KR20200091828A - Cosmetic composition for removing bruise, patch for removing bruise comprising the same and method for manufacturing the patch - Google Patents

Abstract

The present invention provides a cosmetic composition for reducing a bruise, which contains an aloe vera leaf extract as an active ingredient to provide effects of reducing a bruise and suppressing edema and a bruise reducing patch including the same. More specifically, the present invention provides a cosmetic composition for reducing a bruise, which comprises an aloe vera leaf extract, a licorice root extract, fat-soluble vitamins, a skin-whitening compound, a skin regeneration compound, Arnica Montana, mucopolysaccharide polysulfate, and the remainder of solvents, and a bruise reducing patch including the same, and a manufacturing method thereof. According to the present invention, the method comprises a porous supporter manufacturing step and an edema suppressing cosmetic composition application step.

Description

Cosmetic composition for removing bruise, patch for removing bruise comprising the same and method for manufacturing the patch}

The present invention relates to a cosmetic composition for removing a bruise containing an aloe vera leaf extract, a patch for removing a bruise containing the same, and a method of manufacturing the patch, more specifically, removing the bruise by containing the aloe vera leaf extract as an active ingredient and It relates to a cosmetic composition that can provide an effect of suppressing edema, a patch for removing a bruise comprising the same, and a method of manufacturing the patch.

The skin tissue located on the outermost part of the human body is composed of three layers of the epidermal and dermal subcutaneous layers. The skin tissue prevents the evaporation of moisture or regulates heat loss to maintain the homeostasis of the human body, or has Langerhans cells and melanocytes to protect the human body from immune function and ultraviolet rays. Furthermore, in recent years, it has been revealed that it has functions such as endocrine function and tissue remodeling, and thus the importance of the human body is gradually increasing.

As such, the skin not only plays a role in performing various functions essential to human health and life, but is also considered to be very important as a means to express beauty in appearance.

Recently, as women and men have increased interest in appearance, plastic surgery and procedures are increasing from double eyelid surgery or nose surgery, which has a relatively short recovery period, to jaw surgery, which takes a long recovery period. However, due to bruising and swelling that occurs after surgery or surgery, they suffer from the uncertainty of refraining from going out for a long time or covering with a mask. Since bruising and swelling disappear after a period of time, it is necessary to have time to spare, but since busy office workers and modern people do not have time to spare, there is a need for an external composition for skin that removes bruising and swelling quickly and quickly.

Accordingly, Korean Patent Publication No. 2010-0005538 discloses a composition for treating skin damage containing steroids, antihistamines and vasoconstrictors as an active ingredient, but has a disadvantage that it cannot be applied to patients sensitive to steroids or antihistamines. On the other hand, Korean Patent Registration No. 0971629 contains a mixture of Jeokhasu, Baeksusu, Jigolpi, Baekboknyeong, Geonjihwang, Sukjihwang, Cheonmun-dong, Macmun-dong, and Ginseng, followed by a steam increase to dry, and then contain a dry pharmaceutical mixture, a yeast composition, and a yeast composition. Although disclosed, there is no direct effect on bruising. Furthermore, Korean Patent Publication No. 2018-0097934 discloses a composition for external application for skin having an effect on removing a bruise, but has not reported a substantial effect of removing a bruise and discloses only a sensual effect.

Therefore, there is a need to develop a cosmetic composition that has a practical effect on removing and alleviating bruises and swelling while using non-drug-intensive drugs such as steroids.

The present invention provides an aloe vera leaf extract, and provides a cosmetic composition for removing a bruise having an effect of removing a bruise and suppressing edema.

The present invention provides a patch for removing a bruise comprising the cosmetic composition for removing the bruise.

The present invention provides a method for manufacturing the patch for removing the bruise.

According to one aspect of the present invention, the present invention includes aloe vera leaf extract, licorice extract, fat-soluble vitamins, whitening compounds, skin regeneration compounds, Arnica montana, Mucopolysaccharide Polysulfate and the residual solvent Provides a cosmetic composition for removing bruises.

According to another aspect of the present invention, there is provided a patch for removing a bruise comprising the cosmetic composition for removing a bruise of the present invention and a porous support containing the cosmetic composition.

According to another aspect of the present invention, the present invention comprises the steps of manufacturing a porous support in a melt-blown manner; Impregnating the porous support in a processing solution containing alcohols of C1 to C4; Performing mercerization by adding NaOH to the processing solution; Gelling the porous support by further adding monochloroacetic acid to the processing solution; And applying a cosmetic composition for removing bruises of the present invention to the gelled porous support.

Since the cosmetic composition and patch of the present invention use natural materials, there is a low risk of side effects on the skin, has an effect of removing and alleviating bruises, and can further obtain a cosmetic composition and patch having an effect of suppressing edema.

1 is a tissue biopsy (Skin Biopsy) of the tissue to which the cosmetic composition of Example 1 of the present invention is applied to the skin (right side of FIG. 1) and bruises and edema without applying anything (left side of FIG. 1) The image taken by the invasive skin measuring device (SkinDex 300, a skin measuring device) is shown.
FIG. 2 is a skin biopsy of the tissue in which the cosmetic composition of Example 1 of the present invention was applied to the skin (left side in FIG. 2) and the tissue in which the ointment in Comparative Example 1 was applied to the skin (right side in FIG. 2). The image taken by the invasive skin measuring device (SkinDex 300, a skin measuring device) is shown.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings. However, embodiments of the present invention may be modified in various other forms, and the scope of the present invention is not limited to the embodiments described below.

One embodiment of the present invention includes an extract obtained from aloe vera leaves, and provides a cosmetic composition effective in removing and alleviating bruising and swelling.

In detail, the present invention is an aloe vera leaf extract, licorice extract, fat-soluble vitamin, whitening compound, skin regeneration compound, Arnica montana, mucopolysaccharide polysulfate, and the remainder of the bruise cosmetic composition comprising a solvent Gives

The components may be included in the same weight, respectively, based on the total weight of the cosmetic composition, but the content can be adjusted according to the properties of each component.

Therefore, in detail, the present invention, the aloe vera leaf extract 0.001 to 10% by weight, the licorice extract 0.05 to 1.1% by weight, the fat-soluble vitamin 0.1 to 2.5% by weight, the whitening compound 0.1 to 2.8% by weight, for skin regeneration Provides 0.08 to 3.0% by weight of the compound, 6 to 10% by weight of the Arnica Montana, 0.05 to 1.2% by weight of the Mucopolysaccharide Polysulfate, and the remainder solvent do.

The aloe vera leaf extract is dried and pulverized aloe vera leaves at room temperature to obtain a pulverized product, and an aloe vera leaf extract is obtained from the crushed product using an extraction solvent. The extraction solvent may be, for example, an aqueous ethanol solution.

The aloe vera leaf extract contains 0.001 to 10% by weight, preferably 0.05 to 5% by weight based on the total weight of the cosmetic composition. The anthraquinone component (aloe emogene, aloin) and the polymer water-soluble substance (polysaccharide) possessed by aloe are added because they have the effect of promoting regeneration and moisturizing, and if the content of the aloe vera leaf extract is less than 0.001%, incomplete addition The effect cannot be expected, and if it exceeds 10% by weight, the price increases and there is a process problem that agitation with the formulation becomes difficult.

The licorice extract is added because it has antibacterial, anti-inflammatory and antioxidant effects due to the components of glycyrrhizine, polyphenol and gravridine. The licorice extract, based on the total weight of the cosmetic composition, comprises 0.05 to 1.1% by weight, preferably 0.6 to 1.1% by weight. When the content of the licorice extract is less than 0.05% by weight, an effect cannot be expected due to inadequate addition, and when it exceeds 1.1% by weight, side effects such as skin rash may be caused by fructose components.

Further, the fat-soluble vitamin may be at least one selected from vitamin K and vitamin E (tocopherol), for example, based on the total weight of the cosmetic composition, the vitamin K is 0.05 to 1.5% by weight, the vitamin E (tocopherol) ) May include 0.05 to 1.0% by weight.

At this time, the vitamin K promotes the formation of active prothrombin in the liver, improves blood clotting, and has an excellent effect in alleviating bruising. The vitamin K, based on the total weight of the cosmetic composition, comprises 0.05 to 1.5% by weight, preferably 0.07 to 0.2% by weight. If the content of the vitamin K is less than 0.05% by weight, there is a problem that the effect of vitamin K is insufficient, and when it exceeds 1.5% by weight, there is a side effect of redness, taste change, and swelling of the face or lips.

The vitamin E (tocopherol) inhibits the aging of cells by oxidation, has the effect of preventing blood clotting and dissolving blood clots. In other words, by increasing the number of red blood cells that carry oxygen by extending the lifespan of red blood cells, the oxygen content in the blood is increased, thereby providing sufficient oxygen to damaged areas of the wound or capillaries to solve problems caused by lipid peroxide. have. The vitamin E, based on the total weight of the cosmetic composition, comprises 0.05 to 1.0% by weight, preferably 0.5 to 1.0% by weight. If the content of vitamin E is less than 0.05% by weight, efficacy cannot be expected, and if it exceeds 1.0% by weight, side effects such as skin rash may occur.

In addition, the whitening compound may be at least one selected from arbutin and niacinamide, for example, based on the total weight of the cosmetic composition, the arbutin is 0.05 to 1.0% by weight, the niacinamide is 0.05 to 1.8% by weight It can contain.

At this time, the arbutin is added because it inhibits the activation of the melanin pigment and prevents pigmentation of the skin, thereby helping skin whitening. The arbutin comprises 0.05 to 1.0% by weight, preferably 0.5 to 1.0% by weight, based on the total weight of the cosmetic composition. If the content of arbutin is less than 0.05% by weight, efficacy cannot be expected, and if it exceeds 1.0% by weight, side effects such as vitiligo, skin allergies, and dermatitis may occur due to excessive arbutin, which is a component of arbutin, hydroquinone and glucose. May appear.

The niacinamide inhibits and reduces melanin migration from melanocytes to keratinocytes, thereby providing nutrition, oxidizing defense, whitening, normalizing sebum secretion, and improving trouble. The niacinamide comprises 0.05 to 1.8% by weight, preferably 0.8 to 1.8% by weight, based on the total weight of the cosmetic composition. If the content of the niacinamide is less than 0.05% by weight, efficacy cannot be expected, and when it exceeds 1.8% by weight, a side effect of increasing melanin cells that interfere with whitening may appear.

In addition, the skin regeneration compound may be at least one selected from vitamin C (ascorbic acid) and adenosine, for example, based on the total weight of the cosmetic composition, the vitamin C (ascorbic acid) is 0.05 to 1.2% by weight , The adenosine may include 0.03 to 1.8% by weight.

At this time, since the vitamin C (ascorbic acid, Asocorbic acid) blocks the damage caused by free radicals, wound healing and red blood cells are produced through reversible oxidation of ascorbic acid to dehydro ascorbic acid in the body along with the effect of healing the wound. It is added because it has the effect of promoting the regeneration of skin tissue. The ascorbic acid comprises 0.05 to 1.2% by weight, preferably 0.08 to 0.5% by weight, based on the total weight of the cosmetic composition. When the content of the ascorbic acid is less than 0.05% by weight, the effect of the wound is insufficient, so a wound healing effect cannot be obtained. If it exceeds 1.2% by weight, flushing or redness of the skin or pain in the bruised area may occur.

The adenosine synthesizes a protein inside the skin due to ATP, which is directly involved in cell growth, differentiation, and homeostasis of adenosine triphosphate (ATP), thereby improving cell regeneration and enhancing skin elasticity. do. The adenosine comprises 0.03 to 1.8% by weight, preferably 0.5 to 1.8% by weight, based on the total weight of the cosmetic composition. If the content of the adenosine is less than 0.03% by weight, efficacy cannot be expected, and if it exceeds 1.8% by weight, the component itself is expensive, and thus has a disadvantage in that price competitiveness is poor.

On the other hand, the Arnica motana (Arnica monata) is effective in reducing bruising and edema. The Arnica montana contains 6 to 10% by weight, preferably 7 to 8% by weight, based on the total weight of the cosmetic composition. If the content of the Arnica montana is less than 7% by weight, efficacy cannot be expected, and when it exceeds 10% by weight, side effects such as gastroenteritis, muscle weakness, cardiovascular disease, and bleeding may occur.

The mucopolysaccharide polysulfate may continuously increase non-ester fatty acids by activating plasma lipoprotein lipolytic enzyme and liver lipolytic enzyme, and reduce triglyceride to suppress blood fat. . Furthermore, it is possible to increase the utilization rate of the plasminogen by reducing the fibrinolysis inhibitor (antiplasmin), thereby exhibiting antithrombotic action by activating the fibrinolysis process. The mucopolysaccharide polysulfate comprises 0.05 to 1.2% by weight, preferably 0.8 to 1.2% by weight, based on the total weight of the cosmetic composition. If the content of the mucopolysaccharide polysulfate is less than 0.05% by weight, the effect is insufficient, and when it exceeds 1.2% by weight, side effects such as rash or allergic skin reaction may be caused.

Meanwhile, the solvent may be water, alcohol, or a mixture thereof, but is not limited thereto, and for example, water may be used.

Furthermore, the cosmetic composition for removing bruises of the present invention may further include at least one component selected from the group consisting of silicone oil, polyhydric alcohol, and additional skin active ingredients and additives.

The silicone oil is cyclopentasiloxane, cyclohexasiloxane, cycloheptasiloxane, cyclomethicone, cyclophenylmethicone, cyclotetrasiloxane, cyclotrisiloxane, dimethicone, capryl dimethicone, caprylyltrimethicone, capryl Reelmethicone, cetearylmethicone, hexadecylmethicone, hexylmethicone, laurylmethicone, myrischilmethicone, phenylmethicone, stearylmethicone, kearyldimethicone, trifluoropropylmethicone, cetyldimethicone It may be at least one selected from the group consisting of chicon, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methylxtrimethicone and phenyltrimethicone, but is not limited thereto. Preferably, cyclopentasiloxane and dimethicone can be used.

The polyhydric alcohol may be at least one selected from the group consisting of glycerin, ethylene glycol, propylene glycol, dipropylene glycol, hexylene glycol, 1,2-hexanediol and butylene glycol, but is not limited thereto. More preferably, glycerin can be used.

The additional skin active ingredients include vitamin A or a precursor thereof, vitamin C precursor, vitamin E precursor, coenzyme cuten, elastin, collagen, hyaluronic acid, ceramide, caffeine, chitosan, alpha bisabolol, betaine, capertripeptide At least one selected from the group consisting of -1 and panthenol can be used.

The additive is at least one selected from the group consisting of surfactants, emulsifiers, pH adjusting agents, acid alkalis, skin conditioning agents, ion blockers, moisturizers, brighteners, preservatives, flavoring agents, fragrances, gelling agents, stabilizers, colorants and pigments It may be, if necessary, can be added to the cosmetic composition.

For example, the cosmetic composition of the present invention may further include 3 to 15% by weight of silicone oil, 2 to 10% by weight of polyhydric alcohol, and 1 to 5% by weight of skin active ingredient based on the total weight of the cosmetic composition, , Preferably 2 to 10% by weight of cyclopentasiloxane, 1 to 3% by weight of dimethicone, 2 to 8% by weight of glycerin, 1 to 4% by weight of niacinamide.

Furthermore, the cosmetic composition for removing bruises of the present invention may be formulated as a solution, suspension, emulsion, paste, gel, cream or spray, and the formulation is not particularly limited.

For example, the cosmetic composition may be formulated with at least one cosmetic selected from the group consisting of skin, lotion, essence, mist, eye cream, nutrition cream, moisture cream, sunblock, foam cleanser and mask pack.

Another embodiment of the present invention provides a bruise removal patch comprising a cosmetic composition for removing bruises of the present invention and a porous support containing the cosmetic composition.

The porous support may be manufactured in a melt-blown manner, and the melt-blown form, by spinning synthetic polymers, generates ultrafine fibers by a high-pressure hot air, resulting in a uniform molten fiber web. Refers to the form produced in combination. The synthetic polymer may be prepared using at least one thermoplastic elastomer selected from the group consisting of polyurethane-based, polystyrene-based, polyolefin-based, polyvinyl chloride-based, polyester-based and polyamide-based, but is not limited thereto. Preferably, a thermoplastic polyurethane elastomer can be used.

Another embodiment of the present invention comprises the steps of preparing a porous support in a melt-blown manner; Impregnating the porous support in a processing solution containing alcohols of C1 to C4; Performing mercerization by adding NaOH to the processing solution; Gelling the porous support by further adding monochloroacetic acid to the processing solution; And applying a cosmetic composition for removing bruises of the present invention to the gelled porous support.

At this time, when manufacturing the porous support in the melt-blown method, the nozzle is controlled to be made of fibers having a cross section of 0.3 to 0.9 µm in diameter, and preferably has pores of 3 µm or less in diameter. By including the pore size and fiber as described above, the patch for removing the bruise of the present invention can be maximized.

On the other hand, the porous support prepared through the nozzle control as described above may be subjected to mercerization and gelation in a processing solution in which alcohols of C1 to C4 are mixed.

The processing liquid may be prepared as follows. First, an alcohol solution in which water and alcohol are mixed in a weight ratio of 7:3 to 3:7 is prepared. The alcohol may be used by mixing isopropyl alcohol and ethanol in a weight ratio of 1:1, but is not limited thereto, and preferably, the alcohol may be at least one selected from the group consisting of isopropyl alcohol, isopropanol and ethanol. .

For mercerization, the entire surface of the porous support is immersed in the processing solution so as to be evenly added, and NaOH is injected at 6 to 17 parts by weight per 100 parts by weight of the processing solution, followed by stirring for 30 minutes to 3 hours. can do. Due to this, the reactivity of the porous support is increased to increase the absorption amount of the cosmetic composition by 10 to 25%, thereby improving the feel. Furthermore, the tensile strength of the porous support can be increased.

Furthermore, it is possible to control the viscosity by gelling the porous support. The gelling can be gelled while forming oxidized cellulose, and the gelling can be gelled by causing an oxidation reaction by mixing the porous support with monochloroacetic acid.

The oxidation reaction may be performed with hydrochloric acid, acetic acid, monochloroacetic acid, and the like, preferably monochloroacetic acid.

For the gelation of the mercerized porous support, monochloroacetic acid may be added to the working solution so that 3 to 10 parts by weight per 100 parts by weight of the working solution. Due to this, as the cellulose oxide is formed on the porous support, gelation proceeds.

Furthermore, the gel-processed porous support can perform any cleaning step if necessary. When performing the washing step, the type of the washing liquid is not particularly limited, and the washing step may be performed two or more times, and a different washing liquid may be used in each washing step. At this time, the cleaning solution may be, for example, water, alcohol, or a combination thereof, and more specifically, the cleaning step is, for example, after washing with 60 to 80% ethanol, neutralizing, and then washing with 90% ethanol. And dried to obtain a gelled porous support from which impurities have been removed. In this case, the drying method is not particularly limited, and may be performed by room temperature drying, hot air drying, vacuum drying, and the like, and may be dried by vacuum drying at 40 to 80° C. for 20 to 40 hours.

By coating the cosmetic composition for removing a bruise of the present invention on the gelled porous support as described above, a patch for removing a bruise can be prepared.

Hereinafter, the present invention will be described in more detail through specific examples. The following examples are only examples for helping the understanding of the present invention, and the scope of the present invention is not limited thereto.

Example

1. For bruising Cosmetic Composition preparation

<Aloe Vera leaves Preparation of extract>

After washing the aloe vera leaves, dried completely at room temperature and pulverized to obtain 300 g of a pulverized product. Aloe vera leaf extract obtained by immersing and extracting by filtration for 8 hours at a temperature of 60°C using a 20-volume ethanol aqueous solution (65% mass concentration) as a solvent for 300 g of pulverized material, and filtering through a filter. Was obtained.

Example 1: For bruising Cosmetic Preparation of the composition

The aloe vera leaf extract, licorice extract, vitamin K, vitamin C (ascorbic acid), arbutin, adenosine, niacinamide, vitamin E (tocopherol), Arnica Montana, and mucopolysaccharide poly in 73.44 g of water Sulfate (Mucopolysaccharide Polysulfate) is mixed with 1 g each, then 6 g of cyclopentasiloxane, 4 g of glycerin, 1 g of dimethicone, 0.5 g of vitamin K, copper tripeptide-1 0.01 g, ceramide-3 0.05 g, hyaluronic acid 0.1 g and panthenol 5 g The mixture was further mixed and slowly stirred at room temperature to prepare a cosmetic composition for removing bruises.

Comparative example One

Commercial Arnica Montana ointment (Deswell eye gel, Clearwater Inc., USA), which is effective in reducing bruising and edema, was used as Comparative Example 1.

Experimental Example 1

In order to measure the effect of removing the bruise of the cosmetic composition of Example 1, after removing the hair on the back of 5 mice 10 weeks old, the wound was cut on the skin and soft tissue with a needle holder with a blunt end and a wide face. A trauma without this was formed.

The cosmetic composition of Example 1 was evenly applied to the portion corresponding to 1/2 of the trauma, and nothing was applied to the portion corresponding to the other 1/2.

The cosmetic composition of Example 1 was applied 3 times a day for 1 week, and the portion after applying the cosmetic composition of Example 1 and the uncoated portion of the day after 1 week were collected to change the gap between collagen fibers and interstitial fluid. Was confirmed.

In order to confirm the gap change of the collagen fiber, 1/2 of each part is stained with hematoxylin-eosin, and the other half is alcian to confirm the presence or absence of interstitial fluid. After staining with Alcian blue, a biopsy was performed. The results are shown in FIG. 1.

The left side of FIG. 1 shows the results of biopsy of the portion where the cosmetic composition of Example 1 was not applied, and the lower portion of the left side of FIG. 1 is a portion dyed with hematoxylin-eosine, and the upper portion is a cyan blue It is dyed. Furthermore, the right side of FIG. 1 shows the biopsy results of the portion to which the cosmetic composition of Example 1 was applied, and the lower portion of the right side of FIG. 1 is a portion dyed with hematoxylin-eosin, and the upper portion is Alcian blue It is dyed with.

Comparative Experimental Example 1

In order to measure the effect of removing the bruise of the ointment of Comparative Example 1, after removing the hair on the back of 5 mice 10 weeks old, the wound was cut into the skin and soft tissue with a needle holder with a blunt end and a wide face. No trauma was formed.

Ointment of Comparative Example 1 was applied to the portion corresponding to 1/2 of the trauma, and nothing was applied to the portion corresponding to the remaining 1/2.

The next day, the portion to which the ointment of Comparative Example 1 was applied and the portion to which nothing was applied were collected to confirm the change in the gap between collagen fibers and the presence of interstitial fluid.

In order to confirm the gap change of the collagen fiber, 1/2 of each part is stained with hematoxylin-eosin, and the other half is alcian to confirm the presence or absence of interstitial fluid. After staining with Alcian blue, a biopsy was performed. The results are shown in FIG. 2.

The left side of FIG. 2 shows the biopsy result of the portion where nothing was applied, and the lower portion of the left side of FIG. 2 is a portion stained with hematoxylin-eosin, and the upper portion is a portion dyed with Alsian Blue. Furthermore, the right side of FIG. 2 shows the biopsy results of the portion to which the ointment of Comparative Example 1 was applied, and the lower portion of the right side of FIG. 2 is a portion stained with hematoxylin-eosine, and the upper portion is a cyan blue It is dyed.

<Evaluation criteria>

The biopsy showed the degree of edema reduction on the basis of the portion where the cosmetic composition of Example 1 was not applied, and edema disappeared (++) and edema compared to the portion where the cosmetic composition of Example 1 was not applied. Although it was reduced, it was not completely removed (+) and edema was measured by classifying it as being maintained at the same level as the portion without applying the cosmetic composition of Example 1 (-). The difference of the comparison was tested for significance at the significance level p<0.05 using the χ ² test of SPSS 11.0.

As a result, as shown in the right side of FIG. 1, the portion coated with the cosmetic composition of Example 1 is a gap of collagen fibers in the portion dyed with hematoxylin-eosin compared to the portion not coated with the cosmetic composition of Example 1 It was confirmed that this was reduced, and it was confirmed that the swelling was reduced by reducing the interstitial fluid in the portion stained with Alcian blue. In addition, due to the above phenomenon, the dermis became thinner, and it was found to be effective in reducing bruising and edema.

Furthermore, in the χ ² test of SPSS 11.0, it was confirmed that all mice of Experimental Example 1 were evaluated as (+).

* In addition, as shown in the right side of Figure 2, the portion injected with the ointment of Comparative Example 1 showed a biopsy result similar to that of the portion coated with the cosmetic composition of Example 1, and the cosmetic composition of Example 1 The degree of bruising and edema reduction was more pronounced than the applied part, and it was confirmed that all of the mice of Comparative Experimental Example 1 were evaluated as (++) in the χ ² test of SPSS 11.0.

2. Manufacturing patch for removing bruise

In order to more easily absorb the cosmetic composition of the present invention into the skin, a cosmetic composition in the form of a patch was prepared.

< Cosmetic Preparation of porous support to which composition is applied>

Thermoplastic polyurethane elastomer was used to prepare the porous support in a meltblown form. The thermoplastic polyurethane elastomer was used commercially easily obtainable.

When manufacturing the porous support, the nozzle was controlled to form a porous support having a pore diameter of 3 µm and a diameter of 0.5 µm in cross-section.

Furthermore, in order to perform mercerization and gelation of the porous support, an alcohol mixture in which isopropyl alcohol and ethanol were mixed in a 1:1 ratio was prepared by mixing a 3:7 ratio with water.

The porous support was impregnated with the processing solution so that the entire surface was evenly introduced, and NaOH was injected to be 10% by weight based on the total weight of the processing solution, followed by stirring for 1 hour to perform mercerization.

Furthermore, to the processing solution that was subjected to mercerization, monochloroacetic acid was added so that 5% by weight based on the total weight of the processing solution was performed to gel the porous support.

The gelled porous support was washed with 70% ethanol, neutralized, then washed with 90% ethanol and vacuum dried at 50°C for 30 hours to obtain a gelled porous support with impurities removed.

Preparation Example 1

After cutting the gelled porous support to be 0.4 cm 2 (0.8 cm×0.5 cm), 150 μg of the cosmetic composition of Example 1 was evenly applied to the porous support to prepare a patch for removing bruises.

Comparative Production Example 1

The patch containing the ointment of Comparative Example 1 was purchased commercially, and was cut to have the same area as in Preparation Example 1.

Experimental Example 2 And Comparative Experimental Example 2

The following experiments were performed to confirm the bruising removal effect and the swelling removal effect on the patches of Preparation Example 1 and Comparative Preparation Example 1.

A male Wistar rat (n=47) of about 8 weeks of age with a weight of about 180 g was used, and in order to confirm the effect of Production Example 1 and Comparative Production Example 1, the rat was inhaled by inhalation of isoflurane. .

The hair of the skin around the lower right eyelid of the anesthetized rat was shaved using an electric barber and an electric razor until the skin became smooth. The next day, after attaching the patch of Preparation Example 1 and the patch of Comparative Preparation Example 1 to the lower right eyelid of the rat, a cover tape is applied on each patch to prevent each patch from detaching from the skin. Did. The patch was removed after attachment for 8 hours. The rat to which the patch of Production Example 1 was attached was set as Experimental Example 2, and the rat to which the patch of Comparative Production Example 1 was attached was set as Comparative Experimental Example 2.

Then, the weight difference of the edema was measured by using a 1 mm punch to measure the edema weight of the rat. At the time of measurement, an accurate measurement was induced after the specimen was culminated using the cervical dislocation method. Table 1 summarizes the results.

group Edema weight [mg] Inhibition rate [%] Rat of Experimental Example 2 34.0±3.0 50.7 Rat of Comparative Experimental Example 2 67.8±1.6 -

As shown in Table 1, the rat with the patch of Preparation Example 1 (rat of Experimental Example 2) had an eyelid edema weight of 34.0±3.0 (mg, mean±SE n=8), and the patch of Comparative Preparation Example 1 It was found that the rat (Ret of Comparative Experimental Example 2) with the weight of the eyelid edema was 67.8±1.6, and the patch prepared by the present invention was effective in suppressing edema. Although described above, the scope of the present invention is not limited to this, and it is obvious to those skilled in the art that various modifications and variations are possible without departing from the technical spirit of the present invention as set forth in the claims. something to do.

Claims (15)

Aloe vera leaf extract, licorice extract, fat-soluble vitamin, whitening compound, skin regeneration compound, Arnica montana, Mucopolysaccharide Polysulfate and the remainder solvent, cosmetic composition for inhibiting edema, and
The cosmetic composition is applied, and includes a porous support treated with monochloroacetic acid after mercerization, a patch for suppressing edema.
According to claim 1, Based on the total weight of the cosmetic composition, the aloe vera leaf extract 0.001 to 10% by weight, the licorice extract 0.05 to 1.1% by weight, the fat-soluble vitamin 0.1 to 2.5% by weight, the whitening compound 0.1 to 2.8% by weight, 0.08 to 3.0% by weight of the skin regeneration compound, 6 to 10% by weight of the Arnica Montana, 0.05 to 1.2% by weight of the Mucopolysaccharide Polysulfate, and the remainder of the solvent Patch to suppress edema.
The method of claim 1, wherein the fat-soluble vitamin is at least one selected from vitamin K and vitamin E, the whitening compound is at least one selected from arbutin and niacinamide, and the skin regeneration compound is at least one selected from vitamin C and adenosine. A patch for suppressing phosphorus and edema.
According to claim 3, Based on the total weight of the cosmetic composition, vitamin K 0.05 to 1.5% by weight, vitamin E 0.05 to 1.0% by weight, arbutin 0.05 to 1.0% by weight, niacinamide 0.05 to 1.8% by weight, vitamin C 0.05 to A patch for suppressing edema, comprising 1.2% by weight, 0.03 to 1.8% by weight of adenosine, and the remainder of the solvent.
The patch for suppressing edema according to claim 1, wherein the cosmetic composition further comprises at least one component selected from the group consisting of silicone oil, polyhydric alcohol, additional skin active ingredients and additives.
The method of claim 5, wherein the silicone oil is cyclopentasiloxane, cyclohexasiloxane, cycloheptasiloxane, cyclomethicone, cyclophenylmethicone, cyclotetrasiloxane, cyclotrisiloxane, dimethicone, capryldimethicone, caprylyl Trimethicone, caprylylmethicone, cetearylmethicone, hexadecylmethicone, hexylmethicone, laurylmethicone, myristolmethicone, phenylmethicone, stearylmethicone, skaryyldimethicone, trifluoro A patch for suppressing edema, which is at least one selected from the group consisting of propylmethicone, cetyldimethicone, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methylxtrimethicone and phenyltrimethicone.
The patch for inhibiting edema according to claim 5, wherein the polyhydric alcohol is at least one selected from the group consisting of glycerin, ethylene glycol, propylene glycol, dipropylene glycol, hexylene glycol, 1,2-hexanediol and butylene glycol. .
The method of claim 5, wherein the additional skin active ingredient is vitamin A or a precursor thereof, a precursor of vitamin C, a precursor of vitamin E, coenzyme cuten, elastin, collagen, hyaluronic acid, ceramide, caffeine, chitosan, alpha bisabolol, A patch for suppressing edema, which is at least one selected from the group consisting of betaine, copper tripeptide-1, and panthenol.
The method of claim 5, wherein the additive is composed of a surfactant, emulsifier, pH adjusting agent, acid alkali agent, skin conditioning agent, ion blocker, moisturizer, brightener, preservative, flavoring agent, fragrance, gelling agent, stabilizer, colorant and pigment A patch for suppressing edema, which is at least one selected from the group.
According to claim 2, Based on the total weight of the cosmetic composition, the cosmetic composition further comprises 3 to 15% by weight of silicone oil, 2 to 10% by weight of polyhydric alcohol and 1 to 5% by weight of additional skin active ingredient, edema Suppression patch.
The patch for inhibiting edema according to claim 1, wherein the cosmetic composition has any one formulation selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, and creams.
The patch for suppressing edema according to claim 1, wherein the porous support is formed of at least one thermoplastic resin selected from the group consisting of polyurethane, polystyrene, polyolefin, polyvinyl chloride, polyester and polyamide.
Preparing a porous support in a melt-blown manner;
Impregnating the porous support in a processing solution containing alcohols of C1 to C4;
Performing mercerization by adding NaOH to the processing solution;
Adding a monochloroacetic acid to the processing solution to process the mercerized porous support; And
After mercerization, aloe vera leaf extract, licorice extract, fat-soluble vitamin, whitening compound, skin regeneration compound, arnica montana, mucopolysaccharide polysulfate and the remainder on the porous support treated with monochloroacetic acid A method of manufacturing a patch for suppressing edema, comprising the step of applying a cosmetic composition for suppressing edema, comprising a solvent.
The method of claim 13, wherein the porous support is made of fibers having a cross section of 0.3 to 0.9 µm in diameter and has pores of 3 µm or less in diameter.
The method of claim 13, wherein the alcohol is at least one selected from the group consisting of isopropyl alcohol, isopropanol, and ethanol.

Images