KR20200120997A - Chocolate Chip for Preventing Alcoholic Dementia - Google Patents

Chocolate Chip for Preventing Alcoholic Dementia Download PDF

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KR20200120997A
KR20200120997A KR1020190043422A KR20190043422A KR20200120997A KR 20200120997 A KR20200120997 A KR 20200120997A KR 1020190043422 A KR1020190043422 A KR 1020190043422A KR 20190043422 A KR20190043422 A KR 20190043422A KR 20200120997 A KR20200120997 A KR 20200120997A
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extract
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alcoholic dementia
composition
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이현웅
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오션스바이오 주식회사
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/42Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G1/423Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
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    • A23G1/00Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/42Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
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    • A23G1/00Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/48Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135Compounds containing heavy metals
    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
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    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/334Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels

Abstract

The present invention provides a chocolate chip for preventing alcoholic dementia containing Hovenia dulcis, which contains, based on the total weight, a Hovenia dulcis extract, and 5 to 20 wt% of a mixture containing, based on 100 parts by weight of the Hovenia dulcis extract, 50 to 100 parts by weight of a digestive agent composition, 20 to 30 parts by weight of a proteolytic enzyme composition, and 1 to 5 parts by weight of vitamins. The chocolate chip for preventing alcoholic dementia containing Hovenia dulcis of the present invention has advantages of significantly preventing alcoholic dementia, having excellent palatability, having a remarkable hangover relief effect, and being able to manufacture hangover relief beverages at a low cost compared to an existing hangover relief beverage composition.

Description

알콜성 치매 예방용 초코렛칩{Chocolate Chip for Preventing Alcoholic Dementia}Chocolate Chip for Preventing Alcoholic Dementia {Chocolate Chip for Preventing Alcoholic Dementia}

본 발명은 알콜성 치매 예방용 초코렛칩 조성물에 관한 것으로 보다 상세하게는 소화제 조성물, 단백질분해효소 조성물 및 비타민을 포함하는 알콜성 치매 예방용 초코렛칩에 관한 것이다.The present invention relates to a chocolate chip composition for preventing alcoholic dementia, and more particularly, to a chocolate chip for preventing alcoholic dementia including a digestive agent composition, a protease composition, and a vitamin.

회식과 접대가 잦고 스트레스가 많은 현대인들에게 음주 기회가 날로 증가하고 있다. 알코올은 뇌의 억제중추를 마비시켜 섭취 시 외관상 흥분한 상태를 보여주는데, 의식과 동작을 억제하고 수면 및 마취 효과가 현대인들의 스트레스 해소를 위한 주요한 기호식품으로 이용되고 있다. 정상적인 알코올 대사과정에서 알코올이 체내로 유입되면 물에 잘 녹는 알코올의 특성에 의해 위장관에서 흡수되어 혈류를 통해 뇌와 간을 포함한 신체 각 조직에 분포된다. 간세포에는 알콜탈수소화 효소(알콜 분해 효소)가 있어 알콜을 아세트알데히드로 산화시키고, 아세트알데히드는 간세포에 있는 아세트알데히드 탈수소화 효소에 의해 초산으로 분해되어 전신의 근육이나 지방조직으로 옮겨진 후, 최종적으로 탄산가스와 물로 분해된다. 간에서 대사되지 않은 알코올은 혈중에 남아있다가 호흡기, 피부 또는 소변으로 배출된다. 알코올은 섭취량이나 혈중 농도에 관계없이 매 시간당 일정량만 대사되며, 알코올의 대사에 관여하는 효소의 역가나 농도는 각 개인의 유전적인 정도나 환경적인 요인에 의해 결정되며, 각 개인의 성별, 연령, 체중, 영양상태 및 신체 조건에 따라 영향을 받게 된다.Drinking opportunities are increasing day by day for modern people who have a lot of stress and have frequent dinners and entertainment. Alcohol paralyzes the inhibitory center of the brain and shows an excitement when ingested. It suppresses consciousness and movement, and has sleep and anesthetic effects, and is used as a major favorite food for relieving stress in modern people. When alcohol is introduced into the body during normal alcohol metabolism, it is absorbed in the gastrointestinal tract by the characteristics of alcohol that is well soluble in water, and distributed through the bloodstream to each body tissue including the brain and liver. Hepatocytes contain alcohol dehydrogenase (alcohol degrading enzyme) that oxidizes alcohol to acetaldehyde, and acetaldehyde is decomposed into acetic acid by the acetaldehyde dehydrogenase in hepatocytes and transferred to muscle or adipose tissue throughout the body, and finally It is decomposed into carbon dioxide and water. Alcohol, which is not metabolized by the liver, remains in the blood and is excreted into the respiratory tract, skin, or urine. Alcohol is metabolized in a certain amount per hour regardless of intake or blood concentration, and the titer or concentration of enzymes involved in alcohol metabolism is determined by each individual's genetic degree or environmental factors, and each individual's sex, age, and It is affected by weight, nutritional status and physical condition.

한편 아세트알데히드 탈수소화 효소에는 아세트알데히드가 저농도이더라도 산화를 개시하는 Ⅱ형과 아세트알데히드가 고농도로 되지 않으면 작용을 하지 않은 Ⅰ형이 있다. 동양인은 일반적으로 Ⅱ형 아세트알데히드효소가 결핍 또는 부족하기 때문에 아세트알데히드의 산화가 느리며 산화되지 아니한 아세트알데히드 및/또는 알코올의 독성에 의하여 정상적인 신진대사가 방해받아 여러 숙취 현상을 느끼게 된다. 이와 같이 음주는 일시적으로 두근거림, 두통, 갈증, 멀미, 위장장애, 설사 등의 숙취현상을 유발하며, 중독증으로 발전할 수도 있고, 뇌 등의 중추 신경계 뿐 아니라 소화기관 및 간 등의 대사기관도 손상시키는 문제가 있다. 최근들어, 알코올 및 알코올 대사물의 독성을 경감시키거나 독성의 발현을 저해하는 것에 의해 알코올이 인체에 미치는 영향을 최소화할 수 있는 물질들에 대한 연구와 실험이 진행되고 있다. On the other hand, in acetaldehyde dehydrogenase, there are Type II, which initiates oxidation even at low concentrations of acetaldehyde, and Type I, which does not work unless acetaldehyde is at a high concentration. Asians generally lack or lack type Ⅱ acetaldehyde enzyme, so the oxidation of acetaldehyde is slow, and normal metabolism is disturbed by the toxicity of unoxidized acetaldehyde and/or alcohol, causing various hangovers. In this way, drinking alcohol temporarily induces hangover phenomena such as palpitations, headache, thirst, motion sickness, gastrointestinal disorders, and diarrhea, and may develop into addiction, and metabolic organs such as the digestive system and liver as well as the central nervous system such as the brain There is a damaging problem. In recent years, research and experiments on substances that can minimize the effect of alcohol on the human body by reducing the toxicity of alcohol and alcohol metabolites or inhibiting the expression of toxicity have been conducted.

KR 공개특허 10-2011-0129534(발명의 명칭 : 숙취 해소용 음료 조성물)에서는 홍삼추출물, 혼합과일추출물 및 혼합식물추출물을 포함하는 숙취 해소용 음료 조성물을 제공하고 있고, KR Patent Publication 10-2011-0129534 (name of the invention: drink composition for relieving hangover) provides a beverage composition for relieving hangovers, including red ginseng extract, mixed fruit extract, and mixed plant extract,

KR 공개특허 10-2000-0071310(발명의 명칭 : 천연 생약제 추출물을 포함하는 숙취해소용 조성물 및 이를 유효성분으로 함유하는 건강보조식품)호에서는 두충, 홍삼, 결명자 및 황연 추출물 등을 포함하는 숙취해소용 음료 조성물을 제공하고 있으며, In KR Patent Publication No. 10-2000-0071310 (Name of the invention: a hangover relief composition containing a natural herbal extract and a health supplement containing the same as an active ingredient), hangovers including headworm, red ginseng, Cassia tora and Hwangyeon extract, etc. We provide a beverage composition for use,

KR 공개특허 10-2002-0079429(발명의 명칭 : 숙취해소용 조성물)호에서는 아스파라거스, 녹차, 양파 및 매실 추출물 등을 포함하는 숙취해소용 음료 조성물을 제공하고 있다.KR Patent Publication No. 10-2002-0079429 (name of the invention: hangover relief composition) provides a hangover relief beverage composition including asparagus, green tea, onion and plum extracts.

상기 숙취 해소용 음료 조성물은 뛰어난 숙취 해소 효과를 나타내나 그 맛이 매우 떫고, 홍삼, 아스파라거스 또는 밀크씨슬 등 고가의 원료를 포함하고 있어, 제품 양산 과정에서 비용 부담이 증가하는 문제가 존재한다.The hangover-relieving beverage composition exhibits an excellent hangover-relieving effect, but its taste is very astringent, and contains expensive raw materials such as red ginseng, asparagus, or milk thistle, so there is a problem that the cost burden increases in the mass production process of the product.

본 명세서 전체에 걸쳐 다수의 논문 및 특허문헌이 참조되고 그 인용이 표시되어 있다. 인용된 논문 및 특허문헌의 개시 내용은 그 전체로서 본 명세서에 참조로 삽입되어 본 발명이 속하는 기술 분야의 수준 및 본 발명의 내용이 보다 명확하게 설명된다. Throughout this specification, a number of papers and patent documents are referenced and citations are indicated. The disclosure contents of the cited papers and patent documents are incorporated by reference in this specification as a whole, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly described.

본 발명자들은 저렴한 가격에 제조가 가능하면서도 숙취해소 능력이 탁월한 숙취해소용 초코렛칩을 개발하고자 예의 연구 노력하였다. 그 결과, 지구자, 소화제 조성물, 단백질분해효소 조성물 및 비타민을 혼합하여 숙취해소용 초코렛칩을 제조할 경우 기호성이 탁월하고, 숙취해소 효과가 현저하며, 기존의 숙취해소음료 조성물에 비해 저렴한 가격에 숙취해소용 초코렛칩을 제조할 수 있다는 사실을 발견하여 본 발명을 완성하였다.The present inventors have tried to develop a hangover-relieving chocolate chip that can be manufactured at a low price and has excellent hangover-relieving ability. As a result, when preparing chocolate chips for hangover relief by mixing the earth ruler, digestive agent composition, proteolytic enzyme composition and vitamins, the palatability is excellent, the hangover relief effect is remarkable, and at a lower price than the existing hangover drink composition. The present invention was completed by discovering that it is possible to manufacture chocolate chips for relieving hangovers.

따라서 본 발명의 목적은 지구자를 포함하는 알콜성 치매 예방용 초코렛칩을 제공하는데 있다.Accordingly, an object of the present invention is to provide a chocolate chip for preventing alcoholic dementia, including a terrestrial character.

본 발명의 다른 목적 및 이점은 하기의 발명의 상세한 설명, 청구범위 및 도면에 의해 보다 명확하게 된다.Other objects and advantages of the present invention will become more apparent by the following detailed description, claims and drawings.

본 발명은 초코렛칩을 제공한다.The present invention provides a chocolate chip.

본 발명자들은 저렴한 가격에 제조가 가능하면서도 숙취해소 능력이 탁월한 숙취해소용 초코렛칩을 개발하고자 예의 연구 노력하였다. 그 결과, 지구자, 소화제 조성물, 단백질분해효소 조성물 및 비타민을 혼합하여 숙취해소용 초코렛칩을 제조할 경우 기호성이 탁월하고, 숙취해소 효과가 현저하며, 기존의 숙취해소음료 조성물에 비해 저렴한 가격에 숙취해소용 초코렛칩을 제조할 수 있다는 사실을 확인하였다.The present inventors have tried to develop a hangover-relieving chocolate chip that can be manufactured at a low price and has excellent hangover-relieving ability. As a result, when preparing chocolate chips for hangover relief by mixing the earth ruler, digestive agent composition, proteolytic enzyme composition and vitamins, the palatability is excellent, the hangover relief effect is remarkable, and at a lower price than the existing hangover drink composition. It was confirmed that chocolate chips for hangover relief can be manufactured.

본 발명의 일 양태에 따르면, 본 발명은 총 중량을 기준으로 지구자 추출물, 상기 지구자 추출물 100 중량부를 기준으로 50 중량부 내지 100 중량부의 소화제 조성물, 20 중량부 내지 30 중량부의 단백질분해효소 조성물 및 1 중량부 내지 5 중량부의 비타민을 포함하는 혼합물 5-20 중량%를 포함하는 지구자를 포함하는 알콜성 치매 예방용 아이스크림을 제공한다.According to one aspect of the present invention, the present invention is based on the total weight of the extract, 50 parts by weight to 100 parts by weight of the digestive agent composition based on 100 parts by weight of the extract, 20 parts by weight to 30 parts by weight of the protease composition And it provides an alcoholic dementia prevention ice cream comprising a terrestrial containing 5-20% by weight of a mixture containing 1 to 5 parts by weight of vitamins.

본 명세서에서 사용하는 용어‘지구자’는 갈매나무과의 헛개나무(Hovenia dulcis Thunb.)의 과병을 가진 열매 또는 씨를 의미할 수 있다.The term “earth” used in the present specification may refer to a fruit or seed of the Hovenia dulcis Thunb.

본 명세서에서 사용하는 용어‘창출’은 삽주의 뿌리 열매를 의미할 수 있다.The term “changchul” used herein may mean the root fruit of sapju.

본 명세서에서 사용하는 용어‘진피’는 운향과의 귤(Citrus unshiu Markovich) 또는 동속 근연식물의 성숙한 과피를 의미할 수 있다.The term “dermis” used herein may refer to Citrus unshiu Markovich or a mature pericarp of a plant close to the genus.

본 명세서에서 사용하는 용어‘갈화’는 칡 Pueraria lobata Ohwi (콩과 Leguminosae)의 꽃봉오리 또는 막 피기 시작한 꽃을 의미할 수 있다.The term “galhwa” used in the present specification may refer to a bud of arrowroot Pueraria lobata Ohwi (Leguminosae) or a flower that has just started to bloom.

본 명세서에서 사용하는 용어‘감초’는 쌍떡잎식물 장미목 콩과의 여러해살이 약용식물을 의미할 수 있다.The term “licorice” used herein may mean a perennial medicinal plant of the dicotyledonous plant rosewood leguminous family.

본 명세서에서 사용하는 용어‘감미료’단맛을 느끼게 하는 조미료 및 식품첨가물을 의미할 수 있다.The term “sweetener” used herein may mean seasonings and food additives that make you feel sweet.

본 명세서에서 사용하는 용어‘조미료’는 음식을 만드는 주재료인 식품에 첨가해서 음식의 맛을 돋우며 조절하는 물질을 의미할 수 있다.The term “seasoning” used in the present specification may mean a substance that enhances and controls the taste of food by adding it to food, which is a main ingredient for making food.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 지구자는 바람직하게는 헛개나무의 열매일 수 있고, 가장 바람직하게는 발효된 헛개나무 열매일 수 있다.According to a preferred embodiment of the present invention, the earth jaw of the present invention may preferably be a fruit of a birch tree, and most preferably a fermented fruit of a birch tree.

여기서, 발효된 지구자를 사용하면, 발효 지구자의 항산화 효과가 일반적인 지구자의 항산화 효과에 비해 월등하여 다량의 알코올 섭취에 따른 장기 손상을 방지하는 것은 물론, 지구자의 쓴맛을 현저히 감소시켜 숙취해소음료 조성물 또는 숙취해소용 차의 풍미를 비약적으로 증가시킬 수 있기 때문이다. Here, when the fermented sprouts are used, the antioxidant effect of the fermented sprouts is superior to that of general sprouts, preventing organ damage caused by ingestion of large amounts of alcohol, as well as remarkably reducing the bitter taste of the sprouts to relieve hangovers or This is because it can dramatically increase the flavor of hangover tea.

실제로 발효 지구자를 사용하여 숙취해소음료 조성물을 제조할 경우, 발효되지 않은 지구자를 사용하여 숙취해소음료 조성물을 제조하는 것과 비교하여, 맛은 1.5 배, 혈중 알코올 농도 저해 효과는 1.2 배 증가하는 것을 확인할 수 있었다.In fact, when manufacturing a hangover-relieving beverage composition using a fermented sprout, compared to manufacturing a hangover-relieving beverage composition using a non-fermented sprout, it was confirmed that the taste increased 1.5 times and the effect of inhibiting blood alcohol concentration increased 1.2 times. Could

상기 발효된 지구자를 제조하는 것은 매우 간단하다. 준비한 지구자를 물에 세척하여 표면에 붙은 흙 따위의 이물질을 제거하고, 분쇄기를 이용하여 분쇄한 이후, 상기 절단한 지구자, 당원 및 유산균 혼합액(수원시 농업기술센터 제공)을 혼합하여 질그릇 입 큰 항아리에 넣고 한지로 봉한 뒤 뚜껑을 덮고, 숙성시켜 제조할 수 있다. It is very simple to prepare the fermented Earth. Washing the prepared earthenware with water to remove foreign matters such as soil attached to the surface, and pulverizing it using a grinder, and then mixing the cut earther, sugar source, and lactic acid bacteria mixture (provided by the Suwon Agricultural Technology Center), and a large earthenware jar It can be prepared by putting it in and sealing it with Korean paper, covering it with a lid, and aging it.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 당원은 바람직하게는 설탕, 꿀, 올리고당, 포도당 및 조청을 포함하는 군으로부터 선택될 수 있고, 보다 바람직하게는 꿀 또는 설탕일 수 있으며, 가장 바람직하게는 설탕일 수 있다. 포도당을 이용하여 발효를 진행할 경우 발효는 잘 진행되나, 풍미가 떨어지는 문제가 있고, 꿀을 이용하여 발효를 진행할 경우 완성된 결과물의 풍미는 뛰어나나, 발효가 잘 진행되지 않아, 약효가 떨어지는 문제가 있기 때문이다.According to a preferred embodiment of the present invention, the saccharide source of the present invention may be preferably selected from the group containing sugar, honey, oligosaccharide, glucose, and jocheong, more preferably honey or sugar, and most preferably Can be sugar. When fermentation is performed using glucose, the fermentation proceeds well, but there is a problem that the flavor is poor. When fermentation is performed using honey, the flavor of the finished product is excellent, but the fermentation does not proceed well, so there is a problem that the medicinal effect is poor. Because there is.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 당원은 상기 지구자 100 중량부에 대해 바람직하게는 50 중량부 내지 200 중량부를 혼합할 수 있고, 보다 바람직하게는 70 중량부 내지 150 중량부를 혼합할 수 있으며, 가장 바람직하게는 90 중량부 내지 110 중량부를 혼합할 수 있다.According to a preferred embodiment of the present invention, the sugar source of the present invention may preferably be mixed with 50 parts by weight to 200 parts by weight, and more preferably 70 parts by weight to 150 parts by weight, based on 100 parts by weight of the earth. It may be, and most preferably 90 parts by weight to 110 parts by weight may be mixed.

상기 당원을 50 중량부 미만으로 포함시킬 경우 발효가 잘 진행되지 않는 문제가 있고, 200 중량부를 초과하여 포함시킬 경우 완성된 결과물의 당도가 높아지는 문제가 있다.When the sugar source is included in an amount of less than 50 parts by weight, fermentation does not proceed well, and when it is included in an amount exceeding 200 parts by weight, the sugar content of the finished product is increased.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 유산균 혼합액은 상기 지구자 100 중량부에 대해 바람직하게는 1 중량부 내지 100 중량부를 첨가할 수 있고, 보다 바람직하게는 5 중량부 내지 50 중량부 첨가할 수 있으며, 가장 바람직하게는 8-15 중량부 첨가할 수 있다.According to a preferred embodiment of the present invention, the lactic acid bacteria mixture of the present invention may preferably be added in an amount of 1 to 100 parts by weight, more preferably 5 to 50 parts by weight, based on 100 parts by weight of the earth character. It can be, and most preferably, 8-15 parts by weight may be added.

상기 유산균 혼합액을 1 중량부 미만으로 포함시킬 경우 발효가 잘 진행되지 않는 문제가 있고, 100 중량부를 초과하여 포함시킬 경우 발효 효율이 증가하지 않는 문제가 존재한다.When the lactic acid bacteria mixture is included in an amount of less than 1 part by weight, there is a problem that fermentation does not proceed well, and when it is included in an amount exceeding 100 parts by weight, there is a problem that fermentation efficiency does not increase.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 유산균은 바람직하게는 락토바실러스 불가리쿠스(L. bulgarcus), 락토바실러스 애시도필러스(L. acidophilus), 락토바실러스 델브리키(L. delbrichii), 락토바실러스 카제이(L. casei), 락토바실러스 플란타룸(L. plantarum), 락토바실러스 비피더스(L. bifidus), 락토바실러스 김치(L. kimchii), 스트렙토코쿠스 패칼리스(S. faecalis), 스트렙토코쿠스 락티스(S. lactis), 페디오코쿠스 소이아에(P. soyae) 및 페디오코쿠스 펜토사케우스(P. pentosaceus)를 포함하는 군으로부터 선택될 수 있고, 보다 바람직하게는 락토바실러스 김치 또는 락토바실러스 비피더스일 수 있으며, 가장 바람직하게는 락토바실러스 비피더스일 수 있다.According to a preferred embodiment of the present invention, the lactic acid bacteria of the present invention are preferably Lactobacillus bulgarcus (L. bulgarcus), Lactobacillus acidophilus (L. acidophilus), Lactobacillus delbrichii (L. delbrichii), Lactobacillus casei, L. plantarum, L. bifidus, Lactobacillus kimchi, S. faecalis, Streptococcus lactis (S. lactis), Pediococcus soyae (P. soyae) and Pediococcus pentosaceus (P. pentosaceus) may be selected from the group containing, more preferably Lactobacillus. It may be kimchi or Lactobacillus bifidus, most preferably Lactobacillus bifidus.

락토바실러스 비피더스를 이용하여 지구자 발효물을 제조할 경우 다른 유산균주를 사용하는 것에 비해 영양학적으로 우수할 뿐만 아니라, 완성된 조성물의 풍미를 보다 좋게 만들 수 있는 장점이 있다.When preparing a fermented product using Lactobacillus bifidus, it is not only excellent nutritionally compared to using other lactic acid strains, but also has the advantage of making the flavor of the finished composition better.

본 발명의 바람직한 양태에 따르면, 상기 발효 시 발효 온도는 바람직하게는 15-40℃일 수 있고, 가장 바람직하게는 20-30℃일 수 있으며, 가장 바람직하게는 22-27℃일 수 있다. 발효 온도가 40℃를 초과할 경우 발효가 급격하게 진행되어, 완성된 조성물에 쓴 맛이 날 수 있는 문제가 있고, 15℃ 미만일 경우 발효가 잘 진행되지 않는 문제가 존재할 수 있다.According to a preferred embodiment of the present invention, the fermentation temperature during the fermentation may be preferably 15-40°C, most preferably 20-30°C, and most preferably 22-27°C. If the fermentation temperature exceeds 40°C, fermentation proceeds rapidly, and there may be a problem in that the finished composition may have a bitter taste, and if it is less than 15°C, there may be a problem that fermentation does not proceed well.

본 발명의 바람직한 양태에 따르면, 상기 발효 시 발효 기간은 바람직하게는 7일 내지 12 개월일 수 있고, 보다 바람직하게는 1-6 개월일 수 있으며, 가장 바람직하게는 2-3개월일 수 있다. 발효 기간이 12 개월을 초과할 경우 완성된 조성물의 색도가 좋지 않고, 완성된 조성물에 쓴 맛이 날 수 있는 문제가 있고, 발효 기간이 7일 미만일 경우 발효가 잘 진행되지 않는 문제가 존재한다.According to a preferred embodiment of the present invention, the fermentation period during the fermentation may be preferably 7 days to 12 months, more preferably 1-6 months, and most preferably 2-3 months. If the fermentation period exceeds 12 months, the color of the finished composition is not good, there is a problem that the finished composition may have a bitter taste, and if the fermentation period is less than 7 days, there is a problem that fermentation does not proceed well.

본 명세서에서 혼합 약재 추출물을 언급하면서 사용되는 용어 “추출물”은 상기 언급한 혼합 약재의 잎 및/또는 줄기에 추출용매를 처리하여 얻은 추출 결과물뿐만 아니라 상기 혼합 약재의 잎 및/또는 줄기 자체를 섭취할 수 있도록 제형화(예컨대, 분말화)된 가공물도 포함하는 의미를 갖는다.The term “extract” used while referring to the mixed medicinal extract in this specification refers to the extract result obtained by treating the leaves and/or stems of the aforementioned mixed medicinal material with an extraction solvent, as well as the leaves and/or the stem itself of the mixed medicinal material. It is meant to include a processed product formulated (eg, powdered) to be able to do so.

만일, 본 발명의 조성물에서 이용되는 추출물을 상기 혼합 약재의 잎 및/또는 줄기에 추출용매를 처리하여 얻는 경우에는, 다양한 추출용매가 이용될 수 있다. 바람직하게는, (a) 물, (b) 탄소수 1-4의 무수 또는 함수 저급 알코올 (예: 메탄올, 에탄올, 프로판올, 부탄올, 노말-프로판올, 이소-프로판올 및 노말-부탄올 등), (c) 상기 저급 알코올과 물과의 혼합용매, (d) 아세톤, (e) 에틸 아세테이트, (f) 클로로포름, (g) 1,3-부틸렌글리콜, (h) 헥산, (i) 디에틸에테르, 또는 (j) 부틸아세테이트를 식물에 처리하여 추출물을 얻을 수 있다. If the extract used in the composition of the present invention is obtained by treating the leaves and/or stems of the mixed medicine with an extraction solvent, various extraction solvents may be used. Preferably, (a) water, (b) an anhydrous or hydrous lower alcohol having 1-4 carbon atoms (e.g. methanol, ethanol, propanol, butanol, normal-propanol, iso-propanol and normal-butanol, etc.), (c) A mixed solvent of the lower alcohol and water, (d) acetone, (e) ethyl acetate, (f) chloroform, (g) 1,3-butylene glycol, (h) hexane, (i) diethyl ether, or (j) An extract can be obtained by treating the plant with butyl acetate.

본 명세서에서 사용되는 용어 “추출물”은 상술한 바와 같이 당업계에서 조추출물(crude extract)로 통용되는 의미를 갖지만, 광의적으로는 추출물을 추가적으로 분획(fractionation)한 분획물도 포함한다. 즉, 혼합 약재의 잎 및/또는 줄기 추출물은 상술한 추출용매를 이용하여 얻은 것뿐만 아니라, 여기에 정제과정을 추가적으로 적용하여 얻은 것도 포함한다. 예컨대, 상기 추출물을 일정한 분자량 컷-오프 값을 갖는 한외 여과막을 통과시켜 얻은 분획, 다양한 크로마토그래피(크기, 전하, 소수성 또는 친화성에 따른 분리를 위해 제작된 것)에 의한 분리 등, 추가적으로 실시된 다양한 정제 방법을 통해 얻어진 분획도 본 발명의 혼합 약재의 잎 및/또는 줄기 추출물에 포함되는 것이다.As used herein, the term "extract" has the meaning commonly used as a crude extract in the art as described above, but broadly includes a fraction obtained by further fractionating the extract. That is, the leaf and/or stem extract of the mixed medicinal material includes not only those obtained using the above-described extraction solvent, but also those obtained by additionally applying a purification process thereto. For example, fractions obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatography (made for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through the purification method are also included in the leaf and/or stem extract of the mixed medicine of the present invention.

본 발명에서 이용되는 혼합 약재의 잎 및/또는 줄기 추출물은 감압 증류 및 동결 건조 또는 분무 건조 등과 같은 추가적인 과정에 의해 분말 상태로 제조될 수 있다.The leaf and/or stem extract of the mixed medicine used in the present invention may be prepared in a powder state by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 감미료는 액상과당 및 스테비오사이드일 수 있고, 상기 액상과당은 숙취해소음료 조성물 총 중량을 기준으로 바람직하게는 5-20 중량% 포함할 수 있고, 가장 바람직하게는 9-12 중량% 포함할 수 있다.According to a preferred embodiment of the present invention, the sweetener of the present invention may be liquid fructose and stevioside, and the liquid fructose may preferably contain 5-20% by weight based on the total weight of the hangover-relieving beverage composition. It may preferably contain 9-12% by weight.

상기 액상과당을 5 중량% 미만으로 포함할 경우 음용자에게 숙취해소음료 조성물의 쓴맛이 강하게 느껴질 수 있고, 20 중량%를 초과하여 포함할 경우 단맛이 너무 강하게 나는 문제가 존재한다.When the liquid fructose is included in an amount of less than 5% by weight, the bitter taste of the hangover-relieving beverage composition may be strongly felt by the drinker, and when it is included in more than 20% by weight, there is a problem that the sweet taste is too strong.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 소화제 조성물은 바람직하게는 창출 열수 추출물 및 진피 열수 추출물의 혼합물일 수 있다.According to a preferred embodiment of the present invention, the extinguishing agent composition of the present invention may preferably be a mixture of a hot water extract and a hot water extract of the dermis.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 단백질분해효소 조성물은 바람직하게는 갈화 열수 추출물 및 감초 열수 추출물의 혼합물일 수 있다.According to a preferred embodiment of the present invention, the proteolytic enzyme composition of the present invention may preferably be a mixture of hot water extract and hot water licorice extract.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 비타민은 바람직하게는 비타민B12일 수 있다.According to a preferred embodiment of the present invention, the vitamin of the present invention may preferably be vitamin B12.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 조성물은 바람직하게는 5-10 중량%의 포도당을 추가적으로 포함할 수 있다.According to a preferred embodiment of the present invention, the composition of the present invention may additionally contain 5-10% by weight of glucose.

본 발명의 바람직한 양태에 따르면, 본 발명의 상기 감미료 및 조미료는 바람직하게는 액상과당, 구연산, 비타민C, 스테비오사이드 및 합성착향료를 포함하는 군으로부터 선택될 수 있다.According to a preferred embodiment of the present invention, the sweetener and seasoning of the present invention may be preferably selected from the group containing liquid fructose, citric acid, vitamin C, stevioside and synthetic flavoring.

본 발명의 특징 및 이점을 요약하면 다음과 같다: The features and advantages of the present invention are summarized as follows:

(a) 본 발명은 총 중량을 기준으로 지구자 추출물, 상기 지구자 추출물 100 중량부를 기준으로 50 중량부 내지 100 중량부의 소화제 조성물, 20 중량부 내지 30 중량부의 단백질분해효소 조성물 및 1 중량부 내지 5 중량부의 비타민을 포함하는 혼합물 5-20 중량%를 포함하는 지구자를 포함하는 알콜성 치매 예방용 초코렛칩을 제공한다.(a) The present invention is based on the total weight of the extract, 50 parts by weight to 100 parts by weight of the digestive agent composition, 20 parts by weight to 30 parts by weight of the protease composition and 1 part by weight based on 100 parts by weight of the extract It provides a chocolate chip for preventing alcoholic dementia containing 5-20% by weight of a mixture containing 5 parts by weight of vitamins.

(b) 본 발명의 지구자를 포함하는 알콜성 치매 예방용 초코렛칩은 기존의 숙취해소음료 조성물과 비교하여 알콜성 치매를 유의적으로 예방하고, 기호성이 탁월하며, 숙취해소 효과가 현저하며, 저렴한 가격에 숙취해소 초코렛칩을 제조할 수 있는 장점이 존재한다.(b) The chocolate chip for preventing alcoholic dementia comprising the earth character of the present invention significantly prevents alcoholic dementia compared to the existing hangover relief beverage composition, has excellent palatability, has remarkable hangover relief effect, and is inexpensive. There is an advantage of being able to manufacture hangover-relieving chocolate chips at a price.

도 1은 본 발명인 알콜성 치매 예방용 초코렛칩의 단면을 나타낸다.1 is a cross-sectional view of a chocolate chip for preventing alcoholic dementia according to the present invention.

이하, 실시예를 통하여 본 발명을 더욱 상세히 설명 하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로서, 본 발명의 요지 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에게 있어서 자명할 것이다. Hereinafter, the present invention will be described in more detail through examples. These examples are only for describing the present invention in more detail, and that the scope of the present invention is not limited by these examples according to the gist of the present invention, for those of ordinary skill in the art to which the present invention belongs. It will be self-evident.

실시예Example

본 명세서 전체에 걸쳐, 특정 물질의 농도를 나타내기 위하여 사용되는 “%“는 별도의 언급이 없는 경우, 고체/고체는 (중량/중량) %, 고체/액체는 (중량/부피) %, 그리고 액체/액체는 (부피/부피) %이다.Throughout this specification, the “%” used to indicate the concentration of a specific substance is (weight/weight)% for solids/solids, (weight/volume)% for solids/liquids, and Liquid/liquid is (vol/vol) %.

제조예Manufacturing example

제조예 1 : 약재 추출물의 제조Preparation Example 1: Preparation of herbal extract

우선, 지구자, 창출, 진피, 갈화 및 감초 시료를 각각 1.0 kg 준비하였다. 상기 시료들 각각 중량대비 5배의 정제수에 넣고 105℃에서 5시간 가온 추출하였다. 추출공정이 종료되면 거름종이(Whatman paper No. 1)로 거르고, 0.45 ㎛의 멤브레인 필터(TF-450, 60173, PALL Life Sciences)로 재여과한 후 다음으로 물을 제거하기 위해 우선 회전 진공 증발기(Rotary vacuum evaporator)로 농축하고 이어서 동결 건조하는 방법을 사용하였다. 이로써 지구자 추출물 80.21 g, 창출 추출물 90.14 g, 진피 추출물 72.17 g, 갈화 추출물 69.82 g 및 감초 추출물 100.92 g을 수득하였다.First of all, 1.0 kg of samples of Earth Ja, Chang, dermis, brown flower and licorice were prepared. Each of the samples was put in purified water 5 times the weight of each of the samples and extracted by heating at 105°C for 5 hours. When the extraction process is finished, filter it with a filter paper (Whatman paper No. 1), filter it again with a 0.45 µm membrane filter (TF-450, 60173, PALL Life Sciences), and then first remove the water with a rotary vacuum evaporator ( Rotary vacuum evaporator), followed by freeze-drying. Thereby, 80.21 g of Earthworm extract, 90.14 g of creation extract, 72.17 g of dermis extract, 69.82 g of brown flower extract, and 100.92 g of licorice extract were obtained.

제조예 2 : 혼합 약재 추출물을 포함하는 한방차 제조Preparation Example 2: Preparation of herbal tea containing mixed herbal extracts

숙취해소에 탁월한 효과가 있고, 저렴한 가격에 제조가 가능하며, 음용 시 거부감 없는 풍미를 나타내는 숙취해소음료를 제조하기 위해 베이스 원료로 상술한 지구자 열수 추출물을 혼합 약재 추출물 중량기준 50% 사용하였다. 지구자는 비교적 저렴한 가격에 입수할 수 있고, 탁월한 숙취해소 및 해갈 효과가 있을 뿐만 아니라, 맛이 좋아 한국인의 입맛에 잘 맞는 숙취해소음료의 제조가 가능하여 이를 베이스 원료로 사용하였다. 상기 지구자 추출물을 베이스 원료로 창출, 진피, 갈화, 감초 추출물를 포함하는 군으로부터 선택된 최소 1종 이상의 추출물을 추가적으로 포함시켜 혼합 약재 추출물을 포함하는 한방차 조성물을 제조하는 실험을 150 회 이상 반복하였다. 맛 및 향을 기준으로, 현저히 쓰거나, 불쾌한 풍미를 나타내는 한방차 조성물은 혼합 약재 추출물 후보군에서 제외하였고, 직관적으로 우수한 풍미를 나타내는 한방차 조성물 5개를 선별하였으며, 구체적인 혼합 약재 추출물의 조성비는 하기 표 1과 같다. 한편, 상기 혼합 약재 추출물을 포함하는 한방차 조성물은 상기 혼합 약재 추출물 및 꿀을 중량기준 1 : 1 내지 2의 비율로 혼합한 이후 끓는 물을 적량 첨가한 후 교반하여 제조하였다.In order to produce a hangover-relieving beverage that has excellent effect on relieving hangovers, can be manufactured at an inexpensive price, and exhibits a taste without reluctance when drinking, 50% of the above-described hot water extract of Earth's japonica was used as a base material. Earthja is available at a relatively inexpensive price, has excellent hangover-relieving effects, and has good taste, making it possible to manufacture a hangover-relieving drink that suits the taste of Koreans, so it was used as a base material. The experiment was repeated more than 150 times to prepare an herbal tea composition comprising a mixed medicinal extract by additionally including at least one or more extracts selected from the group including the extract of the extract as a base material, dermis, brown flower, and licorice extract. Based on taste and aroma, the herbal tea composition showing remarkably bitter or unpleasant flavor was excluded from the mixed herbal extract candidate group, and five herbal tea compositions that intuitively exhibited excellent flavor were selected, and the composition ratio of the specific mixed herbal extract is shown in the following table. Same as 1. On the other hand, the herbal tea composition comprising the mixed medicinal extract was prepared by mixing the mixed medicinal extract and honey in a ratio of 1: 1 to 2 by weight, then adding an appropriate amount of boiling water and stirring.

실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 지구자Earth ruler 50%50% 50%50% 50%50% 50%50% 50%50% 창출Creation 18%18% -- 35%35% 18%18% 18%18% 진피dermis 17%17% 35%35% -- 17%17% 17%17% 갈화Galhwa 5%5% 5%5% 5%5% -- 10%10% 감초licorice 5%5% 5%5% 5%5% 10%10% --

제조예 3 : 혼합 약재 추출물을 포함하는 숙취해소음료 조성물의 제조Preparation Example 3: Preparation of a hangover-relieving beverage composition containing a mixed herbal extract

하기 표 2의 조성(중량기준)으로 상기 표 1에서 제조한 실시예 1 내지 실시예 5의 혼합 약재 추출물, 포도당, 구연산(결정), 비타민B12, 스테비오사이드, 허브향(합성착향료) 및 정제수를 혼합하여 하기 실시예 6 내지 실시예 10의 혼합 약재 추출물을 포함하는 숙취해소음료 조성물을 제조하였다.In the composition (by weight) of Table 2, the mixed herbal extracts of Examples 1 to 5 prepared in Table 1, glucose, citric acid (crystal), vitamin B12, stevioside, herbal flavor (synthetic flavor) and purified water By mixing to prepare a hangover-relieving beverage composition comprising the mixed herbal extracts of Examples 6 to 10.

실시예 6Example 6 실시예 7Example 7 실시예 8Example 8 실시예 9Example 9 실시예 10Example 10 실시예 1Example 1 14%14% 실시예 2Example 2 14%14% 실시예 3Example 3 14%14% 실시예 4Example 4 14%14% 실시예 5Example 5 14%14% 포도당glucose 11.0%11.0% 11.0%11.0% 11.0%11.0% 11.0%11.0% 11.0%11.0% 구연산Citric acid 0.38%0.38% 0.38%0.38% 0.38%0.38% 0.38%0.38% 0.38%0.38% 비타민CVitamin C 0.04%0.04% 0.04%0.04% 0.04%0.04% 0.04%0.04% 0.04%0.04% 스테비오사이드Stevioside 0.035%0.035% 0.035%0.035% 0.035%0.035% 0.035%0.035% 0.035%0.035% 합성착향료Synthetic flavoring agent 0.18%0.18% 0.18%0.18% 0.18%0.18% 0.18%0.18% 0.18%0.18% 정제수Purified water 74.35%74.35% 74.35%74.35% 74.35%74.35% 74.35%74.35% 74.35%74.35%

실험예Experimental example

실험예 1 : 관능평가Experimental Example 1: Sensory evaluation

실험예 1-1 : 혼합 약재 추출물을 포함하는 한방차의 관능평가Experimental Example 1-1: Sensory evaluation of herbal tea containing mixed medicinal extract

기호 평가에서는 상기 실시예 1 내지 실시예 5의 방법으로 제조한 혼합 약재 추출물을 포함하는 한방차의 풍미와 후각적 기호를 조사하였으며, 30명을 선정하여 해당 인원을 대상으로 하여 실시하였다. 상기 실시예 1 내지 실시예 5의 방법으로 제조한 혼합 약재 추출물을 포함하는 한방차를 그 대상으로 하여, 시식 후 1에서 10까지 10단계로 제조방법 별 처리구의 기호성을 평가하여 기록하게 하였다. 시식 시에는 상기 실시예 1 내지 실시예 5의 방법으로 제조한 혼합 약재 추출물을 포함하는 한방차 100 mL를 제공하였다. 기호성은 풍미와 후각적 특성 두 가지 요소로 분리하여 시식 및 기록하였다. 비교예로는 칡뿌리 추출물만을 포함하는 한방차 100 mL를 사용하였다.In the preference evaluation, the flavor and olfactory taste of herbal tea containing the mixed medicinal extract prepared by the method of Examples 1 to 5 were investigated, and 30 people were selected and carried out for the corresponding personnel. Herbal tea containing the mixed medicinal extract prepared by the method of Examples 1 to 5 was used as a target, and after tasting, the taste of each treatment group was evaluated and recorded in 10 steps from 1 to 10. At the time of tasting, 100 mL of herbal tea containing the mixed medicinal extract prepared by the method of Examples 1 to 5 was provided. The palatability was tasted and recorded by separating them into two factors: flavor and olfactory characteristics. As a comparative example, 100 mL of herbal tea containing only arrowroot extract was used.

실험 결과, 상기 실시예 1 내지 실시예 5의 방법으로 제조한 혼합 약재 추출물을 포함하는 한방차의 기호도는 하기 표 3과 같다. As a result of the experiment, the preference diagram of herbal tea containing the mixed medicinal extract prepared by the method of Examples 1 to 5 is shown in Table 3 below.

정리하자면 본 발명의 실시예 1, 실시예 3, 실시예 2, 실시예 4, 실시예 5 및 비교예의 방법으로 제조한 혼합 약재 추출물을 포함하는 한방차 순으로 풍미가 높게 평가되었으며, 후각적 기호성 측면에서도 상기 풍미 기호성 평가와 동일한 결과가 나왔다. 즉 두 측면의 답변 모두에서 실시예 1에 해당하는 시료가 가장 높은 선호도를 얻어냈으며, 그 수치에 있어서도 비교예와 비교하여 의미 있는 수준의 유의확률을 보였다. 이는 본 발명에서 제시하는 방식과 비율의 제조 방법이 기타 제조 방법에 비하여 뛰어난 효과를 가지고 있음을 입증한다. In summary, the flavor was highly evaluated in the order of herbal tea containing mixed herbal teas prepared by the method of Example 1, Example 3, Example 2, Example 4, Example 5 and Comparative Example of the present invention, and olfactory palatability From the side, the same results were obtained as in the flavor palatability evaluation. That is, the sample corresponding to Example 1 obtained the highest preference in both answers from both sides, and the numerical value also showed a significant level of significance compared to the comparative example. This proves that the method of manufacturing the method and ratio presented in the present invention has superior effects compared to other manufacturing methods.

위 결과를 바탕으로 판단하였을 때 본 발명에서 제시하는 제조 방법으로 제조한 한방차의 풍미 및 후각적 기호성이 다른 제조 방법에 의한 것에 비하여 월등히 향상되었음을 확인할 수 있었다. Judging on the basis of the above results, it was confirmed that the flavor and olfactory palatability of the herbal tea manufactured by the manufacturing method presented in the present invention was significantly improved compared to that of other manufacturing methods.

실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 비교예Comparative example 풍미zest 8.248.24 7.267.26 7.357.35 6.986.98 6.676.67 6.226.22 1.211.21 0.950.95 1.501.50 1.621.62 0.860.86 3.213.21 후각적 특성Olfactory traits 8.768.76 7.537.53 8.138.13 5.985.98 6.786.78 8.598.59 1.481.48 1.321.32 0.980.98 1.791.79 1.141.14 2.292.29

각 항목별 상단칸은 평균값, 하단칸은 그 표준편차For each item, the upper column is the mean value, and the lower column is its standard deviation

실험에 1-2 : 혼합 약재 추출물을 포함하는 숙취해소음료 조성물의 관능평가Experiment 1-2: Sensory evaluation of hangover relief beverage composition containing mixed herbal extracts

기호 평가에서는 상기 실시예 6 내지 실시예 10의 방법으로 제조한 숙취해소음료 조성물의 풍미와 후각적 기호를 조사하였으며, 30명을 선정하여 해당 인원을 대상으로 하여 실시하였다. 상기 실시예 6 내지 실시예 10의 방법으로 제조한 숙취해소음료 조성물을 그 대상으로 하여, 시식 후 1에서 10까지 10단계로 제조방법 별 처리구의 기호성을 평가하여 기록하게 하였다. 시식 시에는 상기 실시예 6 내지 실시예 10의 방법으로 제조한 숙취해소음료 조성물 100 mL를 제공하였다. 기호성은 풍미와 후각적 특성 두 가지 요소로 분리하여 시식 및 기록하였다. 비교예로는 약채 추출물로 지구자 추출물만을 포함하는 것을 제외하고는 상기 실시예 6 내지 실시예 10의 방법으로 제조한 숙취해소음료 조성물과 동일한 방법으로 제조한 숙취해소음료 조성물 100 mL를 사용하였다.In the preference evaluation, the flavor and olfactory taste of the hangover-relieving beverage composition prepared by the method of Examples 6 to 10 were investigated, and 30 people were selected and carried out for the corresponding personnel. The hangover-relieving beverage composition prepared by the method of Examples 6 to 10 was used as a target, and after tasting, the palatability of each treatment was evaluated and recorded in 10 steps from 1 to 10. At the time of tasting, 100 mL of a hangover relief beverage composition prepared by the method of Examples 6 to 10 was provided. The palatability was tasted and recorded by separating them into two factors: flavor and olfactory characteristics. As a comparative example, 100 mL of a hangover-relieving beverage composition prepared in the same manner as the hangover-relieving beverage composition prepared by the method of Examples 6 to 10 was used, except that the herbal extracts included only the extract of Earthquake.

실험 결과, 상기 실시예 6 내지 실시예 10의 방법으로 제조한 숙취해소음료 조성물의 기호도는 하기 표 4와 같다. As a result of the experiment, the preferences of the hangover relief beverage compositions prepared by the method of Examples 6 to 10 are shown in Table 4 below.

정리하자면 본 발명의 실시예 6, 실시예 8, 실시예 7, 실시예 9, 실시예 10 및 비교예의 방법으로 제조한 숙취해소음료 조성물 순으로 풍미가 높게 평가되었으며, 후각적 기호성 측면에서도 상기 풍미 기호성 평가와 동일한 결과가 나왔다. 즉 두 측면의 답변 모두에서 실시예 6에 해당하는 시료가 가장 높은 선호도를 얻어냈으며, 그 수치에 있어서도 비교예와 비교하여 의미 있는 수준의 유의확률을 보였다. 이는 본 발명에서 제시하는 방식과 비율의 제조 방법이 기타 제조 방법에 비하여 뛰어난 효과를 가지고 있음을 입증한다. In summary, the flavor was evaluated high in the order of hangover-relieving beverage compositions prepared by the methods of Examples 6, 8, 7, Example 9, Example 10, and Comparative Examples of the present invention. The same results as in palatability evaluation were obtained. That is, the sample corresponding to Example 6 obtained the highest preference in both answers from both sides, and the numerical value also showed a significant level of significance compared to the comparative example. This proves that the method of manufacturing the method and ratio presented in the present invention has superior effects compared to other manufacturing methods.

위 결과를 바탕으로 판단하였을 때 본 발명에서 제시하는 제조 방법으로 제조한 한방차의 풍미 및 후각적 기호성이 다른 제조 방법에 의한 것에 비하여 월등히 향상되었음을 확인할 수 있었다. Judging on the basis of the above results, it was confirmed that the flavor and olfactory palatability of the herbal tea manufactured by the manufacturing method presented in the present invention was significantly improved compared to that of other manufacturing methods.

실시예 6Example 6 실시예 7Example 7 실시예 8Example 8 실시예 9Example 9 실시예 10Example 10 비교예Comparative example 풍미zest 8.138.13 7.527.52 7.607.60 7.097.09 6.886.88 5.525.52 0.980.98 1.221.22 1.101.10 1.331.33 2.122.12 1.121.12 후각적 특성Olfactory traits 8.598.59 7.707.70 7.727.72 7.217.21 6.666.66 6.096.09 2.292.29 1.561.56 0.880.88 2.072.07 1.361.36 1.041.04

각 항목별 상단칸은 평균값, 하단칸은 그 표준편차For each item, the upper column is the mean value, and the lower column is its standard deviation

실험예 2 : 혈중 알코올 농도 평가Experimental Example 2: Evaluation of blood alcohol concentration

실험예 2-1 : 동물실험Experimental Example 2-1: Animal experiment

본 발명에 따른 상기 실시예 6의 숙취해소용음료 조성물의 알코올 분해 정도를 측정하기 위해 쥐를 이용한 혈중 알코올 농도의 감소 속도를 측정하였다. 이를 위하여 체중 200-250 g의 Sparague-Dawlay(SD)계 수컷 흰쥐 10마리를 5마리씩 두 군으로 나누고 각각 1일간 절식 후 실험 개시 30분전에 하나의 군에는 상기 실시예 6의 숙취해소용음료 조성물 100 mg/kg 생수에 현탁시켜 쥐들에 경구 투여하고, 다른 군에는 생수만을 동일한 양 투여하였다. 30분 후에 순수 에탄올을 증류수에 40 ㎎/ml 의 농도로 희석시켜 1 g/kg의 농도로 각군의 실험쥐들에게 경구 투여하였다. 이와 같이 알코올을 투여한 쥐들을 2시간 후에 폐로부터 0.7 ml의 혈액을 채취한 후 4℃에서 5000 rpm으로 10 분간 원심 분리하여 혈청을 분리하였다. 분리된 혈장액을 디지털 에탄올 농도계(Atago PET-109, Japan)를 이용해 혈액 내 알코올 농도를 측정하였으며, 그 결과를 하기 표 5에 나타내었다. 하기 표 5에서 확인할 수 있는 바와 같이 상기 실시예 6의 숙취해소용음료 조성물을 투여한 쥐들의 경우 알코올 농도가 현저하게 떨어짐을 확인할 수 있었다.In order to measure the degree of alcohol decomposition of the hangover relief beverage composition of Example 6 according to the present invention, the rate of decrease in blood alcohol concentration using mice was measured. To this end, 10 Sparague-Dawlay (SD) male rats weighing 200-250 g were divided into two groups of 5 mice each, and after each fasting for 1 day, 30 minutes before the start of the experiment, one group contained the hangover-relieving beverage composition of Example 6. It was suspended in 100 mg/kg mineral water and orally administered to mice, and the same amount of only mineral water was administered to the other groups. After 30 minutes, pure ethanol was diluted in distilled water to a concentration of 40 mg/ml and administered orally to the mice in each group at a concentration of 1 g/kg. As described above, after 2 hours of alcohol-administered rats, 0.7 ml of blood was collected from the lungs and then centrifuged for 10 minutes at 5000 rpm at 4°C to separate serum. The separated plasma liquid was measured for alcohol concentration in blood using a digital ethanol concentration meter (Atago PET-109, Japan), and the results are shown in Table 5 below. As can be seen in Table 5 below, it was confirmed that the alcohol concentration in the rats to which the hangover relief beverage composition of Example 6 was administered significantly decreased.

개체번호Individual number 에탄올농도(%w/v)Ethanol concentration (%w/v) 알코올 투여군Alcohol administration group 알코올 및 조성물 투여군Alcohol and composition administration group 1One 1.081.08 0.390.39 22 1.131.13 0.560.56 33 1.211.21 0.420.42 44 1.011.01 0.430.43 55 0.990.99 0.410.41

실험예 2-2 : 임상실험Experimental Example 2-2: Clinical experiment

개인에 따라 알콜 분해 능력이 다른 점을 감안하여, 개인별로 일주일 간격으로 각 알코올과 함께 각 조성물을 섭취하고 음주측정을 하는 방법으로 실험을 실시하였다. 30대 중반에서 40대 초반의 중년 남성 10명을 대상으로 하였으며, 이들의 평균 음주회수는 1주일 2회, 평균음주량은 소주(1병 360 mL) 2병이었다. 실험은 매주 수요일 실시하였으며 실험 전 2일(월, 화)간은 금주하도록 하였다. 기본 시료(대조구)로는 소주(360 ml, 19.5%)1병과 두부 154 g, 오이25 g, 김치 40 g을 30분에 걸쳐 섭취하도록 하였으며, 시식이 완료된 시점부터 음주측정기(센텍코리아, AL1102)를 사용하여 30분 간격으로 혈중 알코올 농도(%BAC)를 측정하고 그 결과를 하기 표 6에 나타냈다. 상기 실시예 6의 숙취해소용음료 조성물 100 mL는 상기 기본 시료의 섭취를 시작한 후 10분 후에 음용하였으며, 시료 이외의 음식이나 음료는 금지하고 음주 측정동안 행동도 자제하도록 하였다. 비교예로는 시판 숙취해소음료인 컨*션 100 mL를 음용시킨 후 음주측정을 실시하였다.In consideration of the difference in alcohol decomposition ability between individuals, the experiment was conducted by ingesting each composition with each alcohol at weekly intervals for each individual and measuring alcohol consumption. Ten middle-aged men in their mid-30s to early 40s were targeted, and their average drinking frequency was 2 times a week, and the average amount of drinking was 2 bottles of soju (1 bottle 360 mL). The experiment was conducted every Wednesday, and he was allowed to stop drinking for 2 days (Mon, Tuesday) before the experiment. As a basic sample (control), a bottle of soju (360 ml, 19.5%), 154 g of tofu, 25 g of cucumber, and 40 g of kimchi were consumed over 30 minutes. The blood alcohol concentration (%BAC) was measured at intervals of 30 minutes, and the results are shown in Table 6 below. 100 mL of the hangover-relieving beverage composition of Example 6 was drunk 10 minutes after the start of the intake of the basic sample, and food and beverages other than the sample were prohibited, and behavior during the drinking measurement was refrained. As a comparative example, alcohol consumption was measured after drinking 100 mL of a commercial hangover-relieving drink.

대조구Control 실시예 6Example 6 비교예Comparative example 시식완료직후Immediately after tasting 0.0890.089 0.0680.068 0.0760.076 30분 후30 minutes later 0.0910.091 0.0600.060 0.0710.071 60분 후60 minutes later 0.0830.083 0.0560.056 0.0660.066 90분 후90 minutes later 0.0770.077 0.0490.049 0.0590.059

상기 표 6에서 확인할 수 있는 바와 같이 상기 실시예 6의 숙취해소용음료 조성물은 초기 알코올 분해능력 뿐만 아니라, 지속적인 알코올 분해능력 또한 대조구 및 비교예와 비교하여 우수함을 알 수 있었다.As can be seen in Table 6, it was found that the hangover-relieving beverage composition of Example 6 was superior to the initial alcohol decomposition ability as well as the continuous alcohol decomposition ability compared to the control and comparative examples.

Claims (8)

총 중량을 기준으로 지구자 추출물, 상기 지구자 추출물 100 중량부를 기준으로 50 중량부 내지 100 중량부의 소화제 조성물, 20 중량부 내지 30 중량부의 단백질분해효소 조성물 및 1 중량부 내지 5 중량부의 비타민을 포함하는 혼합물 5-20 중량%를 포함하는
지구자를 포함하는 알콜성 치매 예방용 초코렛칩.
Based on the total weight of the extract, 50 parts by weight to 100 parts by weight of the digestive agent composition, 20 parts by weight to 30 parts by weight of the protease composition, and 1 part by weight to 5 parts by weight of vitamins based on 100 parts by weight of the extract Containing 5-20% by weight of the mixture
Chocolate chips for the prevention of alcoholic dementia including Earth's ruler
제 1 항에 있어서,
상기 추출물의 추출용매는 물, 에탄올, 메탄올, 메틸렌클로라이드, 에틸아세테이트, 부탄올, 헥산, 부틸렌글리콜, 클로로포름 및 이들의 혼합물을 포함하는 군으로부터 선택된 것을 특징으로 하는 지구자를 포함하는 알콜성 치매 예방용 초코렛칩.
The method of claim 1,
The extraction solvent of the extract is selected from the group containing water, ethanol, methanol, methylene chloride, ethyl acetate, butanol, hexane, butylene glycol, chloroform, and mixtures thereof. Chocolate chips.
제 2 항에 있어서,
상기 추출물의 추출용매는 물인 것을 특징으로 하는 알콜성 치매 예방용 초코렛칩.
The method of claim 2,
Chocolate chips for preventing alcoholic dementia, characterized in that the extraction solvent of the extract is water.
제 1 항에 있어서,
상기 소화제 조성물은 창출 열수 추출물 및 진피 열수 추출물의 혼합물인 것을 특징으로 하는 지구자를 포함하는 알콜성 치매 예방용 초코렛칩.
The method of claim 1,
The extinguishing agent composition is a chocolate chip for preventing alcoholic dementia comprising a terrestrial character, characterized in that the mixture of the hot water extract and the dermis hot water extract.
제 1 항에 있어서,
상기 단백질분해효소 조성물은 갈화 열수 추출물 및 감초 열수 추출물의 혼합물인 것을 특징으로 하는 지구자를 포함하는 알콜성 치매 예방용 초코렛칩.
The method of claim 1,
The proteolytic enzyme composition is a chocolate chip for preventing alcoholic dementia comprising a terrestrial character, characterized in that the mixture of hot water extract and licorice hot water extract.
제 1 항에 있어서,
상기 비타민은 비타민B12인 것을 특징으로 하는 지구자를 포함하는 알콜성 치매 예방용 초코렛칩.
The method of claim 1,
The vitamin is a chocolate chip for preventing alcoholic dementia comprising a terrestrial character, characterized in that vitamin B12.
제 1 항에 있어서,
상기 초코렛칩은 아이스크림부 및 상기 아이스크림부의 전부 또는 일부를 감싸고 있는 콘부를 포함하는 아이스크림 중 상기 아이스크림부에 포함된 것을 특징으로 하는 알콜성 치매 예방용 초코렛칩.
The method of claim 1,
The chocolate chip for preventing alcoholic dementia, wherein the chocolate chip is included in the ice cream unit among ice cream units including an ice cream unit and a cone unit surrounding all or part of the ice cream unit.
제 7 항에 있어서,
상기 아이스크림부에는 지구자 추출물을 포함하고, 상기 초코렛칩에는 소화제 조성물 및 단백질분해효소 조성물을 포함하는 것을 특징으로 하는 알콜성 치매 예방용 초코렛칩.
The method of claim 7,
The chocolate chip for preventing alcoholic dementia, characterized in that the ice cream unit includes a terrestrial extract, and the chocolate chip includes a digestive agent composition and a protease composition.
KR1020190043422A 2019-04-14 2019-04-14 Chocolate Chip for Preventing Alcoholic Dementia KR20200120997A (en)

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