JP2022512395A - 分泌治療モダリティを送達するためのアネロソーム - Google Patents

分泌治療モダリティを送達するためのアネロソーム Download PDF

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JP2022512395A
JP2022512395A JP2021533524A JP2021533524A JP2022512395A JP 2022512395 A JP2022512395 A JP 2022512395A JP 2021533524 A JP2021533524 A JP 2021533524A JP 2021533524 A JP2021533524 A JP 2021533524A JP 2022512395 A JP2022512395 A JP 2022512395A
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nucleic acid
anerosome
sequence
synthetic
orf1
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JP2022512395A5 (https=
JPWO2020123773A5 (https=
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エリカ ガブリエル ワインスタイン,
アバク カーベジアン,
サイモン デラグレイブ,
ネイサン ローレンス ヨズウィアク,
ケビン ジェイムズ レボ,
フェルナンド マーティン ディアズ,
ダナンジャイ マニクラール ナワンダル,
ライアン ディー. テッドストーン,
ジャレド デイビッド ピッツ,
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フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド
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Publication of JP2022512395A publication Critical patent/JP2022512395A/ja
Publication of JP2022512395A5 publication Critical patent/JP2022512395A5/ja
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JP2021533524A 2018-12-12 2019-12-12 分泌治療モダリティを送達するためのアネロソーム Pending JP2022512395A (ja)

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JP2024083619A JP2024100936A (ja) 2018-12-12 2024-05-22 分泌治療モダリティを送達するためのアネロソーム

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US201862778866P 2018-12-12 2018-12-12
US201862778869P 2018-12-12 2018-12-12
US62/778,869 2018-12-12
US62/778,866 2018-12-12
PCT/US2019/065919 WO2020123773A2 (en) 2018-12-12 2019-12-12 Anellosomes for delivering secreted therapeutic modalities

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JP2024083619A Division JP2024100936A (ja) 2018-12-12 2024-05-22 分泌治療モダリティを送達するためのアネロソーム

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JP2022512395A true JP2022512395A (ja) 2022-02-03
JP2022512395A5 JP2022512395A5 (https=) 2022-12-20
JPWO2020123773A5 JPWO2020123773A5 (https=) 2022-12-20

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JP2021533524A Pending JP2022512395A (ja) 2018-12-12 2019-12-12 分泌治療モダリティを送達するためのアネロソーム
JP2024083619A Pending JP2024100936A (ja) 2018-12-12 2024-05-22 分泌治療モダリティを送達するためのアネロソーム

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US (2) US20230048858A1 (https=)
EP (1) EP3894568A2 (https=)
JP (2) JP2022512395A (https=)
KR (1) KR20210131309A (https=)
CN (1) CN113631717A (https=)
AU (1) AU2019396520A1 (https=)
BR (1) BR112021009379A2 (https=)
CA (1) CA3119531A1 (https=)
IL (1) IL283778A (https=)
MX (1) MX2021006943A (https=)
WO (1) WO2020123773A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11624061B2 (en) 2017-04-28 2023-04-11 Agrospheres, Inc. Compositions and methods for enzyme immobilization
BR112020005803A2 (pt) 2017-09-25 2020-12-01 Agrospheres, Inc. composições e métodos para produção e administração moduláveis de produtos biológicos
BR112021011124A2 (pt) * 2018-12-12 2022-03-15 Flagship Pioneering Innovations V Inc Anelossomos e métodos de uso
JP2022513459A (ja) * 2018-12-12 2022-02-08 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド タンパク質代替治療モダリティを送達するためのアネロソーム
JP2023530451A (ja) * 2020-06-17 2023-07-18 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド アネロウイルスを同定し及び特徴付ける方法並びにその使用
JP2023548838A (ja) * 2020-10-29 2023-11-21 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド ニワトリ貧血ウイルス(cav)に基づくベクター
KR20230146560A (ko) * 2021-02-08 2023-10-19 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 하이브리드 aav-아넬로벡터
WO2022241013A1 (en) * 2021-05-12 2022-11-17 Flagship Pioneering Innovations V, Inc. Anellovectors and methods of use
CN118284411A (zh) * 2021-10-12 2024-07-02 旗舰先锋创新V股份有限公司 新颖的指环载体组合物和方法
EP4415695A4 (en) * 2021-10-12 2025-11-26 Flagship Pioneering Innovations V Inc NEW ANELLOVECTOR COMPOSITIONS AND METHODS
TW202430215A (zh) 2022-12-14 2024-08-01 美商旗艦先鋒創新有限責任(Vii)公司 用於將治療劑遞送至骨之組成物和方法
TW202529819A (zh) 2023-10-13 2025-08-01 美商旗艦先鋒創新公司 組織特異性指環載體(anellovector)遞送
CN117695410B (zh) * 2024-02-06 2024-05-03 中国人民解放军军事科学院军事医学研究院 CRISPR/Cas9纳米抗菌剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003525583A (ja) * 1999-02-05 2003-09-02 アボット・ラボラトリーズ Ttウイルスの使用法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014361781B2 (en) * 2013-12-12 2021-04-01 Massachusetts Institute Of Technology Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
CN108291216B (zh) * 2015-09-24 2022-09-16 宾夕法尼亚州大学信托人 用于治疗补体介导的疾病的组合物和方法
IL271275B1 (en) * 2017-06-13 2026-04-01 Flagship Pioneering Innovations V Inc Preparations containing croons and their uses
BR112020007405A2 (pt) * 2017-10-18 2020-12-08 Regenxbio Inc. Produtos terapêuticos de anticorpo pós-translacionalmente modificados totalmente humanos

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003525583A (ja) * 1999-02-05 2003-09-02 アボット・ラボラトリーズ Ttウイルスの使用法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EUR RESPIR J, vol. 42, JPN6024024626, 2013, pages 470 - 479, ISSN: 0005380016 *
J VIROLOGY, vol. 78, JPN6023043858, 2004, pages 10820 - 10824, ISSN: 0005380014 *
JOURNAL OF VIROLOGY, vol. 85, no. 14, JPN6024024627, 2011, pages 7284 - 7295, ISSN: 0005380015 *
VIROLOGY, vol. 321, JPN6023043859, 2004, pages 341 - 348, ISSN: 0005380013 *

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WO2020123773A9 (en) 2020-08-27
WO2020123773A2 (en) 2020-06-18
MX2021006943A (es) 2021-11-17
EP3894568A2 (en) 2021-10-20
KR20210131309A (ko) 2021-11-02
BR112021009379A2 (pt) 2021-08-17
CN113631717A (zh) 2021-11-09
IL283778A (en) 2021-07-29
US20230048858A1 (en) 2023-02-16
JP2024100936A (ja) 2024-07-26
WO2020123773A3 (en) 2020-07-23
CA3119531A1 (en) 2020-06-18
AU2019396520A1 (en) 2021-05-27
US20260009050A1 (en) 2026-01-08

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