KR20210005942A - Il-33을 포함하는 매트릭스 결합 소포 (mbvs) 및 그 용도 - Google Patents
Il-33을 포함하는 매트릭스 결합 소포 (mbvs) 및 그 용도 Download PDFInfo
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- KR20210005942A KR20210005942A KR1020207034813A KR20207034813A KR20210005942A KR 20210005942 A KR20210005942 A KR 20210005942A KR 1020207034813 A KR1020207034813 A KR 1020207034813A KR 20207034813 A KR20207034813 A KR 20207034813A KR 20210005942 A KR20210005942 A KR 20210005942A
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- fibrosis
- nanovesicles
- mbv
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
- C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
- C12Y104/03013—Protein-lysine 6-oxidase (1.4.3.13), i.e. lysyl-oxidase
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862666624P | 2018-05-03 | 2018-05-03 | |
| US62/666,624 | 2018-05-03 | ||
| PCT/US2019/030547 WO2019213482A1 (en) | 2018-05-03 | 2019-05-03 | Matrix bound vesicles (mbvs) containing il-33 and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210005942A true KR20210005942A (ko) | 2021-01-15 |
Family
ID=68386862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207034813A Ceased KR20210005942A (ko) | 2018-05-03 | 2019-05-03 | Il-33을 포함하는 매트릭스 결합 소포 (mbvs) 및 그 용도 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12440444B2 (https=) |
| EP (1) | EP3787642A4 (https=) |
| JP (2) | JP7548567B2 (https=) |
| KR (1) | KR20210005942A (https=) |
| CN (1) | CN112805016A (https=) |
| AU (2) | AU2019263479B2 (https=) |
| CA (1) | CA3098149A1 (https=) |
| WO (1) | WO2019213482A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015231110B2 (en) | 2014-03-21 | 2019-03-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix |
| CA3049990A1 (en) | 2017-03-02 | 2018-09-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer |
| EP3589292B1 (en) | 2017-03-02 | 2023-08-23 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Ecm hydrogel for treating esophageal inflammation |
| KR102872720B1 (ko) | 2017-05-05 | 2025-10-16 | 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 기질 결합 소낭의 안구에의 적용 |
| US20240226170A9 (en) * | 2019-10-23 | 2024-07-11 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of mbv for treating autoimmune disease |
| JP2023514821A (ja) | 2020-02-28 | 2023-04-11 | テキサス メディカル センター | 癒着阻止および組織治癒向上のための噴霧可能刺激応答性マイクロヒドロゲル |
| EP4135727A4 (en) * | 2020-04-16 | 2024-05-22 | University of Pittsburgh - of the Commonwealth System of Higher Education | MATRIX-BOUND VESICLES (MBV) FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME |
| US20230210898A1 (en) * | 2020-04-24 | 2023-07-06 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Microparticle-Assisted Treg Therapy for Treatment of Tissue Injury and Fibrosis |
| AU2023249793A1 (en) * | 2022-04-08 | 2024-11-21 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Matrix bound nanovesicles encapsulated in hydrogels |
| EP4712988A1 (en) * | 2023-05-17 | 2026-03-25 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for treating muscle wasting diseases using mbv |
| CN118416023B (zh) * | 2024-05-07 | 2025-01-28 | 山东大学 | 用于特发性肺纤维化治疗的仿生纳米递送系统m@rcpda纳米粒及其制备方法 |
| CN119033723B (zh) * | 2024-08-15 | 2025-05-02 | 南京鼓楼医院 | 一种氨氯地平药物靶向递送系统及其制备方法和应用 |
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| US4978668A (en) | 1986-09-02 | 1990-12-18 | Purdue Research Foundation | Treatment to reduce ischemic tissue injury |
| US4956178A (en) | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
| US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
| US5007927A (en) | 1989-10-24 | 1991-04-16 | Purdue Research Foundation | Muscle-powered cardiac assist device |
| US5281422A (en) | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
| US5352463A (en) | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
| US5275826A (en) | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
| US6653291B1 (en) | 1992-11-13 | 2003-11-25 | Purdue Research Foundation | Composition and method for production of transformed cells |
| US5641518A (en) | 1992-11-13 | 1997-06-24 | Purdue Research Foundation | Method of repairing bone tissue |
| US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US6485723B1 (en) | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
| WO1996031232A1 (en) | 1995-04-07 | 1996-10-10 | Purdue Research Foundation | Tissue graft and method for urinary bladder reconstruction |
| US5711969A (en) | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
| US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
| CA2160647C (en) | 1995-10-16 | 2002-05-28 | Thomas William Garay | Helical bearing anchor catcher |
| US5755791A (en) | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
| DK0925067T3 (da) | 1996-09-16 | 2004-05-03 | Purdue Research Foundation | Graft fra submucosavæv til reparation af neurologisk væv |
| WO1998019719A1 (en) | 1996-11-05 | 1998-05-14 | Purdue Research Foundation | Myocardial graft constructs |
| DE69720252T2 (de) | 1996-12-10 | 2003-12-04 | Purdue Research Foundation, West Lafayette | Gewebetransplantat aus der magensubmukosa |
| ATE249182T1 (de) | 1996-12-10 | 2003-09-15 | Purdue Research Foundation | Rohrförmige transplantatkonstruktionen aus submucosalem gewebe |
| JP2001505807A (ja) | 1996-12-10 | 2001-05-08 | パーデュー・リサーチ・ファウンデーション | 人工血管弁 |
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| US6696270B2 (en) | 1996-12-10 | 2004-02-24 | Purdue Research Foundation | Gastric submucosal tissue as a novel diagnostic tool |
| AU732726B2 (en) | 1996-12-10 | 2001-04-26 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
| WO2000015765A1 (en) | 1998-09-11 | 2000-03-23 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
| GB2361187A (en) | 1998-12-01 | 2001-10-17 | Purdue Research Foundation | Submucosa modulation of mammalian immune response |
| US6918396B1 (en) | 1998-12-01 | 2005-07-19 | Purdue Research Foundation | Method for vocal cord reconstruction |
| GB2360948B (en) | 1998-12-01 | 2003-12-10 | Purdue Research Foundation | Composition suitable for vocal cord reconstruction |
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| US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
| US20090053279A1 (en) | 1999-12-22 | 2009-02-26 | Badylak Stephen F | Tissue regenerative composition |
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| AU2019263479A1 (en) | 2021-01-07 |
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| EP3787642A1 (en) | 2021-03-10 |
| CN112805016A (zh) | 2021-05-14 |
| EP3787642A4 (en) | 2022-09-21 |
| JP7548567B2 (ja) | 2024-09-10 |
| US12440444B2 (en) | 2025-10-14 |
| WO2019213482A8 (en) | 2020-11-05 |
| WO2019213482A1 (en) | 2019-11-07 |
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