KR20210088900A - Composition for pervention or improvement of herpes zoster - Google Patents

Abstract

The present invention provides a health functional composition for preventing and alleviating herpes zoster comprising 5 to 40 wt% of amino acids, 30 to 70 wt% of physiological saline, and 1 to 30 wt% of a Trachycarpus fortunei leaf extract based on a total weight of the composition. The present invention is devised to solve the above disadvantages of the prior art, and an object of the present invention is to provide a composition for preventing and alleviating herpes zoster that provides an excellent effect in preventing and alleviating symptoms of herpes zoster without side effects.

Description

Composition for preventing and improving herpes zoster {COMPOSITION FOR PERVENTION OR IMPROVEMENT OF HERPES ZOSTER}

The present invention relates to a composition for preventing and improving herpes zoster.

Chickenpox-herpes zoster virus is a human pathogenic virus that is highly contagious and occurs mainly in children aged 2 to 8 years in winter and spring. During infection, varicella-zoster virus replicates viral DNA through sequential expression of immediate early (IE), Early (E), and late (L) genes. IE62 protein encoded by ORF (open reading frame) 62 is essential for the activation of lytic activity-related genes, and induces the expression of E genes by binding with transcription factors. E genes play a crucial role in varicella-zoster virus replication, and induce the expression of L genes to promote transcription of components constituting virions.

Chickenpox is caused by primary infection with the varicella-zoster virus, but when the virus remains dormant in the ganglion and is reactivated, it can also occur as shingles.

Although varicella-zoster usually has a good course in normal people, it can be fatal in patients with hematological tumors, patients with solid organ transplantation or hematopoietic stem cell transplantation, or patients with autoimmune diseases or congenital immunodeficiency diseases.

A vaccine against varicella-zoster virus was developed in Japan in the 1970s, and since the varicella vaccine was introduced in 1988 in Korea, it has been included in the national mandatory vaccination program since 2005. After the introduction of the varicella vaccine, the incidence and hospitalization rates of varicella and varicella-zoster significantly decreased. In the United States, as vaccination rates increased, the incidence of chickenpox decreased by 71-84% compared to pre-vaccination, and hospitalizations associated with chickenpox decreased by 75-88%. In addition, the mortality rate due to chickenpox was reduced by 66% in children under 50 years of age, and in particular, the mortality rate in children aged 1 to 4 years was reduced by 92%.

However, even in Korea, 180,000-240,000 cases are reported every year, despite the high vaccination rate exceeding 80% since the chickenpox vaccine was included in the national mandatory vaccination list. This is because the rate of production of antibodies by the chickenpox vaccine when vaccinated is 77-82%, which is low compared to other vaccines, so breakthrough infection or a decrease in immunity, which occurs despite vaccination, is not likely to occur. It is presumed to be the cause, and the risk is higher in immunocompromised patients or those who have not been vaccinated. Therefore, chickenpox is a disease that requires not only prevention but also treatment.

Varicella-zoster virus is a virus belonging to the herpesviridae family and causes various symptoms such as blisters, skin peeling, encephalitis, pain, paresthesia and damage to the nervous system.

Currently, for the treatment of varicella-zoster virus, DNA polymerase including acyclovir (ACV), famciclovir, valacyclovir and foscarnet (DNA polymerase) Drugs that work are used. However, the antiviral agent is known to cause side effects in chronically infected patients with weakened immunity, and a type resistant to the antiviral agent appears, so it is suitable for the varicella-zoster virus for treatment of the varicella-zoster virus. The development of a therapeutic agent that eliminates the side effects is required.

Republic of Korea Patent Publication No. 10-2017-0011441

The present invention has been devised to solve the above disadvantages of the prior art, and an object of the present invention is to provide a composition for preventing and improving herpes zoster, which provides an excellent effect in preventing and improving symptoms of herpes zoster without side effects.

The present invention is

Based on the total weight of the composition, it provides a health functional composition for preventing and improving herpes zoster comprising 5 to 40% by weight of amino acids, 30 to 70% by weight of physiological saline, and 1 to 30% by weight of palm leaf extract.

The composition for preventing and improving herpes zoster of the present invention provides an excellent effect in preventing and improving symptoms of herpes zoster without side effects.

1 is a graph showing the confirmation result of the varicella-herpes zoster virus (VZV) proliferation inhibitory effect of a palm leaf extract carried out in Experimental Example 2 of the present invention.
FIG. 2 is a graph showing the results of confirming the varicella-zoster virus (VZV) proliferation inhibitory efficacy of sunflower oil extract of fermented seaweed carried out in Experimental Example 3 of the present invention.
3 shows a sequence listing of the ORF62 primers used in Experimental Examples 2 and 3.

Hereinafter, the present invention will be described in detail.

The present invention relates to a health functional composition for preventing and improving herpes zoster comprising 5 to 40% by weight of amino acids, 30 to 70% by weight of physiological saline, and 1 to 30% by weight of palm leaf extract based on the total weight of the composition.

The health functional composition of the present invention contains 1 to 10% by weight of a sunflower oil extract of fermented seaweed together with the above components; 1 to 10% by weight of coconut oil; 1 to 10% by weight of abyssinia kale seed oil; Maca powder, mastic gum powder, jibuja (Kochia scoparia) powder and paracres powder in a weight ratio of 1-3: 1-3: 1-3: 1 to 5% by weight of a mixture of hot water extract; It may further include 1 to 5% by weight of roasted garlic and roasted turmeric hot water extract.

Furthermore, the health functional composition of the present invention may contain 1 to 5% by weight of castor oil together with the above ingredients; Sweet almond oil (Sweet almond oil) 1 to 5% by weight; 0.3 to 3% by weight of allantoin; And 1 to 3% by weight of squalane; may further include.

The amino acid comprises 0.5 to 3% by weight of N-acetyl-L-cysteine, 3 to 20% by weight of L-leucine, 3 to 18% by weight of L-valine, 1 to 10% by weight of L-serine, 2 to 10% by weight of L-arginine %, L-alanine 2 to 12% by weight, L-isoleucine 3 to 20% by weight, L-threonine 1 to 10% by weight, L-tryptophan 1 to 10% by weight, L-phenylalanine 2 to 15% by weight, L- 3 to 20% by weight of proline, 1 to 15% by weight of L-histidine, 3 to 20% by weight of L-glycine, 1 to 5% by weight of L-methionine, and 3 to 20% by weight of L-lysine.

The palm leaf extract may be an ethanol extract.

The evergreen tall tree, the palm tree, is of the palm family Trachycarpus fortunei. The palm tree is very unique in that it has strong leaf stems and the leaves spread out like a fan toward the sky. It is native to the southern regions of Korea and Jeju Island, and is cultivated and planted as an ornamental tree. Its origin is Japan and China, and it is estimated that it was washed away by waves in Korea and settled in Jeju Island and southern regions. Palm leaves are known to be effective in preventing hematemesis, fatigue, fatigue, weakness, high blood pressure, and stroke, the inventors of the present invention completed the present invention by discovering that the palm leaf extract is effective in preventing and improving herpes zoster. did.

The seaweed (Agarum cribrosum) belongs to the kelp family and is distributed in Japan's Hokkaido, Kuril Islands, the Americas Pacific coast, and the Bering Sea, and in Korea, it is distributed in the central and northern regions of the east coast of Korea. The shape of the leaf has a round feature, the round leaf has many holes, and it lives at a depth of 30 m and has recently been used as food.

As for the study of seaweed, it was reported that nitrite, one of the carcinogenic nitrosamine producing factors, was effectively converted to inhibit carcinogenic nitrosamine production (Park YB. 2005. Determination of nitrite-scavenging activity of seaweed. J Korean Soc Food Sci Nutr 34:1293-1296), a study showing that the inhibitor of 5-lipoxygenase, which causes chronic disease, is contained in aquatic organisms such as seaweed (Cho SY, You BJ, Chang MH, Lee SJ, Sung NJ, Lee EH. 1994. Screening for porare lipoxygenase-inhibitor in unused marine resources by the polarographic method. Agricultural Chemistry and Biotechnology 37:451-455) was also reported, and recently, screening for substances for the prevention and treatment of dementia (Jeon) YE, Yin XF, Lim SS, Chung CK, Kang IJ. 2012. Antioxidant activities and acetylcholinesterase inhibitory activities from seaweed extracts. J Korean Soc Food Sci Nutr 41:434-449), nutrients and physiological activity (Park SJ, Min KJ) , Park TG. 2012. Nutritional Characteristics and Screening of the Biological Activity of Agarum cribrosum. Korean J Food & Nutr 25:842-849) research is being actively conducted.

The present inventors have completed the present invention by discovering that the extract obtained by extracting the component of the seaweed with sunflower oil provides an effect in the prevention and improvement of herpes zoster.

In addition, the present inventors have completed the present invention by discovering that coconut oil and abyssinia kale seed oil provide an effect in preventing and ameliorating herpes zoster.

The health functional composition is a mixture of maca powder, mastic gum powder, jibuja (Kochia scoparia) powder, and paracres powder in a weight ratio of 1-3: 1-3: 1-3: 1 to 5 hot water extract mixture It may further include % by weight.

The maca (Lepidium meyenii Walp) is a cruciferous plant that is native to the Andes Mountains of Peru, South America, at an elevation of more than 4.000 meters above sea level, and is known as Peruvian ginseng. The maca is a plant that grows wild in the harsh climate of the highlands and has been cultivated since 2000 BC in the Andean Highlands as a food with high nutritional value. Maca is rich in protein, unsaturated fatty acids and minerals. In particular, maca powder contains 55-60% carbohydrate, 9-12% protein, 1-2% lipid, 8-9% fiber, a large amount of essential amino acids, iron and calcium, etc. It is known as a nutritious food containing In addition to the above ingredients, maca also contains important fatty acids such as linolenic acid, palmitic acid, and oleic acid, and a large amount of plant sterols and minerals. ) or macamide, there are inherent unsaturated fatty acids not found in other plants, and these components are reported to have physiological activity. The present inventors confirmed that the maca provides an excellent effect in improving the symptoms of herpes zoster.

The mastic (scientific name: Pistacia lentiscus LINNE) is a food additive registered in Food Additives National Natural Flavoring No. 272, and mastic black is a viscous natural sap from the Sumacaceae mastic that grows only on the island of Chios in the southeastern part of Greece. it is sword The mastic contains 60 to 70% resin, 33% αβ-Boswellic acid, 33% olibanoresene, and contains arabic acid, etc. are doing Mastic extract is known to have anti-inflammatory, antioxidant and anticancer effects, and is widely used in oriental medicine for the treatment or prevention of inflammatory diseases including arthritis, asthma and inflammatory bowel disease. The present inventors confirmed that the mastic provides an excellent effect in improving the symptoms of herpes zoster.

The jibuja (Kochia scoparia) is a dicotyledonous plant in the family Apiaceae, and is called Dapsari, Nakchuja, and Chunduja, and its origin is Europe and Asia. After drying, a broom is made and the seeds are used for medicinal purposes. In oriental medicine, the fruits are called Jibuja, Cheonduja, and Nakchuja. Received in September and dried in the shade as a tonic, used as a medicinal for yin, edema, chest pain, aches, spleen, gonorrhea, jaundice, gonorrhea, diuresis, cystitis, urination, sore throat, fruit poisoning, constipation, etc. It is effective against various inflammations, eczema, sore throat, scabies, and ringworm. The present inventors have confirmed that the branch provides an excellent effect in improving the symptoms of herpes zoster.

The paraclass (paraclass, Acmella oleracea) is an annual plant or perennial plant of the Asteraceae family, and is native to tropical Brazil of East India and South America. The corolla and leaves are used mainly as spices because they give off a unique flavor. In the present invention, all of the corolla, leaves, stems and roots can be used for Paracres, and in particular, the corolla and leaves can be preferably used. The Paracres extract also provides an effect to improve herpes zoster symptoms.

The health functional composition of the present invention has a characteristic comprising roasted garlic and roasted turmeric hot water extract.

Garlic prevents heart disease, supplies vitamins that are easily deficient, helps overcome weakness, has strong sterilization and antibacterial action, helps with fatigue recovery, and prevents vascular diseases such as hyperlipidemia, arteriosclerosis, and high blood pressure. It helps, reduces blood cholesterol and triglyceride levels, stimulates gastric mucosa, promotes gastric secretion, promotes intestinal intestinal function, calms nerve cell excitement, relieves stress and helps with insomnia, cancer It is effective in preventing cancer, suppressing allergic reactions, improving high blood pressure, strengthening the liver with a strong detoxification action, excreting heavy metals and removing bacteria, and improving diabetes. is known

Turmeric (Curcuma longa) is a plant belonging to the genus Ginger and Curcuma, has yellowish flesh, and is also called 'Golden from the Field'. Also, turmeric contains flavonoids, which are antioxidants, calcium, potassium, and various other vitamins and minerals, so it is also called 'food from the gods'. In particular, 'curcumin', the main ingredient, is the ingredient that makes the yellow color of turmeric and is effective in preventing cardiovascular diseases such as diabetes and high blood pressure and dementia. It has excellent anti-inflammatory and anti-cancer properties that inhibit inflammation or tumor growth, and has recently been used for anti-cancer treatment. It is very helpful for skin beauty by alleviating skin inflammation. It is excellent for relieving clogged eohyeol and improving blood circulation, improving women's diseases such as menstrual pain and irregular menstruation. It is also known to help improve liver function as it has the effect of excreting bad components from the body.

In the present invention, the garlic and turmeric are roasted, steamed, and extracted with hot water. The reason for using garlic and turmeric prepared in this way is that the antibacterial and anti-inflammatory effects associated with herpes zoster can be increased by such processing.

The health functional composition of the present invention is castor oil (Caster oil) 1 to 5% by weight; Sweet almond oil (Sweet almond oil) 1 to 5% by weight; 0.3 to 3% by weight of allantoin; And 1 to 3% by weight of squalane; may further include. These ingredients can help improve the symptoms of herpes zoster.

The castor oil (Castor Oil-or castor oil) is made by squeezing castor seeds (Ricinus communis). It is a type of triglyceride composed of fatty acids with 90% ricinolic acid, the main healing component of castor oil. The sweet almond oil (Sweet almond oil) contains a large amount of minerals, protein, vitamin A and the like.

The health functional composition of the present invention may further comprise 1 to 5% by weight of hot water extract of gazania. The gazania (gazania) hot water extract provides an excellent effect in improving the symptoms of herpes zoster.

The gazania (gazania) is an annual plant of the family Asteraceae, the origin of which is Southern Africa, in the family Asteraceae. Gazania has been reported to have hepatoprotective and antioxidant activity (International Journal of Pharmacognosy and Phytochemical Research 2016; 8(7); 1121-1131). The present inventors have confirmed that the gazania provides an excellent effect in improving the symptoms of herpes zoster.

The health functional composition may further include, without limitation, well-known adjuvants, excipients, and the like generally included in health functional compositions. The adjuvant may include, for example, additional nutrients or ingredients for improving taste.

The health functional composition of the present invention is taken in an amount of 10 ml to 200 ml once a day depending on the condition of the user, and it is preferable to take it several times at least once a day and not more than 5 times a day. However, since the composition of the present invention is all composed of natural ingredients, even if the above dose is exceeded, a dangerous situation rarely occurs.

The health functional composition of the present invention may be prepared in various forms known in the art. For example, it may be prepared in various forms, such as liquids, powders, tablets, pills, capsules, syrups, and the like.

Hereinafter, the present invention will be described in more detail through examples. However, the following examples are provided to illustrate the present invention in more detail, and the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Preparation Example 1: Preparation of palm leaf extract

After washing 3 Kg of palm leaves, it was added to 5 liters of 70% ethanol (EtOH), and extracted while boiling until the total mixture was 4 liters. After that, it was concentrated with a rotary vacuum concentrator to 300 ml of an extract was obtained.

Preparation Example 2: Preparation of sunflower oil extract of seaweed

1 Kg of seaweed was added to 2 liters of sunflower oil, and the mixture was extracted while heating to 70° C. until the total mixture was 2.5 liters. Thereafter, the substrate was removed and filtered to prepare a sunflower oil extract of the seaweed.

Preparation Example 3: Preparation of hot water extract mixed with maca powder, mastic gum powder, jibuja powder, and paracres powder

100 g of maca powder, 100 g of mastic gum powder, 100 g of jibuja (Kochia scoparia) powder, 100 g of paracress powder, and 800 ml of water were put in a pot, boiled, and concentrated by heating until the hot water extract was 120-200 ml to obtain a hot water extract. The final obtained hot water extract was 125 ml.

Preparation Example 4: Preparation of mixed hot water extract of roasted garlic and roasted turmeric

Put 5 garlic cloves (20g) in a cauldron and bake for 20 minutes. Bake 30g of turmeric in a cauldron for 10 minutes. The roasted garlic and roasted turmeric were placed in a tray, put in a pressure steamer filled with water on the bottom, heated and steamed with steam for 10 minutes, and then rapidly cooled with cooling water.

The cooled roasted garlic, roasted turmeric, and 300 ml of water were put in a pot and concentrated by heating until the filtered hot water extract reached 40 to 60 ml to obtain a mixed hot water extract of roasted garlic and roasted turmeric.

Examples 1 to 3: Preparation of health functional composition for preventing and improving herpes zoster

A health functional composition for preventing and improving herpes zoster was prepared by mixing the ingredients of Table 1 below in the corresponding composition ratio.

ingredient Example 1 Example 2 Example 3 N-Acetyl-L-Cysteine 0.5 0.5 0.5 L-leucine 5 5 5 L-valine 3 3 3 L-serine 1.5 1.5 1.5 L-Arginine 1.5 1.5 1.5 L-alanine 2.5 2.5 2.5 L-Isoleucine 4 4 4 L-Threonine 2 2 2 L-Tryptophan 2 2 2 L-Phenylalanine 3 3 3 L-proline 4 4 4 L-Histidine 3 3 3 L-glycine 4 4 4 L-Methionine 0.5 0.5 0.5 L-lysine 3.5 3.5 3.5 physiological saline 50 40 40 palm leaf extract 10 5 5 Sunflower oil extract of seaweed - 5 5 coconut oil - 2 One Abyssinia Kale Seed Oil - 2 One A mixture of maca powder, mastic gum powder, jibuja (Kochia scoparia) powder, and paracres powder in a weight ratio of 1-3: 1-3: 1-3: Hot water extract - 3 2 Roasted Garlic and Roasted Turmeric Hot Water Extract - 3 2 Castor oil - - One Sweet almond oil - - One allantoin - - One squalane - - One Sum 100% by weight 100% by weight 100% by weight

(Unit: % by weight)

Experimental Example 1: Cytotoxicity of palm leaf extract

Although palm leaves are known to be edible, this study was conducted to determine the presence or absence of cytotoxicity of palm leaf extracts in consideration of safety.

MRC-5 cells were treated with palm extract at concentrations of 0, 5, 10, 25 and 50 μg/ml, respectively, and CellTiter-Glo luminescent cell viability assay (Promega) was prepared at 0, 24, 48 or 72 hours. was performed according to the protocol of

As a result, when treated with the palm extract, there was no decrease in cell viability even when treated at the highest concentration of 50 μg/ml for 72 hours. Therefore, it was confirmed experimentally that it is a safe ingredient.

Experimental Example 2: Confirmation of varicella-zoster virus (VZV) proliferation inhibitory efficacy of palm leaf extract

We investigated whether palm leaf extract could inhibit varicella-zoster virus replication.

Uninfected MRC-5 cells (Korean Cell Line Bank no.10171) were infected with an artificially recombined varicella-zoster virus pOka strain expressing green fluorescent protein (Chungbuk National University) at an MOI (multiplicity of infection) of 0.1. and the palm leaf extract was treated at a concentration of 50 μg/ml. At 0, 24, 48 or 72 hours after treatment, analysis was performed using a digital camera and a Nikon TS100-F inverted fluorescence microscope (Tokyo, Japan) equipped with Nikon NIS-Elements microscope imaging software. In addition, at 0, 24, 48 or 72 hours after treatment, the amount of VZV-pOka-GFP DNA was measured by quantitative PCR (qPCR) using the ORF62 primers in Table 2. Specifically, for qPCR, total DNA was isolated using the Accuprep Genomic DNA Extraction kit (Bioneer), and amplified and measured using the StepOnePlus Real-Time PCR system (Applied Biosystem) according to the manufacturer's protocol.

As a result, after 72 hours of treatment, the fluorescence expression of the cells treated with the palm leaf extract was significantly reduced compared to the DMSO-treated group. Also, as shown in FIG. 1, when DMSO was treated as a control, VZV-pOka-GFP DNA was amplified 170,000-fold and 280,000-fold, respectively, after 48 and 72 hours. However, in the case of cells treated with palm leaf extract, VZV-pOka-GFP DNA replication was reduced to 1/3.8 and 1/4.7, respectively, compared to the control after 48 and 72 hours. The above results suggest that palm leaf extract can inhibit the replication of varicella-zoster virus.

Primer name order SEQ ID NO: VZV ORF62 Forward 5’-TCTTGTCGAGGAGGCTTCTG-3’ One VZV ORF62 Reverse 5’-TGTGTGTCCACCGGATGAT-3’ 2 GAPDH Forward 5’-CATGAGAAGTATGACAACAGCCT-3’ 3 GAPDH Reverse 5’-AGTCCTTCCACGATACCAAAGT-3’ 4

Experimental Example 3: Confirmation of varicella-herpes zoster virus (VZV) proliferation inhibitory efficacy of sunflower oil extract of seaweed

It was investigated whether the sunflower oil extract of black seaweed can inhibit the replication of varicella-zoster virus.

Uninfected MRC-5 cells (Korean Cell Line Bank no.10171) were infected with an artificially recombined varicella-zoster virus pOka strain expressing green fluorescent protein (Chungbuk National University) at an MOI (multiplicity of infection) of 0.1. and the palm leaf extract was treated at a concentration of 50 μg/ml. At 0, 24, 48 or 72 hours after treatment, analysis was performed using a digital camera and a Nikon TS100-F inverted fluorescence microscope (Tokyo, Japan) equipped with Nikon NIS-Elements microscope imaging software. In addition, at 0, 24, 48 or 72 hours after treatment, the amount of VZV-pOka-GFP DNA was measured by quantitative PCR (qPCR) using the ORF62 primers in Table 1. Specifically, for qPCR, total DNA was isolated using the Accuprep Genomic DNA Extraction kit (Bioneer), and amplified and measured using the StepOnePlus Real-Time PCR system (Applied Biosystem) according to the manufacturer's protocol.

As a result, after 72 hours of treatment, the fluorescence expression of the cells treated with the sunflower oil extract of seaweed was significantly reduced compared to the DMSO-treated group. In addition, as shown in FIG. 2, when DMSO was treated as a control, VZV-pOka-GFP DNA was amplified 170,000-fold and 280,000-fold, respectively, after 48 hours and 72 hours. However, in the case of the cells treated with the sunflower oil extract of seaweed, the VZV-pOka-GFP DNA replication was reduced to 1/3.9 and 1/4.9, respectively, compared to the control after 48 and 72 hours. The above results suggest that the sunflower oil extract of black seaweed can inhibit the replication of varicella-zoster virus.

Experimental Example 4: Effect test of health functional composition for preventing and improving herpes zoster

12 patients (females in their 30s and 60s) with herpes zoster symptoms were divided into 4 groups of 3 each, and the health functional composition of Example 1 in the first group, the health functional composition of Example 2 in the second group, In the third group, the health functional composition of Example 3 was taken after meals by 50 ml each time 3 times a day. The fourth group was set as a control group and did not take the health functional composition of the present invention. The degree of improvement of herpes zoster on the 5th day was confirmed according to the following criteria, and the average was shown in Table 3 below.

<Evaluation criteria>

5 points: Significantly improved

4 points: improved

3 points: no change,

2 points: Worse

control Example 1 Example 2 Example 3 Subject 1 2 4 4.3 4.5 Subject 2 3 4 4.5 5 Subject 3 2 4 4.5 5 Average 2.3 4 4.4 4.8

As can be seen in Table 3 above, the test group taking the health functional composition of the present invention showed a very good improvement in symptoms of herpes zoster compared to the control group. In particular, the health functional composition of Example 3 showed a very remarkable effect compared to other compositions.

Claims (6)

A health functional composition for preventing and improving herpes zoster comprising 5 to 40% by weight of amino acids, 30 to 70% by weight of physiological saline, and 1 to 30% by weight of palm leaf extract based on the total weight of the composition. According to claim 1,
1 to 10% by weight of a sunflower oil extract of fermented seaweed; 1 to 10% by weight of coconut oil; 1 to 10% by weight of abyssinia kale seed oil; Maca powder, mastic gum powder, jibuja (Kochia scoparia) powder and paracres powder in a weight ratio of 1-3: 1-3: 1-3: 1 to 5% by weight of a mixture of hot water extract; A health functional composition for preventing and improving herpes zoster, comprising 1 to 5% by weight of roasted garlic and roasted turmeric hot water extract. 3. The method of claim 2,
Castor oil (Caster oil) 1 to 5% by weight; Sweet almond oil (Sweet almond oil) 1 to 5% by weight; 0.3 to 3% by weight of allantoin; And 1 to 3% by weight of squalane; Health functional composition for preventing and improving herpes zoster, characterized in that it further comprises. According to claim 1,
The amino acid comprises 0.5 to 3% by weight of N-acetyl-L-cysteine, 3 to 20% by weight of L-leucine, 3 to 18% by weight of L-valine, 1 to 10% by weight of L-serine, 2 to 10% by weight of L-arginine %, L-alanine 2 to 12% by weight, L-isoleucine 3 to 20% by weight, L-threonine 1 to 10% by weight, L-tryptophan 1 to 10% by weight, L-phenylalanine 2 to 15% by weight, L- 3 to 20% by weight of proline, 1 to 15% by weight of L-histidine, 3 to 20% by weight of L-glycine, 1 to 5% by weight of L-methionine, and 3 to 20% by weight of L-lysine Health functional composition for preventing and improving herpes zoster. According to claim 1,
A health functional composition for preventing and improving herpes zoster, characterized in that the palm leaf extract is an ethanol extract. According to claim 1,
The health functional composition is a health functional composition for preventing and improving herpes zoster, characterized in that it is prepared in a solution, powder, tablet, pill, capsule, or syrup.

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