KR20210131309A - 분비형 치료 양식을 운반하기 위한 아넬로좀 - Google Patents

분비형 치료 양식을 운반하기 위한 아넬로좀 Download PDF

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KR20210131309A
KR20210131309A KR1020217021775A KR20217021775A KR20210131309A KR 20210131309 A KR20210131309 A KR 20210131309A KR 1020217021775 A KR1020217021775 A KR 1020217021775A KR 20217021775 A KR20217021775 A KR 20217021775A KR 20210131309 A KR20210131309 A KR 20210131309A
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nucleic acid
sequence
anellosome
genetic element
orf1
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Korean (ko)
Inventor
에리카 가브리엘 웨인스테인
아바크 카베지안
사이먼 델라그레이브
나탄 로렌스 요지아크
케빈 제임스 레보
페르난도 마틴 디아즈
다난자이 마니클랄 나완다
리안 디. 테드스톤
제러드 데이비드 피츠
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플래그쉽 파이어니어링 이노베이션스 브이, 인크.
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Publication of KR20210131309A publication Critical patent/KR20210131309A/ko
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184—Virus capsids or envelopes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2750/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
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    • C12N2750/00023—Virus like particles [VLP]
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/00042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
KR1020217021775A 2018-12-12 2019-12-12 분비형 치료 양식을 운반하기 위한 아넬로좀 Pending KR20210131309A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862778866P 2018-12-12 2018-12-12
US201862778869P 2018-12-12 2018-12-12
US62/778,869 2018-12-12
US62/778,866 2018-12-12
PCT/US2019/065919 WO2020123773A2 (en) 2018-12-12 2019-12-12 Anellosomes for delivering secreted therapeutic modalities

Publications (1)

Publication Number Publication Date
KR20210131309A true KR20210131309A (ko) 2021-11-02

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KR1020217021775A Pending KR20210131309A (ko) 2018-12-12 2019-12-12 분비형 치료 양식을 운반하기 위한 아넬로좀

Country Status (11)

Country Link
US (2) US20230048858A1 (https=)
EP (1) EP3894568A2 (https=)
JP (2) JP2022512395A (https=)
KR (1) KR20210131309A (https=)
CN (1) CN113631717A (https=)
AU (1) AU2019396520A1 (https=)
BR (1) BR112021009379A2 (https=)
CA (1) CA3119531A1 (https=)
IL (1) IL283778A (https=)
MX (1) MX2021006943A (https=)
WO (1) WO2020123773A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11624061B2 (en) 2017-04-28 2023-04-11 Agrospheres, Inc. Compositions and methods for enzyme immobilization
BR112020005803A2 (pt) 2017-09-25 2020-12-01 Agrospheres, Inc. composições e métodos para produção e administração moduláveis de produtos biológicos
BR112021011124A2 (pt) * 2018-12-12 2022-03-15 Flagship Pioneering Innovations V Inc Anelossomos e métodos de uso
JP2022513459A (ja) * 2018-12-12 2022-02-08 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド タンパク質代替治療モダリティを送達するためのアネロソーム
JP2023530451A (ja) * 2020-06-17 2023-07-18 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド アネロウイルスを同定し及び特徴付ける方法並びにその使用
JP2023548838A (ja) * 2020-10-29 2023-11-21 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド ニワトリ貧血ウイルス（ｃａｖ）に基づくベクター
KR20230146560A (ko) * 2021-02-08 2023-10-19 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 하이브리드 aav-아넬로벡터
WO2022241013A1 (en) * 2021-05-12 2022-11-17 Flagship Pioneering Innovations V, Inc. Anellovectors and methods of use
CN118284411A (zh) * 2021-10-12 2024-07-02 旗舰先锋创新V股份有限公司 新颖的指环载体组合物和方法
EP4415695A4 (en) * 2021-10-12 2025-11-26 Flagship Pioneering Innovations V Inc NEW ANELLOVECTOR COMPOSITIONS AND METHODS
TW202430215A (zh) 2022-12-14 2024-08-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 用於將治療劑遞送至骨之組成物和方法
TW202529819A (zh) 2023-10-13 2025-08-01 美商旗艦先鋒創新公司 組織特異性指環載體(anellovector)遞送
CN117695410B (zh) * 2024-02-06 2024-05-03 中国人民解放军军事科学院军事医学研究院 CRISPR/Cas9纳米抗菌剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395472B1 (en) * 1999-02-05 2002-05-28 Abbott Laboratories Methods of utilizing the TT virus
AU2014361781B2 (en) * 2013-12-12 2021-04-01 Massachusetts Institute Of Technology Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
CN108291216B (zh) * 2015-09-24 2022-09-16 宾夕法尼亚州大学信托人 用于治疗补体介导的疾病的组合物和方法
IL271275B1 (en) * 2017-06-13 2026-04-01 Flagship Pioneering Innovations V Inc Preparations containing croons and their uses
BR112020007405A2 (pt) * 2017-10-18 2020-12-08 Regenxbio Inc. Produtos terapêuticos de anticorpo pós-translacionalmente modificados totalmente humanos

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Publication number Publication date
WO2020123773A9 (en) 2020-08-27
WO2020123773A2 (en) 2020-06-18
MX2021006943A (es) 2021-11-17
EP3894568A2 (en) 2021-10-20
JP2022512395A (ja) 2022-02-03
BR112021009379A2 (pt) 2021-08-17
CN113631717A (zh) 2021-11-09
IL283778A (en) 2021-07-29
US20230048858A1 (en) 2023-02-16
JP2024100936A (ja) 2024-07-26
WO2020123773A3 (en) 2020-07-23
CA3119531A1 (en) 2020-06-18
AU2019396520A1 (en) 2021-05-27
US20260009050A1 (en) 2026-01-08

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