KR20210109934A - Standard phantom for brain illness clinic - Google Patents

Abstract

The present invention relates to a standard phantom for a medical image and, more specifically, to a standard phantom for a brain disease clinical test. To achieve the purpose, the standard phantom for a medical image includes: a plurality of spread blocks (200b) having a spread reference substance embedded therein to measure the degree of spread of a brain disease; a spread part (400) storing the spread blocks (200b) along with a solution (440); a T1 part (300) comprising a plurality of T1 blocks (200a) having a T1 reference substance embedded therein; and a T2 part (300) comprising a plurality of T2 blocks (200c) having a T2 reference substance embedded therein. At least one among the spread blocks (200b), the spread part (400), the T1 blocks (200a) and the T2 blocks (200c) also includes an upper protrusion (124) in an upper side, and a lower protrusion (150) in a lower side to be assembled with each other and disassembled from each other. Therefore, the present invention is capable of considerably reducing economic burden.

Description

Standard phantom for brain disease clinical trial {Standard phantom for brain illness clinic}

The present invention relates to a standard phantom for medical imaging, and more specifically, to a standard phantom for clinical trials for brain diseases.

MEDICAL PHANTOM is a model that simulates the physical properties of the whole or part of the human body. do. In particular, since the physical mechanism of image acquisition is different depending on the imaging device and the size and shape of the imaging device are different, there are currently dedicated phantoms with various shapes and properties.

That is, medical phantoms have to be manufactured in various shapes to suit the various sizes and shapes of imaging devices, and in the end, the phantoms are limited by the characteristics of the devices.

Moreover, in order to make a phantom in a shape similar to the human body, it must be made in a size similar to the human body, and since the medium is put in it, it is heavy and there are many difficulties in operation.

After all, by applying the above concept to a medical phantom, a phantom can be configured in units of voxels, and the best implementation of this is a phantom using Lego blocks. In the past, there was a case where a brick, the unit block of Lego, was combined to form a phantom of a certain shape, and then used to evaluate the performance of an imaging device. Moreover, there was a technical requirement that a medium with specific physical properties was needed inside the block even for image evaluation and dosimetry.

In particular, there are clinical trials that require quantitative image evaluation such as volume measurement and region measurement in brain diseases such as cerebral infarction and cerebral hemorrhage. In these clinical trials, it is necessary to evaluate the accuracy and reproducibility of quantitative measurements of images. That is, in the acute stroke clinical trial, the degree of diffusion was measured using diffusion weighted MRI and T2 relaxation time was measured using gradient MRI.

However, the conventional phantom existed in the form of a dedicated phantom for evaluating each physical quantity. Therefore, to measure various physical quantities in a clinical trial, it was necessary to prepare a dedicated phantom for each, but the dedicated phantom was very expensive and could not be used for other purposes, so its usefulness was low.

1. Republic of Korea Patent Registration No. 10-0739187 2. Korean Patent Registration No. 10-1856352

Therefore, the present invention has been devised to solve the above problems, and the problem to be solved by the present invention is a clinical trial requiring quantitative image evaluation such as volume measurement and region measurement in brain diseases such as cerebral infarction and cerebral hemorrhage. The goal is to provide a standard phantom for brain disease clinical trials that can simultaneously evaluate the accuracy and reproducibility of quantitative measurements of images, and can be combined in various ways.

In addition, it is to provide a standard phantom for brain disease clinical trials that can be used for various purposes by filling the desired reference material inside each phantom block.

However, the technical problems to be achieved in the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned are clearly to those of ordinary skill in the art to which the present invention belongs from the description below. can be understood

In order to achieve the above technical problem, in the standard phantom for medical imaging, in order to measure the degree of diffusion of brain diseases, a diffusion block (200b) for embedding a diffusion reference material; a diffusion unit 400 for accommodating the diffusion block 200b together with the solution 440; and a T1 block (200a) which is assembled on the upper or lower surface of the diffusion unit 400 and contains a T1 reference material; is provided in a standard phantom for clinical trials for brain disease, characterized in that it includes.

In addition, the T1 reference material includes nickel chloride (NiCl ₂ ).

As another embodiment of the present invention, in the standard phantom for medical imaging, in order to measure the degree of diffusion of brain diseases, a diffusion block 200b containing a diffusion reference material; a diffusion unit 400 for accommodating the diffusion block 200b together with the solution 440; and a T2 block (200c) that is assembled on the upper or lower surface of the diffusion unit 400, and contains a T2 reference material;

In addition, the T2 reference material may _{include manganese chloride (MnCl 2} ), the diffusion reference material may include polyvinylpyrrolidone (PVP), and the solution 440 may include water.

In addition, the diffusion unit 400 includes a lower substrate 450 on which the substrate protrusions 455 are uniformly formed; a diffusion block 200b that can be assembled on the lower substrate 450; A container body 430 assembled to the lower substrate 450 and accommodating the diffusion block 200b and the solution 440; and an upper substrate 410 assembled to the container body 430 and formed with a plurality of substrate protrusions 455 .

In addition, a pair of cross-section selection blocks 100a and 100b may be further assembled on the upper or lower surface of the diffusion unit 400 , and a triangular prism in which the vertices are specified in the medical image inside the cross-section selection blocks 100a and 100b. (190) may be further included.

An object of the present invention as described above, as another embodiment, in the standard phantom for medical imaging, in order to measure the degree of diffusion of brain diseases, a plurality of diffusion blocks 200b containing a diffusion reference material; a diffusion unit 400 for accommodating the diffusion block 200b together with the solution 440; and a T1 part 300 comprising a plurality of T1 blocks 200a containing a T1 reference material; A T2 portion 500 comprising a plurality of T2 blocks 200c containing a T2 reference material; and at least one of a diffusion block 200b, a diffusion portion 400, a T1 block 200a, and a T2 block 200c. One further includes a protrusion 124 on the upper surface, and further includes a lower protrusion 150 on the lower surface to enable mutual assembly and disassembly.

Also, the plurality of diffusion blocks 200b may be arranged in a 3×3 shape.

In addition, at least one of the diffusion block 200b, the diffusion unit 400, the T1 block 200a, and the T2 block 200c is a bolt hole 128 for discharging air bubbles on the upper surface; Sealing material 115 is inserted into the bolt hole 128; And the bolt 110 is fastened to the bolt hole 128; may further include.

In addition, each of the diffusion block 200b, the T1 block 200a, and the T2 block 200c has a cylindrical shape or a rectangular parallelepiped shape.

In addition, the brain disease is any one of stroke, cerebral infarction, cerebral hemorrhage and its associated side effects.

According to an embodiment of the present invention, when there is a clinical trial that requires quantitative image evaluation such as volume measurement and region measurement in brain diseases such as cerebral infarction and cerebral hemorrhage, the accuracy and reproducibility of quantitative measurement values of images can be evaluated at the same time. This allows for quick and accurate identification.

In addition, a desired reference material can be filled inside each phantom block, and various combinations of phantom blocks are possible, so it is possible to actively cope with various measurement environments required in medical fields or clinical trials. For this reason, the utilization of the phantom block is high. Therefore, there is no need to prepare a phantom for all cases required for clinical trials, and the interior of the phantom and the combination of the phantom can be easily changed according to the needs of the medical field. Accordingly, the economic burden of purchasing and maintaining the phantom can be greatly reduced.

The following drawings attached to this specification illustrate preferred embodiments of the present invention, and serve to further understand the technical spirit of the present invention together with the detailed description of the present invention to be described later, so the present invention is described in such drawings It should not be construed as being limited only to
1 is an exploded perspective view of a cross-section selection block 100 used in a standard phantom 10 for clinical trials for brain diseases according to the present invention;
Figure 2 is a perspective view of the section selection block 100 shown in Figure 1,
3 is an exploded perspective view of the phantom block 200 used in the standard phantom 10 for clinical trials for brain diseases according to the present invention;
4 is a perspective view of the phantom block 200 shown in FIG. 3;
5 is a front view of the standard phantom 10 for brain disease clinical trials according to the present invention;
6 is a plan view of the standard phantom 10 shown in FIG. 5;
7 is an exploded perspective view of the diffusion unit 400 of the standard phantom 10 shown in FIG. 5;
8 is a bottom view of the standard phantom 10 shown in FIG. 5;
FIG. 9 is an example of a medical image 600 obtained by photographing the standard phantom 10 for a clinical trial for brain disease according to the present invention by an MRI apparatus.

Hereinafter, with reference to the accompanying drawings, embodiments of the present invention will be described in detail so that those of ordinary skill in the art to which the present invention pertains can easily implement them. However, since the description of the present invention is merely an embodiment for structural or functional description, the scope of the present invention should not be construed as being limited by the embodiment described in the text. That is, since the embodiment may have various changes and may have various forms, it should be understood that the scope of the present invention includes equivalents capable of realizing the technical idea. In addition, since the object or effect presented in the present invention does not mean that a specific embodiment should include all of them or only such effects, it should not be understood that the scope of the present invention is limited thereby.

The meaning of the terms described in the present invention should be understood as follows.

Terms such as “first” and “second” are for distinguishing one component from another, and the scope of rights should not be limited by these terms. For example, a first component may be termed a second component, and similarly, a second component may also be termed a first component. When a component is referred to as being “connected” to another component, it may be directly connected to the other component, but it should be understood that other components may exist in between. On the other hand, when it is mentioned that a certain element is "directly connected" to another element, it should be understood that the other element does not exist in the middle. Meanwhile, other expressions describing the relationship between elements, that is, “between” and “immediately between” or “neighboring to” and “directly adjacent to”, etc., should be interpreted similarly.

The singular expression is to be understood as including the plural expression unless the context clearly dictates otherwise, and terms such as "comprises" or "have" refer to the described feature, number, step, action, component, part or these It is intended to indicate that a combination exists, and it should be understood that it does not preclude the possibility of the existence or addition of one or more other features or numbers, steps, operations, components, parts, or combinations thereof.

All terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, unless otherwise defined. Terms defined in the dictionary should be interpreted as being consistent with the meaning of the context of the related art, and cannot be interpreted as having an ideal or excessively formal meaning unless explicitly defined in the present invention.

Section selection block (100)

Hereinafter, the configuration of the preferred embodiment will be described in detail with reference to the accompanying drawings. 1 is an exploded perspective view of the cross-section selection block 100 used in the standard phantom 10 for clinical trials for brain disease according to the present invention, and FIG. 2 is a perspective view of the cross-section selection block 100 shown in FIG. 1 and 2 , the cross-section selection block 100 is approximately composed of a head block 120 , an air separation unit 130 , a body block 140 , and a triangular pole 190 . The head block 120, the air separation unit 130, the body block 140 and the triangular pole 190 are made of polycarbonate, ABS resin, PE (polyethylene), PP (polypropylene), acrylic, urethane, PVC, etc. It can be manufactured using polymer or plastic materials.

In addition, the head block 120 , the air separation unit 130 , the body block 140 , and the triangular pole 190 can be manufactured using injection molding, cutting processing, or a 3D printer.

The head block 120 has a rectangular cross section and four protrusions 124 are formed on the upper surface 122 to enable assembly with other phantom blocks. The bolt hole 128 is formed through the central region and the edge of the head block 120, and is used for sealing after injecting a liquid such as a reference material and water or discharging air bubbles. A sealing material 115 is inserted into the bolt hole 128 to further enhance the sealing force, and the bolt 110 is fastened to completely seal the liquid filled in the inner cavity 146 .

The air separation unit 130 has a rectangular cross section, is made of a thin thickness, and is placed between the head block 120 and the body block 140 . The through hole 136 is formed in the central region of the air separation unit 130 to function as a passage for air bubbles to move upward, and also serves as a passage for liquid injection. The air separation unit 130 is positioned to be caught on the engaging protrusion 144 of the body block 140 .

The body block 140 has a hexahedral shape, and a cavity 146 is formed inside to accommodate the liquid and the triangular prism 190 . In the upper region, the locking protrusion 144 protrudes from the inner wall so that the air separation unit 130 can be assembled.

The triangular prism 190 is adhesively fixed to the cavity 146 . The vertex of the triangular prism 190 helps to designate a point in the medical image 600 . Therefore, when a pair of cross-section selection blocks are assembled, the vertices of the triangular pillars 190 facing each other are photographed in the medical image 600 . The cross section 610 may be selected by interconnecting these two vertices.

The upper surface of the main body of the body block 140 is bonded or bonded to the lower surface of the head block (120). For bonding, ultrasonic welding, friction welding, compression, etc. may be applied, and for bonding, an adhesive may be applied and cured. The body block 140 and the head block 120 may be bolted together by forming a separate screw hole.

The liquid filled in the cavity 146 may be a solution containing water or a paramagnetic material (eg, iron, nickel, cobalt, manganese, chromium, platinum, aluminum, etc.).

_{As the other solution 152 , CuSO 4 , MnCl 2} , NiCl ₂ , which are signal sources required for magnetic resonance imaging, and a Gd-based, iron oxide-based, and gel-type medium capable of producing a contrast effect may be added. _{In addition, a medium such as water, iodine, barium, CaCO 3} , paraffin, and lipid (Adipose) that can be used for image evaluation in X-ray computed tomography may be added as a solution, and nuclear medicine imaging Positron-emmitting isotopes and gamma-emitting isotopes, which are signal sources for PET and SPECT devices, can also be added.

If it is determined that a lot of air bubbles or air bubbles have been generated, the air bubbles or air bubbles may be removed by loosening the bolt 110 and injecting more liquid through the bolt hole 128 . Through such a simple repair process, continuous use is possible even with the cross-section selection block 100 having air bubbles or air bubbles.

In addition, when a phantom block filled with another liquid is required, the bolt 110 may be loosened, all the prefilled liquid may be discharged, and then filled again with a desired liquid may be used.

The protrusions 124 and the lower protrusions 150 of the present invention are made to have the same size as children's block toys (eg, Lego blocks) and can be easily assembled or disassembled. can be decorated

Phantom Block (200)

Hereinafter, the operation of the preferred embodiment will be described in detail with reference to the accompanying drawings. 3 is an exploded perspective view of the phantom block 200 used in the standard phantom 10 for clinical trials for brain diseases according to the present invention, and FIG. 4 is a perspective view of the phantom block 200 shown in FIG. 3 . 3 and 4 , the phantom block 200 is approximately composed of a head block 120 , an air separation unit 130 , and a body block 140 . Polycarbonate, ABS resin, PE (polyethylene), PP (polypropylene), acrylic, urethane, PVC, etc. Polymer and plastic materials are used for the head block 120, the air separation unit 130 and the body block 140. can be produced by

In addition, the head block 120 , the air separation unit 130 , and the body block 140 may be manufactured using injection molding, cutting, or a 3D printer.

The head block 120 has a circular cross section and four protrusions 124 are formed on the upper surface 122 to enable assembly with other phantom blocks. The bolt hole 128 is formed through the center region and the edge of the head block 120, and is used for sealing after injecting the reference material 152 or discharging air bubbles. A sealing material 115 is inserted into the bolt hole 128 to further enhance the sealing force, and the bolt 110 is fastened to completely seal the reference material 152 filled therein.

The air separation unit 130 has a circular cross section, is made of a thin thickness, and is placed between the head block 120 and the body block 140 . The through hole 136 is formed in the central region of the air separation unit 130 to function as a passage for air bubbles to move upward, and also serves as a passage when the reference material 152 is injected. The air separation unit 130 is positioned to be caught on the clasp of the body block 140 .

The body block 140 has a cylindrical shape, and a cavity 146 is formed therein to accommodate the reference material 152 . In the upper region, the locking jaw protrudes from the inner wall so that the air separation unit 130 can be assembled.

The upper surface of the main body of the body block 140 is bonded or bonded to the lower surface of the head block (120). For bonding, ultrasonic welding, friction welding, compression, etc. may be applied, and for bonding, an adhesive may be applied and cured. The body block 140 and the head block 120 may be bolted together by forming a separate screw hole.

The reference material 152 filled in the cavity 146 is nickel chloride (NiCl ₂ ) when used in the T1 part 300 . And, the reference material 152 filled in the cavity 146 is manganese chloride (MnCl ₂ ) when used in the T2 part 500 .

If it is determined that a large number of air bubbles or air bubbles have been generated, the air bubbles or air bubbles may be removed by loosening the bolt 110 and further injecting the reference material 152 through the bolt hole 128 . Through such a simple repair process, continuous use is possible even with the phantom block 200 having air bubbles or air bubbles.

In addition, if the phantom block 200 filled with another reference material 152 is required, loosen the bolt 110 , discharge all of the prefilled reference material 152 , and then refill with the desired reference material 152 . can also be used.

The protrusions 124 and the lower protrusions 150 of the present invention are made to have the same size as children's block toys (eg, Lego blocks) and can be easily assembled or disassembled. can be decorated

Standard Phantom(10)

5 is a front view of the standard phantom 10 for brain disease clinical trials according to the present invention. As shown in FIG. 5 , the standard phantom 10 may be composed of three layers. The standard phantom 10 is stacked in the order of the T1 part 300 , the diffusion part 400 , and the T2 part 500 from above. The standard phantom 10 has an outer diameter of about 170 to 180 mm, and a height of about 150 mm. Optionally, the standard phantom 10 may be stacked in the order of the T2 unit 500, the diffusion unit 400, and the T1 unit 300, and may consist of only the T1 unit 300 and the diffusion unit 400, It may be composed of only the T2 unit 500 and the diffusion unit 400 .

6 is a plan view of the standard phantom 10 shown in FIG. 5 . As shown in FIG. 6 , the T1 part 300 is assembled in a 3×3 form with seven phantom blocks 200 and two first and second cross-section selection blocks 100a and 100b on an upper substrate 410 . has been The upper substrate 410 has a disk shape, and a plurality of substrate protrusions 455 regularly protrude from the upper surface. Therefore, the phantom block 200 and the cross-section selection block 100 can be freely assembled in any combination.

The inside of the seven phantom blocks 200 is filled with _{nickel chloride (NiCl 2 ) as a reference material.} The T1 unit 300 is used to evaluate the accuracy and reproducibility of quantitative measurements of medical images in clinical trials requiring quantitative image evaluation such as cerebral infarct volume measurement and cerebral hemorrhage site measurement. This makes it possible to calibrate the MRI equipment. In general, T1 (weighted) images show the ventricles in black, white matter in white, gray matter in gray, and calcifications and bones in black.

The two first and second cross-section selection blocks 100a and 100b are assembled on both sides with one phantom block 200 interposed therebetween.

7 is an exploded perspective view of the diffusion unit 400 of the standard phantom 10 shown in FIG. 5 . As shown in FIG. 7 , the diffusion unit 400 may measure the degree of diffusion using diffusion weighted MRI in an acute stroke clinical trial.

The diffusion unit 400 is composed of an upper substrate 410 , a container body 430 , and a lower substrate 450 , and the phantom block 200 is accommodated together with the solution 440 in the container body 430 .

The upper substrate 410 forms the T1 part 300 on the upper surface, and the phantom block 200 for the diffusion part 400 is positioned on the lower surface.

The container body 430 is made of a transparent synthetic resin material, and has a cylindrical shape. The upper substrate 410 is assembled on the upper surface, and the lower substrate 450 is assembled on the lower surface. Assembling can be applied in various ways such as fusion, screwing, bonding, and fitting.

The solution 440 may be water.

The phantom block 200 for the diffusion unit 400 is fitted on the lower substrate 450 in a 3×3 shape, and polyvinylpyrrolidone (PVP) is filled therein.

The lower substrate 450 may be the same member as the upper substrate 410 , and a plurality of substrate protrusions 455 are formed on the upper surface so that the phantom block 200 can be freely assembled in any combination.

8 is a bottom view of the standard phantom 10 shown in FIG. 5 . As shown in FIG. 8 , the T2 part 500 has seven phantom blocks 200 and two third and fourth cross-section selection blocks 100c and 100d on the lower surface of the lower substrate 450 in a 3×3 shape. is assembled. The lower substrate 450 has a disk shape, and has a structure in which a plurality of substrate protrusions 455 are regularly protruded from the upper surface, and the lower substrate protrusions 124 can be inserted thereinto. Therefore, the phantom block 200 and the cross-section selection block 100 can be freely assembled in any combination.

The inside of the seven phantom blocks 200 is filled with _{manganese chloride (MnCl 2 ) as a T2 reference material.} The T2 unit 500 may be used to measure a T2 relaxation time using gradient magnetic resonance imaging (MRI). In general, T2 (weighted) images show the ventricles in white, white matter in black, gray matter in gray, and calcifications and bones in black.

The two third and fourth section selection blocks 100c and 100d are assembled on both sides with one phantom block 200 in the center therebetween.

FIG. 9 is an example of a medical image 600 obtained by photographing the standard phantom 10 for a clinical trial for brain disease according to the present invention by an MRI apparatus. As shown in FIG. 9 , first, a section 610 is selected from the images of the third and fourth section selection blocks 100c and 100d of the T2 part 500 . That is, the position indicated by the triangular pole 190 of the third cross-section selection block 100c and the position indicated by the triangular pole 190 of the fourth cross-sectional selection block 100d are connected. This cross-section 610 is used as a reference to measure the T1 image and T2 image of the medical image 600 and the degree of diffusion.

When the standard phantom 10 and solutions of different concentrations are filled, the position and accuracy of contrast (grayscale or gradation), grayscale, grayscale, spatial resolution, signal-to-noise ratio, uniformity, and section selection , geometrical accuracy, etc. can be determined at once.

In a modified embodiment of the present invention, in addition to the 3x3 arrangement, various arrangements such as 2x2, 4x4, 4x3, 2x3, etc. are possible. In addition, the phantom block may also have various shapes (eg, elliptical cross-section, triangular cross-section, hexagonal cross-section, etc.) in addition to the cylindrical or rectangular parallelepiped shape.

The detailed description of the preferred embodiments of the present invention disclosed as described above is provided to enable any person skilled in the art to make and practice the present invention. Although the above has been described with reference to preferred embodiments of the present invention, it will be understood by those skilled in the art that various modifications and changes can be made to the present invention without departing from the scope of the present invention. For example, those skilled in the art can use each configuration described in the above-described embodiments in a way in combination with each other. Accordingly, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

The present invention may be embodied in other specific forms without departing from the spirit and essential characteristics of the present invention. Accordingly, the above detailed description should not be construed as restrictive in all respects but as exemplary. The scope of the present invention should be determined by a reasonable interpretation of the appended claims, and all modifications within the equivalent scope of the present invention are included in the scope of the present invention. The present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. In addition, claims that are not explicitly cited in the claims may be combined to form an embodiment, or may be included as new claims by amendment after filing.

10: standard phantom,
100: section selection block,
100a, 100b, 100c, 100d: 1st, 2nd, 3rd, 4th section selection block,
110: volts,
115: sealing material,
120: head block,
124: turn,
128: bolt ball,
130: air separation unit,
132: sidewall;
136: through hole,
140: body block,
144: jamming jaw,
146: joint,
150: lower protrusion,
152: reference substance;
160: opening,
190: triangular prism,
200: phantom block,
300: T1 part,
400: diffuser,
410: upper substrate,
430: container body;
440: solution;
450: lower substrate,
455: substrate protrusion,
500: T2 part,
600: medical imaging,
610: cross section.

Claims (14)

In the standard phantom for medical imaging,
In order to measure the degree of diffusion of brain disease, a diffusion block (200b) for embedding a diffusion reference material;
a diffusion unit 400 for accommodating the diffusion block 200b together with the solution 440; and
A standard phantom for clinical trials for brain disease, characterized in that it comprises a; T1 block (200a) assembled on the upper surface or the lower surface of the diffusion unit (400), the T1 reference material is embedded. The method of claim 1,
The T1 reference material is nickel chloride (NiCl ₂ ) Standard phantom for brain disease clinical trial, characterized in that it contains. In the standard phantom for medical imaging,
In order to measure the degree of diffusion of brain disease, a diffusion block (200b) for embedding a diffusion reference material;
a diffusion unit 400 for accommodating the diffusion block 200b together with the solution 440; and
A standard phantom for brain disease clinical trial, characterized in that it comprises a; T2 block (200c) that is assembled on the upper or lower surface of the diffusion unit (400) and contains a T2 reference material. 4. The method of claim 3,
The T2 reference material is manganese chloride (MnCl ₂ ) Standard phantom for brain disease clinical trial, characterized in that it contains. 4. The method of claim 1 or 3,
The diffusion reference material is a standard phantom for brain disease clinical trials, characterized in that it comprises polyvinylpyrrolidone (PVP). 4. The method of claim 1 or 3,
The solution 440 is a standard phantom for brain disease clinical trials, characterized in that it contains water. 4. The method of claim 1 or 3,
The diffusion unit 400,
a lower substrate 450 on which the substrate protrusions 455 are uniformly formed;
the diffusion block 200b that can be assembled on the lower substrate 450;
a container body 430 assembled on the lower substrate 450 and accommodating the diffusion block 200b and the solution 440; and
The standard phantom for brain disease clinical trial, characterized in that it comprises a; assembled to the container body (430), the upper substrate (410) formed with a plurality of substrate protrusions (455). 4. The method of claim 1 or 3,
A standard phantom for brain disease clinical trial, characterized in that a pair of cross-section selection blocks (100a, 100b) are further assembled on the upper surface or the lower surface of the diffusion unit (400). 9. The method of claim 8,
A standard phantom for brain disease clinical trial, characterized in that it further includes a triangular prism (190) in which the vertex is specified in the medical image (600) inside the cross-section selection block (100a, 100b). In the standard phantom for medical imaging,
In order to measure the degree of diffusion of brain disease, a plurality of diffusion blocks 200b for embedding a diffusion reference material;
a diffusion unit 400 for accommodating the diffusion block 200b together with the solution 440; and
a T1 part 300 comprising a plurality of T1 blocks 200a containing a T1 reference material;
Includes; T2 portion 500 consisting of a plurality of T2 blocks (200c) containing a T2 reference material;
At least one of the diffusion block 200b, the diffusion unit 400, the T1 block 200a, and the T2 block 200c further includes a protrusion 124 on its upper surface, and a lower protrusion 150 on its lower surface. Standard phantom for brain disease clinical trials, characterized in that it can be assembled and disassembled with each other, including further. 11. The method of claim 10,
The plurality of diffusion blocks (200b) are standard phantom for brain disease clinical trials, characterized in that arranged in a 3×3 shape. 11. The method of claim 10,
At least one of the diffusion block 200b, the diffusion unit 400, the T1 block 200a, and the T2 block 200c has a bolt hole 128 for discharging air bubbles on its upper surface;
a sealing material 115 inserted into the bolt hole 128; and
A standard phantom for brain disease clinical trial, characterized in that it further comprises; a bolt 110 that is fastened to the bolt hole 128. 11. The method of claim 10,
The diffusion block (200b), the T1 block (200a), and the T2 block (200c) each is a standard phantom for brain disease clinical trials, characterized in that the cylindrical or rectangular shape. 11. The method of any one of claims 1, 3 and 10,
The brain disease is a standard phantom for brain disease clinical trials, characterized in that any one of stroke, cerebral infarction, and cerebral hemorrhage.

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