KR20200083512A - 수술 중의 외과적 마진 평가를 위한 이미징 방법 및 시스템 - Google Patents
수술 중의 외과적 마진 평가를 위한 이미징 방법 및 시스템 Download PDFInfo
- Publication number
- KR20200083512A KR20200083512A KR1020207015037A KR20207015037A KR20200083512A KR 20200083512 A KR20200083512 A KR 20200083512A KR 1020207015037 A KR1020207015037 A KR 1020207015037A KR 20207015037 A KR20207015037 A KR 20207015037A KR 20200083512 A KR20200083512 A KR 20200083512A
- Authority
- KR
- South Korea
- Prior art keywords
- image
- target anatomy
- fov
- collapsed
- fluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000003384 imaging method Methods 0.000 title claims description 32
- 238000001356 surgical procedure Methods 0.000 title abstract description 14
- 238000011156 evaluation Methods 0.000 title abstract description 5
- 208000035346 Margins of Excision Diseases 0.000 title abstract description 4
- 210000003484 anatomy Anatomy 0.000 claims abstract description 75
- 230000005284 excitation Effects 0.000 claims abstract description 38
- 230000035790 physiological processes and functions Effects 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims description 88
- 238000005286 illumination Methods 0.000 claims description 21
- 206010027476 Metastases Diseases 0.000 claims description 18
- 238000001514 detection method Methods 0.000 claims description 8
- 230000009401 metastasis Effects 0.000 claims description 8
- 230000002503 metabolic effect Effects 0.000 claims description 6
- 238000012937 correction Methods 0.000 claims description 3
- 238000003491 array Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 56
- 210000004027 cell Anatomy 0.000 description 28
- 230000006870 function Effects 0.000 description 19
- 206010028980 Neoplasm Diseases 0.000 description 17
- 230000000875 corresponding effect Effects 0.000 description 16
- 238000001727 in vivo Methods 0.000 description 14
- 230000000849 parathyroid Effects 0.000 description 13
- 238000000338 in vitro Methods 0.000 description 11
- 239000003925 fat Substances 0.000 description 10
- 210000003205 muscle Anatomy 0.000 description 9
- 238000004422 calculation algorithm Methods 0.000 description 8
- 102000008186 Collagen Human genes 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 7
- 229920001436 collagen Polymers 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 238000004590 computer program Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000002271 resection Methods 0.000 description 5
- 238000004364 calculation method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 230000003211 malignant effect Effects 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036978 cell physiology Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000002292 fluorescence lifetime imaging microscopy Methods 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 201000002740 oral squamous cell carcinoma Diseases 0.000 description 2
- 210000002990 parathyroid gland Anatomy 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001685 thyroid gland Anatomy 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- 102000015404 Amino Acid Receptors Human genes 0.000 description 1
- 108010025177 Amino Acid Receptors Proteins 0.000 description 1
- 206010061819 Disease recurrence Diseases 0.000 description 1
- 102100035650 Extracellular calcium-sensing receptor Human genes 0.000 description 1
- 101710159793 Extracellular calcium-sensing receptor Proteins 0.000 description 1
- 201000002980 Hyperparathyroidism Diseases 0.000 description 1
- 206010020707 Hyperparathyroidism primary Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- 201000000981 Primary Hyperparathyroidism Diseases 0.000 description 1
- 208000030714 Recurrent Laryngeal Nerve injury Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000007489 histopathology method Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000003703 image analysis method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011503 in vivo imaging Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002559 palpation Methods 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4866—Evaluating metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3937—Visible markers
- A61B2090/3941—Photoluminescent markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
- A61B2505/05—Surgical care
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/04—Arrangements of multiple sensors of the same type
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Obesity (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762580383P | 2017-11-01 | 2017-11-01 | |
| US62/580,383 | 2017-11-01 | ||
| PCT/US2018/058806 WO2019089998A1 (en) | 2017-11-01 | 2018-11-01 | Imaging method and system for intraoperative surgical margin assessment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200083512A true KR20200083512A (ko) | 2020-07-08 |
Family
ID=66333381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207015037A Ceased KR20200083512A (ko) | 2017-11-01 | 2018-11-01 | 수술 중의 외과적 마진 평가를 위한 이미징 방법 및 시스템 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200323431A1 (enExample) |
| EP (1) | EP3704482A4 (enExample) |
| JP (1) | JP7221285B2 (enExample) |
| KR (1) | KR20200083512A (enExample) |
| CN (1) | CN111433603B (enExample) |
| WO (1) | WO2019089998A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3523054A4 (en) | 2016-10-04 | 2020-06-03 | The Regents of The University of California | MULTI-FREQUENCY HARMONIC ACOUSTOGRAPHY FOR TARGET IDENTIFICATION AND BOUNDARY DETECTION |
| WO2020245726A1 (en) | 2019-06-03 | 2020-12-10 | Merunova Pty Ltd. | Mri post-processing systems and methods |
| WO2021034838A1 (en) * | 2019-08-20 | 2021-02-25 | Intuitive Surgical Operations, Inc. | Systems and a method for directing an imaging device to detect fluorescence and for determining a lifetime of the fluorescence |
| WO2021211668A1 (en) | 2020-04-14 | 2021-10-21 | The Regents Of The University Of California | Method and system for selective spectral illumination for optical image guided surgery |
| WO2021222629A1 (en) * | 2020-04-29 | 2021-11-04 | The Regents Of The University Of California | System and method for dynamic optical contrast imaging |
| WO2024060018A1 (en) * | 2022-09-20 | 2024-03-28 | Juan Liu | Non-invasive method for detection, visualization and/or quantification of an endogenous fluorophore such as melanin in a biological tissue |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5467767A (en) * | 1991-11-25 | 1995-11-21 | Alfano; Robert R. | Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy |
| EP1372483A2 (en) * | 2001-03-01 | 2004-01-02 | Trustees of Dartmouth College | Fluorescence lifetime spectrometer (fls) and methods of detecting diseased tissues |
| JP2005534946A (ja) * | 2001-07-06 | 2005-11-17 | パランティア リサーチ，エルエルシー | 撮像システムおよび逆空間光学設計を用いる方法 |
| US7116437B2 (en) * | 2001-09-14 | 2006-10-03 | Dmetrix Inc. | Inter-objective baffle system |
| US20120302892A1 (en) * | 2005-07-25 | 2012-11-29 | Niyom Lue | Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis |
| US8770203B2 (en) * | 2008-07-14 | 2014-07-08 | Immunolight, Llc. | Advanced methods and systems for treating cell proliferation disorders |
| JP5415805B2 (ja) * | 2009-03-31 | 2014-02-12 | オリンパスメディカルシステムズ株式会社 | 診断支援装置 |
| CN105907634B (zh) * | 2010-01-20 | 2018-09-07 | Emd密理博公司 | 细胞图像捕捉和远程监控方法 |
| JP6389763B2 (ja) * | 2012-03-02 | 2018-09-12 | ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 時間分解蛍光画像化およびパルス成形のためのシステムおよび方法 |
| GB201205607D0 (en) * | 2012-03-29 | 2012-05-16 | Ltd Technopath Distrib | A fluorescence microtitre plate reader |
| CN107072505B (zh) * | 2014-04-05 | 2021-03-12 | 手术感应设备公司 | 用于组织氧合的绘制的装置、系统和方法 |
| US10712272B2 (en) * | 2016-09-27 | 2020-07-14 | Trustees Of Tufts College | System and method for assessing cellular metabolic activity |
-
2018
- 2018-11-01 JP JP2020523716A patent/JP7221285B2/ja active Active
- 2018-11-01 CN CN201880076496.7A patent/CN111433603B/zh active Active
- 2018-11-01 EP EP18872191.4A patent/EP3704482A4/en not_active Withdrawn
- 2018-11-01 KR KR1020207015037A patent/KR20200083512A/ko not_active Ceased
- 2018-11-01 WO PCT/US2018/058806 patent/WO2019089998A1/en not_active Ceased
-
2020
- 2020-04-25 US US16/858,594 patent/US20200323431A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN111433603B (zh) | 2022-08-02 |
| EP3704482A4 (en) | 2021-08-18 |
| US20200323431A1 (en) | 2020-10-15 |
| EP3704482A1 (en) | 2020-09-09 |
| JP2021501883A (ja) | 2021-01-21 |
| WO2019089998A1 (en) | 2019-05-09 |
| JP7221285B2 (ja) | 2023-02-13 |
| CN111433603A (zh) | 2020-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20200083512A (ko) | 수술 중의 외과적 마진 평가를 위한 이미징 방법 및 시스템 | |
| US6902935B2 (en) | Methods of monitoring effects of chemical agents on a sample | |
| US10634615B2 (en) | Method of correcting a fluorescence image | |
| US20080015446A1 (en) | Systems and methods for generating fluorescent light images | |
| Jo et al. | Endogenous fluorescence lifetime imaging (FLIM) endoscopy for early detection of oral cancer and dysplasia | |
| US11977027B2 (en) | Device and method for determining the depth of a subsurface fluorescent object within an optically absorbing and scattering medium and for determining concentration of fluorophore of the object | |
| Xie et al. | Wide-field spectrally resolved quantitative fluorescence imaging system: toward neurosurgical guidance in glioma resection | |
| Takahama Junior et al. | Usefulness of tissue autofluorescence imaging in actinic cheilitis diagnosis | |
| WO2021009205A2 (en) | Method and system for electromagnetic spectroscopy of a sample | |
| CN113792568B (zh) | 确定用于判断细胞状态的关键特征的方法 | |
| US10422749B2 (en) | Facilitating real-time visualization of tissue features derived from optical signals | |
| Sherman et al. | Normalized fluorescence lifetime imaging for tumor identification and margin delineation | |
| US20230218154A1 (en) | System and Method for Dynamic Optical Contrast Imaging | |
| Patalay et al. | Non-invasive imaging of skin cancer with fluorescence lifetime imaging using two photon tomography | |
| Jo et al. | Autofluorescence lifetime endoscopy for early detection of oral dysplasia and cancer | |
| US10605736B2 (en) | Optical pathology systems and methods | |
| JPWO2015037055A1 (ja) | 蛍光画像取得装置 | |
| Hu et al. | Dynamic optical contrast imaging for real-time delineation of tumor resection margins using head and neck cancer as a model | |
| WO2025158179A1 (en) | A fluorescence device for oral health | |
| Talbot et al. | A multispectral FLIM tomograph for in-vivo imaging of skin cancer | |
| Priyanka et al. | A survey paper on development of screening device for oral cancer detection | |
| Cuenca Martinez | Novel Technologies for Real-Time Fluorescent Lifetime Imagind Data Acquisition and Processing for Clinical Diagnosis | |
| Schwarz et al. | A comparative study of different instrumental concepts for spectrally and lifetime-resolved multiphoton intravital tomography (5D-IVT) in dermatological applications | |
| Themelis et al. | Advancing the technology and applications of surgical fluorescence imaging with targeted fluorochromes | |
| Wu et al. | Fluorescence detection of neoplastic growths in vivo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20200526 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20211020 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20231002 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20240409 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20231002 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |