KR20210059584A - Glp-1 수용체 작용제 및 이의 용도 - Google Patents
Glp-1 수용체 작용제 및 이의 용도 Download PDFInfo
- Publication number
- KR20210059584A KR20210059584A KR1020200022485A KR20200022485A KR20210059584A KR 20210059584 A KR20210059584 A KR 20210059584A KR 1020200022485 A KR1020200022485 A KR 1020200022485A KR 20200022485 A KR20200022485 A KR 20200022485A KR 20210059584 A KR20210059584 A KR 20210059584A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- carboxylic acid
- imidazole
- benzo
- oxy
- Prior art date
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- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 title claims description 9
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 title description 3
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 54
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 39
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 35
- 239000001257 hydrogen Substances 0.000 claims description 23
- 229910052739 hydrogen Inorganic materials 0.000 claims description 23
- 125000001072 heteroaryl group Chemical group 0.000 claims description 21
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- 125000003118 aryl group Chemical group 0.000 claims description 17
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW109139809A TWI786467B (zh) | 2019-11-15 | 2020-11-13 | Glp-1受體激動劑及其用途 |
| JP2022527842A JP7386997B2 (ja) | 2019-11-15 | 2020-11-13 | Ｇｌｐ－１受容体アゴニストおよびその使用 |
| CA3160518A CA3160518A1 (en) | 2019-11-15 | 2020-11-13 | Glp-1 receptor agonist and use thereof |
| EP20886669.9A EP4059929A4 (en) | 2019-11-15 | 2020-11-13 | GLP-1 RECEPTOR AGONIST AND ITS USE |
| US17/776,052 US20230002348A1 (en) | 2019-11-15 | 2020-11-13 | GLP-1 Receptor Agonist and Use Thereof |
| KR1020227015926A KR20220101092A (ko) | 2019-11-15 | 2020-11-13 | Glp-1 수용체 작용제 및 이의 용도 |
| JP2022528212A JP7375194B2 (ja) | 2019-11-15 | 2020-11-13 | Ｇｌｐ－１受容体アゴニストおよびその使用 |
| US17/777,193 US11643403B2 (en) | 2019-11-15 | 2020-11-13 | GLP-1 receptor agonist and use thereof |
| MX2022005886A MX2022005886A (es) | 2019-11-15 | 2020-11-13 | Agonista del receptor glp-1 y uso de este. |
| EP20887271.3A EP4058445A4 (en) | 2019-11-15 | 2020-11-13 | GLP-1 RECEPTOR AGONISTS AND USE THEREOF |
| AU2020384121A AU2020384121B2 (en) | 2019-11-15 | 2020-11-13 | GLP-1 receptor agonist and use thereof |
| BR112022009287A BR112022009287A2 (pt) | 2019-11-15 | 2020-11-13 | Agonista do receptor de glp-1 e uso do mesmo |
| CN202080079007.0A CN114728940A (zh) | 2019-11-15 | 2020-11-13 | Glp-1受体激动剂及其用途 |
| PCT/KR2020/015985 WO2021096284A1 (ko) | 2019-11-15 | 2020-11-13 | Glp-1 수용체 작용제 및 이의 용도 |
| KR1020200152019A KR102344561B1 (ko) | 2019-11-15 | 2020-11-13 | Glp-1 수용체 작용제 및 이의 용도 |
| UY0001038958A UY38958A (es) | 2019-11-15 | 2020-11-13 | Agonista del receptor glp-1 y uso de este |
| PE2022000789A PE20221422A1 (es) | 2019-11-15 | 2020-11-13 | Agonista del receptor glp-1 y uso de este |
| IL292943A IL292943A (en) | 2019-11-15 | 2020-11-13 | glp-1 receptor agonist and use thereof |
| PCT/KR2020/016019 WO2021096304A1 (en) | 2019-11-15 | 2020-11-13 | Glp-1 receptor agonist and use thereof |
| CN202080077871.7A CN114728939B (zh) | 2019-11-15 | 2020-11-13 | Glp-1受体激动剂及其用途 |
| TW111148492A TWI817870B (zh) | 2019-11-15 | 2020-11-13 | Ｇｌｐ-１受體激動劑及其用途 |
| CU2022000028A CU20220028A7 (es) | 2019-11-15 | 2020-11-13 | Compuestos derivados sustituidos del anillo de imidazol fusionado |
| TW109139808A TW202128658A (zh) | 2019-11-15 | 2020-11-13 | Ｇｌｐ－１受體促效劑及其用途 |
| KR1020210165905A KR20210149005A (ko) | 2019-11-15 | 2021-11-26 | Glp-1 수용체 작용제 및 이의 용도 |
| CONC2022/0006183A CO2022006183A2 (es) | 2019-11-15 | 2022-05-12 | Agonista del receptor glp-1 y uso de este |
| DO2022000100A DOP2022000100A (es) | 2019-11-15 | 2022-05-13 | Agonista del receptor glp-1 y uso de este |
| ZA2022/05346A ZA202205346B (en) | 2019-11-15 | 2022-05-13 | Glp-1 receptor agonist and use thereof |
| CL2022001271A CL2022001271A1 (es) | 2019-11-15 | 2022-05-13 | Agonista del receptor glp-1 y uso de este |
| US18/120,876 US11932618B2 (en) | 2019-11-15 | 2023-03-13 | GLP-1 receptor agonist and use thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| KR1020190146798 | 2019-11-15 | ||
| KR20190146798 | 2019-11-15 |
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| KR20210059584A true KR20210059584A (ko) | 2021-05-25 |
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| KR1020200022485A KR20210059584A (ko) | 2019-11-15 | 2020-02-24 | Glp-1 수용체 작용제 및 이의 용도 |
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| KR (1) | KR20210059584A (es) |
| AR (1) | AR120458A1 (es) |
| TW (2) | TW202128658A (es) |
| UY (1) | UY38958A (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022235136A1 (ko) | 2021-05-07 | 2022-11-10 | 주식회사 엘지화학 | 가교구조 함유 올레핀고분자 다공지지체, 이를 포함하는 리튬 이차전지용 가교구조 함유 분리막, 이의 제조 방법, 및 상기 분리막을 구비한 리튬 이차전지 |
| WO2023182869A1 (en) * | 2022-03-25 | 2023-09-28 | Ildong Pharmaceutical Co., Ltd. | Novel salt of glp-1 receptor agonist compound, preparation method thereof and pharmaceutical composition comprising thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022335887A1 (en) * | 2021-08-30 | 2024-04-18 | Mindrank Ai Ltd. | Novel aryl ether substituted heterocyclic compound as glp1r agonist |
| US12024507B2 (en) | 2021-10-25 | 2024-07-02 | Terns Pharmaceuticals, Inc. | Compounds as GLP-1R agonists |
| CN117362282A (zh) * | 2022-07-07 | 2024-01-09 | 杭州德睿智药科技有限公司 | Glp-1r激动剂的盐及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008012623A1 (en) * | 2006-07-25 | 2008-01-31 | Pfizer Products Inc. | Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor |
| PE20191501A1 (es) * | 2016-12-16 | 2019-10-22 | Pfizer | Agonistas receptores de glp-1 y sus usos de los mismos |
| CR20220178A (es) * | 2019-10-25 | 2022-06-15 | Gilead Sciences Inc | Compuestos moduladores de glp-1r |
-
2020
- 2020-02-24 KR KR1020200022485A patent/KR20210059584A/ko unknown
- 2020-11-13 TW TW109139808A patent/TW202128658A/zh unknown
- 2020-11-13 TW TW109139809A patent/TWI786467B/zh active
- 2020-11-13 AR ARP200103146A patent/AR120458A1/es unknown
- 2020-11-13 UY UY0001038958A patent/UY38958A/es unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022235136A1 (ko) | 2021-05-07 | 2022-11-10 | 주식회사 엘지화학 | 가교구조 함유 올레핀고분자 다공지지체, 이를 포함하는 리튬 이차전지용 가교구조 함유 분리막, 이의 제조 방법, 및 상기 분리막을 구비한 리튬 이차전지 |
| WO2023182869A1 (en) * | 2022-03-25 | 2023-09-28 | Ildong Pharmaceutical Co., Ltd. | Novel salt of glp-1 receptor agonist compound, preparation method thereof and pharmaceutical composition comprising thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| UY38958A (es) | 2021-05-31 |
| TW202128658A (zh) | 2021-08-01 |
| AR120458A1 (es) | 2022-02-16 |
| TWI786467B (zh) | 2022-12-11 |
| TW202128659A (zh) | 2021-08-01 |
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