KR20210003313A - 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치 - Google Patents

만성 통증 완화에 이용되는 점막 관통 약물 전달 장치 Download PDF

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Publication number
KR20210003313A
KR20210003313A KR1020207038099A KR20207038099A KR20210003313A KR 20210003313 A KR20210003313 A KR 20210003313A KR 1020207038099 A KR1020207038099 A KR 1020207038099A KR 20207038099 A KR20207038099 A KR 20207038099A KR 20210003313 A KR20210003313 A KR 20210003313A
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KR
South Korea
Prior art keywords
buprenorphine
pain
subjects
opioid
subject
Prior art date
Application number
KR1020207038099A
Other languages
English (en)
Korean (ko)
Inventor
앤드류 핀
니라이 바시슈트
Original Assignee
바이오딜리버리 사이언시스 인터내셔널 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 filed Critical 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드
Priority to KR1020227011298A priority Critical patent/KR20220047889A/ko
Publication of KR20210003313A publication Critical patent/KR20210003313A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020207038099A 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치 KR20210003313A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227011298A KR20220047889A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161578755P 2011-12-21 2011-12-21
US61/578,755 2011-12-21
PCT/US2012/071330 WO2013096811A2 (fr) 2011-12-21 2012-12-21 Dispositifs d'administration transmucosale de médicament pour une utilisation dans le soulagement de la douleur chronique

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197027379A Division KR20190110628A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227011298A Division KR20220047889A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치

Publications (1)

Publication Number Publication Date
KR20210003313A true KR20210003313A (ko) 2021-01-11

Family

ID=48669710

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020207038099A KR20210003313A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치
KR1020197027379A KR20190110628A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치
KR1020147020237A KR102026321B1 (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치
KR1020227011298A KR20220047889A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020197027379A KR20190110628A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치
KR1020147020237A KR102026321B1 (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치
KR1020227011298A KR20220047889A (ko) 2011-12-21 2012-12-21 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치

Country Status (16)

Country Link
EP (1) EP2793870A4 (fr)
JP (1) JP6255349B2 (fr)
KR (4) KR20210003313A (fr)
CN (2) CN104125828A (fr)
AU (4) AU2012358308A1 (fr)
BR (1) BR112014015329A2 (fr)
CA (1) CA2859859A1 (fr)
EA (2) EA201992762A1 (fr)
HK (1) HK1203365A1 (fr)
IL (2) IL233075A0 (fr)
IN (1) IN2014DN06117A (fr)
MX (2) MX362217B (fr)
SG (3) SG10202012743WA (fr)
UA (1) UA118540C2 (fr)
WO (1) WO2013096811A2 (fr)
ZA (1) ZA201804381B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021163529A2 (fr) * 2020-02-13 2021-08-19 Biodelivery Sciences International, Inc. Procédés de traitement avec de la buprénorphine

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800832A (en) 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
DE19652188C2 (de) * 1996-12-16 2002-02-14 Lohmann Therapie Syst Lts Flache Arzneizubereitung zur Applikation und Freisetzung von Buprenorphin oder einer pharmakologisch vergleichbaren Substanz in der Mundhöhle und Verfahren zu ihrer Herstellung
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
DE19960154A1 (de) * 1999-12-14 2001-07-12 Lohmann Therapie Syst Lts Flache Arzneizubereitung zur transmucosalen Verabreichung von Oxycodon oder einem vergleichbaren Wirkstoff in der Mundhöhle, für die Anwendung in der Schmerztherapie und Suchttherapie
OA12215A (en) 2000-02-08 2006-05-09 Euro Celtique Sa Tamper-resistant oral opioid agonist formulations.
CA2445346C (fr) 2001-04-27 2010-04-06 Ajinomoto Co., Inc. Derives pyrazolyl-o-glycoside n-substitues et medicament contre le diabete en contenant
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
DE102005007859A1 (de) * 2005-02-21 2006-08-24 Lts Lohmann Therapie-Systeme Ag Vefahren für eine medikamentöse Kombinations-Behandlung, sowie hierfür geeignete Arzneimittel-Kombinationen
US20060281775A1 (en) * 2005-06-14 2006-12-14 Applied Pharmacy Services, Inc. Two-component pharmaceutical composition for the treatment of pain
US9522188B2 (en) 2005-12-13 2016-12-20 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device
CA2649107A1 (fr) 2006-04-12 2007-10-25 Spinal Motion, Inc. Dispositif vertebral posterieur et procede associe
MX2009000745A (es) * 2006-07-21 2009-04-16 Biodelivery Sciences Int Inc Dispositivos de suministro transmucosa con admision mejorada.
EP1897543A1 (fr) * 2006-08-30 2008-03-12 Euro-Celtique S.A. Gaufre de buprénorphine pour la thérapie de substitution
GB0620661D0 (en) * 2006-10-18 2006-11-29 Pharmasol Ltd Novel compounds
US20090270438A1 (en) * 2006-10-18 2009-10-29 Clive Booles Novel compositions and formulations
GB2447016A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Buprenorphine/naloxone compositions
CN102056578A (zh) * 2008-06-23 2011-05-11 生物递送科学国际公司 多向粘膜给药装置及使用方法
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions

Also Published As

Publication number Publication date
ZA201804381B (en) 2022-12-21
AU2017258916B2 (en) 2019-01-17
EA201992762A1 (ru) 2020-07-31
KR20140106720A (ko) 2014-09-03
WO2013096811A3 (fr) 2014-07-24
MX2021012154A (es) 2021-11-03
BR112014015329A8 (pt) 2017-06-13
MX2014007350A (es) 2014-09-15
EP2793870A2 (fr) 2014-10-29
JP2015500886A (ja) 2015-01-08
CN110123792A (zh) 2019-08-16
SG10202012743WA (en) 2021-01-28
KR20220047889A (ko) 2022-04-19
BR112014015329A2 (pt) 2017-06-13
EA201491046A1 (ru) 2014-11-28
IL233075A0 (en) 2014-07-31
HK1203365A1 (en) 2015-10-30
SG11201403075XA (en) 2014-07-30
AU2017258916A1 (en) 2017-11-30
UA118540C2 (uk) 2019-02-11
SG10201710667YA (en) 2018-02-27
AU2012358308A1 (en) 2014-07-24
AU2019202602A1 (en) 2019-05-02
EP2793870A4 (fr) 2016-02-17
IN2014DN06117A (fr) 2015-08-14
KR102026321B1 (ko) 2019-09-27
CA2859859A1 (fr) 2013-06-27
WO2013096811A2 (fr) 2013-06-27
IL285091A (en) 2021-08-31
KR20190110628A (ko) 2019-09-30
EA034529B1 (ru) 2020-02-18
JP6255349B2 (ja) 2017-12-27
AU2021202042A1 (en) 2021-04-29
CN104125828A (zh) 2014-10-29
MX362217B (es) 2019-01-09

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