KR20210003585A - Cosmetic for promoting collagen synthesis for suppressing and improving wrinkles - Google Patents

Abstract

The present invention relates to a composition for promoting collagen synthesis comprising prangenidin and genistein represented by chemical formula 1 and chemical formula 2. The composition of the present invention has excellent collagen formation promoting ability and collagenase inhibitory ability, and has the advantage of exhibiting excellent efficacy even when a small amount of the active ingredient is included. Accordingly, the composition of the present invention can be used in various formulations, and cosmetics including the same have excellent wrinkle suppression and alleviation effects.

Description

Cosmetic for promoting collagen synthesis for suppressing and improving wrinkles}

The present invention relates to a composition for promoting collagen synthesis and a cosmetic for suppressing and improving wrinkles comprising the same, and more specifically, a composition for promoting collagen synthesis, comprising frangenidine and genistein, and a composition for promoting collagen synthesis, including the above It relates to cosmetic products for improvement.

Collagen is a major component of the extracellular matrix, a major matrix protein produced by fibroblasts in the skin, and is present in the extracellular matrix. In addition, it is an important protein that accounts for about 30% of the total weight of a biological protein and has a solid triple helix structure. Collagen forms most of the organic substances in skin, tendons, bones and teeth, especially in bone and skin (dermis). Collagen also exists as fibrous inclusion bodies in most other body structures.

Collagen is a relatively weak immunogen, due to the shielding of latent antigenic determinants by a helix structure, and this helix structure also makes collagen resistant to protein degradation. The main functions of collagen are known for its mechanical firmness, connective tissue resistance, tissue bonding, support for cell adhesion, and induction of cell division and differentiation (when the growth of organisms or wound healing) is performed (Van der Rest, etc.). , Ann NY Acad Sci, 1990) These collagens are reduced by age and photoaging caused by UV irradiation, which is known to be closely related to the formation of wrinkles in the skin (Arthur KBalin et al, Aging and the skin, 1989). Plays an important role in wound healing, and promotes the synthesis of collagen in the damaged epithelium, allowing the wound to heal quickly and without scarring.

Conventionally, in order to take advantage of the skin moisturizing effect and wound healing effect of collagen, products containing collagen in external preparations for skin such as cosmetics or ointments have been released, but these products apply collagen itself to the skin surface, and are a polymer substance called collagen. Because it is difficult to absorb percutaneously, it cannot be expected to have a moisturizing or wound healing effect, so it does not exhibit essential skin function improvement and wound healing functions.

Accordingly, interest in collagen synthesis promoting substances has increased, and conventionally known collagen synthesis promoting substances include vitamin C, retinoic acid, and transforming growth factor (TGF), Cardinale G et al, Adv Enzymol, 41, p. 425, 1974).

In addition, Japanese Patent Laid-Open Publication No. Hei 8-231370 discloses a protein derived from an animal placenta as a collagen synthetic material, and Japanese Patent Laid-Open Publication No. Hei 8-208424 discloses betulinic acid and Japanese Patent Laid-Open No. Hei 9-40523. No. 10-36283 discloses a chlorella extract and the like showing a fibroblast proliferation promoting effect.

However, the above-described conventional substances are limited in use due to safety problems such as irritation and redness when applied to the skin, or their effects are insignificant, and thus the effect of substantially improving skin function or wound healing cannot be expected. Therefore, there is an urgent need to develop a new composition for external application for skin that is safer to the living body and is more effective than the existing composition for external application for skin.

The present invention provides a composition for promoting collagen synthesis that can be applied in various formulations because it has excellent stability to the living body and excellent collagen synthesis promoting effect, and excellent processability such as solubility in a solvent is provided to solve the above problems. It aims to do.

Accordingly, it is an object of the present invention to provide a composition for promoting collagen synthesis comprising frangenidine and genistein represented by a specific formula.

Another object of the present invention is to provide cosmetics in various formulations comprising the composition for promoting collagen synthesis.

The present invention provides a composition for promoting collagen synthesis comprising a compound of the following formula 1 and a compound of the following formula 2 as a means for solving the above problems.

[Formula 1] [Formula 2]

The content of frangenidine represented by Formula 1 contained in the composition of the present invention is preferably 1 × 10 -5 to 10 parts by weight based on 100 parts by weight of the total composition.

The content of genistein represented by Formula 2 contained in the composition of the present invention is preferably 1 × 10 -5 to 10 parts by weight based on 100 parts by weight of the total composition.

The present invention provides a cosmetic for suppressing and improving skin wrinkles comprising the composition for promoting collagen synthesis as another means for solving the above problems.

The composition for promoting collagen synthesis of the present invention has excellent stability to a living body and exhibits an excellent collagen formation promoting effect, and thus can be applied in various ways for cosmetics or pharmaceutical uses. In particular, the composition of the present invention is applied as a cosmetic and exhibits excellent efficacy in suppressing and improving wrinkles.

1 is an H-NMR spectrum graph of frangenidine prepared in Preparation Example 1 of the present invention.
2 is a C-NMR spectrum graph of frangenidine prepared in Preparation Example 1 of the present invention.
3 is a mass spectrum graph of frangenidine prepared in Preparation Example 1 of the present invention.
4 is an H-NMR spectrum graph of genistein prepared in Preparation Example 2 of the present invention.
5 is a mass spectrum graph of genistein prepared in Preparation Example 2 of the present invention.

The present invention relates to a composition for promoting collagen synthesis comprising frangenidine and genistein represented by a specific formula. The composition of the present invention has an excellent ability to promote collagen formation and inhibit collagenase, and has the advantage of exhibiting excellent efficacy even when a small amount of the active ingredient is included.

Hereinafter, the composition for promoting collagen synthesis of the present invention will be described in detail.

Frangenidine contained in the composition for promoting collagen synthesis of the present invention is represented by the following formula (1).

[Formula 1]

Since frangenidine represented by Chemical Formula 1 is safe for the living body and has the effect of promoting collagen synthesis in skin fibroblasts, it is suitable for use as a collagen synthesis promoter and improves skin wrinkles and wounds by improving the elasticity of the skin. The healing effect is very excellent.

Frangenidine is a compound mainly present in the roots of umbels and plants, and can be chemically synthesized by conventional methods known in the art, or extracted from plants. For example, frangenidine is extracted by warming by cutting the roots (white paper) of umbels and copper stalks of plants into small pieces, adding water, anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms, ethyl acetate, acetone, chloroform, or a mixture thereof. , It can be obtained by fractionating the solvent and recrystallization.

The content of frangenidine is preferably 1×10-5 to 10 parts by weight, and more preferably 1×10-5 to 5 parts by weight based on 100 parts by weight of the total composition. If the content is less than 1 × 10 -5 parts by weight, the effect of synthesizing collagen is insignificant, and if it exceeds 10 parts by weight, it is not preferable in terms of application to cosmetic preparation and stability.

Genistein contained in the composition for promoting collagen synthesis of the present invention is represented by the following formula (2).

[Formula 2]

Genistein represented by Chemical Formula 2 has an inhibitory effect on the increase in the expression of collagenase, a collagen-degrading enzyme caused by ultraviolet rays, is safe for a living body, and is suitable for use as a collagen synthesis promoter. In addition, it has excellent skin wrinkle improvement and wound healing effects such as improving the elasticity of the skin.

Genistein is a compound mainly present in seeds and fruits of legumes, and most genistein is known to exist in the form of a sugar-bound genistin.

The genistein may be chemically synthesized by a conventional method known in the art, or may be extracted from plants. For example, genistein is extracted by heating the fruit of the leguminous plant, Pseudomonas, and adding water, anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms, ethyl acetate, acetone, chloroform, or a mixture thereof. It can be obtained by recrystallization afterwards.

The content of genistein is preferably 1 × 10-5 to 10 parts by weight, more preferably 1 × 10-5 to 5 parts by weight, based on 100 parts by weight of the total composition. If the content is less than 1 × 10 -5 parts by weight, the effect of synthesizing collagen is insignificant, and if the content is more than 10 parts by weight, it is not preferable in terms of production and stability as a cosmetic.

In addition, the composition for promoting collagen synthesis according to the present invention preferably has a weight ratio of frangenidine and genistein (genistein/frangenidine) of 1 to 100, and more preferably 1 to 50.

When the weight ratio of francenidine and genistein is less than 1 or exceeds 100, there is a concern that the increase in collagen synthesis effect may be insignificant.

In the composition for promoting collagen synthesis of the present invention, additives other than the active ingredient are not particularly limited, and those commonly used in this field may be used without limitation. For example, when the composition is used for medical purposes, a conventional pharmaceutically acceptable carrier may be included, and when applied to cosmetics or the like, conventional additives commonly used in the cosmetic field may be used without limitation.

The present invention also relates to a cosmetic for suppressing and improving skin wrinkles comprising the composition for promoting collagen synthesis.

Frangenidine is limited in use in cosmetics due to its low solubility in commonly used cosmetic solvents. However, using frangenidine and genistein at the same time as in the present invention can solve the above problem, and as described above, it has excellent human stability and collagen synthesis promoting effect, so that it can be effectively applied to cosmetics for suppressing and improving skin wrinkles. have.

The cosmetic product according to the present invention may be prepared by using a composition for promoting collagen synthesis as an active ingredient by a method generally used in the cosmetic field, and the method is not particularly limited.

Also, the formulation of the cosmetic according to the present invention is not particularly limited. For example, the cosmetic of the present invention is powder, gel, spray, ointment, cream, liquid, skin adhesive type formulation, cream, foam, lotion, pack, softening water, emulsion, foundation, makeup base, essence, soap, liquid cleaning. It can be prepared as a material, bath agent, sunscreen cream, sun oil, or spray-type liquid. The additives added in each of the above formulations are also not particularly limited, and additives generally used in the cosmetic field may be appropriately added according to their use.

Examples of such general additives include antibiotics, binders, disintegrants, diluents, lubricants, stabilizers, preservatives, fragrances, oils, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, and preservatives. And one or more selected.

Claims (9)

For promoting collagen synthesis, characterized in that it contains a compound of Formula 1 and a compound of Formula 2, and the weight ratio of the compound of Formula 1 and the compound of Formula 2 (compound of Formula 2/compound of Formula 1) is 1 to 100 Composition:
[Formula 1]

[Formula 2]

The method of claim 1,
The compound of formula 1 is a composition for promoting collagen synthesis, characterized in that it is contained in an amount of 1 × 10 -5 to 10 parts by weight based on 100 parts by weight of the total composition. The method of claim 2,
The compound of formula 1 is a composition for promoting collagen synthesis, characterized in that it is contained in an amount of 1 × 10-5 to 5 parts by weight based on 100 parts by weight of the total composition. The method of claim 1,
The compound of formula 2 is a composition for promoting collagen synthesis, characterized in that it is contained in an amount of 1 × 10 -5 to 10 parts by weight based on 100 parts by weight of the entire composition. The method of claim 4,
The compound of formula 2 is a composition for promoting collagen synthesis, characterized in that it is contained in an amount of 1 × 10 -5 to 5 parts by weight based on 100 parts by weight of the entire composition. The method of claim 1,
A composition for promoting collagen synthesis, characterized in that the weight ratio of the compound of Formula 1 and the compound of Formula 2 (compound of Formula 2/compound of Formula 1) is 1 to 50. A cosmetic for suppressing and improving skin wrinkles comprising a composition for promoting collagen synthesis according to any one of claims 1 to 5 and 7. The method of claim 8,
Formulation is powder, gel, spray, ointment, cream, liquid, skin adhesive type formulation, cream, foam, lotion, pack, softening water, emulsion, foundation, makeup base, essence, soap, liquid detergent, bathing agent, sunscreen A cosmetic for suppressing and improving skin wrinkles, characterized in that it is a cream, sun oil or spray-type liquid. The method of claim 8,
Antibiotics, binders, disintegrants, diluents, lubricants, stabilizers, preservatives, fragrances, oils, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, and preservatives containing one or more selected from the group consisting of Cosmetics for suppressing and improving skin wrinkles.

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