KR20210043472A - Photovoltaic transition materials and RF microchips inducing movement of brain cancer cells and use thereof for brain cancer treatment or brain cancer removal surgery - Google Patents

Abstract

The present invention relates to a composition for intratumoral transplantation for cancer treatment, including any one photosensitizer selected from a group consisting of titanium dioxide (TiO_2), zirconium dioxide (ZrO_2), hafnium dioxide (HfO_2), and combinations thereof, a kit for intratumoral transplantation for cancer treatment including the same, and a method for treating cancer.

Description

Photovoltaic transition materials and RF microchips inducing movement of brain cancer cells and use thereof for brain cancer treatment or brain cancer removal surgery}

The present invention relates to a brain cancer treatment and brain cancer removal technology using a photosensitive transition metal oxide and an RF microchip for inducing the movement of brain cancer cells and the use thereof, and more specifically, a composition for intratumoral implantation for brain cancer treatment, and the same It relates to an intratumoral implantation kit for cancer treatment and a method of treating cancer, including.

Korea is experiencing the fastest rate of aging in the world, and the demand for treatments for degenerative brain diseases and senile diseases related thereto is increasing rapidly. In particular, cancer is the number one cause of death among the population over 65 years of age, causing 865.4 deaths per 100,000 people, and cerebrovascular disease (410.7 people), heart disease (332.6 people), and diabetes (146.6 people). Is following. In particular, brain tumors, which refer to all tumors occurring in the skull, were 1,679 cases per year for men and women, according to data from the Central Cancer Registry published in 2013, and by age group, 50s accounted for 17.6%, followed by 16.5% in 60s and 14.9 in 70s. The incidence rate is high in the elderly in the order of %.

Currently, there are three major treatments for brain tumors: first, surgical surgery, second radiation therapy, and third anticancer chemotherapy. In clinical practice, anticancer drugs such as avastin, temozolomide, and doxorubicin, which are anticancer drugs, are widely used in the treatment of brain tumors, but these have severe side effects such as nausea, vomiting, stomatitis, diarrhea, abdominal pain, hair loss, and infection (pneumonia, urinary tract infection). Is known.

Accordingly, in recent years, energy-based minimally invasive cancer treatment methods have been studied in order to kill tumors in their natural state. As a treatment method of the minimally invasive cancer, photodynamic therapy (PDT) using light rays and sonar dynamic therapy (SDP) using sound (ultrasound) instead of light rays are used. Among them, photodynamic therapy is a method of treating tumors by injecting a photosensitizer into the body and irradiating a laser light (ray) having a specific wavelength at the disease site. This can be selectively treated only in the lesion area, and the possibility of side effects is low, so it is possible to repeat the procedure, so it can not only improve its effect, but also can be combined with other treatments such as surgical surgery, radiation therapy, and chemotherapy. It has the advantage of doing it.

However, there is a limitation that the light rays (red light) used in photodynamic therapy can penetrate into the body only to a depth of up to 10 mm, and thus can be applied only to tumors existing in a superficial or local area. In addition, the treatment has limitations in selective delivery to tumor tissues due to inappropriate interactions between biomolecules or aggregation between photosensors. In order to solve this problem, studies on techniques in combination with various carrier systems such as micelles, sealed liposomes, and biopolymers have been conducted, but notable results are still not obtained.

Under this technical background, there is a need for a new photosensitizer or therapeutic approach having bio-friendly stability while improving the photodynamic treatment effect than conventional products on the market.

One aspect of the present invention is any one photosensitizer selected from the group consisting of _{cerium dioxide (CeO 2} ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO _{2 ), and combinations thereof} It is to provide a composition for implantation in a tumor for the treatment of cancer comprising a.

Another aspect includes any one photosensitizer selected from the group consisting of cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), and hafnium dioxide (HfO _{2 ), and combinations thereof} It is to provide a kit for implantation in a tumor for the treatment of cancer.

Another aspect is cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO ₂ ), and any one photosensitizer selected from the group consisting of a combination thereof , It is to provide a method of treating cancer comprising the step of irradiating a light beam to a biological tissue including cancer cells.

One aspect of the present invention is any one photosensitizer selected from the group consisting of _{cerium dioxide (CeO 2} ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO _{2 ), and combinations thereof} It provides a composition for intratumoral implantation for cancer treatment comprising a.

As used herein, the term "cancer" refers to the aggressive (aggressive) characteristic in which cells divide and grow, ignoring the normal growth limit, the invasive characteristic of penetrating the surrounding tissues, and spreading to other parts of the body. It is a generic term for diseases caused by cells with metastatic properties. The cancer may be solid cancer, and the types of cancer according to the onset site include liver cancer, colon cancer, cervical cancer, kidney cancer, gastric cancer, prostate cancer, breast cancer, brain tumor, lung cancer, uterine cancer, colon cancer, bladder cancer, and pancreatic cancer. It may be any one selected from the group, preferably, it may be brain cancer.

As used herein, the term "treatment" may refer to any action in which symptoms of cancer are improved or advantageously changed through implantation or treatment of the composition into a tumor, for example, administration of a photosensitizer into the body And, it may mean a method of treating a tumor by irradiating a laser light (ray) having a specific wavelength on the disease site, that is, photodynamic therapy (PDT).

As used herein, the term "Photosensitizer" refers to a reactive oxygen species (reactive oxygen species) by generating a fluorescent signal or reacting with a surrounding substrate or oxygen after being excited when light of a specific wavelength is irradiated. oxygen species), the produced reactive oxygen species kills or necrosis surrounding cancer cells, thereby bringing about a therapeutic effect of cancer. However, conventional photosensitizers cause photosensitivity reactions such as burns, swelling, erythema, DNA mutations, etc., and are having difficulty in clinical application due to non-selective delivery to tumor tissues. In an embodiment for solving such a conventional problem, the photosensitizer is cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO ₂ ), and combinations thereof It may be any one selected from the group consisting of.

The composition for implantation in a tumor according to an embodiment may be administered in a parenteral form through direct injection or intravenous injection into a cancer-forming tissue site. The composition for parenteral administration may be prepared in the form of particles or powder, and is dispersed and/or dissolved in a pharmaceutically acceptable carrier, for example, sterile purified water, a buffer solution of about pH 7, or physiological saline, and injected into the body. It may be, and if necessary, may contain conventional additives such as preservatives, stabilizers, and the like.

In the other aspect, the other aspect is any one selected from the group consisting of _{cerium dioxide (CeO 2} ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), and hafnium dioxide (HfO _{2 ), and combinations thereof.} It provides a kit for intratumoral implantation for cancer treatment comprising an agent.

The terms “cancer”, “treatment”, and “photosensitizer” are the same as described above.

Intratumoral implantation kit for cancer treatment according to an embodiment may further include an RF absorber including an antenna for irradiating a frequency of 13 to 14 MHz to a biological tissue including cancer cells.

The RF absorber is a configuration for irradiating a frequency of 13 to 14 MHz to a living body tissue, and may be manufactured in a form having various materials and shapes known in the art, for example, in the form of a micro-unit chip (Chip). It can be provided with. In addition, one side of the RF absorber may include an antenna capable of irradiating a frequency of a specific band while facing or in contact with the living tissue. The antenna is a surface closest to a biological tissue in the RF absorber, and may include a structure known in the art for transmitting/receiving frequencies, for example, a cavity backed log spiral conductive structure. The RF absorber may be used in a state that faces or is implanted or attached to a living tissue, and at this time, a frequency of a specific band irradiated from the antenna of the RF absorber, for example, a frequency of 13.56 MHz, is localized in the living tissue. Cancer cells can be moved to the area.

In one embodiment, the RF absorber may be provided in the form of a microchip, and the integrated circuit of the RF absorber is an LC composed of a power supply unit, an inductor L, and a capacitor C mounted on the microchip. An oscillator (LC Oscillator), a modulator that uses any one of AM, FM, ASK, or FSK modulation, and a bandpass filter with a center frequency of 13 to 14 MHz and a bandwidth of 1 to 2 MHz. filter), an amplifier for amplifying a 13 to 14 MHz frequency signal, and an antenna. In addition, an RF absorber, a control unit, and a Bluetooth communication unit known in the art, which are involved in the operation (ON/OFF) of the RF absorber, may be separately provided.

The RF absorber irradiates a frequency of a specific band to a biological tissue including cancer cells, thereby distributing cancer cells widely distributed throughout the living tissue in a local area, for example, on one side of a biological tissue to which the RF absorber is implanted or attached. By moving to the area, it has the effect of reducing the lesion area. Therefore, prior to performing the cancer treatment of a local area such as photodynamic therapy, by performing the above method, the selectivity of the photosensitizer for cancer cells can be improved, and ultimately, the therapeutic effect of cancer can be enhanced.

Another aspect is cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO ₂ ), and any one photosensitizer selected from the group consisting of a combination thereof , It provides a method of treating cancer comprising the step of irradiating a light beam to a biological tissue including cancer cells.

The terms “cancer”, “treatment”, and “photosensitizer” are the same as described above.

The cancer cells may be derived from an individual's biological tissue. The individual may be a vertebrate, specifically mammals, amphibians, reptiles, birds, etc., may be more specifically mammals, for example, humans (Homo sapiens).

In one embodiment, prior to treatment of the photosensitizer, generating a frequency of 13 to 14 MHz by operating an RF absorber (Radio-frequency absorber), which is implanted or attached to a living tissue including cancer cells. It may further include. As described above, the frequency of a specific band irradiated from the antenna of the RF absorber, for example, a frequency of 13.56 MHz, improves the selectivity of the photosensitizer for cancer cells by moving the cancer cells to a local area in the living tissue. , May ultimately contribute to enhancing the therapeutic effect of cancer.

In the step of irradiating the cancer cells with light, the light rays well known in the art such as pulsed infrared light, visible light, light-emitting diodes (LEDs), and filtered white light sources may be applied.

In the above step, by activating the photosensitizing agent located around the cancer cells, the generated reactive oxygen species may kill or necrosis the surrounding cancer cells. In addition, in the above step, a treatment commonly used in the field of cancer treatment may be used alone or in combination. For example, the local treatment of cancer alone, or the local treatment and systemic treatment may be applied simultaneously (simultaneous), separately (separate), or sequentially (sequential).

Compositions and kits according to one aspect of the present invention use any one photosensitizer selected from the group consisting _{of titanium dioxide (TiO 2} ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO _{2 ), and combinations thereof} By doing so, cancer cells can be effectively removed, and prior to this, a frequency of 13 to 14 MHz can be applied to living tissues including cancer cells by operating an RF absorber.

This technology is expected to be applied as a core technology in the field of cancer treatment because it is less harmful to the human body than conventional chemotherapy or radiotherapy, and can more effectively remove cancer cells. .

1 schematically shows cancer cells scattered throughout the brain tissue according to an embodiment.
FIG. 2 is a diagram illustrating a photosensitizing phenomenon of a photosensitizing agent according to an embodiment and their conditions for implantation in a living body.
3 schematically shows a series of processes for treating cancer using a photosensitizer and an RF absorber according to an embodiment.
4 shows an exemplary structure and shape of an RF absorber according to an embodiment.
5 is a schematic diagram of an RF circuit according to an embodiment.
6 shows an operation process of an RF absorber according to an embodiment.
7 is a schematic diagram of a state of electrons and a transition process in a light-sensing process according to an embodiment.
8 is an electronic structure of a photosensitizer (TiO ₂ nanoparticles) according to an embodiment, schematically showing a mechanism for generating an internal band gap and reactive oxygen species.
9 is a result of counting cancer cells moved to the region irradiated with the RF frequency after irradiating the tissue with cancer cells with an RF frequency of about 13.56 MHz for 20 hours (Control: RF frequency is not irradiated group, Treated: RF frequency surveyed group).
FIG. 10 is a result of confirming the change in expression of factors related to motility or mobility in cancer cells after irradiating a tissue with cancer cells with an RF frequency of about 13.56 MHz for 20 hours (Control: RF frequency was not investigated, Treated: RF frequency surveyed group).

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

The following examples are provided to more completely describe the invention to those of ordinary skill in the art, and the following examples may be modified in various other forms, and the scope of the invention is limited to the following examples. It does not become.

The terms used in this specification are used to describe specific embodiments, and are not intended to limit the invention. As used herein, the singular form may include the plural form unless the context clearly indicates another case. In addition, when used herein, "comprise, include" and/or "comprising, including" refer to the mentioned shapes, numbers, steps, actions, members, elements, and/or groups thereof. It specifies existence and does not exclude the presence or addition of one or more other shapes, numbers, actions, members, elements, and/or groups.

FIG. 2 is a diagram illustrating a photosensitizing phenomenon of a photosensitizing agent according to an embodiment and their conditions for implantation in a living body.

The photosensitizer according to an embodiment may be excited when light of a specific wavelength is irradiated and then react with a surrounding substrate or oxygen to generate reactive oxygen species, and the generated reactive oxygen species may be Cells can be killed or necrotized. As a condition for implanting the photosensitizer in vivo, 1) non-toxic in vivo, 2) changing a surface electronic state by light rays is required, and the above The photosensitizer may be any one selected from the group consisting of cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO _{2 ), and combinations thereof used as a photocatalyst.} .

3 schematically shows a series of processes for treating cancer using a photosensitizer and an RF absorber according to an embodiment.

A method of treating cancer according to an embodiment includes the steps of: (a) actuating an RF absorber implanted or attached to a living tissue including cancer cells to deliver a frequency of 13 to 14 MHz to the living tissue; And (b) titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO ₂ ), and a combination thereof. It may include the step of irradiating the tissue with light. In the step (a), the cancer cells widely distributed throughout the living tissue are moved to a local area, for example, a region on one side of the living tissue to which the RF absorber is implanted or attached, thereby allowing the selectivity of the photosensitizer to the cancer cells. Can be improved. In the step (b), by activating a photosensitizing agent located around the cancer cells, the generated reactive oxygen species may kill or necrosis the surrounding cancer cells.

4 and 5 show a schematic structure and shape of an RF absorber and a schematic diagram of an RF circuit according to an embodiment.

The RF absorber according to an embodiment is for generating a frequency of 13 to 14 MHz, more specifically, 13.56 MHz to irradiate the biological tissue, and may be manufactured in various materials and shapes known in the art.

The RF absorber may use an RF absorber that irradiates a frequency (13.56 MHz) of 10 to 200 mW and 13 to 14 MHz to living tissues including cancer cells.

For example, it may be provided as a micro-unit chip having a circular cylinder or a square cylinder shape. In addition, the RF absorber may include an antenna for transmitting a frequency to a living tissue, and the antenna may include a cavity backed log spiral conductive structure to form a frequency of a specific band.

In addition, the RF absorber may be provided in the form of a microchip, and the integrated circuit of the RF absorber is an LC oscillator composed of a power supply unit, an inductor L, and a capacitor C mounted on the microchip. ), AM, FM, ASK, or FSK modulation, a modulator with a center frequency at 13 to 14 MHz and a bandpass filter with a bandwidth of 1 to 2 MHz, 13 to It includes an amplifier and an antenna that amplifies a 14 MHz frequency signal, and is made of Hybrid MIC, MMIC or SoC.

In addition, the RF absorber has a micro LED driving circuit or an optical fiber driving circuit, and a micro LED or optical fiber that irradiates near infrared rays (NIR) having a wavelength of 470 to 700 nm reaching the inside of a living body tissue. It may further include.

In addition, if necessary, a mixer (mixer), a power divider (power divider), a balun filter (Balun filer) may further include, and the RF absorber known in the art involved in the operation (ON / OFF) of the RF absorber and The control unit and the Bluetooth communication unit may be provided separately.

6 shows an operation process of an RF absorber according to an embodiment.

The RF absorber according to an embodiment may be used in a state facing a living tissue, implanted or attached to a living tissue, and at this time, a frequency of a specific band irradiated from the antenna of the RF absorber, for example, a frequency of 13.56 MHz Cancer cells, which are widely distributed throughout the living tissue, are moved to a local area, for example, an area on one side of the living tissue to which an RF absorber is implanted or attached, thereby bringing about the effect of reducing the lesion site. Therefore, prior to performing the cancer treatment of a local area such as photodynamic therapy, by performing the above method, the selectivity of the photosensitizer for cancer cells can be improved, and ultimately, the therapeutic effect of cancer can be enhanced.

7 is a schematic diagram of a state of electrons and a transition process in a light-sensing process according to an embodiment.

The photosensitizer is very unstable in an excited state and releases excess energy as light or heat. The excited state can be converted to a more stable triplet state by an inverted spin derived from one electron. The photosensitizer in the triplet state is destroyed in the absence of radiation and becomes a ground state, or transfers energy to oxygen molecules, which is a unique property seen in the triplet in the ground state. In this process, type I is a reaction that generates reactive oxygen species, and the photosensitizer reacts directly with organic molecules in a microcellular environment, and acquires hydrogen atoms or electrons to generate radicals. The subsequent autooxidation reaction of the reduced photosensitizer produces peroxide anion radicals (O ₂ * ^- ), and mutation or reduction of electrons in the peroxide anion radicals produces hydrogen peroxide (H ₂ O ₂ ), which is a powerful It can be reduced to one electron by the oxidizing agent, hardxyl radical (HO*). On the other hand, type II is a reaction that generates a ^{single molecule 1} O _{2 while relaxation of the triplet state occurs.} The generation of reactive oxygen species by type II is relatively easier than that of type I, and most photosensitizers may act on the reaction of type II, through which cell self-death, necrosis, and autophagy-related It can cause cell death, such as cell death.

8 is an electronic structure of a photosensitizer according to an embodiment, schematically showing a mechanism for generating an internal band gap and reactive oxygen species.

The photosensitizer may be, for example, TiO _{2 nanoparticles.} In this case, the generation of reactive oxygen may be achieved by excitation and calculation of electron-hole pairs on the surface _{of the TiO 2 nanoparticles.} TiO ₂ is a broadband semiconductor with gaps (Eg) of 3.0 and 3.2 eV, respectively, for rutile and anatase. In _{the case of TiO 2} nanoparticles, the gap (Eg) may increase to 3.5 eV, and _{excitation of the TiO 2} nanoparticles may be achieved by irradiation with a UV source having a wavelength of less than 380 nm. On the other hand, the efficiency of the generation of reactive oxygen species is determined by the quantum yield, that is, the ratio of the absorbed photons generating electron-hole pairs to the number of holes in the charge carrier participating in the useful reaction, and the spectrum of the catalytic reaction, which is necessary. Depending on, the enemy can be changed and implemented.

Ce₂O₃

CeO₂)의 효율을 증진시킬 수 있다. 투과 현미경 상에서 수행된 EELS 연구에 따르면, pH 7.5의 배지에서 제조된 CeO₂ 나노입자는 60% 이상 Ce₂O₃ 함량을 가지고 있음을 보여 주었던 반면, pH 5 내지 5.5의 배지에서 준비된 나노 입자는 최대 20%의 Ce₂O₃ 함량으로, 그 함량이 크게 감소됨을 보여 주었다. 따라서, 절개된 CeO₂ 나노입자를 사용하는 경우, 세포질이 약 알칼리성인 건강한 세포에서는 항산화 순환인 CeO₂ 사이클을 통해 광감각 반응에 의한 세포 사멸을 막을 수 있다. 이와 함께, 상기 항산화 사이클은 산성 조건의 세포질을 갖는 암 세포에서는 작용하지 않기 때문에, 자외선에 의해 생성된 반응성 산소종이 암 세포를 효과적으로 파괴할 수 있는 바, 암 세포 특이적인 사멸을 가능하게 한다. The photosensitizer may be, for example, CeO ₂ nanoparticles, in that the CeO ₂ nanoparticles exert a photodynamic therapeutic effect for cancer cells, while providing stable antioxidant protection for healthy cells. Cancer treatment effect can be further improved. Specifically, the CeO ₂ nanoparticles can be obtained through laser ablation, and the nanoparticles obtained as described above have a high content of oxygen vacancies in the surface element layer, so that the antioxidant CeO ₂ cycles (CeO ₂

Ce ₂ O ₃

It can improve the efficiency of _{CeO 2 ).} According to an EELS study conducted on a transmission microscope, _{it was shown that CeO 2 nanoparticles prepared in a medium of pH 7.5 have a Ce 2} O ₃ content of 60% or more, whereas nanoparticles prepared in a medium of pH 5 to 5.5 have a maximum With a 20% Ce ₂ O ₃ content, it was shown that the content was greatly reduced. Therefore, in _{the case of using the cut CeO 2} nanoparticles, in healthy cells with weakly alkaline cytoplasm, it is possible to prevent apoptosis due to the photosensory reaction through the _{CeO 2 cycle, which is an antioxidant cycle.} In addition, since the antioxidant cycle does not act on cancer cells having a cytoplasm under acidic conditions, reactive oxygen species generated by ultraviolet rays can effectively destroy cancer cells, thereby enabling specific death of cancer cells.

The method for treating cancer according to an embodiment includes (a) actuating an RF absorber implanted or attached to a living tissue including cancer cells to deliver a frequency of 13 to 14 MHz (eg, 13.56 MHz) to the living tissue. The step of doing; And (b) removing the cancer cells. In the step (a), the cancer cells widely distributed throughout the living tissue may be moved to a local area, for example, an area on one side of the living tissue to which the RF absorber is implanted or attached, thereby reducing the lesion site. In the step (b), it means not only separating cancer cells from normal tissues in the living body, but also killing cancer cells or reducing its function, as cerium dioxide (CeO ₂ ), titanium dioxide ( TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO ₂ ), and any one photosensitizer selected from the group consisting of a combination thereof is treated, light rays to biological tissues including cancer cells The step of investigating may be applied. More specifically, after selectively administering a photosensitizer in the form of nanoparticles to a tumor tissue by applying a targeted therapy or the like, a special optical fiber probe may be used to irradiate light rays onto the tumor tissue in which the photosensitizer is present. Due to the absorption of optical protons, when electrons in the valence band pass through the conduction band, electron-hole pairs can be formed in the photosensitizer, and reactive oxygen species are produced to kill or necrosis surrounding cancer cells, thereby enhancing the therapeutic effect of cancer. I can bring you.

[Example]

Example 1. Movement of cancer cells by RF frequency

In this example, it was attempted to confirm the effect of the RF frequency on the movement of cancer cells. Specifically, using the RF absorber according to an embodiment, a tissue in which cancer cells are present was irradiated with an RF frequency of about 13.56 MHz for 20 hours. Thereafter, cancer cells moved to the region irradiated with the RF frequency were counted, and changes in expression of factors related to motility or mobility in the cancer cells were evaluated. WM cells or G361 cells known as skin cancer cells were used as the cancer cells, and a group not irradiated with RF frequency was set as a control group.

As a result, as shown in FIG. 9, it was confirmed that a number of cancer cells migrate to the region irradiated with the RF frequency in both WM cells and G361 cells, and this effect was remarkable compared to the control group. In addition, as shown in FIG. 10, the RF frequency up-regulated factors related to the mobility of cancer cells such as EGF and FGF.

From these experimental results, it was found that by applying a frequency of 13 to 14 MHz to a living tissue, cancer cells can be moved to an area on one surface of the living tissue, and through this, cancer cells or tissues can be effectively removed. .

The above description of the present invention is for illustrative purposes only, and those of ordinary skill in the art to which the present invention pertains will be able to understand that other specific forms can be easily modified without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and are not limiting.

Claims (11)

Containing any one photosensitizer selected from the group consisting of cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO _{2 ), and combinations thereof} Composition for implantation in tumors for cancer treatment.
The method according to claim 1, wherein the composition is a photosensitive agent particles or a dispersion containing the photosensitizer particles, the composition for implantation in a tumor for cancer treatment.
Including any one photosensitizer selected from the group consisting of cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), and hafnium dioxide (HfO _{2 ), and combinations thereof} Intratumoral implantation kit for cancer treatment.
The method according to claim 3, wherein the composition further comprises an RF absorber including an antenna for irradiating a frequency of 13 to 14 MHz to a living tissue including cancer cells, for intratumoral implantation for cancer treatment Kit.
The kit of claim 3, wherein the RF absorber irradiates the biological tissue with a frequency of 13.56 MHz.
The method according to claim 4, wherein the RF absorber is implanted or attached to one surface of the biological tissue, and moves cancer cells to an area of one surface of the biological tissue to which the RF absorber is implanted or attached, in a tumor for cancer treatment. Kit for implantation.
The method according to claim 4, wherein the RF absorber is a power supply unit mounted on the microchip, an LC oscillator composed of an inductor (L) and a capacitor (C), AM, FM, ASK, or FSK modulation. A modulator using any one modulation method, a bandpass filter having a center frequency of 13 to 14 MHz and a bandwidth of 1 to 2 MHz, an amplifier that amplifies a 13 to 14 MHz frequency signal, and Intratumoral implantation kit for cancer treatment, including an antenna (Antenna).
The method according to claim 3, wherein the cancer is a solid cancer, intratumoral implantation kit for cancer treatment.
The method according to claim 3, wherein the cancer is brain cancer, the kit for intratumoral transplantation for cancer treatment.
Cerium dioxide (CeO ₂ ), titanium dioxide (TiO ₂ ), zirconium dioxide (ZrO ₂ ), hafnium dioxide (HfO ₂ ), and any one photosensitizer selected from the group consisting of a combination thereof , A method of treating cancer comprising the step of irradiating a light beam to a biological tissue including cancer cells.
The method according to claim 10, before treating the photosensitizer, generating a frequency of 13 to 14 MHz by operating an RF absorber (Radio-frequency absorber), which is implanted or attached to a living tissue including cancer cells. Further comprising, a method of treating cancer.

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