JP7221285B2 - 切除縁を術中に評価するための画像化方法およびシステム - Google Patents

切除縁を術中に評価するための画像化方法およびシステム Download PDF

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JP7221285B2
JP7221285B2 JP2020523716A JP2020523716A JP7221285B2 JP 7221285 B2 JP7221285 B2 JP 7221285B2 JP 2020523716 A JP2020523716 A JP 2020523716A JP 2020523716 A JP2020523716 A JP 2020523716A JP 7221285 B2 JP7221285 B2 JP 7221285B2
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image
anatomical target
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map
cells
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JP2021501883A5 (enExample
JP2021501883A (ja
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セント．ジョン，マイエ
サディック，ジョージ
テイラー，ザッカリー
グランドフェスト，ウォレン
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University of California, San Diego
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University of California, San Diego
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4866—Evaluating metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937—Visible markers
    • A61B2090/3941—Photoluminescent markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
    • A61B2505/05—Surgical care
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Obesity (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2020523716A 2017-11-01 2018-11-01 切除縁を術中に評価するための画像化方法およびシステム Active JP7221285B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762580383P 2017-11-01 2017-11-01
US62/580,383 2017-11-01
PCT/US2018/058806 WO2019089998A1 (en) 2017-11-01 2018-11-01 Imaging method and system for intraoperative surgical margin assessment

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JP2021501883A JP2021501883A (ja) 2021-01-21
JP2021501883A5 JP2021501883A5 (enExample) 2021-12-09
JP7221285B2 true JP7221285B2 (ja) 2023-02-13

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US (1) US20200323431A1 (enExample)
EP (1) EP3704482A4 (enExample)
JP (1) JP7221285B2 (enExample)
KR (1) KR20200083512A (enExample)
CN (1) CN111433603B (enExample)
WO (1) WO2019089998A1 (enExample)

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JP7079244B2 (ja) 2016-10-04 2022-06-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ターゲット識別と境界検出のための多周波数高調波アコーストグラフィ
JP7313595B2 (ja) * 2019-06-03 2023-07-25 メルノヴァ プロプライエタリー リミテッド Ｍｒｉ後処理システムと方法
WO2021034838A1 (en) * 2019-08-20 2021-02-25 Intuitive Surgical Operations, Inc. Systems and a method for directing an imaging device to detect fluorescence and for determining a lifetime of the fluorescence
WO2021211668A1 (en) 2020-04-14 2021-10-21 The Regents Of The University Of California Method and system for selective spectral illumination for optical image guided surgery
US12660997B2 (en) 2020-04-29 2026-06-23 The Regents Of The University Of California System and method for dynamic optical contrast imaging
CN120225861A (zh) * 2022-09-20 2025-06-27 莱雅公司 用于检测、可视化和/或定量生物组织中诸如黑色素之类的内源性荧光团的非侵入性方法

Citations (5)

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JP2005504561A (ja) 2001-03-01 2005-02-17 トラスティーズ・オブ・ダートマウス・カレッジ 蛍光寿命分光計（ｆｌｓ）および病変組織の検出方法
JP2009258746A (ja) 2001-07-06 2009-11-05 Palantyr Research Llc 撮像システムおよび逆空間光学設計を用いる方法
JP2010233843A (ja) 2009-03-31 2010-10-21 Olympus Medical Systems Corp 診断支援装置
JP2015508905A (ja) 2012-03-02 2015-03-23 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 時間分解蛍光画像化およびパルス成形のためのシステムおよび方法
JP2015128427A (ja) 2010-01-20 2015-07-16 イー・エム・デイー・ミリポア・コーポレイシヨン 細胞画像取得および遠隔モニタリングシステム

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US5467767A (en) * 1991-11-25 1995-11-21 Alfano; Robert R. Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
WO2003025838A1 (en) * 2001-09-14 2003-03-27 The Arizona Board Of Regents On Behalf Of The University Of Arizona Inter-objective baffle system
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JP2009258746A (ja) 2001-07-06 2009-11-05 Palantyr Research Llc 撮像システムおよび逆空間光学設計を用いる方法
JP2010233843A (ja) 2009-03-31 2010-10-21 Olympus Medical Systems Corp 診断支援装置
JP2015128427A (ja) 2010-01-20 2015-07-16 イー・エム・デイー・ミリポア・コーポレイシヨン 細胞画像取得および遠隔モニタリングシステム
JP2015508905A (ja) 2012-03-02 2015-03-23 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 時間分解蛍光画像化およびパルス成形のためのシステムおよび方法

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Publication number Publication date
CN111433603B (zh) 2022-08-02
US20200323431A1 (en) 2020-10-15
WO2019089998A1 (en) 2019-05-09
KR20200083512A (ko) 2020-07-08
EP3704482A4 (en) 2021-08-18
CN111433603A (zh) 2020-07-17
JP2021501883A (ja) 2021-01-21
EP3704482A1 (en) 2020-09-09

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