation, and the like are expected.

이하에서는 본 발명을 바람직한 실시예를 기초로 보다 상세히 설명한다. Hereinafter, the present invention will be described in more detail based on preferred embodiments.

본 발명은 산양삼(진세노사이드) 64~72 중량부, 마늘(알리신), 양파(케르세틴), 생강(진저롤) 합산 중량으로 19~24 중량부 및 보존제로서 식물성 소듐클로라이드 9~12 중량부를 포함하는 것을 특징으로 한다. The present invention contains 64 to 72 parts by weight of wild ginseng (ginsenoside), 19 to 24 parts by weight of garlic (alicin), onion (quercetin), ginger (gingerol), and 9 to 12 parts by weight of vegetable sodium chloride as a preservative. characterized in that

여기서, 케르세틴, 진저롤, 알리신 추출물 중에서 선택되는 적어도 1종을 보존제로 첨가한다. Here, at least one selected from quercetin, gingerol, and allicin extract is added as a preservative.

아래의 조성물 제조 과정은 9~12년간 자생한 산양삼에 의하여 수행된다. The composition preparation process below is carried out by wild ginseng that has been grown for 9 to 12 years.

제1단계는 상기 산양삼을 압축기로 압축하고, 용매에 침잠하여 용매온도가 50~70℃인 경우, 20시간 이상, 바람직하게는 24시간 이상으로 하고, 저온인 경우 5.5~6℃의 온도로 하여 30일 이내에 조성물을 숙성하는 단계이다. 상기 용매는 전기분해 환원수를 사용한다. In the first step, the wild ginseng is compressed with a compressor and immersed in a solvent so that when the solvent temperature is 50 to 70 ° C, it is 20 hours or more, preferably 24 hours or more, and in the case of low temperature, the temperature is 5.5 to 6 ° C. It is a step of aging the composition within 30 days. As the solvent, electrolysis reduced water is used.

제2단계는 위 산양삼으로부터 추출물이 생성되는데, 이는 사포닌 진이며, 약 24시간 동안 이를 우려낸 후, 남은 산양삼을 건져내어 1.5~2mm의 크기로 분쇄하는 단계이다. 분쇄는 여러 단계에 의하여 수행될 수 있다. 분쇄 크기도 이와 달리할 수도 있다. In the second step, an extract is generated from the wild ginseng of the stomach, which is saponin gin, and after brewing it for about 24 hours, the remaining wild ginseng is taken out and crushed to a size of 1.5 to 2 mm. Grinding can be performed by several steps. The grind size may also be different.

제3단계는 제2단계의 남은 산양삼을 압축기에 의하여 처리함으로써 이로부터 액상을 추출하며, 추출된 액상 중 상등액을 분리 및 회수하는 단계이다. The third step is to process the remaining wild ginseng from the second step by means of a compressor to extract a liquid phase therefrom, and to separate and recover the supernatant from the extracted liquid phase.

제4단계는 상기 사포닌 진과 추출물들을 전기분해 환원수에 혼합하여 조성물을 제조하는 단계이다. The fourth step is to prepare a composition by mixing the saponin gins and extracts with electrolytic reduced water.

여기서, 상기 산양삼은 64~72 중량부를 가져야 하는데, 위 하한 미만이면 원재료 함량이 미달되어 재료가 주는 효과가 저감되는 문제가 있고, 위 상한을 초과하면 산양삼의 사포닌 진 성분이 갖는 특유의 끈적거림이 과하여 혼합이 잘 이루어지지 않는 문제점이 발생될 수 있다. 따라서, 산양삼은 위 범위에서 임계적 의의를 갖는다.Here, the wild ginseng should have 64 to 72 parts by weight. If it is less than the upper limit, there is a problem in that the content of the raw material is insufficient and the effect of the material is reduced. There may be a problem in that mixing is not performed well due to excessive mixing. Therefore, wild ginseng has a critical significance in the above range.

5단계에서는 첨가제를 추가하는데, 첨가제는 보존제로서 마늘, 양파, 생강 등이며, 이로부터 알리신, 케르세틴, 진저롤이 추출되는데, 첨가량은 위 세가지 성분의 합산 중량으로 조성물 중량 대비 19~24 중량부가 첨가된다. 아울러, 소듐클로라이드을 9~12 중량부 더 추가할 수 있다. 여기서 위 하한 미만이면, 그 사용량이 너무 적어 보존의 효과를 나타낼 수 없고, 위 상한을 초과하면 조성물 성분들간에 엉키는 문제 및 조성물 자체의 점도가 너무 높아지는 문제가 있으므로, 위 첨가량은 위의 범위에서 그 임계적 의의가 있다. In step 5, an additive is added, and the additive is garlic, onion, ginger, etc. as a preservative, and allicin, quercetin, and gingerol are extracted from this. . In addition, 9 to 12 parts by weight of sodium chloride may be further added. Here, if it is less than the above lower limit, the amount used is too small to exhibit the effect of preservation, and if the upper limit is exceeded, there is a problem of entanglement between the composition components and the viscosity of the composition itself becomes too high, so the above addition amount is within the above range It has critical significance.

상기 보존제는 위 함량을 유지한 상태에서 계피 성분, 카테킨 성분, 테아닌 성분 등을 함유하는 원료를 더 첨가할 수 있다. The preservative may further add a raw material containing a cinnamon component, a catechin component, a theanine component, and the like while maintaining the above content.

보존제의 첨가시 조성물에 가온을 하는데, 50℃~70℃로, 바람직하게는 55℃~60℃로 가온한 후, 균질기(homogenizer)에서 30분 ~ 60분 정도 균질화 시킴으로써 충분히 유화(또는 용해)시켜서 항산화 및 항 바이러스 조성물을 제조할 수 있다. 이때, 상기 온도가 50℃ 미만이면 산양삼 추출물, 자연계 보존제 등이 용매에 용해되는 시간이 너무 길어지는 문제가 있을 수 있고, 70℃를 초과하면 용매의 점도가 너무 높아지는 문제가 있을 수 있으므로, 상기 온도 하에서 혼합 및 교반을 수행하는 것이 좋으며, 위 수치 범위에 그 임계적 의의가 존재한다. When the preservative is added, the composition is heated, and after heating to 50°C to 70°C, preferably 55°C to 60°C, homogenize for 30 minutes to 60 minutes in a homogenizer to sufficiently emulsify (or dissolve) It is possible to prepare an antioxidant and antiviral composition. At this time, if the temperature is less than 50 ℃, there may be a problem that the time for dissolving wild ginseng extract, natural preservatives, etc. in the solvent is too long, and if it exceeds 70 ℃, there may be a problem that the viscosity of the solvent is too high, the temperature It is recommended to perform mixing and stirring under the conditions, and the critical significance exists in the above numerical range.

구분division 산양삼wild ginseng 보존제preservative 첨가제additive 실시예 1Example 1 45%45% 5%5% 15%15% 실시예 2Example 2 46%46% 6%6% 16%16% 실시예 3Example 3 47%47% 6%6% 15%15% 실시예 4Example 4 48%48% 7%7% 16%16% 비교예 1Comparative Example 1 9%9% 5%5% 3.5%3.5% 비교예 2Comparative Example 2 9%9% 5%5% 3.4%3.4% 비교예 3Comparative Example 3 7%7% 5%5% 3.4%3.4% 비교예 4Comparative Example 4 9%9% 5%5% 3.4%3.4% 비교예 5Comparative Example 5 8%8% 5%5% 3.4%3.4%

<시험예><Test Example>

제조된 조성물의 위해 우려 안전시험을 시험기관인 한국건설생활환경시험연구소에 의뢰하여, 니켈(Ni), 납,(pb), 비소(As), 카드뮴(Cd), 수은(Hg), 디옥산(1,4-Dioxane), 메탄올(Methanol), 포름알데하이드(HCHO)의 존부 및 함량과 산도(pH)를 측정하였다. 그 결과, 니켈, 납, 비소, 카드뮴, 수은, 디옥산 등은 존재하지 않는 것으로 판명되었다.The safety test of the manufactured composition was commissioned by the Korea Institute of Construction and Living Environment, a testing institution, for nickel (Ni), lead, (pb), arsenic (As), cadmium (Cd), mercury (Hg), dioxane ( The presence and content of 1,4-Dioxane), methanol, and formaldehyde (HCHO) and acidity (pH) were measured. As a result, it was found that nickel, lead, arsenic, cadmium, mercury, dioxane, and the like did not exist.

또한, 본 발명의 조성물에 관한 유해세균의 억제력 측정 실험을 수행하였다.In addition, an experiment for measuring the inhibitory power of harmful bacteria with respect to the composition of the present invention was performed.

유해세균의 억제력은 전기 전도도 변화를 측정함으로써 평가하였다. 본 발명에 따른 유해세균 억제 성분에 대한 시험으로 측정기(Corneometer, Courage + Khazaka, GmbH, Germany)를 이용하였으며, 조성물의 전기 전도도는 조성물을 사용하지 않았을 때 대비 평균 70~72% 수준으로 감소하는 것으로 평가되었다. 이러한 전도도는 유해 세균에 의한 전도도를 의미한다. 측정기에 의한 억제력 측정은 유해 세균이 증식할 수 있는 표면의 유해 세균의 억제력을 정전 부하 용량 계측법(capacitance measurement)으로 측정하는 장비로, 탐침 센서 접촉부위 아래로 0.1~1.1μm 깊이의 일정한 측정 레벨을 유지하여 사용한다.The inhibitory power of harmful bacteria was evaluated by measuring the change in electrical conductivity. A measuring instrument (Corneometer, Courage + Khazaka, GmbH, Germany) was used as a test for the harmful bacteria inhibitory component according to the present invention, and the electrical conductivity of the composition was reduced to an average of 70-72% compared to when the composition was not used. was evaluated. Such conductivity means conductivity by harmful bacteria. Inhibitory force measurement by a measuring instrument is a device that measures the inhibitory power of harmful bacteria on the surface where harmful bacteria can grow by capacitance measurement. keep and use

이때 측정치의 기준 온도는 평균 22~23℃, 상대습도 43~45% 로 유지시킨 항온 항습 조건에서 5명의 피검사자에 대하여 2×2 cm2 의 면적에 제조예 1-1을 0.1~1.1 ㎛ 적용하여 시간별로 측정하였다.At this time, the reference temperature of the measured value is an average of 22 to 23 ° C, and 0.1 to 1.1 μm of Preparation Example 1-1 is applied to an area of 2 × 2 cm 2 for 5 subjects under constant temperature and humidity conditions maintained at 43 to 45% relative humidity. It was measured by time.

<계산예><Calculation example>

유해 세균으로 부터 면역력 유지 증가율(%)을 수치로 계산하여 하기 표 6에 나타 내었으며, 한 측정 부위를 각 5회씩 측정하여 평균값의 (±) 표준편차로 표시하였다. 또한, 항 바이러스 조성물 도포 전에 면역력을 측정하여 기본값으로 하였으며, 대조군은 모두 도포하지 않은 것이다. The increase rate (%) of maintaining immunity from harmful bacteria was calculated numerically and shown in Table 6 below, and each measurement site was measured 5 times and expressed as (±) standard deviation of the average value. In addition, immunity was measured before application of the antiviral composition and was set as a default value, and the control group was not applied at all.

<수학식> <Equation>

항산화 및 항 바이러스 면역력 생성에 따른 전도도 증가율(%) Conductivity increase rate (%) by generation of antioxidant and antiviral immunity

= (실시예1 도포 후 측정값 - 실시예1 도포 전 측정값) / 실시예1 도포 전 측정값) × 100= (Measured value after application of Example 1 - Measurement value before application of Example 1) / Measurement value before application of Example 1) × 100

경과시간elapsed time 비교예(%)Comparative Example (%) 실시예1(%)Example 1 (%) 2~5분2-5 minutes 100100 6060 6분~15분6 to 15 minutes 133.1133.1 6565 30분30 minutes 104.4104.4 6969 1시간 30분 1 hour 30 minutes 102.2102.2 7171 2시간2 hours 101.6101.6 7373 2시간 30분2 hours 30 minutes 102.5102.5 75 75

위 표 2는 비교예와 실시예1에 대해서 시간에 따른 전도도의 상대적 크기를 나타낸 것이다. 위 표에서 나타난 바와 같이, 실시예1은 면역력 억제율 이 매우 탁월한 것을 알 수 있다. Table 2 above shows the relative magnitude of conductivity with time for Comparative Example and Example 1. As shown in the table above, it can be seen that Example 1 has a very excellent immune suppression rate.

결국 이러한 식물성 복합 추출물 조성물을 사용함으로써 인체에 높은 면역력을 부여할 수 있을 것으로 기대된다.In the end, it is expected that high immunity can be imparted to the human body by using such a plant complex extract composition.

Claims (3)

산양삼(진세노사이드) 64~72 중량부, 마늘(알리신), 양파(케르세틴), 생강(진저롤) 합산 중량으로 19~24 중량부를 포함하는 것을 특징으로 하는 산양삼에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물.Wild ginseng (ginsenoside) 64 to 72 parts by weight, garlic (alicin), onion (quercetin), ginger (gingerol), characterized in that it contains 19 to 24 parts by weight as an antiviral using antioxidant saponin components extracted from wild ginseng composition. 제1항에 있어서,
상기 조성물에는 보존제로서 식물성 소듐클로라이드 9~12 중량부가 더 포함되는 것을 특징으로 하는 산양삼에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물.
According to claim 1,
An antiviral composition using an antioxidant saponin component extracted from wild ginseng, characterized in that the composition further contains 9 to 12 parts by weight of vegetable sodium chloride as a preservative.
제1항에 있어서,
상기 추출은 용매에 상기 성분들을 침잠하여 수행하며, 용매온도가 50~70℃인 경우, 20시간 내지 24시간으로 하고, 용매온도가 5.5~6℃인 경우 10일 내지 30일인 것을 특징으로 하는 산양삼에서 추출한 항산화 사포닌 성분을 이용한 항바이러스 조성물.
According to claim 1,
The extraction is performed by immersing the components in a solvent, and when the solvent temperature is 50 to 70 ° C, 20 to 24 hours, and when the solvent temperature is 5.5 to 6 ° C, 10 days to 30 days. Antiviral composition using antioxidant saponin components extracted from
KR1020200054697A 2020-05-07 2020-05-07 Composition for anti-virus using antioxidant saponin extracted from wild-simulated ginseng KR20210137302A (en)

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