KR20210078189A - Manufacturing method of food composition for improving asthma, bronchitis or pneumonia comprising extract of Aster tataricus as effective component - Google Patents
Manufacturing method of food composition for improving asthma, bronchitis or pneumonia comprising extract of Aster tataricus as effective component Download PDFInfo
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- KR20210078189A KR20210078189A KR1020190170004A KR20190170004A KR20210078189A KR 20210078189 A KR20210078189 A KR 20210078189A KR 1020190170004 A KR1020190170004 A KR 1020190170004A KR 20190170004 A KR20190170004 A KR 20190170004A KR 20210078189 A KR20210078189 A KR 20210078189A
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- bronchitis
- pneumonia
- extract
- food composition
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/314—Foods, ingredients or supplements having a functional effect on health having an effect on lung or respiratory system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/31—Mechanical treatment
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/48—Ultrasonic treatment
Abstract
Description
본 발명은 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에 관한 것으로, 개미취의 이미 및 이취가 제거된 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에 관한 것이다.The present invention relates to a method for preparing a food composition for improving asthma, bronchitis or pneumonia containing an extract of Aster tataricus as an active ingredient. It relates to a method for producing a food composition for improving asthma, bronchitis or pneumonia containing.
천식은 집먼지, 진드기 등의 알레르기성 물질이 공기에 섞여 인체로 들어오면서 기관지를 수축시켜, 호흡곤란, 기침, 가슴동통 및 쌕쌕 거리는 소리 등의 증상을 유발하는 질환으로, 기도 수축과 염증을 동반하는 만성 호흡기 질환이다.Asthma is a disease that causes symptoms such as shortness of breath, coughing, chest pain, and wheezing by constricting the bronchi when allergens such as house dust and mites mix with the air and enter the body. It is a chronic respiratory disease.
기관지염은 바이러스, 세균, 흡연, 대기오염, 먼지 등의 자극으로 인해 기관지 점막이 손상을 받아, 염증 및 점액이 다량 발생하여 가래 및 기침 등의 증상을 유발하는 질환이다. 일반적으로 기관지염은 급성 기관지염과 만성 기관지염으로 구분되며, 심각할 경우 폐렴 또는 천식으로 악화되기도 한다.Bronchitis is a disease in which the bronchial mucosa is damaged by stimuli such as viruses, bacteria, smoking, air pollution, and dust, and a large amount of inflammation and mucus is generated, causing symptoms such as sputum and cough. In general, bronchitis is divided into acute bronchitis and chronic bronchitis, and in severe cases, it may worsen into pneumonia or asthma.
폐렴은 폐실질에 염증이 생긴 상태로, 폐간질에 병변에 있는 것을 간질성 폐렴 또는 폐장염이라고 한다. 폐렴은 세균, 바이러스, 곰팡이 등의 미생물로 인한 감염으로 발생하는 폐의 염증이다. 폐렴은 기침, 염증 물질의 배출에 의한 가래, 숨쉬는 기능의 장애에 의한 호흡 곤란 등 폐의 정상적인 기능에 장애가 생기는 폐 증상과, 구역, 구토, 설사 등 소화기 증상 및 두통, 피로감, 근육통, 관절통 등의 신체 전반에 걸친 전신 증상이 발생하는 질환이다. 폐렴은 원인에 따른 치료를 해야 하며, 대부분 항생제를 사용하는 방법을 취한다. 그러나, 폐렴의 증상이 중증일 경우에는 적절한 항생제를 사용하더라도 계속 병이 진행되어 사망하기도 한다.Pneumonia is a condition in which the lung parenchyma is inflamed, and if there is a lesion in the lung interstitium, it is called interstitial pneumonia or pneumonitis. Pneumonia is an inflammation of the lungs caused by infection with microorganisms such as bacteria, viruses, and fungi. Pneumonia is characterized by pulmonary symptoms such as coughing, phlegm due to the discharge of inflammatory substances, and difficulty breathing due to impaired breathing function, digestive symptoms such as nausea, vomiting, and diarrhea, and headache, fatigue, muscle pain, and joint pain. It is a disease that causes systemic symptoms throughout the body. Pneumonia should be treated according to the cause, and most of the time, antibiotics are used. However, if the symptoms of pneumonia are severe, the disease may continue to progress even if appropriate antibiotics are used, leading to death.
개미취(Aster tataricus)는 쌍떡잎식물 초롱꽃목 국화과의 여러해살이풀로서, 한방에서는 뿌리와 풀 전체를 토혈, 천식, 폐결핵성 기침, 만성기관지염, 이뇨 등에 처방한다.Aster tataricus is a dicotyledonous perennial plant of the Asteraceae family, and in oriental medicine, the root and the whole grass are prescribed for haemoptysis, asthma, pulmonary tuberculosis cough, chronic bronchitis, and diuresis.
황칠나무는 두릅나무과에 속하는 상록활엽교목으로 세계에서 오직 한국의 해남 완도 등의 남부 지역과 제주도에서만 자생하며 겨울에도 낙엽이 지지 않는 수종으로 수피에 상처를 주면 황색의 수액이 나오는데, 이를 황칠이라한다. 황칠은 삼국시대부터 황제의 갑옷, 투구, 기타 금속 장신구의 황금색을 발하는 진귀한 도료로 이용되어 왔다. 황칠은 이러한 도료적 기능 이외에 안식향으로서의 신경 안정 효능을 가지고 있고(이영민, 장흥군농업기술센터,2012), 이시진의 본초강목에는 번열 제거, 안질 및 화상 치료, 중풍, 나병 등에 효과에 있다고 기록되어 있으며, 그 뿌리와 줄기는 거풍습, 황멸맥, 풍습비통, 편두통, 월경불순에 효능이 있다고 알려져 왔다(J Korean Soc Agric Chem Biotechnol 43:63-66, 2000). 또한 황칠나무에는 세스퀴페르펜류에 속하는 β-selinene이 가장 많이 함유되어 있고, capnellane-8-one가 다음으로 많이 함유되어 있다고 알려져 있다(Korean J Biotechnol Bioeng 10:393-400, 1995). 최근에 황칠나무 추출물의 피부 미백 활성, 항암 활성, 항염증 활성, 항산화 활성, 숙취 해소 기능, 진해 활성 등 생리활성이 보고된 바 있으며(박수아 등, 한국미생물 생명공학학회지 41(4):407-415, 2013; 유해양, 동아대학교 박사 학위 논문, 2012; 문창곤, 인제대학교 석사 학위 논문, 2007; 한국 공개특허 제2014-0070470호; 한국등록특허 제1283775호), 건강보조식품, 식품 첨가제 등의 소재로 사용되고 있다(한국 등록특허 제1162699호; 한국 등록특허 제1333007호).Hwangchil is an evergreen broad-leaved arboreous tree belonging to the Araliaceae family. It grows only in the southern regions such as Haenam Wando and Jeju Island in the world. It is a tree species that does not lose its leaves even in winter. . Hwangchil has been used as a rare paint that gives off the golden color of the emperor's armor, helmet, and other metal accessories since the Three Kingdoms period. In addition to these paint functions, Hwangchil has a nerve stabilizing effect as an antiseptic (Lee Young-min, Jangheung-gun Agricultural Technology Center, 2012). Its roots and stems have been known to be effective against geopungsup, hwangmeulmaek, pungsupbital, migraine, and menstrual irregularities (J Korean Soc Agric Chem Biotechnol 43:63-66, 2000). In addition, it is known that Hwangchil tree contains the most β-selinene belonging to the sesquiperpenes, and the second most contains capnellane-8-one (Korean J Biotechnol Bioeng 10:393-400, 1995). Recently, physiological activities such as skin whitening activity, anticancer activity, anti-inflammatory activity, antioxidant activity, hangover relieving function, and antitussive activity of Hwangchil tree extract have been reported (Sooah Park et al., Journal of the Korean Society for Microbiology and Biotechnology 41(4):407- 415, 2013; Haeyang Yang, Dong-A University doctoral thesis, 2012; Moon Chang-gon, Inje University master's thesis, 2007; Korean Patent Publication No. 2014-0070470; Korean Patent No. 1283775), health supplements, food additives, etc. (Korean Patent No. 1162699; Korean Patent No. 1333007).
연(Nelumbo nucifera Gaertner)은 수련과(水蓮科, Nymphaeaceae)에 속하는 다년생 수생식물로써, 전세계에 널리 분포하며, 관상용, 식용 및 약용으로 사용하여왔으며, 잎, 꽃, 연자육, 연근 등 거의 모든 부분을 식용으로 사용하고 있다(참조: Luo X et al, Analytica Chemica Acta, 538, pp129-133, 2005). 전통적으로 잎은 하엽이라 하여 해열, 해독 작용에 사용하여 왔으며, 종자와 과육은 강장, 지혈약, 야뇨증, 부인병에 사용하여 왔으며, 뿌리는 해열독, 소어혈, 일체 혈증, 요혈, 장출혈 및 지혈에 사용하여 왔다(참조: 김영배, 한약(생약)규격집(KHP), pp500, 2000 ; 김창민, 중약대사전, pp5956-5959, 1998). 연근(lotus root)은 수련과에 속하는 연(Nelumbo nucifera)의 뿌리로서, 유리아미노산인 아스파라긴, 알기닌, 트로신 등이 포함되어 있고, 레시틴도 들어 있어 맛이 있으며, 면역체계 활성작용, 정력증진, 인슐린 생성촉진 등 인체에 미치는 기능이 많은 약초이다. 또한, 연근과 연자를 잘게 쪼갠 다음 말려서 살짝 볶아 차를 끓여 마시면 피부색이 고와지고, 여드름이나 주근깨, 검버섯이 생기지 않는 등 피부미용에 좋으며, 정력증진 효과, 빈혈, 가슴이 뛰고 불안 초조한 사람에게 효과가 좋다고 한다.Lotus (Nelumbo nucifera Gaertner) is a perennial aquatic plant belonging to the family Nymphaeaceae, which is widely distributed around the world and has been used for ornamental, edible and medicinal purposes. is used for food (see Luo X et al, Analytica Chemica Acta, 538, pp129-133, 2005). Traditionally, the leaves, called lower leaves, have been used for antipyretic and detoxifying actions. The seeds and pulp have been used for tonic, hemostatic, enuresis, and gynecological diseases. (Reference: Youngbae Kim, Specifications of Herbal Medicines (KHP), pp500, 2000; Changmin Kim, Dictionary of Traditional Chinese Medicine, pp5956-5959, 1998). The lotus root is the root of Nelumbo nucifera belonging to the water lily family, and contains free amino acids such as asparagine, arginine, and trosine. It is a medicinal herb that has many functions on the human body, such as promoting insulin production. Also, if you break the lotus root and lotus root into small pieces, then dry them and brew a cup of tea to make a cup of tea, it is good for skin beauty such as brightening the skin color, preventing acne, freckles, and age spots. is said to be good
본 발명자들은 천식, 기관지염 또는 폐렴 개선 효과가 있는 개미취 추출물을 함유하는 식품의 이미 및 이취 제거에 대해 연구하던 중, 개미취, 황칠나무 및 연근의 복합 발효 추출물이 천식, 기관지염 또는 폐렴에 대한 우수한 개선 효과를 가지면서, 동시에 개미취의 이미 및 이취를 제거할 수 있음을 확인함으로써, 본 발명을 완성하게 되었다.While the present inventors were researching on the removal of odors and odors of foods containing ant odor extracts, which have the effect of improving asthma, bronchitis or pneumonia, the complex fermented extracts of ants, hwangchil tree and lotus root have excellent improvement effects on asthma, bronchitis or pneumonia While having a, by confirming that it is possible to remove the odor and odor of ants at the same time, the present invention has been completed.
따라서 본 발명의 목적은 개미취의 이미 및 이취가 제거된 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법을 제공하는데 있다.Accordingly, it is an object of the present invention to provide a method for preparing a food composition for improving asthma, bronchitis or pneumonia, containing an extract of Aster tataricus from which the ant odor and off-flavor are removed as an active ingredient.
상술한 목적을 달성하기 위하여, 본 발명은 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에 있어서, 개미취(Aster tataricus) 잎, 황칠나무 줄기 및 연근을 각각 세척하고 건조시킨 후 분쇄기로 분쇄하여 분말화하는 단계(S10); 상기 개미취(Aster tataricus) 잎 분말 및 황칠나무 줄기 분말을 혼합하고 열수에 침지시켜 개미취(Aster tataricus) 잎 및 황칠나무 줄기 복합 열수 추출물을 제조하는 단계(S20); 상기 복합 열수 추출물에 상기 연근 분말을 발효시킨 연근 발효물을 혼합하여 혼합물을 제조하는 단계(S30); 및 상기 혼합물에 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis)를 혼합하여 발효액을 제조하는 단계(S40);를 포함하는 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법을 제공한다.In order to achieve the above object, the present invention provides a method for preparing a food composition for improving asthma, bronchitis or pneumonia containing an Aster tataricus extract as an active ingredient, Aster tataricus leaves, Hwangchil tree stems and Washing and drying each lotus root and pulverizing it with a grinder (S10); Mixing the Aster tataricus leaf powder and Hwangchil tree stem powder and immersing in hot water to prepare a composite hot water extract of Aster tataricus leaf and Hwangchil tree stem (S20); preparing a mixture by mixing the lotus root fermented product obtained by fermenting the lotus root powder with the complex hot water extract (S30); And preparing a fermentation broth by mixing Saccharomyces oviformis and Lactobacillus parafarraginis in the mixture (S40); containing Aster tataricus extract as an active ingredient It provides a method for preparing a food composition for improving asthma, bronchitis or pneumonia containing.
본 발명에 따른 식품 조성물의 제조방법은 개미취(Aster tataricus) 추출물을 유효성분으로 함유하면서 개미취의 이미 및 이취가 제거된 천식, 기관지염 또는 폐렴의 개선용 식품 조성물을 제공할 수 있다.The method for preparing a food composition according to the present invention can provide a food composition for improving asthma, bronchitis or pneumonia in which the ant odor and off-flavor are removed while containing an Aster tataricus extract as an active ingredient.
또한, 본 발명에 따른 식품 조성물의 제조방법은 개미취(Aster tataricus) 추출물을 유효성분으로 함유하면서 개미취의 이미 및 이취가 제거되고 천식, 기관지염 또는 폐렴의 개선과 동시에 알레르기성 비염을 개선할 수 있는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물을 제공할 수 있다.In addition, the method for preparing a food composition according to the present invention contains an extract of Aster tataricus as an active ingredient while removing the ant odor and off-flavor and improving asthma, bronchitis or pneumonia as well as allergic rhinitis. , it can provide a food composition for the improvement of bronchitis or pneumonia.
본 발명의 목적을 달성하기 위하여, 본 발명은 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에 있어서, 개미취(Aster tataricus) 잎, 황칠나무 줄기, 연근을 각각 세척하고 건조시킨 후 분쇄기로 분쇄하여 분말화하는 단계(S10); 상기 개미취(Aster tataricus) 잎 분말 및 황칠나무 줄기 분말을 혼합하고 열수에 침지시켜 개미취 잎 및 황칠나무 줄기 복합 열수 추출물을 제조하는 단계(S20); 상기 복합 열수 추출물에 상기 연근 분말을 혼합하여 혼합물을 제조하는 단계(S30); 및 상기 혼합물에 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis)를 혼합하여 발효액을 제조하는 단계(S40)를 포함하는 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법을 제공한다.In order to achieve the object of the present invention, the present invention provides a method for preparing a food composition for improving asthma, bronchitis or pneumonia containing an extract of Aster tataricus as an active ingredient, Aster tataricus leaf, Hwangchil tree stem , washing and drying the lotus root, respectively, and pulverizing the lotus root with a grinder (S10); Mixing the Aster tataricus leaf powder and Hwangchil tree stem powder and immersing it in hot water to prepare a composite hot-water extract of the Aster tataricus leaf and Hwangchil tree stem (S20); preparing a mixture by mixing the lotus root powder with the complex hot water extract (S30); And Saccharomyces oviformis (Saccharomyces oviformis) and Lactobacillus parafarraginis to prepare a fermentation broth by mixing the mixture (S40) containing an extract of Aster tataricus as an active ingredient It provides a method for preparing a food composition for improving asthma, bronchitis or pneumonia.
본 발명의 식품 조성물은 개미취(Aster tataricus) 추출물을 유효성분으로 함유한 천식, 기관지염 또는 폐렴의 개선용 식품 조성물로서 개미취의 이미 및 이취가 제거된 점에 특징이 있다.The food composition of the present invention is a food composition for the improvement of asthma, bronchitis or pneumonia containing an Aster tataricus extract as an active ingredient, and is characterized in that the taste and odor of the ant odor are removed.
개미취속(Aster L) 식물은 쌍떡잎식물 초롱꽃목 국화과의 여러해살이풀서, 한국, 일본, 중국 북부 및 북동부, 몽골, 시베리아 등지의 습지에서 서식하며, 개미취속 식물은 개미취(Aster tataricus L f), 갯개미취(Aster tripolium L), 좀개미취(Aster maakii REGEL) 및 벌개미취(Aster koraiensis NaKai) 등이 있으나, 본 발명에서 적용되는 것은 개미취(Aster tataricus)이다.Plants of the genus Aster L are dicotyledonous perennials of the order Asteraceae, and they live in wetlands in Korea, Japan, northern and northeastern China, Mongolia, and Siberia. There are ants such as Aster tripolium L, Aster maakii REGEL and Aster koraiensis NaKai, but it is Aster tataricus that is applied in the present invention.
본 발명의 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에서, 상기 S10단계의 개미취(Aster tataricus)는 바람직하게는 개미취(Aster tataricus)의 잎이다. 본 발명의 시험예에 따르면 개미취의 뿌리인 자완, 또는 개미취의 줄기를 사용할 경우에는 본 발명이 목적하고자 하는 개미취의 이미 및 이취 효과를 달성할 수 없다.In the method for preparing a food composition for improving asthma, bronchitis or pneumonia of the present invention, the Aster tataricus in step S10 is preferably a leaf of Aster tataricus. According to the test example of the present invention, when using the root of anthorn, jawan, or the stem of anthorn, it is not possible to achieve the effect of ant odor and off-flavor desired by the present invention.
본 발명의 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에서, 상기 S20단계의 복합 열수 추출물은 추출처리에 의해 얻어지는 추출액, 추출액의 희석액 또는 농축액, 추출액을 건조하여 얻어지는 건조물, 또는 조정제물 또는 정제물 중 어느 하나를 포함하는 것으로 한다.In the method for producing a food composition for improving asthma, bronchitis or pneumonia of the present invention, the complex hot water extract of step S20 is an extract obtained by extraction treatment, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, or a prepared product or It shall include any one of purified substances.
본 발명의 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에서, 상기 S30단계는 상기 연근 분말을 고상 발효시킨 연근 고상 발효물을 상기 열수 추출물에 혼합하여 혼합물을 제조하는 단계(S32);를 포함한다. 본 발명의 실시예 1에 따르면, 연근 고상 발효물을 사용할 경우 연잎을 사용한 비교예 2, 및 연근 분말을 사용한 비교예 10과 대비하여 텁텁하고 쓴맛 및 전체적인 기호도에서 현저하게 개선되었다. 한편, 본 발명의 제조방법에 있어서, 필요에 따라 기호도 개선을 위하여 상기 혼합물에 도라지, 모과, 대추 및 계피를 추가로 혼합하는 단계를 더 포함할 수도 있다.In the method for producing a food composition for improving asthma, bronchitis or pneumonia of the present invention, the step S30 comprises the steps of preparing a mixture by mixing the solid fermented lotus root powder obtained by fermenting the lotus root powder with the hot water extract (S32); include According to Example 1 of the present invention, when using a solid fermented lotus root, compared to Comparative Example 2 using lotus leaves, and Comparative Example 10 using lotus root powder, the taste was significantly improved and overall preference was improved. On the other hand, in the manufacturing method of the present invention, if necessary, may further include the step of further mixing bellflower, quince, jujube and cinnamon in the mixture in order to improve the preference.
본 발명의 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법에서, 상기 S40단계의 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis) 균주는 생명공학 관련 회사에서 판매하는 것을 구입하여 사용하거나 국내외 미생물 기탁기관(생명공학연구원 유전자은행, 한국미생물보존센타, 농업유전자자원센터, ATCC(American Type Culture CollectionAsociacin))으로부터 분양받아 사용할 수 있다. In the method for producing a food composition for improving asthma, bronchitis or pneumonia of the present invention, the Saccharomyces oviformis and Lactobacillus parafarraginis strains of the S40 step are obtained from biotechnology-related companies. You can purchase and use what is sold, or you can use it after receiving it from domestic and foreign microbial deposit institutions (Genbank of Biotechnology Research Institute, Korea Microbial Conservation Center, Agricultural Gene Resource Center, ATCC (American Type Culture Collection Asociacin)).
본 발명의 실시예 1에 따르면, 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis) 2종의 미생물을 사용하여 발효할 경우 락토바실러스 퍼멘툼, 락토바실러스 락티스 등 다른 유산균을 사용한 비교예 3 및 4와 대비하여 개미취의 이미 및 이취가 현저하게 개선되었다.According to Example 1 of the present invention, when fermentation is performed using two types of microorganisms, Saccharomyces oviformis and Lactobacillus parafarraginis, Lactobacillus fermentum, Lactobacillus lactis, etc. Compared with Comparative Examples 3 and 4 using other lactic acid bacteria, the taste and odor of ant odor were remarkably improved.
또한, 본 발명의 일 구현예에 따른 식품 조성물의 제조방법은, 상기 S40단계 이후에, 상기 발효액에 초음파를 처리하고, 상기 초음파 처리된 용액을 원심분리하고 분리된 상층액을 여과하는 단계(S50)를 더 포함할 수 있다.In addition, the method for producing a food composition according to an embodiment of the present invention, after the step S40, treating the fermentation broth with ultrasonic waves, centrifuging the ultrasonicated solution and filtering the separated supernatant (S50) ) may be further included.
또한, 본 발명의 일 구현예에 따른 식품 조성물의 제조방법에 있어서, 상기 천식은 기관지 천식인 것이 바람직하고, 상기 기관지염은 급성기관지염, 만성기관지염, 알레르기성 기관지염, 감염성 기관지염, 외상성 기관지염, 카타르성 기관지염, 화농성 기관지염, 폐색성 기관지염, 궤양성 기관지염 및 침윤성 기관지염을 포함하나, 이에 한정되는 것은 아니다. 또한, 상기 폐렴은 세균성 폐렴, 마이코플라즈마 폐렴, 바이러스에 의한 폐렴 및 리케차에 의한 폐렴을 포함하나, 이에 한정되는 것은 아니다.In addition, in the method for producing a food composition according to an embodiment of the present invention, the asthma is preferably bronchial asthma, and the bronchitis is acute bronchitis, chronic bronchitis, allergic bronchitis, infectious bronchitis, traumatic bronchitis, catarrhal bronchitis. , purulent bronchitis, obstructive bronchitis, ulcerative bronchitis and infiltrative bronchitis. In addition, the pneumonia includes, but is not limited to, bacterial pneumonia, mycoplasma pneumonia, viral pneumonia and rickettsia pneumonia.
본 발명의 구체적인 실시예에서, 본 발명의 식품 조성물은 개미취의 이미 및 이취가 현저히 개선되었음을 확인하였고, 폐기관지 염증 억제율, 천식 개선율 및 알레르기성 비염 개선율이 비교예에 비하여 현저히 개선되었음을 확인하였다.In a specific example of the present invention, it was confirmed that the food composition of the present invention significantly improved the taste and odor of ant odor, and it was confirmed that the pulmonary bronchial inflammation inhibition rate, asthma improvement rate, and allergic rhinitis improvement rate were significantly improved compared to the comparative example.
본 발명의 천식, 기관지염 또는 폐렴의 개선용 식품 조성물은 식품학적으로 허용가능한 식품 보조 첨가제를 더 포함할 수 있다. 본 발명에 이용될 수 있는 식품학적으로 허용가능한 식품 보조 첨가제는 포도당, 과당, 말토오스, 슈크로스, 덱스트린, 시클로덱스트린과 같은 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당 알코올과 같은 천연 탄수화물, 타우마틴, 스테비아 추출물 등의 천연 향미제, 사카린, 아스파르탐산 등의 합성 향미제, 착색제, 펙트산 또는 그의 염, 알긴산 또는 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산화제 등을 포함하나, 이에 제한되는 것은 아니다. 본 발명의 천식, 기관지염 또는 폐렴의 개선용 식품 조성물 중의 개미취 추출물의 함량은 식품의 형태, 풍미, 맛 등을 고려하여 적절하게 선택될 수 있으며, 예를 들어 식품 조성 전체 중량에 대하여 0.01~30 중량%의 범위일 수 있다. The food composition for the improvement of asthma, bronchitis or pneumonia of the present invention may further include a food additive that is pharmaceutically acceptable. The pharmaceutically acceptable food supplement additives that can be used in the present invention include sugars such as glucose, fructose, maltose, sucrose, dextrin, and cyclodextrin, and natural carbohydrates such as sugar alcohols such as xylitol, sorbitol, and erythritol, thaumatin , natural flavoring agents such as stevia extract, synthetic flavoring agents such as saccharin and aspartamic acid, coloring agents, pectic acid or its salts, alginic acid or its salts, organic acids, protective colloidal thickeners, pH regulators, stabilizers, preservatives, glycerin, alcohols, carbonation agents, and the like. The content of the ant odor extract in the food composition for improving asthma, bronchitis or pneumonia of the present invention may be appropriately selected in consideration of the form, flavor, taste, etc. of the food, for example, 0.01 to 30 weight based on the total weight of the food composition % may be in the range.
상기 식품의 종류에는 특별한 제한은 없다. 상기 식품 조성물을 이용하여 농산물, 축산물 또는 수산물의 특성을 살려 변형시키는 동시에 저장성을 좋게 한 가공식품을 제조할 수 있다. 이런 가공식품에는 예를 들어, 과자, 발효식품, 통조림, 우유가공식품, 육류가공식품, 국수 등을 포함한다. 과자는 비스킷, 파이, 빵, 캔디, 젤리, 껌, 시리얼(곡물푸레이크 등의 식사대용품류 포함) 등을 포함한다. 발효식품은 간장, 된장, 고추장 등을 포함한다. 통조림은 수산물 통조림(예를 들어, 참치, 고등어, 꽁치, 소라 통조림 등), 축산물 통조림(쇠고기, 돼지고기, 닭고기, 칠면조 통조림 등), 농산물 통조림(옥수수, 복숭아, 파인애플 통조림 등)을 포함한다. 우유가공식품은 치즈, 버터, 요구르트 등을 포함한다. 육류가공식품은 돈까스, 비프까스, 치킨까스, 소세지, 탕수육, 너겟류, 너비아니 등을 포함한다. 밀봉포장생면 등의 국수를 포함한다. 이 외에도 상기 조성물은 레토르트식품, 스프류 등에 사용될 수 있다.There is no particular limitation on the type of the food. By using the food composition, it is possible to produce a processed food with good storage properties while at the same time being transformed by taking advantage of the characteristics of agricultural products, livestock products or aquatic products. Such processed foods include, for example, sweets, fermented foods, canned foods, milk products, meat products, noodles, and the like. Confectionery includes biscuits, pie, bread, candy, jelly, gum, cereal (including meal substitutes such as cereal flour), and the like. Fermented foods include soy sauce, soybean paste, red pepper paste, and the like. Canned food includes canned seafood (e.g., canned tuna, mackerel, saury, conch, etc.), canned livestock (canned beef, pork, chicken, turkey, etc.), and canned agricultural products (canned corn, peach, pineapple, etc.). Processed milk products include cheese, butter, yogurt, and the like. Processed meat foods include pork cutlet, beef cutlet, chicken cutlet, sausage, sweet and sour pork, nuggets, and breadcrumbs. Noodles such as sealed packaged raw noodles are included. In addition to this, the composition may be used in retort foods, soups, and the like.
또한, 음료로 사용될 될 경우 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상술한 천연 탄수화물은 포도당, 과당과 같은 모노사카라이드, 말토스, 슈크로스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나, 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100 ㎖당 일반적으로 약 0.01~0.04 g, 바람직하게는 약 0.02~0.03 g 이다.In addition, when used as a beverage, it may contain various flavoring agents or natural carbohydrates as an additional component like a conventional beverage. The above-mentioned natural carbohydrates are monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. As the sweetener, natural sweeteners such as taumatine and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like can be used. The proportion of the natural carbohydrate is generally about 0.01 to 0.04 g, preferably about 0.02 to 0.03 g per 100 ml of the composition of the present invention.
상기 외에 본 발명의 식품 조성물은 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 밖에 본 발명의 식품 조성물은 천연 과일쥬스, 과일쥬스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 혼합하여 사용할 수 있다. 이러한 첨가제의 비율은 크게 중요하진 않지만 본 발명의 조성물 100 중량부당 0.01~0.1 중량부의 범위에서 선택되는 것이 일반적이다.In addition to the above, the food composition of the present invention includes various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols , a carbonation agent used in carbonated beverages, and the like. In addition, the food composition of the present invention may contain flesh for the production of natural fruit juice, fruit juice beverage, and vegetable beverage. These components may be used independently or in combination. The proportion of these additives is not very important, but is generally selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition of the present invention.
이하, 실시예를 통하여 본 발명을 더욱 상세하게 설명하고자 하나, 하기의 실시예는 단지 설명의 목적을 위한 것이며, 본 발명의 범위를 한정하고자 하는 것은 아니다.Hereinafter, the present invention will be described in more detail through examples, but the following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
< 실시예 1><Example 1>
개미취 잎, 황칠나무 줄기 및 연근를 세척 후 40℃에서 16시간 동안 건조하고, 분쇄기로 분쇄하여 분말화하였다. 개미취 잎 분말 및 황칠나무 줄기 분말을 3:2의 중량비로 혼합하고, 혼합 분말 중량 기준으로 20배의 증류수를 첨가하여 115℃에서 180분간 열수에 침지시켜 복합 열수 추출물을 제조하고, 0.45㎛로 1차 여과한 후, 0.22㎛로 2차 여과하여 침전물을 제거하였다. 여과액을 동결건조한 후 회수하여 -20℃에서 보관하면서 실험에 사용하였다.After washing the leaves of the anthill, hwangchil tree trunks and lotus root, it was dried at 40° C. for 16 hours, and pulverized by pulverizing with a grinder. Mix anthorn leaf powder and hwangchil tree stem powder in a weight ratio of 3:2, add distilled water 20 times based on the weight of the mixed powder, and immerse in hot water at 115° C. for 180 minutes to prepare a complex hot water extract, 0.45 μm 1 After secondary filtration, the precipitate was removed by secondary filtration with 0.22 μm. The filtrate was collected after freeze-drying and stored at -20°C for use in the experiment.
이후 연근 분말에 PDB(Potato Dextrose Broth) 배지에서 준비한 홍국균(Monascus purpureus)을 20%(v/w)로 접종하여 물을 첨가함 없이 70±5% 습도, 40℃의 온도에서 18일 동안 고상 발효시켜 연근 고상 발효물을 제조하였다.After that, the lotus root powder was inoculated with 20% (v/w) of Monascus purpureus prepared in PDB (Potato Dextrose Broth) medium, and solid-state fermentation at 70±5% humidity and 40℃ temperature for 18 days without adding water. to prepare a solid fermented lotus root.
복합 열수 추출물에 연근 고상 발효물을 4:1의 중량비로 혼합하여 혼합물을 제조하고, 1000 ㎖ 플라스크에 상기 혼합물을 400 ㎖ 분주하였다. 그 후, 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis) 2종의 미생물을 피펫을 사용하여 총 혼합물 양의 5%로 접종하고 진탕배양기에서 30℃, 140 RPM으로 5일간 배양하여 발효액을 획득하였다. 실험에 사용된 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis) 균주는 생명공학 관련 회사에서 판매하는 것을 구입하여 사용하거나 국내외 미생물 기탁기관(생명공학연구원 유전자은행, 한국미생물보존센타, 농업유전자자원센터, ATCC(American Type Culture CollectionAsociacin))으로부터 분양받아 사용할 수 있다. A mixture was prepared by mixing the solid fermented lotus root with the complex hot water extract in a weight ratio of 4:1, and 400 ml of the mixture was dispensed into a 1000 ml flask. Thereafter, two types of microorganisms, Saccharomyces oviformis and Lactobacillus parafarraginis, were inoculated using a pipette at 5% of the total amount of the mixture, and inoculated at 30° C., 140 RPM in a shaker incubator. was cultured for 5 days to obtain a fermentation broth. The Saccharomyces oviformis and Lactobacillus parafarraginis strains used in the experiment were purchased from biotechnology-related companies and used or domestic and foreign microbial depository institutions (Research Institute for Biotechnology Gene Bank, It can be purchased from the Korea Microbial Conservation Center, Agricultural Gene Resource Center, and ATCC (American Type Culture Collection Asociacin).
상기 발효액을 멸균 후 원심분리하고 분리된 상층액을 여과하여 식품 조성물을 제조하였다.After sterilizing the fermentation broth, centrifugation was performed and the separated supernatant was filtered to prepare a food composition.
< 실시예 2><Example 2>
실시예 1과 동일하게 제조하되, 발효액 획득 후 상기 발효액을 초음파추출기를 사용하여 초음파를 30kHz에서 100W의 세기로 6시간 내지 9시간 동안 처리하였으며, 온도를 일정하게 유지하기 위하여 25℃로 순환식 항온 수조(Circulator Water Bath)에서 사용하였다. 이후 초음파 처리된 용액을 원심분리하고 분리된 상층액을 여과하였다.Prepared in the same manner as in Example 1, but after obtaining the fermentation broth, the fermentation broth was treated with ultrasonic waves at 30 kHz and 100 W intensity for 6 hours to 9 hours using an ultrasonic extractor, and circulating constant temperature at 25° C. to keep the temperature constant It was used in a Circulator Water Bath. Then, the sonicated solution was centrifuged and the separated supernatant was filtered.
< 비교예 1 내지 10><Comparative Examples 1 to 10>
본 비교예에서는 상기 실시예와 대비하여 하기 표 1의 조건(성분 투입: O, 성분 미투입)에 따라 비교예 1 내지 10을 제조하였다(표 1 참조).In this comparative example, Comparative Examples 1 to 10 were prepared according to the conditions of Table 1 below (component input: O, no component input) compared to the above Example (see Table 1).
잎Michaelmas daisy
leaf
고상 발효물Lotus root
solid fermented product
분말Lotus root
powder
처리ultrasonic wave
process
(자완)ant odor root
(Sewan)
<실험예 1> 관능검사<Experimental Example 1> Sensory test
상기 실시예 및 비교예에 따른 식품 조성물에 대하여, 맛, 전체적인 기호도와 같은 관능평가를 측정하고 그 결과를 아래의 표 2에 나타내었다. 상기의 관능평가는 식품관련분야에서 3년 이상 경험을 가진 관능적 식별 능력이 있는 30대~50대 성인남녀 40명(남여 각각 20명)으로 하여 평가하도록 하여 측정한 것이다.For the food compositions according to the Examples and Comparative Examples, sensory evaluations such as taste and overall preference were measured, and the results are shown in Table 2 below. The above sensory evaluation was measured by evaluating 40 adult males and females (20 males and females each) in their 30s and 50s with sensory discrimination ability with 3 or more years of experience in the food-related field.
1점: 맛이 매우 텁텁하고 쓴 맛이 강하고, 개미취 특유의 이미와 이취가 많이 나고, 전체적인 기호도가 매우 좋지 않음.1 point: The taste is very bitter and the bitter taste is strong, there is a lot of taste and odor peculiar to ant odor, and the overall preference is very poor.
3점: 맛이 텁텁하고 쓴 맛이 강하고, 개미취 특유의 이미와 이취가 나고, 전체적인 기호도가 좋지 않음.3 points: The taste is bitter and the bitter taste is strong, there is a peculiar taste and odor of ant odor, and the overall preference is not good.
5점: 맛이 보통이고, 개미취 특유의 이미와 이취가 조금 나고, 전체적인 기호도가 보통임.5 points: The taste is average, there is a slight taste and off-flavor peculiar to ant odor, and the overall preference is average.
7점: 맛이 우수하고, 개미취 특유의 이미와 이취가 거의 나지 않고, 전체적인 기호도가 좋음.7 points: The taste is excellent, there is almost no taste and odor peculiar to ant odor, and the overall preference is good.
9점: 맛이 매우 우수하고, 개미취 특유의 이미와 이취가 나지 않고, 전체적인 기호도가 매우 좋음.9 points: The taste is very good, there is no taste and odor peculiar to ant odor, and the overall preference is very good.
(텁텁하고 쓴맛)flavor
(Tough and bitter)
상기 표 2에 나타낸 바와 같이, 실시예와 비교예에 따른 관능검사에서 맛, 이미와 이취, 및 전체적인 기호도에서 실시예 1 및 2이 비교예 1 내지 10과 대비하여 현저하게 우수한 것으로 나타났다.As shown in Table 2, in the sensory tests according to Examples and Comparative Examples, Examples 1 and 2 were significantly superior to Comparative Examples 1 to 10 in taste, taste and odor, and overall preference.
실시예 1은 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis) 2종의 미생물로 발효시킴으로써 다른 유산균을 사용한 비교예 3 및 4와 대비하여 개미취의 이미 및 이취를 현저하게 개선하였다. Example 1 is Saccharomyces oviformis (Saccharomyces oviformis) and Lactobacillus parafarraginis by fermentation with two types of microorganisms compared to Comparative Examples 3 and 4 using other lactic acid bacteria, the taste and odor of ant odor remarkably improved.
또한, 연근 고상 발효물을 사용한 실시예 1은 연잎을 사용한 비교예 2, 연근 분말을 사용한 비교예 10과 대비하여 텁텁하고 쓴맛 및 전체적인 기호도에서 현저하게 개선되었다.In addition, Example 1 using a solid fermented lotus root was significantly improved in taste and overall preference as compared to Comparative Example 2 using lotus leaves and Comparative Example 10 using lotus root powder.
실시예 2는 실시예 1의 조성물을 초음파 처리한 것으로, 황칠나무 줄기가 제외된 비교예 10과 대비하여 이미에서 현저하게 개선되었다.Example 2 is the ultrasonic treatment of the composition of Example 1, compared to Comparative Example 10 in which the hwangchil tree trunk was excluded, it was significantly improved in the already.
<실험예 2> 기관지 염증 억제 시험<Experimental Example 2> Bronchial inflammation inhibition test
실시예 1, 2, 및 비교예 1 내지 10에서 제조된 식품 조성물이 천식 및 만성폐쇄성호흡기 질환 모델에서 폐기관지 염증 억제 효과가 있는지를 확인하기 위해, 감작된 마우스에 항원을 노출시켜 유발되는 폐기관지의 백혈구 증가반응을 확인(Pharmacological Research, 2010, 61, 288~297; Biochemical Pharmacology, 2010, 79,888~896)하였다.To determine whether the food compositions prepared in Examples 1, 2, and Comparative Examples 1 to 10 have an inhibitory effect on pulmonary bronchial inflammation in asthma and chronic obstructive respiratory disease models, lung bronchial induced by exposing antigens to sensitized mice was confirmed (Pharmacological Research, 2010, 61, 288-297; Biochemical Pharmacology, 2010, 79,888-896).
이를 위해, BALB/c계 암컷마우스(65주령)에 10㎍의 난알부민(Ovalbumin, OVA, sigma)과 수산화알루미늄(4mg, aluminium hydroxide, Alum, Pierce) 1:1 혼합액 0.2㎖을 0, 7 및 14일에 복강 내 투여하여 감작시켰다. 최종 감작일로부터 8일 후와 10일 후에 10% 난알부민을 고압의 압축공기를 이용하여 에어로졸로 만들어 50분간 분무하여 기도염증을 유발하였다. 각 시험물질(각 조성물의 동결건조물 400㎎/㎏, bid)의 투여는 첫 감작 후 21일부터 23일까지 오전 오후 하루 두 차례에 걸쳐 경구 투여하였다. 마지막 경구 투여 24시간 후에 인산완충용액(pH 7.2) 15㎖을 이용하여 기관지폐포 세척을 하여 기관지폐포 세척액을 모았다. 세척액 중의 백혈구 세포수는 헤마톨로지 분석기(Hematology analyzer, Drew Scientific Inc, HEMAVET HV950FS, M-950HV)를 사용하여 백혈구수를 계수하였다. 이에 대한 결과는 음성대조군(1% CMC[carboxymethyl cellulose] 투여군)의 백혈구 세포수 정도를 기준으로 폐기관지 염증 억제율(%)을 계산하여 하기 표 3에 나타냈다.For this, 0.2 ml of a 1:1 mixture of 10 μg of ovalbumin (Ovalbumin, OVA, sigma) and aluminum hydroxide (4 mg, aluminum hydroxide, Alum, Pierce) was added to 0, 7 and It was sensitized by intraperitoneal administration on day 14. After 8 and 10 days from the last sensitization day, 10% egg albumin was made into an aerosol using high-pressure compressed air and sprayed for 50 minutes to induce airway inflammation. Administration of each test substance (400 mg/kg of lyophilisate of each composition, bid) was orally administered twice a day in the morning and afternoon from the 21st to the 23rd after the first sensitization. 24 hours after the last oral administration, bronchoalveolar lavage was collected by bronchoalveolar lavage using 15 ml of phosphate buffer (pH 7.2). The number of white blood cells in the washing solution was counted using a hematology analyzer (Drew Scientific Inc, HEMAVET HV950FS, M-950HV). The results are shown in Table 3 below by calculating the pulmonary bronchial inflammation inhibition rate (%) based on the number of leukocytes in the negative control group (1% CMC [carboxymethyl cellulose] administered group).
표 3에 나타난 바와 같이, 실시예 1 및 2의 폐기관지 염증 억제율이 비교예에 비하여 현저히 개선되었다. As shown in Table 3, the inhibition rate of lung bronchial inflammation of Examples 1 and 2 was significantly improved compared to Comparative Examples.
<실험예 3> 천식 개선 효과 시험<Experimental Example 3> Asthma improvement effect test
실시예 1, 2, 및 비교예 1 내지 10에서 제조된 식품 조성물을 천식 진단을 받은 20~50대의 환자들에게 각 군당 4명씩으로 하여, 20일간 매일 하루 3번 110㎖씩 식후 2시간 후에 복용하게 하였으며, 20일간의 복용 후 개선효과를 조사한 후, 개선효과가 있다고 응답한 비율을 표 4에 나타내었다.Examples 1, 2, and Comparative Examples 1 to 10 were administered to patients in their 20s and 50s diagnosed with asthma, 4 patients in each group, 110 ml 3 times a day for 20 days, 2 hours after meals. After examining the improvement effect after taking it for 20 days, Table 4 shows the ratio of the response that there was an improvement effect.
표 4를 보면, 실시예 1 및 2의 천식 개선율이 비교예에 비하여 현저히 개선되었다. Referring to Table 4, the asthma improvement rates of Examples 1 and 2 were significantly improved compared to Comparative Examples.
<실험예 4> 비염 개선 효과 시험<Experimental Example 4> Rhinitis improvement effect test
실시예 1, 2, 및 비교예 1 내지 10에서 제조된 식품 조성물을 평소 재치기와 콧물이 잦고 코막힘이 심한 사람으로서 병원에서 비염으로 진단된 20~50대 사람들에게 각 군당 6명씩, 20일간 매일 하루 3번 110㎖씩 식후 2시간 후에 복용하게 하였으며, 20일간의 복용 후 일반적인 비염의 증상인 재치기 및 콧물 개선효과를 조사한 후, 개선효과가 있다고 응답한 비율을 표 5에 나타내었다.Examples 1, 2, and Comparative Examples 1 to 10 of the food composition prepared in Examples 1 to 10 as a person who has frequent sneezing and runny nose and severe nasal congestion, 6 people in each group, each group of people in their 20s and 50s diagnosed with rhinitis at the hospital, daily for 20 days After taking 110 ml 3 times a day 2 hours after meals, after 20 days of taking it, the improvement effect of sneezing and runny nose, which are common symptoms of rhinitis, was investigated.
상기 표 5를 참조하면, 실시예 1 및 2의 재치기 및 콧물의 개선율이 비교예에 비하여 현저히 개선되었다. Referring to Table 5, the improvement rate of sneezing and runny nose in Examples 1 and 2 was significantly improved compared to Comparative Examples.
한편, 이상의 상세한 설명은 모든 면에서 제한적으로 해석되어서는 아니되고 예시적인 것으로 고려되어야 한다. 본 발명의 범위는 첨부된 청구항의 합리적 해석에 의해 결정되어야 하고, 본 발명의 등가적 범위 내에서의 모든 변경은 본 발명의 범위에 포함된다.On the other hand, the above detailed description should not be construed as restrictive in all aspects, but should be considered as exemplary. The scope of the present invention should be determined by a reasonable interpretation of the appended claims, and all modifications within the equivalent scope of the present invention are included in the scope of the present invention.
Claims (3)
개미취(Aster tataricus) 잎, 황칠나무 줄기 및 연근을 각각 세척하고 건조시킨 후 분쇄기로 분쇄하여 분말화하는 단계(S10);
상기 개미취(Aster tataricus) 잎 분말 및 황칠나무 줄기 분말을 혼합하고 열수에 침지시켜 개미취(Aster tataricus) 잎 및 황칠나무 줄기 복합 열수 추출물을 제조하는 단계(S20);
상기 복합 열수 추출물에 상기 연근 분말을 발효시킨 연근 발효물을 혼합하여 혼합물을 제조하는 단계(S30); 및
상기 혼합물에 사카로마이세스 오비폴미스(Saccharomyces oviformis) 및 락토바실러스 파라파라기니스(Lactobacillus parafarraginis)를 혼합하여 발효액을 제조하는 단계(S40);
를 포함하는 개미취(Aster tataricus) 추출물을 유효성분으로 함유하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법.
In the method for preparing a food composition for improving asthma, bronchitis or pneumonia containing an extract of Aster tataricus as an active ingredient,
Washing and drying each of Aster tataricus leaves, hwangchil tree trunks and lotus roots, and then pulverizing them with a grinder to powder (S10);
Mixing the Aster tataricus leaf powder and Hwangchil tree stem powder and immersing it in hot water to prepare a composite hot water extract of Aster tataricus leaf and Hwangchil tree stem (S20);
preparing a mixture by mixing the lotus root fermented product obtained by fermenting the lotus root powder with the complex hot water extract (S30); and
Preparing a fermentation broth by mixing Saccharomyces oviformis and Lactobacillus parafarraginis in the mixture (S40);
A method for producing a food composition for improving asthma, bronchitis or pneumonia containing an extract of Aster tataricus as an active ingredient, comprising a.
상기 연근 분말을 고상 발효시킨 연근 고상 발효물을 상기 열수 추출물에 혼합하여 혼합물을 제조하는 단계(S32);를 포함하는 것을 특징으로 하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법.
According to claim 1, wherein the step S30,
A method of preparing a food composition for improving asthma, bronchitis or pneumonia, comprising: preparing a mixture by mixing the solid fermented lotus root powder with the hot water extract (S32).
상기 S40단계 이후에,
상기 발효액에 초음파를 처리하고, 상기 초음파 처리된 용액을 원심분리하고 분리된 상층액을 여과하는 단계(S50);
를 더 포함하는 것을 특징으로 하는 천식, 기관지염 또는 폐렴의 개선용 식품 조성물의 제조방법.According to claim 1,
After step S40,
ultrasonically treating the fermentation broth, centrifuging the sonicated solution, and filtering the separated supernatant (S50);
Method for producing a food composition for improving asthma, bronchitis or pneumonia, characterized in that it further comprises a.
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