KR20210110636A - 미토콘드리아 기능이상을 치료하기 위한 방법 및 제형 - Google Patents

미토콘드리아 기능이상을 치료하기 위한 방법 및 제형 Download PDF

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KR20210110636A
KR20210110636A KR1020217023553A KR20217023553A KR20210110636A KR 20210110636 A KR20210110636 A KR 20210110636A KR 1020217023553 A KR1020217023553 A KR 1020217023553A KR 20217023553 A KR20217023553 A KR 20217023553A KR 20210110636 A KR20210110636 A KR 20210110636A
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ampk
alkyl
mitochondrial
agonist
mitochondrial dysfunction
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테레자 무어
티나 엠. 코완
그레고리 엠. 엔스
메흐르다드 샴루
마이클 제이. 그린
알람 자한지르
롤란도 이. 예인스
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더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
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Publication of KR20210110636A publication Critical patent/KR20210110636A/ko
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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KR1020217023553A 2018-12-31 2019-12-31 미토콘드리아 기능이상을 치료하기 위한 방법 및 제형 Withdrawn KR20210110636A (ko)

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US201862786970P 2018-12-31 2018-12-31
US62/786,970 2018-12-31
PCT/US2019/069145 WO2020142547A1 (en) 2018-12-31 2019-12-31 Methods and formulations to treat mitochondrial dysfunction

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US (1) US12377077B2 (https=)
EP (1) EP3906027A4 (https=)
JP (1) JP7511564B2 (https=)
KR (1) KR20210110636A (https=)
CN (1) CN113347972B (https=)
BR (1) BR112021012799A8 (https=)
CA (1) CA3124838A1 (https=)
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WO2024144330A1 (ko) * 2022-12-29 2024-07-04 주식회사 엣진 레베르 유전성 시신경병증의 미토콘드리아 염기 변이 교정 시스템

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WO2023147312A1 (en) * 2022-01-25 2023-08-03 Evvia Therapeutics, Inc. Ampk agonists and methods of use thereof
WO2024036044A1 (en) * 2022-08-08 2024-02-15 The Johns Hopkins University Compositions and methods for treating and preventing metabolic disorders
EP4688750A1 (en) * 2023-04-06 2026-02-11 Pfizer Inc. Substituted indazole propionic acid derivative compounds and uses thereof as ampk activators

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WO2012114204A2 (en) 2011-02-15 2012-08-30 Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto Methods of treating mitochondrial dysfunction
US8889730B2 (en) * 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2014180908A1 (en) * 2013-05-08 2014-11-13 Deutsches Krebsforschungszentrum Acip/peptide-based inhibition of cancer cachexia
JP2016533385A (ja) * 2013-08-22 2016-10-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ アルキニルアルコール及び使用方法
WO2018118808A1 (en) * 2016-12-19 2018-06-28 The Broad Institute, Inc. Methods of treating autism spectrum disorders

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Publication number Priority date Publication date Assignee Title
WO2024144330A1 (ko) * 2022-12-29 2024-07-04 주식회사 엣진 레베르 유전성 시신경병증의 미토콘드리아 염기 변이 교정 시스템

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BR112021012799A8 (pt) 2021-09-21
BR112021012799A2 (pt) 2021-09-14
EP3906027A4 (en) 2022-09-21
US20220071963A1 (en) 2022-03-10
US12377077B2 (en) 2025-08-05
CA3124838A1 (en) 2020-07-09
EP3906027A1 (en) 2021-11-10
CN113347972A (zh) 2021-09-03
WO2020142547A1 (en) 2020-07-09
WO2020142547A8 (en) 2020-08-27
JP2022516537A (ja) 2022-02-28
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