KR20210133227A - 뉴런 세포 흥분성을 정상화하고 드라베 증후군을 치료하기 위한 개재뉴런-특이적 치료제 - Google Patents

뉴런 세포 흥분성을 정상화하고 드라베 증후군을 치료하기 위한 개재뉴런-특이적 치료제 Download PDF

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KR20210133227A
KR20210133227A KR1020217028274A KR20217028274A KR20210133227A KR 20210133227 A KR20210133227 A KR 20210133227A KR 1020217028274 A KR1020217028274 A KR 1020217028274A KR 20217028274 A KR20217028274 A KR 20217028274A KR 20210133227 A KR20210133227 A KR 20210133227A
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vector
enhancer
polynucleotide sequence
sequence
viral
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조던 디미치슈타인
고든 피셸
오린 데빈스키
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더 브로드 인스티튜트, 인코퍼레이티드
프레지던트 앤드 펠로우즈 오브 하바드 칼리지
뉴욕 유니버시티
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KR1020217028274A 2019-02-05 2020-01-27 뉴런 세포 흥분성을 정상화하고 드라베 증후군을 치료하기 위한 개재뉴런-특이적 치료제 Pending KR20210133227A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962801483P 2019-02-05 2019-02-05
US62/801,483 2019-02-05
US201962823281P 2019-03-25 2019-03-25
US62/823,281 2019-03-25
US201962916477P 2019-10-17 2019-10-17
US62/916,477 2019-10-17
PCT/US2020/015183 WO2020163102A1 (en) 2019-02-05 2020-01-27 Interneuron-specific therapeutics for normalizing neuronal cell excitability and treating dravet syndrome

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KR20210133227A true KR20210133227A (ko) 2021-11-05

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KR1020217028274A Pending KR20210133227A (ko) 2019-02-05 2020-01-27 뉴런 세포 흥분성을 정상화하고 드라베 증후군을 치료하기 위한 개재뉴런-특이적 치료제

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US (1) US20220195457A1 (https=)
EP (1) EP3921326A4 (https=)
JP (2) JP7724157B2 (https=)
KR (1) KR20210133227A (https=)
CN (1) CN113966400A (https=)
CA (1) CA3128525A1 (https=)
IL (1) IL284909A (https=)
SG (1) SG11202107813RA (https=)
WO (1) WO2020163102A1 (https=)

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CN115707773A (zh) * 2021-08-20 2023-02-21 中国科学院深圳先进技术研究院 一种利用交感神经控制血管内皮细胞异质性的方法
US12054486B2 (en) 2021-09-24 2024-08-06 Xenon Pharmaceuticals Inc. Pyridine derivatives and their use as sodium channel activators
WO2023108401A1 (zh) * 2021-12-14 2023-06-22 深圳先进技术研究院 重组载体及其构建方法和应用
JP2024545923A (ja) 2021-12-30 2024-12-13 リーゲル セラピューティクス，インコーポレイティッド ナトリウム電位依存性チャネルアルファサブユニット１の発現を調節するための組成物、及びその使用
GB2621102A (en) * 2022-04-11 2024-02-07 Univ Ramot Treatment and Reversion of Dravet syndrome by CAV-2-Mediated Delivery of an SCN1A Expression Cassette
WO2023200700A2 (en) * 2022-04-11 2023-10-19 The Broad Institute, Inc. Enhancers for directed expression of genes in neuronal cell populations, compositions and methods thereof
CN116024222B (zh) * 2022-11-30 2023-12-22 湖南家辉生物技术有限公司 一种导致婴儿严重肌阵挛性癫痫的nac1基因突变体及其应用

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CN101255424B (zh) * 2007-11-26 2013-02-27 广州医学院第二附属医院 与癫痫相关scn1a基因的启动子及其构建方法和临床应用
EP2635111B1 (en) * 2010-11-05 2018-05-23 The Board of Trustees of the Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
US10682424B2 (en) * 2015-03-31 2020-06-16 New York University Compositions and method for reducing seizures
MX2019011772A (es) * 2017-04-03 2020-01-09 Encoded Therapeutics Inc Expresion transgenica selectiva de tejidos.

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JP2025118768A (ja) 2025-08-13
EP3921326A4 (en) 2022-12-14
US20220195457A1 (en) 2022-06-23
IL284909A (en) 2021-09-30
SG11202107813RA (en) 2021-08-30
EP3921326A1 (en) 2021-12-15
JP2022519623A (ja) 2022-03-24
CA3128525A1 (en) 2020-08-13
CN113966400A (zh) 2022-01-21
JP7724157B2 (ja) 2025-08-15
WO2020163102A1 (en) 2020-08-13

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